Category: 57602-02-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57602-02-5, name is 1,14-Dibromo-3,6,9,12-tetraoxatetradecane, A new synthetic method of this compound is introduced below., Safety of 1,14-Dibromo-3,6,9,12-tetraoxatetradecane

General procedure: Thioacetate 3 (2.2 eq) and dibromide (1eq) were dissolved in dry DMF. DEA was added dropwise and the reaction was stirred for 3 h at room temperature. Then the reaction mixture was washed with 1 M HCl (aq), extracted with CH 2Cl 2, dried with Na 2SO 4. The solution was concentrated and purified by column chromatography.

The synthetic route of 57602-02-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Yang; He, Yun; Li, Xingzhe; Dinh, Hieu; Iyer, Suri S.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 636 – 643;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 57602-02-5, name is 1,14-Dibromo-3,6,9,12-tetraoxatetradecane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57602-02-5, category: ethers-buliding-blocks

1,14-dibramo-3,6,9,12-tetraoxatetradecane (3.35 g, 9.2 mmol) and sodium methanethiosulfonate (2.48 g, 18.5 mmol) were dissolved in dry DMF (40 mL) and stirred at room temperature for 3 days. The solvent was evaporated. The residue was purified by column chromatography on SiO2. Elution with ethyl acetate/hexane (9:1) afforded, after evaporation, 1-(14-bromo-3,6,9,12-tetraoxatetradecyl) methanethiosulfonate (0.85 g) as a pale yellow oil and tetraoxatetradecane-1,14-diyl-bis-methanethiosulfonate (useful as a cross linker) as a slightly yellow colored oil (1.64 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,14-Dibromo-3,6,9,12-tetraoxatetradecane, and friends who are interested can also refer to it.

Reference:
Patent; Dime, David S.; Backx, Peter; Kimmeldirk, Klaus; EP966304; (2005); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57602-02-5, name is 1,14-Dibromo-3,6,9,12-tetraoxatetradecane, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 57602-02-5

Example 2 Synthesis of Double End-Substituted Pentaethyleneglycol-Sumatriptan (SMQT-02) Sumatriptan (236 mg, 0.8 mmol) is dissolved in 2 mL dry DMF, 60% NaH (32 mg, 0.8 mmol) is added, stirred and react 15 minutes, triethylene glycol 2-bromoethyl (145.6 mg, 0.4 mmol) is added, and reaction is performed overnight under nitrogen gas protection. Water is added to the above reaction liquid to quench the reaction, extraction is performed three times by using acetic ether, an organic phase is dried by using anhydrous sodium sulfate, concentrate goes through column separation to obtain 184 mg product, with a yield rate 58%. 1H-NMR (CDCl3): 2.34 (s, 12H), 2.70 (t, 4H), 2.72 (s, 6H), 2.94 (t, 4H), 3.06 (t, 4H), 3.40 (t, 4H), 3.49 (s, 12H), 4.35 (s, 4H), 6.98 (s, 2H), 7.11 (d, 2H), 7.23 (d, 2H), 7.60 (s, 2H), 8.91 (s, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57602-02-5.

Reference:
Patent; JENKEM TECHNOLOGY CO.,LTD.(TIANJIN); XU, Lihua; ZHAO, Xuan; FENG, Zewang; WANG, Jinliang; WANG, Zhenguo; (16 pag.)US2016/82117; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem