Category: 56621-48-8

Velingkar, V. S.; Ahire, D. C.; Koihe, N. S.; Shidore, M. S. published an article about the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8,SMILESS:OC1=CC=C(N2CCNCC2)C=C1 ).Recommanded Product: 4-(Piperazin-1-yl)phenol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56621-48-8) through the article.

The title compounds were synthesized and characterized by spectral anal. (IR, 1H NMR, mass spectroscopy). The effect of the synthesized compounds on inflammation, using the carrageenan induced mouse paw edema model was studied. In general, the compounds were found to be potent antiinflammatory agents. Antiinflammatory activity was influenced by some structural characteristics of the synthesized compounds

Although many compounds look similar to this compound(56621-48-8)Recommanded Product: 4-(Piperazin-1-yl)phenol, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56621-48-8, is researched, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2OJournal, Journal of the Electrochemical Society called Electrochemical oxidation of 4-(piperazin-1-yl)phenol in the presence of aryl sulfinic acids, Author is Nematollahi, Davood; Khazalpour, Sadegh; Amani, Amene, the main research direction is electrochem oxidation piperazinylphenol aryl sulfinic acid addition.COA of Formula: C10H14N2O.

Electrochem. oxidation of 4-(piperazin-1-yl)phenol was studied in the presence of aryl sulfinic acids as nucleophiles in EtOH/H2O mixture (10/90) using cyclic voltammetry and controlled-potential coulometry methods. The electrochem. generated p-quinone-imine participates in Michael type addition reaction with aryl sulfinic acids and via an EC mechanism converts to the new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives The present work led to the development of a facile and environmentally friendly electrochem. method for the synthesis of some new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives under green conditions.

Although many compounds look similar to this compound(56621-48-8)COA of Formula: C10H14N2O, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.COA of Formula: C10H14N2O. The article 《Synthesis, characterization and photovoltaic behaviours of peripheral and non-peripheral tetra-[4-(4-octylpiperazin-1-yl)phenoxy] substituted zinc(II), cobalt(II), copper(II) and indium(III) phthalocyanines》 in relation to this compound, is published in Inorganica Chimica Acta. Let’s take a look at the latest research on this compound (cas:56621-48-8).

The synthesis of zinc(II), cobalt(II), copper(II) and indium(III)(OAc) phthalocyanines carrying four 4-(4-octylpiperazin-1-yl)phenoxy moieties in peripheral/non-peripheral positions were performed by the cyclotetramerization of compounds 4-[4-(4-octylpiperazin-1-yl)phenoxy]phthalonitrile or 3-[4-(4-octylpiperazin-1-yl)phenoxy]phthalonitrile with resp. metal salts. The novel phthalonitriles and phthalocyanines were characterized by elemental and spectroscopic anal., including 1H NMR, 13C NMR, FTIR, UV-visible spectral and MALDI-TOF mass data. To clarify the influence of the position of substituent group and the variety of the central metal atom on the photovoltaic performance, bulk heterojunction devices by using phthalocyanines with different blend ratio, as donor was fabricated and characterized.

Although many compounds look similar to this compound(56621-48-8)Category: ethers-buliding-blocks, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.Category: ethers-buliding-blocks. The article 《Novel N,S- and S,S-substituted dienes synthesized from mercapto triazole and some amine derivatives》 in relation to this compound, is published in Phosphorus, Sulfur and Silicon and the Related Elements. Let’s take a look at the latest research on this compound (cas:56621-48-8).

2-Nitro diene Cl2C:CClC(NO2):CCl2 reacted with 3-mercapto-1,2,4-triazole (I) and cyclohexanethiol to yield the resp. dithioacetals Cl2C:CClC(NO2):C(SR)R1 (II; R = 1,2,4-triazol-3-yl, cyclohexyl; R1 = SR). Dithioacetals II (R = 1,2,4-triazol-3-yl; R1 = octylthio, decylthio, hexdecylthio, cyclohexylthio) were obtained by reactions of appropriate vinyl sulfides with I. Novel N,S-substituted dienes were obtained by treatment of II [R = decyl, R1 = Cl (III)] with piperazines. Compound III was reacted with N-(2-aminoethyl)morpholine to give the corresponding N,S-substituted diene. Compound III gave a new N-butadienylhomopiperazine on reaction with homopiperazine in CH2Cl2. Compound II (R = cyclohexyl, R1 = cyclohexylthio) was characterized by single-crystal x-ray diffraction [monoclinic, space group P21/n, a 12.0862(12), b 11.1625(8), c 16.337(1) Å, β 110.840(4)°, V 2059.9(3) Å3, Z 4].

Although many compounds look similar to this compound(56621-48-8)Computed Properties of C10H14N2O, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Synthesis of propargylamine mycophenolate analogues and their selective cytotoxic activity towards neuroblastoma SH-SY5Y cell line, the main research direction is propargylamine mycophenolate analog preparation mol docking neuroblastoma anticancer; A(3)-coupling reaction; Cytotoxic activity; Molecular docking; Mycophenolic Acid; Neuroblastoma SH-SY5Y cells; Propargylamine mycophenolate.SDS of cas: 56621-48-8.

Twenty six propargylamine mycophenolate analogs were designed and synthesized from mycophenolic acid 1 employing a key step A3-coupling reaction. Their cytotoxic activity was examined against six cancer cell lines. Four compounds exhibited selective cytotoxicity towards neuroblastoma (SH-SY5Y) cancer cells and were less toxic to normal cells in comparison to the lead compound, MPA 1 and a standard drug, ellipticine. Mol. docking results suggested that compound I is fit well in the key amino acid of three proteins (CDK9, EGFR, and VEGFR-2) as targets in cancer therapy. The propargylamine mycophenolate scaffold might be a valuable starting point for development of new neuroblastoma anticancer drugs.

Although many compounds look similar to this compound(56621-48-8)SDS of cas: 56621-48-8, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole. The article 《Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:56621-48-8).

Antagonism of the adenosine A2A receptor offers great promise in the treatment of Parkinson’s disease. Employing the known pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonist SCH 58261 as a starting point, we identified the potent and selective (vs. A1) antagonist 11h (I), orally active in the rat haloperidol-induced catalepsy model. We further optimized this lead to the methoxyethoxyethyl ether 12a (SCH 420814), which shows broad selectivity, good pharmacokinetic properties, and excellent in vivo activity.

Although many compounds look similar to this compound(56621-48-8)Category: ethers-buliding-blocks, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.Synthetic Route of C17H19N3O2S. The article 《Electrochemical Synthesis of a New Derivative of 1,4-Dihydroxybenzene: Embedded Nucleophile in the Structure of Electrophile》 in relation to this compound, is published in Journal of the Electrochemical Society. Let’s take a look at the latest research on this compound (cas:56621-48-8).

The electrochem. oxidation of 4-(Piperazin-1-yl)phenols (1a,b) was studied in the H2O, MeCN and nitromethan by cyclic voltammetry and controlled-potential coulometry. P-quinone-imines generated of oxidation 4-(Piperazin-1-yl)phenols after the hydrolysis reaction participate in Michael-addition reactions with released piperazine of hydrolysis reaction of p-quinone imines. The present work led to the development of a facile and environmentally friendly electrochem. method for the synthesis of a new derivative of 1,4-dihydroxybenzene under green conditions. The effect of H2O as a solute on the electrochem. response of 4-(Piperazin-1-yl)phenols (1a,b) was examined in the MeCN (AN) and nitromethane (NM) solvent.

Although many compounds look similar to this compound(56621-48-8)Electric Literature of C10H14N2O, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic, Author is Pace, Jennifer R.; DeBerardinis, Albert M.; Sail, Vibhavari; Tacheva-Grigorova, Silvia K.; Chan, Kelly A.; Tran, Raymond; Raccuia, Daniel S.; Wechsler-Reya, Robert J.; Hadden, M. Kyle, which mentions a compound: 56621-48-8, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2O, Reference of 4-(Piperazin-1-yl)phenol.

Itraconazole (ITZ) is an FDA-approved member of the triazole class of antifungal agents. Two recent drug repurposing screens identified ITZ as a promising anticancer chemotherapeutic that inhibits both the angiogenesis and hedgehog (Hh) signaling pathways. We have synthesized and evaluated first- and second-generation ITZ analogs for their anti-Hh and antiangiogenic activities to probe more fully the structural requirements for these anticancer properties. Our overall results suggest that the triazole functionality is required for ITZ-mediated inhibition of angiogenesis but that it is not essential for inhibition of Hh signaling. The synthesis and evaluation of stereochem. defined des-triazole ITZ analogs also provides key information as to the optimal configuration around the dioxolane ring of the ITZ scaffold. Finally, the results from our studies suggest that two distinct cellular mechanisms of action govern the anticancer properties of the ITZ scaffold.

Compounds in my other articles are similar to this one(4-(Piperazin-1-yl)phenol)Reference of 4-(Piperazin-1-yl)phenol, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Song, Jiho; Lee, Hyun-e; Kim, Young Jin; Kim, Su Yeon; Kim, Dong-Seok; Min, Kyung Hoon published an article about the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8,SMILESS:OC1=CC=C(N2CCNCC2)C=C1 ).Formula: C10H14N2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56621-48-8) through the article.

5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-MSH (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Three of the compounds (IC50 = 0.67 μM), (IC50 = 1.01 μM) and (IC50 = 0.99 μM) exhibited a potent inhibitory activity approx. 85- to 126-fold greater than kojic acid, a well-known potent inhibitor. A biochem. study indicates that the activity of this series should be displayed via down-regulation of the expression of tyrosinase.

Compounds in my other articles are similar to this one(4-(Piperazin-1-yl)phenol)Formula: C10H14N2O, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, anticancer activity and molecular docking studies of new 4-nitroimidazole derivatives, published in 2021, which mentions a compound: 56621-48-8, Name is 4-(Piperazin-1-yl)phenol, Molecular C10H14N2O, Product Details of 56621-48-8.

Herein, we report the synthesis of 3-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-ylsulfanyl)-1-(4-substituted phenyl-piperazin-1-yl)-propan-1-one I [R = H, 2-F, 4-Cl, etc.] by reaction of 3-(1-benzyl-2-methyl-4-nitro-1H-imidazol-5-ylsulfanyl)-propanoyl chloride (3) with piperazine nucleophiles. Eighteen compounds were assessed for their antiproliferative inhibition potency against four human cancer cell lines (MCF-7, PC3, MDA MB231 and Du145). Compounds I [R = 2-Me, 2-OH]were the most potent anticancer agents on MCF-7 cell lines cell line with IC50 value of 1.0μg/mL, while I [R = 2-CN, 4-Cl] exhibited cytotoxic effect on PC3 and DU145 cell lines with IC50 values of 4.0 and 5.0μg/mL, resp. The mol. docking of compounds I [R = 2-Me, 2-CN, 4-Cl] was studied.

Compounds in my other articles are similar to this one(4-(Piperazin-1-yl)phenol)Product Details of 56621-48-8, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem