Category: 56621-48-8

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry Letters called Synthesis of propargylamine mycophenolate analogues and their selective cytotoxic activity towards neuroblastoma SH-SY5Y cell line, Author is Silalai, Patamawadee; Pruksakorn, Dumnoensun; Chairoungdua, Arthit; Suksen, Kanoknetr; Saeeng, Rungnapha, which mentions a compound: 56621-48-8, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2O, Category: ethers-buliding-blocks.

Twenty six propargylamine mycophenolate analogs were designed and synthesized from mycophenolic acid 1 employing a key step A3-coupling reaction. Their cytotoxic activity was examined against six cancer cell lines. Four compounds exhibited selective cytotoxicity towards neuroblastoma (SH-SY5Y) cancer cells and were less toxic to normal cells in comparison to the lead compound, MPA 1 and a standard drug, ellipticine. Mol. docking results suggested that compound I is fit well in the key amino acid of three proteins (CDK9, EGFR, and VEGFR-2) as targets in cancer therapy. The propargylamine mycophenolate scaffold might be a valuable starting point for development of new neuroblastoma anticancer drugs.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56621-48-8, is researched, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2OJournal, Article, Chemistry – A European Journal called Ordered Layered Dendrimers Constructed from Two Known Dendrimer Families: Inheritance and Emergence of Properties, Author is Dib, Hanna; Rebout, Cyrille; Laurent, Regis; Mallet-Ladeira, Sonia; Sournia-Saquet, Alix; Sarosi, Menyhart B.; Hey-Hawkins, Evamarie; Majoral, Jean-Pierre; Delavaux-Nicot, Beatrice; Caminade, Anne-Marie, the main research direction is triazine piperazine dendrimer; dendrimers; electrochemistry; phosphorus; piperazine; triazines.Product Details of 56621-48-8.

A new concept is presented, namely the synthesis of dendrimers intrinsically composed in alternation of building blocks pertaining to two known families of dendrimers: phosphorhydrazone dendrimers and triazine-piperazine dendrimers. These mixed dendrimers with layered controlled architecture inherit their easy 31P NMR characterization and their thermal stability from the phosphorhydrazone family, and their decreased solubility from the triazine-piperazine family. However, they have also their own and original characteristics. Both parent families are white powders, whereas the mixed dendrimers are yellow, orange, or red powders, depending on the generation. DFT calculations were carried out on model dendrons to understand these special color features. Remarkably, these dendrimers incorporating redox-active organic entities allow for the first time the monitoring of the growth of an organic dendrimer by electrochem. while highlighting an even-odd generation behavior.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56621-48-8, is researched, Molecular C10H14N2O, about Synthesis, anticancer activity and molecular docking studies of new 4-nitroimidazole derivatives, the main research direction is nitroimidazolylsulfanyl phenylpiperazinyl propanone preparation antitumor mol docking.Recommanded Product: 56621-48-8.

Herein, we report the synthesis of 3-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-ylsulfanyl)-1-(4-substituted phenyl-piperazin-1-yl)-propan-1-one I [R = H, 2-F, 4-Cl, etc.] by reaction of 3-(1-benzyl-2-methyl-4-nitro-1H-imidazol-5-ylsulfanyl)-propanoyl chloride (3) with piperazine nucleophiles. Eighteen compounds were assessed for their antiproliferative inhibition potency against four human cancer cell lines (MCF-7, PC3, MDA MB231 and Du145). Compounds I [R = 2-Me, 2-OH]were the most potent anticancer agents on MCF-7 cell lines cell line with IC50 value of 1.0μg/mL, while I [R = 2-CN, 4-Cl] exhibited cytotoxic effect on PC3 and DU145 cell lines with IC50 values of 4.0 and 5.0μg/mL, resp. The mol. docking of compounds I [R = 2-Me, 2-CN, 4-Cl] was studied.

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Electric Literature of C10H14N2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Novel N,S- and S,S-substituted dienes synthesized from mercapto triazole and some amine derivatives. Author is Ibis, Cemil; Aydinli, Goeksin.

2-Nitro diene Cl2C:CClC(NO2):CCl2 reacted with 3-mercapto-1,2,4-triazole (I) and cyclohexanethiol to yield the resp. dithioacetals Cl2C:CClC(NO2):C(SR)R1 (II; R = 1,2,4-triazol-3-yl, cyclohexyl; R1 = SR). Dithioacetals II (R = 1,2,4-triazol-3-yl; R1 = octylthio, decylthio, hexdecylthio, cyclohexylthio) were obtained by reactions of appropriate vinyl sulfides with I. Novel N,S-substituted dienes were obtained by treatment of II [R = decyl, R1 = Cl (III)] with piperazines. Compound III was reacted with N-(2-aminoethyl)morpholine to give the corresponding N,S-substituted diene. Compound III gave a new N-butadienylhomopiperazine on reaction with homopiperazine in CH2Cl2. Compound II (R = cyclohexyl, R1 = cyclohexylthio) was characterized by single-crystal x-ray diffraction [monoclinic, space group P21/n, a 12.0862(12), b 11.1625(8), c 16.337(1) Å, β 110.840(4)°, V 2059.9(3) Å3, Z 4].

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Ether – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Electric Literature of C10H14N2O.Ryu, Eun Kyoung; Choe, Yearn Seong; Kim, Dong Hyun; Ko, Bong-Ho; Choi, Yong; Lee, Kyung-Han; Kim, Byung-Tae published the article 《In vitro metabolism studies of 18F-labeled 1-phenylpiperazine using mouse liver S9 fraction》 about this compound( cas:56621-48-8 ) in Nuclear Medicine and Biology. Keywords: radiolabeled fluorine 18 phenylpiperazine metabolism liver S9 fraction. Let’s learn more about this compound (cas:56621-48-8).

The in vitro metabolism of 1-(4-[18F]fluoromethylbenzyl)-4-phenylpiperazine ([18F]1) and 1-(4-[18F]fluorobenzyl)-4-phenylpiperazine ([18F]2) was investigated using mouse liver S9 fraction. Results were compared to those of in vivo metabolism using mouse blood and bone and to in vitro metabolism using mouse liver microsomes. Defluorination was the main metabolic pathway for [18F]1 in vitro and in vivo. Based on TLC, HPLC and LC-MS data, [18F]fluoride ion and less polar radioactive metabolites derived from aromatic ring oxidation were detected in vitro, and the latter metabolites were rapidly converted into the former with time, whereas only the [18F]fluoride ion was detected in vivo. Similarly, the in vitro metabolism of [18F]2 using either S9 fraction or microsomes showed the same pattern as the in vivo method using blood; however, the radioactive metabolites derived from aromatic ring oxidation were not detected in vivo. These results demonstrate that liver S9 fraction can be widely used to investigate the intermediate radioactive metabolites and to predict the in vivo metabolism of radiotracers.

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Ether – Wikipedia,
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Synthetic Route of C10H14N2O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Design and development of 1,3,5-triazine derivatives as protective agent against spinal cord injury in rat via inhibition of NF-kB. Author is Guan, Binggang; Jiang, Chang.

Spinal cord injury (SCI) is a chronic disease causing motor and sensory loss in the affected individuals. The SCI has a huge impact on the lives of patients that makes them susceptible to life-long disability. However, the current clin. modalities are ineffective to cope the aftermath of SCI. Thus, in the present study, we aimed to develop a series of 1,3,5-triazine derivatives I (R = Cl, Br, Me, O2N, HO, MeO) as a protective agent against SCI. The mols. were developed by facile synthetic route and obtained in excellent yield. The compounds were tested for their efficacy to inhibit the transcription of NF-κB in RAW 264.7 cells, where they displayed mild to potent activity. I (R = Cl) was identified as most potent NF-κB inhibitor among the tested analogs. The effect of I (R = Cl) was further scrutinized against the SCI injury in rats induced by contusion injury. It has been found that I (R = Cl) improves motor function of rats together with reduction in inflammation and edema in spinal cord of rats. It also showed to inhibit oxidative stress and inflammation in the SCI rats. In a western blot anal., after SCI induction, I (R = Cl) inhibited NF-κB and its upstream regulator TLR4 in a dose-dependent manner. Collectively, our study provides a novel class of agent that provide protective action against SCI.

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Ether – Wikipedia,
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SDS of cas: 56621-48-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Electrochemical Synthesis of a New Derivative of 1,4-Dihydroxybenzene: Embedded Nucleophile in the Structure of Electrophile. Author is Goodarzi, Hassan; Asghari, Alireza; Amani, Ameneh; Rajabi, Maryam; Nematollahi, Davood; Khazalpour, Sadegh.

The electrochem. oxidation of 4-(Piperazin-1-yl)phenols (1a,b) was studied in the H2O, MeCN and nitromethan by cyclic voltammetry and controlled-potential coulometry. P-quinone-imines generated of oxidation 4-(Piperazin-1-yl)phenols after the hydrolysis reaction participate in Michael-addition reactions with released piperazine of hydrolysis reaction of p-quinone imines. The present work led to the development of a facile and environmentally friendly electrochem. method for the synthesis of a new derivative of 1,4-dihydroxybenzene under green conditions. The effect of H2O as a solute on the electrochem. response of 4-(Piperazin-1-yl)phenols (1a,b) was examined in the MeCN (AN) and nitromethane (NM) solvent.

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Ether – Wikipedia,
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Name: 4-(Piperazin-1-yl)phenol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).

Post-translational S-palmitoylation directs the trafficking and membrane localization of hundreds of cellular proteins, often involving a coordinated palmitoylation cycle that requires both protein acyltransferases (PATs) and acylprotein thioesterases (APTs) to actively redistribute S-palmitoylated proteins toward different cellular membrane compartments. This process is necessary for the trafficking and oncogenic signaling of S-palmitoylated Ras isoforms, and potentially other peripheral membrane proteins. Depalmitoylating enzymes APT1 and APT2 are sep. conserved in all vertebrates, suggesting unique functional roles for each enzyme. The recent discovery of APT isoform-selective inhibitors ML348 and ML349 has opened new possibilities to probe the function of each enzyme, yet it remains unclear how each inhibitor achieves orthogonal inhibition. Here, the authors report the high-resolution structure of human APT2 in complex with ML349 (1.64 Å), as well as the complementary structure of human APT1 bound to ML348 (1.55 Å). Although the overall peptide backbone structures are nearly identical, each inhibitor adopted a distinct conformation within each active site. In APT1, ML348 was positioned above the catalytic triad, but in APT2, the sulfonyl group of ML349 formed H-bonds with active site resident water mols. to indirectly engage the catalytic triad and oxyanion hole. Reciprocal mutagenesis and activity profiling revealed several differing residues surrounding the active site that served as critical gatekeepers for isoform accessibility and dynamics. Structural and biochem. anal. suggested that the inhibitors occupy a putative acyl-binding region, establishing the mechanism for isoform-specific inhibition, hydrolysis of acyl substrates, and structural orthogonality important for future probe development.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.Synthetic Route of C35H27N2O2Ir. The article 《Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4》 in relation to this compound, is published in Biotechnology & Biotechnological Equipment. Let’s take a look at the latest research on this compound (cas:56621-48-8).

Six new aryl/aralkyl substituted piperazine derivatives, containing methylxanthine moiety I (R = Bn, 4-FC6H4, 4-HOC6H4, etc.) were synthesized. All compounds were in vitro screened for their activity as antioxidants using DPPH (2,2′-Diphenyl-1-picrylhydrazyl), ABTS (2,2′-azinobis-(3-ethylbenzothiazine-6-sulfonic acid)) and FRAP (ferric reducing/antioxidant power) methods. The antioxidant activity of the studied compounds against lipid peroxidation was also measured. The highest antioxidant activity was demonstrated by compound I (R = 4-HOC6H4). It is obvious that the presence of a hydroxyl group in the structure is essential for the antioxidant properties and should be taken into consideration in further design of structures with potential antioxidant properties.

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Synthetic Route of C10H14N2O. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Development of 1,3,4-Thiadiazole and Piperazine Fused Hybrid Quinazoline Derivatives as Dynamic Antimycobacterial Agents. Author is Patel, Amit B.; Rohit, Jignesh V..

Novel series of 1,3,4-thiadiazole and piperazine substituted quinazoline derivatives I [R = H, Cl, CF3, etc] were designed, synthesized, and tested in vitro for antimycobacterial activity. The synthetic procedure involved Suzuki C-C cross-coupling on a quinazoline ring and subsequently by the formation of 1,3,4-thiadiazole based piperazines. Many synthesized analogs were observed active against Mycobacterium H37Rv strain in preliminary anal. using the BACTEC MGIT method. A secondary antimycobacterial assay using the Lowenstein-Jensen MIC method indicates that I [R = bromo, trifluoromethyl, hydroxy] groups substituted analogs was showed strong efficacy in the range of 3.12-6.25 μg/mL. Active compounds were also tested for their cytotoxic activity against Human cervical (HeLa) cells at their MICs. The synthesized analogs were analyzed by IR, 1H NMR, 13 C NMR, MS, and elemental anal. for their structure determination

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Ether – Wikipedia,
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