Category: 56621-48-8

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry called Discovery of a new potent inhibitor of mushroom tyrosinase (Agaricus bisporus) containing 4-(4-hydroxyphenyl)piperazin-1-yl moiety, Author is De Luca, Laura; Germano, Maria Paola; Fais, Antonella; Pintus, Francesca; Buemi, Maria Rosa; Vittorio, Serena; Mirabile, Salvatore; Rapisarda, Antonio; Gitto, Rosaria, which mentions a compound: 56621-48-8, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2O, Computed Properties of C10H14N2O.

Tyrosinase (TYR, EC 1.14.18.1) plays a pivotal role in mammalian melanogenesis and enzymic browning of plant-derived food. Therefore, tyrosinase inhibitors (TYRIs) can be of interest in cosmetics and pharmaceutical industries as depigmentation compounds as well as anti-browning agents. Starting from 4-benzylpiperidine derivatives that showed good inhibitory properties toward tyrosinase from Agaricus bisporus (TyM), we synthesized a new series of TYRIs named 3-(4-benzyl-1-piperidyl)-1-(4-phenylpiperazin-1-yl)propan-1-one and 2-(4-benzyl-1-piperidyl)-1-(4-phenylpiperazin-1-yl)ethanone derivatives Among them, compound 4b proved to be the most potent inhibitor (IC50 = 3.80μM) and it also showed a good antioxidant activity. These new data furnished addnl. information about the SAR for this class of TYRIs.

There is still a lot of research devoted to this compound(SMILES：OC1=CC=C(N2CCNCC2)C=C1)Computed Properties of C10H14N2O, and with the development of science, more effects of this compound(56621-48-8) can be discovered.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kondeva-Burdina, Magdalena; Valkova, Iva; Andonova, Lily; Georgieva, Maya; Tzankova, Virginia; Zlatkov, Alexander published the article 《Quantitative structure-hepatotoxicity assessment of series arylpiperazine-N1-substituted theobromine derivatives》. Keywords: arylpiperazinylalkyl theobromine preparation hepatotoxicity.They researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).Synthetic Route of C10H14N2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56621-48-8) here.

In this work series new theobromines, compounds I [R = benzyl, 4-hydroxyphenyl, bis(4-fluorophenyl)methyl, etc.; n = 3,4] with established antioxidant and antiproliferative activities were evaluated for their hepatotoxic effects on cellular and sub-cellular level. On isolated rat hepatocytes, compounds I [R = 4-hydroxyphenyl, n = 3,4] expressed lowest toxicity, while compounds I [R = bis(4-fluorophenyl)methyl, n = 3,4] showed highest toxicity. Compounds I [R = bis(4-fluorophenyl)methyl, n = 3,4] showed the most evident pro-oxidant effect in a lipid peroxidation model on rat liver microsomes, followed by compounds I [R = 4-fluorophenyl, n = 3,4], while the other compounds didn’t reveal statistically significant pro-oxidant effects. The performed quant. structure-toxicity relationship (QSTR) anal. show that increased lipophilicity of the tested compounds pos. correlates to their hepatotoxicity. Opposite, the presence in the structure of highly pos. H-atoms and strongly neg. oxygen, possibly originating from hydrogen bond donor groups, are associated with reduced hepatotoxicity.

There is still a lot of research devoted to this compound(SMILES：OC1=CC=C(N2CCNCC2)C=C1)Synthetic Route of C10H14N2O, and with the development of science, more effects of this compound(56621-48-8) can be discovered.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 4-(Piperazin-1-yl)phenol. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. Author is Pace, Jennifer R.; Teske, Kelly A.; Chau, Lianne Q.; Dash, Radha Charan; Zaino, Angela M.; Wechsler-Reya, Robert J.; Hadden, M. Kyle.

The Food and Drug Administration-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biol. properties. In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to serve as an anticancer chemotherapeutic against several Hh-dependent malignancies. We have extended our studies on ITZ analogs as Hh pathway inhibitors through the design, synthesis, and evaluation of novel des-triazole ITZ analogs that incorporate modifications to the triazolone/side chain region of the scaffold. Our overall results suggest that the triazolone/side chain region can be replaced with various functionalities (hydrazine carboxamides and meta-substituted amides) resulting in improved potency when compared to ITZ. Our studies also indicate that the stereochem. orientation of the dioxolane ring is important for both potent Hh pathway inhibition and compound stability. Finally, our studies suggest that the ITZ scaffold can be successfully modified in terms of functionality and stereochem. to further improve its anti-Hh potency and physicochem. properties.

There is still a lot of research devoted to this compound(SMILES：OC1=CC=C(N2CCNCC2)C=C1)Reference of 4-(Piperazin-1-yl)phenol, and with the development of science, more effects of this compound(56621-48-8) can be discovered.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C10H14N2O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about SuFEx-enabled, chemoselective synthesis of triflates, triflamides and triflimidates.

Sulfur(VI) Fluoride Exchange (SuFEx) chem. has emerged as a next-generation click reaction, designed to assemble functional mols. quickly and modularly. Here, we report the ex situ generation of trifluoromethanesulfonyl fluoride (CF3SO2F) gas in a two chamber system, and its use as a new SuFEx handle to efficiently synthesize triflates and triflamides. This broadly tolerated protocol lends itself to peptide modification or to telescoping into coupling reactions. Moreover, redesigning the SVI-F connector with a S=O → S=NR replacement, furnished the analogous triflimidoyl fluorides as SuFEx electrophiles, which were engaged in the synthesis of rarely reported triflimidate esters. Notably, experiments showed H2O to be the key towards achieving chemoselective trifluoromethanesulfonation of phenols vs. amine groups, a phenomenon best explained-using ab initio metadynamics simulations-by a hydrogen bonded termol. transition state for the CF3SO2F triflylation of amines.

There is still a lot of research devoted to this compound(SMILES：OC1=CC=C(N2CCNCC2)C=C1)Synthetic Route of C10H14N2O, and with the development of science, more effects of this compound(56621-48-8) can be discovered.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gomes, Tatiana F.; Pompeu, Thais E. T.; Rodrigues, Daniel A.; Noel, Francois; Menegatti, Ricardo; Andrade, Carolina H.; Sabino, Jose R.; Gil, Eric S.; Dalla Costa, Teresa; Betti, Andresa H.; Antonio, Camila B.; Rates, Stela M. K.; Fraga, Carlos A. M.; Barreiro, Eliezer J.; de Oliveira, Valeria researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).Category: ethers-buliding-blocks.They published the article 《Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound》 about this compound( cas:56621-48-8 ) in European Journal of Medicinal Chemistry. Keywords: antipsychotic resistance LASSBio579 organic synthesis phydroxylated metabolite biosynthesis redox; crystal structure LASSBio579 metabolite CYP1A2 enzymic hydroxylation pharmacokinetics hematotoxicity; mol dynamics simulation docking structure LASSBio579 metabolism antipsychotic schizophrenia. We’ll tell you more about this compound (cas:56621-48-8).

Using a combination of docking and mol. dynamics simulations, we predicted that p-hydroxylation by CYP1A2 would be the main metabolic pathway for the 1-[1-(4-chlorophenyl)-1H-4pyrazolylmethyl] phenylhexahydropiperazine, LASSBio-579. As the result of a screening process with strains of filamentous fungi, Cunninghamella echinulata ATCC 9244 was chosen to scale up the preparation of the p-hydroxylated metabolite. About 30 min after i.p. administration of LASSBio-579 to rats was identified as the p-hydroxylated metabolite, confirming our in silico previsions. Chem. synthesis of the metabolite was performed and allowed its pharmacol. evaluation in binding assays revealing its high affinity for D2 and D4 receptors, indicating that this metabolite should participate to the antipsychotic effect of LASSBio-579 in vivo. Furthermore, we report here that both LASSBio-579 and its p-hydroxylated metabolite have a much lower affinity than clozapine for two receptors involved in adverse reactions. Voltammetric assays were useful to understand the redox profile of LASSBio-579.

If you want to learn more about this compound(4-(Piperazin-1-yl)phenol)Category: ethers-buliding-blocks, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56621-48-8).

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Synthesis and characterization of 3-substituted indole derivatives as novel Mannich bases, the main research direction is piperazinyl methyl indole preparation; indole piperazine formalin Mannich microwave irradiation.Name: 4-(Piperazin-1-yl)phenol.

In this study, indole-based 4-substituted piperazine derivatives I [R = Me, 4-BrC6H4, 4-HOC6H4, 4-F3C6H4, etc.] were synthesized via Mannich reaction with microwave assisted synthesis and the conventional reflux heating method. Microwave assisted synthesis was more preferable than reflux method since the microwave irradiation lead to a higher product yields with better purity and improved energy efficiency with shortened reaction time. The structures of 3-substituted indole derivatives I were characterized by FT-IR, elemental anal., 1H NMR and 13C NMR spectroscopy.

If you want to learn more about this compound(4-(Piperazin-1-yl)phenol)Name: 4-(Piperazin-1-yl)phenol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56621-48-8).

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Recommanded Product: 56621-48-8.Kulig, Katarzyna; Sapa, Jacek; Maciag, Dorota; Filipek, Barbara; Malawska, Barbara published the article 《Synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxypropyl]-pyrrolidin-2-one derivatives with anti-arrhythmic, hypotensive, and α-adrenolytic activity》 about this compound( cas:56621-48-8 ) in Archiv der Pharmazie (Weinheim, Germany). Keywords: piperazine pyrrolidinone preparation antiarrhythmic hypotensive adrenolytic SAR. Let’s learn more about this compound (cas:56621-48-8).

A series of novel arylpiperazines bearing a pyrrolidin-2-one fragment was synthesized and evaluated for the binding affinity of the α1- and α2-adrenoceptors (AR) and for the antiarrhythmic and hypotensive activities of the compounds The most potent and selective compound 1-[2-hydroxy-3-[4-[(2-hydroxyphenyl)piperazin-1-yl]propyl]pyrrolidin-2-one 8 binds with pKi = 6.71 for α1-AR. Derivative 8 (I) was also the most active in the prophylactic antiarrhythmic test in adrenaline-induced arrhythmia in anesthetized rats. Its ED50 value equals 1.9 mg/kg (i.v.). Compounds with substituents such as a fluorine atom 4, a Me 5, or a hydroxyl 8 group, or two substituents such as fluorine/chlorine atoms and methoxy groups in the Ph ring, significantly decreased the systolic and diastolic pressure in normotensive anesthetized rats at a dosages of 5-10 mg/kg (i.v.). It was found that the presence of the piperazine ring and a hydroxy group in the second position of the Pr chain are critical structural features in determining the affinity of the compounds tested.

If you want to learn more about this compound(4-(Piperazin-1-yl)phenol)Recommanded Product: 56621-48-8, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56621-48-8).

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 56621-48-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Design, synthesis, and structure-activity relationship studies of novel pleuromutilin derivatives having a piperazine ring. Author is Luo, Jian; Yang, Qiu-E.; Yang, Yuan-Yuan; Tang, You-Zhi; Liu, Ya-Hong.

A series of novel pleuromutilin derivatives I (R = 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 2-HOC6H4, 3-HOC6H4, 4-HOC6H4, 2-NO2C6H4, 3-NO2C6H4, 4-NO2C6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, Ph, Me), possessing piperazine moieties were synthesized under mild conditions. The in vitro antibacterial activities of these derivatives against Staphylococcus aureus and Escherichia coli were tested by the agar dilution method. Structure-activity relationship studies resulted in compounds 11b (R = 3-MeOC6H4), 13b (R = 3-HOC6H4), and 14a (R = 2-NO2C6H4) with the most potent in vitro antibacterial activity among the series (minimal inhibitory concentration of 0.0625-0.125 μg/mL). The binding of compounds 11b, 13b, and 14a to the E. coli ribosome was investigated by mol. modeling, and it was found that there is a reasonable correlation between the binding free energy and the antibacterial activity.

If you want to learn more about this compound(4-(Piperazin-1-yl)phenol)Recommanded Product: 56621-48-8, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56621-48-8).

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 4-(Piperazin-1-yl)phenol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Divergent Pathways for Reactions of 3-Formylchromone with Cyclic Secondary Amines in Alcoholic Media.

Reaction of 3-formylchromone with cyclic secondary amines in methanol results in (E)-chromanones I [X = CH, R = Ph; X = O, R = none; X = N, R = 4-MeC6H4, 2,6-Me2C6H3, 2-MeOC6H4, etc.] and II, while use of ethanol leads to (E)-bis(morpholino)chromanone III or enaminoketones as dihydropyran ring-opening products. The solubility of the formed products in alc. media is postulated to be a key factor that determines the reaction pathway.

If you want to learn more about this compound(4-(Piperazin-1-yl)phenol)Recommanded Product: 4-(Piperazin-1-yl)phenol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56621-48-8).

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors, Author is Pace, Jennifer R.; Teske, Kelly A.; Chau, Lianne Q.; Dash, Radha Charan; Zaino, Angela M.; Wechsler-Reya, Robert J.; Hadden, M. Kyle, which mentions a compound: 56621-48-8, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2O, Name: 4-(Piperazin-1-yl)phenol.

The Food and Drug Administration-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biol. properties. In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to serve as an anticancer chemotherapeutic against several Hh-dependent malignancies. We have extended our studies on ITZ analogs as Hh pathway inhibitors through the design, synthesis, and evaluation of novel des-triazole ITZ analogs that incorporate modifications to the triazolone/side chain region of the scaffold. Our overall results suggest that the triazolone/side chain region can be replaced with various functionalities (hydrazine carboxamides and meta-substituted amides) resulting in improved potency when compared to ITZ. Our studies also indicate that the stereochem. orientation of the dioxolane ring is important for both potent Hh pathway inhibition and compound stability. Finally, our studies suggest that the ITZ scaffold can be successfully modified in terms of functionality and stereochem. to further improve its anti-Hh potency and physicochem. properties.

If you want to learn more about this compound(4-(Piperazin-1-yl)phenol)Name: 4-(Piperazin-1-yl)phenol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56621-48-8).

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem