Category: 54916-28-8

Evaluation of acrylophenones and related bis-Mannich bases against murine P388 leukemia was written by Dimmock, Jonathan R.;Patil, Shirish A.;Leek, Donald M.;Warrington, Robert C.;Fang, Wei D.. And the article was included in European Journal of Medicinal Chemistry in 1987.HPLC of Formula: 54916-28-8 This article mentions the following:

Mannich reaction of acetophenones with bases gave acrylophenones and bis-Mannich bases I and II (R = H, Me, Cl, OMe; R¹ = H, Cl; R² = H, OMe, Me, OPh, OC₆H₄OMe-4, OC₆H₄Me-4, OC₆H₄Cl-4; R³ = H, OMe, Me). I and II were tested against P388 lymphocyte leukemia in mice. I (R = R¹ = R³ = H, R² = OMe) shows potent activity against P388 cells in vitro. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8HPLC of Formula: 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Microwave-Assisted Cross-Coupling and Hydrogenation Chemistry by Using Heterogeneous Transition-Metal Catalysts: An Evaluation of the Role of Selective Catalyst Heating was written by Irfan, Muhammed;Fuchs, Michael;Glasnov, Toma N.;Kappe, C. Oliver. And the article was included in Chemistry – A European Journal in 2009.Formula: C15H14O3 This article mentions the following:

The concept of specific microwave effects in solid/liquid catalytic processes resulting from the selective heating of a microwave-absorbing heterogeneous transition-metal catalyst by using 2.45 GHz microwave irradiation was evaluated. As model transformations Ni/C-, Cu/C-, Pd/C-, and Pd/Al₂O₃-catalyzed carbon-carbon/carbon-heteroatom cross-couplings and hydrogenation reactions were studied. To probe the existence of specific microwave effects by selective catalyst heating in these transformations, control experiments comparing microwave dielec. heating and conventional thermal heating at the same reaction temperature were performed. Although the supported metal catalysts were exptl. found to be strongly microwave absorbing, for all chem. examples studied herein no differences in reaction rate or selectivity between microwave and conventional heating experiments under carefully controlled conditions were observed This was true also for reactions that use low-absorbing or microwave transparent solvents, and was independent of the microwave absorptivity of the catalyst support material. In the case of hydrogenation reactions, the stirring speed is a critical factor on the mass transfer between gas and liquid phase, influencing the rate of the hydrogenation in both microwave and conventionally heated experiments In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Formula: C15H14O3).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C15H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of Arylglyoxylic Acids and Their Collision-Induced Dissociation was written by Wadhwa, Kuldeep;Yang, Chengxi;West, Paul R.;Deming, Kris C.;Chemburkar, Sanjay R.;Reddy, Rajarathnam E.. And the article was included in Synthetic Communications in 2008.Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

A variety of substituted arylglyoxylic acids (2a-g) were synthesized via oxidation of the corresponding aryl Me ketones (1a-e) using selenium dioxide or Friedel-Crafts acylation of phenol (3) with Et chlorooxoacetate and further transformations. It was found that the arylglyoxylic acids (2) undergo facile unimol. dissociation with loss of carbon monoxide to give the corresponding arylcarboxylic acids (7) under collisionally induced mass spectrometric conditions. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Infrared absorption spectrum of deuteriated polyvinyl alcohol was written by Ukida, Junji;Nishino, Yutaka;Komiami, Tsugio. And the article was included in Nippon Kagaku Kaishi (1921-47) in 1955.HPLC of Formula: 54916-28-8 This article mentions the following:

Polyvinyl alc. (I) (0.05 g.) (degree of polymerization, 920) was dissolved in 1 cc. 46.4% D₂O, warmed in a sealed vessel at 70鎺?for 1 hr. and then at 50鎺?for 3 hrs., poured onto a Hg surface, and dried to obtain a transparent film of 0.03-mm. thickness. The film showed a characteristic band at 4.01 娓?of O椤氬儊 stretching vibration, which is ascribed to OD radical formed by replacing OH radical in I with D₂O; the O椤氬儊 absorption of D₂O appeared at 3.88 娓? In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8HPLC of Formula: 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.HPLC of Formula: 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

An Ullmann C-O Coupling Reaction Catalyzed by Magnetic Copper Ferrite Nanoparticles was written by Yang, Shuliang;Wu, Cunqi;Zhou, Hua;Yang, Yanqin;Zhao, Yongxia;Wang, Chenxu;Yang, Wei;Xu, Jingwei. And the article was included in Advanced Synthesis & Catalysis in 2013.Computed Properties of C15H14O3 This article mentions the following:

Herein, an efficient method for the Ullmann C-O coupling reaction between various kinds of phenols and aryl halides, including amino, ketone, cyano, Me, methoxy, fluoro, chloro and bromo derivatives, is described. The catalyst used, copper ferrite (CuFe₂O₄) nanoparticles, are easily made, air-stable, and of low cost. The catalyst can be recycled easily just by using an external magnet. Even in the presence of sensitive substituents, the reaction proceeds successfully to provide the desired products in high yields without protection of other functional groups. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Computed Properties of C15H14O3).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Computed Properties of C15H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ligand free copper-catalyzed heterogeneous O-arylation reaction under green condition was written by Maity, Tanmoy;Saha, Debraj;Das, Soma;Bhunia, Susmita;Koner, Subratanath. And the article was included in Catalysis Communications in 2015.Safety of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

A highly porous Zn-based iso-reticular metal-organic framework (IRMOF-3) has been selected for covalent modification. Pyridine-2-aldehyde has been used to decorate the free amine group of IRMOF-3 in the porous matrix. Schiff base moiety thus generated has been availed to anchor copper(II) ions to prepare the desired catalyst that catalyzes O-arylation reactions heterogeneously under mild reaction conditions. Porous catalyst demonstrates size selectivity in products when various substrates undergo O-arylation with 浼?and 灏?naphthol. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Safety of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton’s tyrosine kinase was written by Zhang, Dandan;Xu, Guiqing;Zhao, Jie;Wang, Yue;Wu, Xiaofang;He, Xing;Li, Wei;Zhang, Shuting;Yang, Shouning;Ma, Chunhua;Jiang, Yuqin;Ding, Qingjie. And the article was included in European Journal of Medicinal Chemistry in 2021.Related Products of 54916-28-8 This article mentions the following:

BTK (Bruton’s tyrosine kinase) inhibitors are the most promising drugs for the treatment of hematol. tumors. A high selectivity of BTK inhibitors ensures reduced side effects from off-targeting. Accordingly, here, based on Zanubrutinib, we designed and synthesized a new range of I, II and III. as novel BTK inhibitors that retained the amide group for improved selectivity. These compounds revealed potent inhibitory activity against BTK in vitro. Remarkably, compounds I [R¹ = acryloyl, R² = R³ = H; m = 1, n = 2] (IC₅₀ 5.2 nM) and I [R¹ = but-2-ynoyl, R² = R³ = H; m = 1, n = 2] (IC₅₀ 4.9 nM) possessed the highest kinase selectivity. Both of these effectively inhibited the auto-phosphorylation of BTK, blocked the cell cycle in G0/G1 phase, and induced apoptosis in the TMD8 cells. In a TMD8 cells xenograft model, a twice-daily dose of compound I [R¹ = acryloyl, R² = R³ = H; m = 1, n = 2] at 25 mg/kg and a thrice-daily dose of compound I [R¹ = but-2-ynoyl, R² = R³ = H; m = 1, n = 2] at 15 mg/kg significantly suppressed the tumor growth without obvious toxicity. Collectively, I [R¹ = acryloyl, R² = R³ = H; m = 1, n = 2] and I [R¹ = but-2-ynoyl, R² = R³ = H; m = 1, n = 2] are the potential selective BTK inhibitors that can be developed further. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Related Products of 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Related Products of 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

C-5-Disubstituted Barbiturates as Potential Molecular Probes for Noninvasive Matrix Metalloproteinase Imaging was written by Breyholz, Hans-Joerg;Schaefers, Michael;Wagner, Stefan;Hoeltke, Carsten;Faust, Andreas;Rabeneck, Helmut;Levkau, Bodo;Schober, Otmar;Kopka, Klaus. And the article was included in Journal of Medicinal Chemistry in 2005.Application In Synthesis of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

Studies have demonstrated a pos. correlation between inflammation, metastasis, or atherosclerosis and the unbalanced or culminated expression of matrix metalloproteinases (MMPs). The mol. imaging of locally upregulated MMP activity in vivo is a clin. challenge. Actually, radioligands based on nonpeptidyl MMP inhibitors (MMPIs) are currently in development as putative radiopharmaceutical agents for the noninvasive in vivo assessment of activated MMPs. Nonpeptidyl MMPIs bind to the zinc active site of the activated enzyme via mono- (e.g. carboxylate) or bidentate (e.g. hydroxamate) complexation thereby exhibiting a broad-spectrum MMP binding potency. Thus, these mentioned endopeptidase inhibitors should be useable lead compounds for the redevelopment as diagnostic MMPI radiotracers. Recently, the non-hydroxamate C-5-disubstituted pyrimidine-2,4,6-triones were disclosed as subgroup-selective MMP inhibitors. We here describe a set of fine-tuned barbiturates as a new class of MMPI radiotracers for the noninvasive in vivo visualization of activated MMPs using scintigraphic techniques such as SPECT or PET. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Application In Synthesis of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton’s tyrosine kinase was written by Zhang, Dandan;Xu, Guiqing;Zhao, Jie;Wang, Yue;Wu, Xiaofang;He, Xing;Li, Wei;Zhang, Shuting;Yang, Shouning;Ma, Chunhua;Jiang, Yuqin;Ding, Qingjie. And the article was included in European Journal of Medicinal Chemistry in 2021.Related Products of 54916-28-8 This article mentions the following:

BTK (Bruton’s tyrosine kinase) inhibitors are the most promising drugs for the treatment of hematol. tumors. A high selectivity of BTK inhibitors ensures reduced side effects from off-targeting. Accordingly, here, based on Zanubrutinib, we designed and synthesized a new range of I, II and III. as novel BTK inhibitors that retained the amide group for improved selectivity. These compounds revealed potent inhibitory activity against BTK in vitro. Remarkably, compounds I [R¹ = acryloyl, R² = R³ = H; m = 1, n = 2] (IC₅₀ 5.2 nM) and I [R¹ = but-2-ynoyl, R² = R³ = H; m = 1, n = 2] (IC₅₀ 4.9 nM) possessed the highest kinase selectivity. Both of these effectively inhibited the auto-phosphorylation of BTK, blocked the cell cycle in G0/G1 phase, and induced apoptosis in the TMD8 cells. In a TMD8 cells xenograft model, a twice-daily dose of compound I [R¹ = acryloyl, R² = R³ = H; m = 1, n = 2] at 25 mg/kg and a thrice-daily dose of compound I [R¹ = but-2-ynoyl, R² = R³ = H; m = 1, n = 2] at 15 mg/kg significantly suppressed the tumor growth without obvious toxicity. Collectively, I [R¹ = acryloyl, R² = R³ = H; m = 1, n = 2] and I [R¹ = but-2-ynoyl, R² = R³ = H; m = 1, n = 2] are the potential selective BTK inhibitors that can be developed further. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Related Products of 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Related Products of 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

C-5-Disubstituted Barbiturates as Potential Molecular Probes for Noninvasive Matrix Metalloproteinase Imaging was written by Breyholz, Hans-Joerg;Schaefers, Michael;Wagner, Stefan;Hoeltke, Carsten;Faust, Andreas;Rabeneck, Helmut;Levkau, Bodo;Schober, Otmar;Kopka, Klaus. And the article was included in Journal of Medicinal Chemistry in 2005.Application In Synthesis of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

Studies have demonstrated a pos. correlation between inflammation, metastasis, or atherosclerosis and the unbalanced or culminated expression of matrix metalloproteinases (MMPs). The mol. imaging of locally upregulated MMP activity in vivo is a clin. challenge. Actually, radioligands based on nonpeptidyl MMP inhibitors (MMPIs) are currently in development as putative radiopharmaceutical agents for the noninvasive in vivo assessment of activated MMPs. Nonpeptidyl MMPIs bind to the zinc active site of the activated enzyme via mono- (e.g. carboxylate) or bidentate (e.g. hydroxamate) complexation thereby exhibiting a broad-spectrum MMP binding potency. Thus, these mentioned endopeptidase inhibitors should be useable lead compounds for the redevelopment as diagnostic MMPI radiotracers. Recently, the non-hydroxamate C-5-disubstituted pyrimidine-2,4,6-triones were disclosed as subgroup-selective MMP inhibitors. We here describe a set of fine-tuned barbiturates as a new class of MMPI radiotracers for the noninvasive in vivo visualization of activated MMPs using scintigraphic techniques such as SPECT or PET. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Application In Synthesis of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem