Category: 578-57-4

Electric Literature of 578-57-4, The chemical industry reduces the impact on the environment during synthesis 578-57-4, name is 1-Bromo-2-methoxybenzene, I believe this compound will play a more active role in future production and life.

A screw-cap vial equipped with a magnetic stir bar was charged with aryl halide (1 mmol), hexa-n-butylditin (0.5 mmol),palladium acetate (0.01 mmol) and tricyclohexylphosphine (0.02 mmol),followed by anhydrous cesium fluoride (1.5 mmol). The resulting mixture was manually homogenized with a magnet. A vial was transferred to a preheated oil bath (110 C). After 24 h, the mixture was cooled, dissolved in CH2Cl2-H2O mixture (1:1), the organic phase was separated, the solvent was evaporated in vacuo and the product was isolated by flash chromatography on a silica gel by elution with hexane-CH2Cl2 mixture.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Gribanov, Pavel S.; Golenko, Yulia D.; Topchiy, Maxim A.; Philippova, Anna N.; Kirilenko, Nikita Yu.; Krivoshchapov, Nikolai V.; Sterligov, Grigorii K.; Asachenko, Andrey F.; Bermeshev, Maxim V.; Nechaev, Mikhail S.; Mendeleev Communications; vol. 28; 3; (2018); p. 323 – 325;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 578-57-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 578-57-4, name is 1-Bromo-2-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: CuI (0.05 mmol), aryl halide (0.5 mmol), Na3PO4 (0.5 mmol), 25-28% aqueous ammonia (1 mL), and PEG-400 (2 mL) were added to a sealed tube. The reaction mixture was stirred at 100 C (aryl iodides for 15 h and aryl bromides for 24 h) and then cooled to room temperature and extracted with diethyl ether (3 times). The combined organic phase was then dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The remaining residue was purified by column chromatography on silica gel to provide the desired aryl amines.

The synthetic route of 1-Bromo-2-methoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Junmin; Yuan, Tangjun; Hao, Wenyan; Cai, Mingzhong; Tetrahedron Letters; vol. 52; 29; (2011); p. 3710 – 3713;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 578-57-4, A common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 186 mg (1mmol) 2 – bromoanisole, 186 mg (2mmol) aniline, 9.05 mg (0.05mmol) Cu (OAc)2, 36.1 mg (0.1mmol) ligand L3, 489mg (1.5mmol) Cs2CO3, 2 ml MeOH, adding 10 ml reaction tube, sealing, 60 C reaction under the condition of 3h. After the stop of the reaction, water, extracted with ethyl acetate, washing, saturated salt water washing, after drying with anhydrous sodium sulfate, filtered, the filtrate is distilled under reduced pressure, purification by silica gel chromatography separation column column, shall be 2 – methoxy – N – phenylaniline 175 mg, yield 88%.

The synthetic route of 578-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun Yat-sen University; Wan Yiqian; Ding Xiaomei; Huang Manna; Zhu Xinhai; Yi Zhou; CN106883132; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 578-57-4,Some common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, molecular formula is C7H7BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: DMF (40 mL), NaI (375 mg, 2.5 mmol), and 1,2-dibromoethane (100muL, 1.16 mmol) were added to an undivided electrochemical cell, fitted with an iron/nickel (64/36) anode, and surrounded by a nickel foam as the cathode (surface: 40 cm2, porosity: 500 mum, Goodfellow).The mixture was electrolyzed under argon at a constant current intensityof 0.2 A at r.t. for 15 min. The current was then stopped, then NiBr2bpy (187 mg, 0.5 mmol) and aryl or heteroaryl halide (5 mmol),were sequentially added. The solution was electrolyzed at 0.2 A untilthe starting aryl or heteroaryl halide had been totally consumed (2-5h). Sat. aq EDTA-Na2 solution (50 mL) was added, and the resultingsolution was extracted either with EtOAc (for aryl halides) or withCH2Cl2 (for heteroaryl halides) (3 × 50 mL). The combined organic layerswere washed with brine (50 mL), dried (MgSO4), filtered, and concentratedunder vacuum. The crude product was purified by flashchromatography (silica gel, 70-200 mum).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-methoxybenzene, its application will become more common.

Reference:
Article; Rahil, Rima; Sengmany, Stephane; Le Gall, Erwan; Leonel, Eric; Synthesis; vol. 50; 1; (2018); p. 146 – 154;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 578-57-4, A common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 186 mg (1mmol) 2 – bromoanisole, 186 mg (2mmol) aniline, 9.05 mg (0.05mmol) Cu (OAc)2, 36.1 mg (0.1mmol) ligand L3, 489mg (1.5mmol) Cs2CO3, 2 ml MeOH, adding 10 ml reaction tube, sealing, 60 C reaction under the condition of 3h. After the stop of the reaction, water, extracted with ethyl acetate, washing, saturated salt water washing, after drying with anhydrous sodium sulfate, filtered, the filtrate is distilled under reduced pressure, purification by silica gel chromatography separation column column, shall be 2 – methoxy – N – phenylaniline 175 mg, yield 88%.

The synthetic route of 578-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun Yat-sen University; Wan Yiqian; Ding Xiaomei; Huang Manna; Zhu Xinhai; Yi Zhou; CN106883132; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 578-57-4,Some common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, molecular formula is C7H7BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: DMF (40 mL), NaI (375 mg, 2.5 mmol), and 1,2-dibromoethane (100muL, 1.16 mmol) were added to an undivided electrochemical cell, fitted with an iron/nickel (64/36) anode, and surrounded by a nickel foam as the cathode (surface: 40 cm2, porosity: 500 mum, Goodfellow).The mixture was electrolyzed under argon at a constant current intensityof 0.2 A at r.t. for 15 min. The current was then stopped, then NiBr2bpy (187 mg, 0.5 mmol) and aryl or heteroaryl halide (5 mmol),were sequentially added. The solution was electrolyzed at 0.2 A untilthe starting aryl or heteroaryl halide had been totally consumed (2-5h). Sat. aq EDTA-Na2 solution (50 mL) was added, and the resultingsolution was extracted either with EtOAc (for aryl halides) or withCH2Cl2 (for heteroaryl halides) (3 × 50 mL). The combined organic layerswere washed with brine (50 mL), dried (MgSO4), filtered, and concentratedunder vacuum. The crude product was purified by flashchromatography (silica gel, 70-200 mum).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-methoxybenzene, its application will become more common.

Reference:
Article; Rahil, Rima; Sengmany, Stephane; Le Gall, Erwan; Leonel, Eric; Synthesis; vol. 50; 1; (2018); p. 146 – 154;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 578-57-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578-57-4, name is 1-Bromo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

n-BuLi (3.5 ml of a 1.6 M solution in hexane) was added with stirring at 0 C to a solution of 2-bromoanisole (1.0 g, 5.34 mmol) in dry hexane (10 ml) and the mixture was allowed to stir at room temperature. After 2 h stirring the n-butyl bromide formed in the reaction mixture was evaporated under reduced pressure without introduction of air. Dry THF (10 ml) was added followed by the addition of the finely ground selenium powder (0.42 g, 5.34 mmol) at 0 C. It was stirred for 4 h. It was poured to the ice-cooled saturated NaHCO3 solution and O2 gas was passed to the mixture in a moderate rate for 15 min. The compound was extracted with diethyl ether and dried with anhydrous Na2SO4. The solvent was evaporated to obtain yellow-colored solid. The compound was purified in flash chromatography using petroleum ether and ethyl acetate as solvent. It was characterized by NMR spectroscopy. Yield: 0.58 g (31%), 1H NMR (CDCl3), delta (ppm): 3.91 (s, 6H, OCH3), 6.80-6.83 (d, 2H, ArH), 6.85-6.89 (m, 2H, ArH), 7.19-7.23 (m, 2H, ArH), 7.53-7.55 (d, 2H, ArH); 13C NMR (CDCl3), delta (ppm): 56.4, 110.6, 119.1, 122.4, 128.6, 131.0, 157.3; 77Se NMR (CDCl3), delta (ppm): 328. ESI-MS: m/z: calcd for C14H13O2Se2 [M+Na]+: 396.9222; found: 397.0495.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Bhowmick, Debasish; Mugesh, Govindasamy; Tetrahedron; vol. 68; 51; (2012); p. 10550 – 10560,11;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 578-57-4,Some common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, molecular formula is C7H7BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a 10 mL sealed vial was added Cu(OAc)2·H2O (10 mg, 0.05mmol), N-methoxy-1H-pyrrole-2-carboxamide (7 mg, 0.05 mmol), aryl bromide (1.0 mmol), amine (3.0 mmol), K3PO4 (318 mg, 1.5 mmol),PEG-100 (2.0 g) and a magnetic stir bar. The reaction mixture was stirred in an oil bath preheated to 90 C for 12 h. After allowing the mixture to cool to room temperature, the reaction mixture was extracted with ethyl acetate (3 × 25 mL) and water (20 mL). The combined organic phases were washed with brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel to afford the desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-methoxybenzene, its application will become more common.

Reference:
Article; Huang, Manna; Hou, Jianying; Yang, Ruiqiao; Zhang, Liting; Zhu, Xinhai; Wan, Yiqian; Synthesis; vol. 46; 24; (2014); p. 3356 – 3364;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 578-57-4, These common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 10 mL vial was charged with CuI (9.5 mg, 0.05 mmol), PSAP (30 mg,0.05 mmol, > 100 mesh), K3PO4 (424 mg, 2 mmol), aryl bromides (1mmol), amines (1.5 mmol), DEG (2 mL), and a magnetic stir bar. The vessel was sealed with a septum and placed into a preheated oil batchat 70 C. The reaction mixture was held at this temperature for 14 hours. After cooling to r.t., the reaction mixture was filtered, and the precipitates were thoroughly washed with water and EtOAc (3 × 20mL). The combined organic phases were washed with water and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. Theresidue was purified using flash column chromatography on silica gel(eluting with petroleum ether/EtOAc) to afford the desired products.

Statistics shows that 1-Bromo-2-methoxybenzene is playing an increasingly important role. we look forward to future research findings about 578-57-4.

Reference:
Article; Yi, Zhou; Huang, Manna; Wan, Yiqian; Zhu, Xinhai; Synthesis; vol. 50; 19; (2018); p. 3911 – 3920;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 578-57-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578-57-4, name is 1-Bromo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

In a reaction tube, dissolve palladium complex [Pd] (0.03 mmol) and o-methoxybromobenzene (1.0 mmol) in 3 mL of toluene,extract and ventilate three timesin a CO2atmosphere, and connect a CO2balloonunder normal pressure. The reaction was carried out at 60 C for 8 hours. After the reaction, the reaction mixture was acidified. The reaction solution was concentrated and separated by column chromatography to obtain the corresponding product C8H8O3(yield 91%).

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Institute of Technology; Yao Zijian; Chen Jing; (9 pag.)CN110483581; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem