Category: 5397-31-9

Reference of 5397-31-9, A common heterocyclic compound, 5397-31-9, name is 3-((2-Ethylhexyl)oxy)propan-1-amine, molecular formula is C11H25NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1 Red Complex from Reactive Red 120, 3-(2-Ethylhexyloxyl)Propylamine and Aliquat 336 (0102) 14.7 gram of Reactive Red 120 (50% dye content), 2.81 gram of 3-(2-ethylhexyloxy)-propyl amine, 0.84 gram of sodium bicarbonate and 30 mL of water were charged into a reactor equipped with agitator, temperature control and condenser. The mixture was heated to 80 C. for several hours until the starting material Reactive Red 120 was gone as monitored by TLC. Then 12.1 gram of Aliquat 336 was added slowly and stirred at 80 C. for one hour. The reaction mixture was cooled to room temperature and dark red solid was precipitated. The solid was filtered and washed with water to remove salts. 24.1 gram of red solid with color value of 12.8 was obtained.

The synthetic route of 5397-31-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Milliken & Company; Hong, Xiaoyong Michael; Xie, Peter; Sun, Brian; Mason, Mary E.; US2015/299468; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 5397-31-9, name is 3-((2-Ethylhexyl)oxy)propan-1-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C11H25NO

c) 19.9 parts of the trisazo dyestuffs of part b) above are suspended in 100 parts of water, 10.0 parts of [DIPROPYLENE] glycol monomethyl ether and 4. [8] parts of sodium acetate. After warming at [96C] for over one hour, 5.9 parts of copper sulphate are added in small portions for over one hour, followed by 20.0 parts of 25% ammonia. The mixture is heated to reflux for 12 hours whereupon a voluminous suspension of the copper complex results. The temperature is allowed to fall to [45C] over 2 hours (while stirring well) and the suspension is slowly reacted with a solution of 13.3 parts of [3-[(2-ETHYLHEXYL) OXY]-1-] propanamine in 70 parts of water and [8.] 3 parts of 30% HCI. The resulting precipitate is stirred a further hour at room temperature, filtered and the residue is washed salt free and dried. A compound of formula wherein R is methoxy, is obtained.

The synthetic route of 3-((2-Ethylhexyl)oxy)propan-1-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CLARIANT INTERNATIONAL LTD; WO2003/99937; (2003); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

5397-31-9, name is 3-((2-Ethylhexyl)oxy)propan-1-amine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-((2-Ethylhexyl)oxy)propan-1-amine

Example 13A reaction vessel was charged with 180 parts by weight of 3-(2-ethylhexyloxy)propylamine, 180 parts by weight of DL-4,4-dimethyl pyroglutamine acid, and 100 parts by weight of methanol, and the mixture was stirred at 70 C. for 3 hours. The resulting reaction mixture was stripped at 90 C. under reduced pressure to remove the methanol, and 335 parts by weight of white solid was obtained at a yield of 93%. Results of the 13C-NMR shown in Table 13, below, and absorption at 1685 cm-1 (from amide bond) in the measurement of IR spectrum confirmed that the resulting product was an amino acid compound represented by the following formula: TABLE 13 13C-NMR (CDCl3) 11.2~74.3ppm (CH, -CH2-, -CH3) 180.9ppm (-NH-CO-) 35.0ppm (-CO-C) 22.4ppm (C-CH3) 41.8ppm (-C-CH2-) 56.4ppm [-CH(NH2)(COOH)] 179.2ppm (-COOH)

The synthetic route of 5397-31-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MORIYA, Hiroyuki; US2011/144369; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

5397-31-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5397-31-9, name is 3-((2-Ethylhexyl)oxy)propan-1-amine, This compound has unique chemical properties. The synthetic route is as follows.

52 grams of 3 amino BENZOTRIFLUORIDE is mixed with 50 grams of 2 methyl 2 butanol and 200 mis of water are added, followed by 38 grams of sulfuric acid 96%. The mixture is iced to 5C and diazotized by the addition of 55 grams of a 40% solution of sodium nitrite. When the solution has become clear excess nitrous acid is reduced with SULFAMIC acid. This diazo is then added to a solution of 38 grams of 2 amino para cresol which has been dissolved in a mixture of 100 grams of 2 methyl 2 butanol and 100 grams of an aqueous solution containing 0.3 equivalents of naphthalene SULFONIC acids to which 1 gram each of acrylic acid and butyl methacrylate have been added as free radical suppressors. Coupling proceeds quickly at 5-10C and is brought to completion by the addition of sufficient sodium acetate solution to raise the pH to 2.5. When the azo coupling is complete 150 grams of toluene and 55 grams of hydrochloric acid 32% is added to the reaction. 60 grams of a 40% solution of sodium nitrite is now added to diazotize the amino azo compound. When this reaction is complete 0.3 molar equivalents of a composition made by condensing 0.3 equivalents of 3 amino phenol and 0.6 equivalents of 2 ethyl hexyl glycidyl ether dissolved as an 80% solution in toluene is added to the system. Coupling proceeds readily with the formation of a magenta red bisazo dye. The coupling is now adjusted to pH 9 by the addition of aqueous ammonia and heated to 60C. 0.3 molar equivalents of nickel chloride are now added to the system together with sufficient ammonia to stop the pH falling below 8.0. Formation of the metal complex is essentially instant as determined by TLC. 60 grams of 2 ethyl hexoxy propylamine is now added to the system and after a few minutes stirring agitation is stopped and the dye layer allowed to separate as an upper phase. The dye is then dried under vacuum to 110C and brought to a total weight of 700 grams with n-propanol. The product is a violet black with very good light fastness and solvent compatibility.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; UNITED COLOR MANUFACTURING, INC.; WO2005/30875; (2005); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem