562085-85-2 Archives - Page 3 of 3 - Ethers-buliding-blocks

Deng, Qinyue et al. published their research in Chemistry – An Asian Journal in 2017 | CAS: 562085-85-2

Robust Acenaphthoimidazolylidene Palladacycles: Highly Efficient Catalysts for the Amination of N-Heteroaryl Chlorides was written by Deng, Qinyue;Zhang, Yang;Zhu, Haibo;Tu, Tao. And the article was included in Chemistry – An Asian Journal in 2017.Category: ethers-buliding-blocks The following contents are mentioned in the article:

A series of robust N-heterocyclic carbene palladacycles were successfully developed. These showed high catalytic activity and selectivity toward the challenging amination of N-heteroaryl chlorides. Different primary and secondary amines were fully compatible with this catalytic system. Remarkably, no double amination products could be detected when primary amines were utilized in this catalytic transformation. Furthermore, the protocol has been successfully extended to synthesize rosiglitazone, a clin. drug for diabetes mellitus, highlighting its potential pharmaceutical feasibility. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Category: ethers-buliding-blocks).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Khorsandi, Zahra et al. published their research in Molecular Catalysis in 2022 | CAS: 562085-85-2

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: N-(4-Methoxyphenyl)pyridin-3-amine

Sustainable synthesis of potential antitumor new derivatives of Abemaciclib and Fedratinib via C-N cross coupling reactions using Pd/Cu-free Co-catalyst was written by Khorsandi, Zahra;Keshavarzipour, Fariba;Varma, Rajender S.;Hajipour, Abdol R.;Sadeghi-Aliabadi, Hojjat. And the article was included in Molecular Catalysis in 2022.Name: N-(4-Methoxyphenyl)pyridin-3-amine The following contents are mentioned in the article:

Herein, chitosan as an inexpensive, abundant, and biodegradable bio-material, produced from a key constituent of the exoskeletons of crustaceans, was used to generate the cobalt-based magnetic silica nanocomposite for the performance of the C-N cross-coupling reaction as the main step of the synthesis of Abemaciclib and Fedratinibs. Several derivatives of these recently FDA-approved anti-cancer drugs were synthesized for the first time by using Pd/Cu-free co-catalyzed under both, the conventional heating and microwave (MW) irradiation conditions. The potential anticancer activity of synthesized compounds was investigated by mol. docking study. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Name: N-(4-Methoxyphenyl)pyridin-3-amine).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhu, Lei et al. published their research in Tetrahedron in 2012 | CAS: 562085-85-2

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C12H12N2O

Well-defined NHC-Pd(II)-Im (NHC=N-heterocyclic carbene; Im=1-methylimidazole) complex catalyzed C-N coupling of primary amines with aryl chlorides was written by Zhu, Lei;Ye, Yue-Mei;Shao, Li-Xiong. And the article was included in Tetrahedron in 2012.COA of Formula: C12H12N2O The following contents are mentioned in the article:

We report herein a well-defined NHC-Pd(II)-Im (NHC=N-heterocyclic carbene; Im=1-methylimidazole) complex catalyzed C-N coupling of primary amines with aryl chlorides. Under the optimal reaction conditions, a variety of primary amines can be coupled with aryl chlorides to give the amination products in good to high yields within 4 h. It is worthy of noting here that the NHC-Pd(II)-Im complex showed especially high catalytic activity toward challenging sterically hindered substrates including both of aryl amines and aryl chlorides. In addition, alkyl amines were also proved to be suitable reaction partners to give the corresponding amination products in good to high yields. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2COA of Formula: C12H12N2O).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ogata, Tokutaro et al. published their research in Journal of the American Chemical Society in 2008 | CAS: 562085-85-2

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C12H12N2O

Palladium-catalyzed amination of aryl and heteroaryl tosylates at room temperature was written by Ogata, Tokutaro;Hartwig, John F.. And the article was included in Journal of the American Chemical Society in 2008.Electric Literature of C12H12N2O The following contents are mentioned in the article:

Mild palladium-catalyzed aminations of aryl tosylates and the first aminations of heteroaryl tosylates are described. In the presence of the combination of L₂Pd(0) (L = P(o-tol)₃) and the hindered Josiphos ligand CyPF-t-Bu, a variety of primary alkylamines and arylamines react with both aryl and heteroaryl tosylates at room temperature to form the corresponding secondary arylamines in high yields with complete selectivity for the monoarylamine. These reactions at room temperature occur in many cases with catalyst loadings of 0.1 mol % and 0.01 mol % in one case, constituting the most efficient aminations of aryl tosylates by nearly 2 orders of magnitude. This catalyst is made practical by the development of a convenient method to synthesize the L₂Pd(0) precursor. This complex is stable to air as a solid. In contrast to conventional relative rates for reactions of aryl sulfonates, the reactions of aryl tosylates are faster than parallel reactions of aryl triflates, and the reactions of aryl tosylates are faster than parallel or competitive reactions of aryl chlorides. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Electric Literature of C12H12N2O).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hanthorn, Jason J. et al. published their research in Journal of Organic Chemistry in 2012 | CAS: 562085-85-2

Preparation of Highly Reactive Pyridine- and Pyrimidine-Containing Diarylamine Antioxidants was written by Hanthorn, Jason J.;Valgimigli, Luca;Pratt, Derek A.. And the article was included in Journal of Organic Chemistry in 2012.Related Products of 562085-85-2 The following contents are mentioned in the article:

We recently reported a preliminary account of our efforts to develop novel diarylamine radical-trapping antioxidants wherein we demonstrated that the incorporation of ring nitrogens into diphenylamines affords compounds which display a compromise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation Herein we provide the details of the synthetic efforts associated with that report, which have been substantially expanded to produce a library of substituted heterocyclic diarylamines that we have used to provide further insight into the structure-reactivity relationships of these compounds as antioxidants. The diarylamines were prepared in short, modular sequences from 2-aminopyridine and 2-aminopyrimidine wherein aminations of intermediate pyri(mi)dyl bromides and then Pd-catalyzed cross-coupling reactions of the amines and precursor bromides were the key steps to yield the diarylamines. The cross-coupling reactions were found to proceed best with Pd(η³-1-PhC₃H₄)(η⁵-C₅H₅) as precatalyst, which gave higher yields than the conventional Pd source, Pd₂(dba)₃. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Related Products of 562085-85-2).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shen, Qilong et al. published their research in Journal of the American Chemical Society in 2008 | CAS: 562085-85-2

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: N-(4-Methoxyphenyl)pyridin-3-amine

Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure-Activity Relationships was written by Shen, Qilong;Ogata, Tokutaro;Hartwig, John F.. And the article was included in Journal of the American Chemical Society in 2008.Name: N-(4-Methoxyphenyl)pyridin-3-amine The following contents are mentioned in the article:

The authors describe a systematic study of the scope and relation between ligand structure and activity for a highly efficient and selective class of catalysts containing sterically hindered chelating alkylphosphines for the amination of heteroaryl and aryl chlorides, bromides, and iodides. In the presence of this catalyst, aryl and heteroaryl chlorides, bromides, and iodides react with many primary amines in high yields with part-per-million quantities of palladium precursor and ligand. Many reactions of primary amines with both heteroaryl and aryl chlorides, bromides, and iodides occur to completion with 0.0005-0.05 mol % catalyst. A comparison of the reactivity of this catalyst for the coupling of primary amines at these loadings is made with catalysts generated from hindered monophosphines and carbenes, and these data illustrate the benefits of chelation. Studies on structural variants of the most active catalyst indicate that a rigid backbone in the bidentate structure, strong electron donation, and severe hindrance all contribute to its high reactivity. Thus, these complexes constitute a fourth-generation catalyst for the amination of aryl halides, whose activity complements catalysts based on monophosphines and carbenes. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Name: N-(4-Methoxyphenyl)pyridin-3-amine).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Eric, Slavica et al. published their research in Bioorganic & Medicinal Chemistry in 2012 | CAS: 562085-85-2

Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity was written by Eric, Slavica;Ke, Song;Barata, Teresa;Solmajer, Tom;Antic Stankovic, Jelena;Juranic, Zorica;Savic, Vladimir;Zloh, Mire. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Product Details of 562085-85-2 The following contents are mentioned in the article:

A set of 16 previously synthesized aryl-aminopyridine and aryl-aminoquinoline derivatives have been evaluated for cytotoxic activity against three cancer cell lines (human cervical cancer-HeLa; human chronic myeloid leukemia-K562; human melanoma-Fem-x) and two types of normal peripheral blood mononuclear cells, with and without phytohemagglutinin (PBMC – PHA; PBMC + PHA). Twelve of the studied compounds showed moderate cytotoxicity, with selectivity against K562 but not the remaining two cancer cell lines. Four compounds were not active in cytotoxicity assays, presumably due to high predicted lipophilicity and low solubility To rationalize the observed cytotoxic effects, structure-based virtual screening was carried out against a pool of potential targets constructed using the inverse docking program Tarfisdock and bibliog. references The putative targets were identified on the basis of the best correlation between docking scores and in vitro cytotoxicity. It is proposed that the mechanism of action of the studied aminopyridines involves the disruption of signaling pathways and cancer cell cycle through the inhibition of cyclin-dependent kinases and several tyrosine kinases, namely Bcr-Abl kinase and KIT receptor kinase. The obtained results can guide further structural modifications of the studied compounds aimed at developing selective agents targeting proteins involved in cancer cell survival and proliferation. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Product Details of 562085-85-2).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Laffoon, Joshua D. et al. published their research in ACS Catalysis in 2019 | CAS: 562085-85-2

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 562085-85-2

Pd-Catalyzed Cross-Coupling Reactions Promoted by Biaryl Phosphorinane Ligands was written by Laffoon, Joshua D.;Chan, Vincent S.;Fickes, Michael G.;Kotecki, Brian;Ickes, Andrew R.;Henle, Jeremy;Napolitano, Jose G.;Franczyk, Thaddeus S.;Dunn, Travis B.;Barnes, David M.;Haight, Anthony R.;Henry, Rodger F.;Shekhar, Shashank. And the article was included in ACS Catalysis in 2019.Recommanded Product: 562085-85-2 The following contents are mentioned in the article:

The authors report the use of biaryl phosphorinanes as ligands for Pd catalyzed cross-coupling reactions. A modular synthesis was developed that employs a double conjugate addition of primary biaryl phosphines into 1,1,5,5-tetraalkyl penta-1,4-diene-3-ones. Notably, this synthesis does not require the use of Cu, a known contaminant in structurally related biaryl phosphine ligands. Using the synthetic strategy described above, the authors synthesized a library of biaryl phosphorinanes, varying their substitution about P and the steric and electronic nature of the biaryl motif. The authors then benchmarked their performance as ligands in Pd-catalyzed cross coupling reactions such as aryl sulfonamidation, aryl alkoxylation, and aryl amination in the presence of soluble organic bases. In each reaction studied, many ligands outperformed biaryl phosphines known to promote the given transformation. Detailed substrate scopes were determined using high throughput screening technol. Several biaryl phosphorinanes and their corresponding Pd(II) oxidative-addition complexes were extensively characterized using NMR spectroscopy and x-ray crystallog. General observations support that biaryl phosphorinanes promote reductive elimination and form robust catalysts with Pd. In many cases the use of these biaryl phosphorinanes may be advantageous over the use of biaryl phosphines with respect to lower catalyst loadings, shorter reaction times, and robustness. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Recommanded Product: 562085-85-2).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Feilong et al. published their research in Organic Chemistry Frontiers in 2022 | CAS: 562085-85-2

Decarboxylative amination of benzoic acids bearing electron-donating substituents and nonactivated amines was written by Wang, Feilong;Han, Ying;Yu, Le;Zhu, Dianhu. And the article was included in Organic Chemistry Frontiers in 2022.Electric Literature of C12H12N2O The following contents are mentioned in the article:

A highly desirable and straightforward decarboxylative amination of readily available benzoic acids, with the long-inaccessible extension of decarboxylative amination to normally poorly reactive electron-rich benzoic acids and non-activated amines for synthesis of anilines RNR¹R² [R = 2-MeOC₆H₄, 2,6-di-MeC₆H₃, 2-methoxy-3-pyridyl, etc.; R¹ = H, Me; R² = Ph, Bn, 2-naphthyl, etc.; R¹R² = CH₂CH₂OCH₂CH₂] in moderate to high yields with excellent functional-group tolerance was reported. This aniline synthesis was applicable to a wide range of aryl/alkyl/heterocyclic amines under oxidant-free conditions, preventing adverse reactions compared to traditional methods. It also provided decarboxylative C-N modifications of complex bioactive nitrogen-bearing mols. to highlight the synthetic utility of this protocol. The theor. calculation had supported that this decarboxylative amination might proceeded via a concerted decarboxylation-iodination-type process to afford aryl iodine intermediates, which promoted a palladium-catalyzed C-N cross-coupling pathway under mild conditions. Notably, this efficient reaction featured a fine choice of the same base/solvent system to successfully achieve two independent reactions in a one-pot continuous operation process. This strategy provided a method for previously inaccessible decarboxylative amination of benzoic acids bearing electron-donating substituents, as a new alternative to the existing decarboxylative oxidative couplings. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Electric Literature of C12H12N2O).

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem