Category: 5367-32-8

An assessment of the toxicity of some pesticides and their metabolites affecting a natural aquatic environment using the Microtox system was written by Amoros, I.;Connon, R.;Garelick, H.;Alonso, J. L.;Carrasco, J. M.. And the article was included in Water Science and Technology in 2000.Synthetic Route of C8H9NO3 This article mentions the following:

The conservation and preservation of aquatic ecosystems is of utmost importance due to the high diversity and d. of species and their complex food network. The evaluation of the potential adverse environmental impact caused by pesticides entering water bodies is an important parameter in aquatic toxicity. The toxicity of the insecticide, fenitrothion and two of its metabolites, 3-methyl-4-nitrophenol and 3-methyl-4-nitroanisole, and of the herbicides thiobencarb and molinate, commonly used in rice fields in Valencia near the protected area of lake Albufera, was tested by the Microtox system. The 15 min EC₅₀ values obtained with the marine luminescent bacterium Vibrio fischeri showed that the thiobencarb was the most toxic of the 3 tested pesticides with an EC₅₀ value of 0.03 mg/L. The EC₅₀ values of the first 2 steps of the fenitrothion hydrolysis indicated that while the first metabolite, 3-methyl-4-nitrophenol, was as toxic as its parent compound, a decreased toxicity was observed for the second metabolite, 3-methyl-4-nitroanisole. To analyze the toxic effects of pesticides in complex mixtures the EC₅₀ values of fenitrothion, molinate, and thiobencarb as pure substances and their mixtures were compared. The impact of the pesticides in the natural ecosystem was also studied and a protective effect of lake water was observed In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Synthetic Route of C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Synthetic Route of C8H9NO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Linear polystyrene-stabilized Pt nanoparticles catalyzed indole synthesis in water via aerobic alcohol oxidation was written by Ohtaka, Atsushi;Kozono, Mao;Takahashi, Kazuhiro;Hamasaka, Go;Uozumi, Yasuhiro;Shinagawa, Tsutomu;Shimomura, Osamu;Nomura, Ryoki. And the article was included in Chemistry Letters in 2016.Synthetic Route of C8H9NO3 This article mentions the following:

The one-pot synthesis of indoles in water by aerobic alc. oxidation and subsequent cyclization was achieved using linear polystyrene-stabilized Pt nanoparticles as a catalyst. The catalyst can be reused although a slight increase in particle size was observed by TEM of the recovered catalyst. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Synthetic Route of C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Synthetic Route of C8H9NO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Indoles from 2-methylnitrobenzenes by condensation with formamide acetals followed by reduction: 4-benzyloxyindole (1H-indole, 4-(phenylmethoxy)-) was written by Batcho, Andrew D.;Leimgruber, Willy. And the article was included in Organic Syntheses in 1985.Name: 3-Methyl-4-nitroanisole This article mentions the following:

Indoles, substituted in the benzene ring, were prepared by reductive cyclization of nitrocinnamylamines. Thus, 2-methyl-3-nitrophenol was O-benzylated and treated with Me₂NCH(OMe)₂ and pyrrolidine to give a mixture of 2,6-O₂N(PhCH₂O)C₆H₃CH:CHR (R = pyrrolidino, NMe₂), which was treated with N₂H₄-Raney Ni to give the indole I. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Name: 3-Methyl-4-nitroanisole).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Name: 3-Methyl-4-nitroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Biomembrane lipids as components of chromatographic phases: comparative chromatography on coated and bonded phases was written by Hanna, M.;De Biasi, V.;Bond, B.;Camilleri, P.;Hutt, A. J.. And the article was included in Chromatographia in 2000.SDS of cas: 5367-32-8 This article mentions the following:

Preparation of biomembrane lipid based stationary phases has been achieved by recycling 1 mM solutions of the appropriate lipid (soybean lecithin phosphatidylcholine, SLPC; phosphatidylcholine, sphingomyelin, phosphatidylethanolamine or phosphatidylserine) in methanol: water (80:20 volume/volume) through reversed-phase (C8) HPLC columns for 18 h at 0.25 mL min^-1. The chromatog. characteristics (retention, peak symmetry and reproducibility and phase stability) have been assessed and compared with two com. available bonded Immobilized Artificial Membrane (IAM) phases (IAM.PC.MG and IAM.PC.DD) by examination of the retention properties of a range of structurally diverse analytes (n = 119). The application of the SLPC phase for prediction of analyte lipophilicity (log Poctanol/water) is shown to be comparable to the IAM.PC.MG and superior to the IAM.PC.DD bonded phases. Cross-phase comparison of analyte retention characteristics on four different lipid phases indicate that such phases may provide a rapid evaluation of analyte-lipid interactions. The dynamic coating methodol. is economically viable for the small laboratory, rapid and reproducible, resulting in phase surfaces which are stable over longer periods of time than those of the com. available bonded phases. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8SDS of cas: 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Development of a scalable synthesis of SIRT1 modulator macrocycles was written by Tatai, Janos;Molnar, Mark;Villeneuve, Maud;Haberkorn, Laure;Nyerges, Miklos. And the article was included in Heterocycles in 2022.Recommanded Product: 3-Methyl-4-nitroanisole This article mentions the following:

An improved multigram route to key intermediate for macrocyclic SIRT1 modulators was developed. The increasing demand for this key intermediate caused the rerouting of the initial discovery route resulted in increase of overall yield to 8.3% over 8 steps, with the elimination of some tedious chromatog. purifications and the substitution of critical reaction steps, which hindered a feasible scale-up. The key modification was the introduction of the microwave assisted intramol. Suzuki reaction for the macrocyclization step, which provided in a reliable and reproducible manner of the targeted product. This newly developed synthetic access to this first described macrocyclic ring system was capable of ensuring the supply of our medicinal chem. program. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Recommanded Product: 3-Methyl-4-nitroanisole).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 3-Methyl-4-nitroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photolytic and photocatalytic decomposition of fenitrothion by PW₁₂O₄₀^3- and TiO₂: a comparative study was written by Kormali, P.;Dimoticali, D.;Tsipi, D.;Hiskia, A.;Papaconstantinou, E.. And the article was included in Applied Catalysis, B: Environmental in 2004.Category: ethers-buliding-blocks This article mentions the following:

The photocatalytic degradation of fenitrothion under UV and near visible light in the presence of the polyoxometallate (POM) photocatalyst PW₁₂O₄₀^3- in aqueous solutions has been studied and compared with the photodegradation by TiO₂ suspensions. Fenitrothion is effectively degraded in the presence of both photocatalysts following pseudo-first-order kinetics. Complete mineralization of fenitrothion is achieved using both photocatalysts, leading to the formation of CO₂ and inorganic ions (PO₄^3-, SO₄^2-, NO₂^–, and NO₃^–) as final products. Various intermediates, identical in the presence of both photocatalysts, have been detected and identified using HPLC and gas chromatog.-mass spectrometry (GC-MS) techniques. The similarity of the intermediates by these two methods, i.e., PW₁₂O₄₀^3- and TiO₂, tends to suggest that the photodegradation mechanism of fenitrothion in as other cases as well takes place mainly via a common reagent, i.e., OH radicals. A photodegradation mechanism is proposed. Photolysis of fenitrothion, i.e., in the absence of catalysts, is very slow and far from producing complete mineralization. A relatively large number of intermediates is observed, most of which are not detected in the photocatalytic processes. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Category: ethers-buliding-blocks).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Azomethine Ylide Cycloaddition/Reductive Heterocyclization Approach to Oxindole Alkaloids: Asymmetric Synthesis of (-)-Horsfiline was written by Cravotto, Giancarlo;Giovenzana, Giovanni Battista;Pilati, Tullio;Sisti, Massimo;Palmisano, Giovanni. And the article was included in Journal of Organic Chemistry in 2001.Recommanded Product: 3-Methyl-4-nitroanisole This article mentions the following:

The intermol. [3+2] annulation of azomethine ylides with 2(2-nitrophenyl)acrylate dienophiles followed by reductive heterocyclization affords the spiro(indole-pyrrolidine) ring system. Hence, this enable us to accomplish a concise and highly enantioselective synthesis of (-)-horsfiline, based on chiral auxiliary-directed 锜?face discrimination in the 1,3-dipolar cycloaddition of (1S,2R)-2-phenyl-1-cyclohexyl ester I with N-methylazomethine ylide. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Recommanded Product: 3-Methyl-4-nitroanisole).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 3-Methyl-4-nitroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-Activity Studies for 浼?Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid Receptors: Acidic Hydroxyphenylalanines was written by Hill, Ronald A.;Wallace, Lane J.;Miller, Duane D.;Weinstein, David M.;Shams, Gamal;Tai, Henry;Layer, Richard T.;Willins, David;Uretsky, Norman J.;Danthi, Satyavijayan Narasimhan. And the article was included in Journal of Medicinal Chemistry in 1997.Product Details of 5367-32-8 This article mentions the following:

Antagonists of 浼?amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptors may have therapeutic potential as psychotropic agents. A series of mononitro- and dinitro-2- and 3-hydroxyphenylalanines was prepared, and their activity compared with willardiine, 5-nitrowillardiine, AMPA, and 2,4,5-trihydroxyphenylalanine (6-hydroxydopa) as inhibitors of specific [³H]AMPA and [³H]kainate binding in rat brain homogenates. The most active compounds were highly acidic (pK_a 3-4), namely, 2-hydroxy-3,5-dinitro-DL-phenylalanine (13; [³H]AMPA IC₅₀ 閳?25 娓璏) and 3-hydroxy-2,4-dinitro-DL-phenylalanine (19; [³H]AMPA IC₅₀ 閳?5 娓璏). Two other dinitro-3-hydroxyphenylalanines, and 3,5-dinitro-DL-tyrosine, were considerably less active. Various mononitrohydroxyphenylalanines, which are less acidic, were also less active or inactive, and 2- and 3-hydroxyphenylalanine (o- and m-tyrosine) were inactive. Compounds 13 and 19, DL-willardiine (pK_a 9.3, [³H]AMPA IC₅₀ = 2 娓璏), and 5-nitro-DL-willardiine (pK_a 6.4, [³H]AMPA IC₅₀ = 0.2 娓璏) displayed AMPA 閳?kainate selectivity in binding studies. Compound 19 was an AMPA-like agonist, but 13 was an antagonist in an AMPA-evoked norepinephrine release assay in rat hippocampal nerve endings. Also, compound 13 injected into the rat ventral pallidum antagonized the locomotor activity elicited by systemic amphetamine. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Product Details of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Product Details of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient cosubstrate enzyme pairs for sequence-specific methyltransferase-directed photolabile caging of DNA was written by Heimes, Michael;Kolmar, Leonie;Brieke, Clara. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Application of 5367-32-8 This article mentions the following:

Supplemented with synthetic surrogates of their natural cosubstrate S-adenosyl-L-methionine (AdoMet), methyltransferases represent a powerful toolbox for the functionalization of biomols. By employing novel cosubstrate derivatives in combination with protein engineering, we show that this chemo-enzymic method can be used to introduce photolabile protecting groups into DNA even in the presence of AdoMet. This approach enables optochem. control of gene expression in a straight-forward manner and we have termed it reversible methyltransferase directed transfer of photoactivatable groups (re-mTAG). In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Application of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Degradation and fate of fenitrothion applied to harvested rice grains was written by Takimoto, Yoshiyuki;Oshima, Masako;Miyamoto, Junshi. And the article was included in Nippon Noyaku Gakkaishi in 1978.Reference of 5367-32-8 This article mentions the following:

Studies were conducted on the fate of fenitrothion (I) [122-14-5] labeled with ¹⁴C at the meta Me group and applied to rice grains at 6 or 15 ppm after harvest. During rice storage at 30 and 15鎺? I was decomposed with half-lives of 4 and >12 mo, resp. Major decomposition products were the demethyl derivative (II) [21847-47-2] of I and 3-methyl-4-nitrophenol (III) [2581-34-2]. 3-Hydroxymethyl-4-nitrophenol [60463-12-9], P:S isomers and P:O analogs of both I and II, 4-methyl-5-nitropyrocatechol (IV) [68906-21-8], III Me ether [5367-32-8], and IV di-Me ether [7509-11-7], were formed in small amounts I and its decomposition products penetrated into the grains about 100 娓璵 in depth from the surface during 12 mo-storage. Milling removed approx. 60% of the applied ¹⁴C in rice. Cooking I-treated unpolished rice decomposed I mainly into II and III. Malathion (V) [121-75-5] in stored rice was decomposed at similar rates to those of I mainly into the demethyl derivative [68906-22-9] and V mono- and diacids. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Reference of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Reference of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem