Category: 53136-21-3

On June 30, 2014, Soleiman-Beigi, Mohammad; Kazemi, Mosstafa; Aryan, Reza; Shiri, Lotfi published an article.Quality Control of Benzyl(4-bromophenyl)sulfane The title of the article was TBAOH mediated: An efficient and simple procedure for alkylation of alcohols, phenols and thiols under neat aqueous conditions. And the article contained the following:

Aqueous Bu4NOH (TBAOH) solution was used as a green reaction medium and efficient catalyst for the O-alkylation of alcs. and phenols as well as S-alkylation of thiols under a novel, mild, and convenient procedure. Herein, TBAOH was used as a strong base, medium of reaction, and phase transfer reagent. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Quality Control of Benzyl(4-bromophenyl)sulfane

The Article related to alc alkyl halide alkylation butylammonium hydroxide water, phenol alkyl halide alkylation butylammonium hydroxide water, thiol alkyl halide alkylation butylammonium hydroxide water, ether preparation green chem, thioether preparation green chem and other aspects.Quality Control of Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 1, 2021, Hao, Guiyun; Li, Hao; Yang, Fei; Dong, Duoling; Li, Zezhong; Ding, Yingying; Pan, Wei; Wang, Enduo; Liu, Rujuan; Zhou, Huchen published an article.Computed Properties of 53136-21-3 The title of the article was Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors. And the article contained the following:

1-Hydroxy-2,1-benzoxaboroles I were prepared and examined for inhibitory activity against leucyl-tRNA synthetase (LeuRS) and antibacterial activity against multidrug-resistant S. pneumoniae pathogen. Pneumonia caused by bacterium S. pneumoniae is a severe acute respiratory infectious disease with high morbidity and mortality, especially for children and immunity-compromised patients. The emergence of multidrug-resistant S. pneumoniae also presents a challenge to human health. Leucyl-tRNA synthetase (LeuRS) catalyzes the attachment of L-leucine to tRNALeu, which plays an essential role in protein translation and is considered an attractive antimicrobial drug target. In the present work, benzhydrol-oxaborole hybrid compounds were designed and synthesized as inhibitors of S. pneumoniae LeuRS. Exploration of the Ph ring near Lysine 389 eventually yielded compounds 46 and 54 with submicromolar inhibitory potency. The co-crystal of compound 54 in the editing domain pocket of SpLeuRS was obtained and confirmed the formation of an addnl. hydrogen bond between the carbonyl of 54 and Lysine 389. It also showed anti-pneumococcal activity in vitro. The structure-activity relationship was discussed. This work will provide an essential foundation for the further development of anti-pneumococcal agents by targeting LeuRS. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Computed Properties of 53136-21-3

The Article related to benzoxaborole boronate preparation leucyl trna synthetase inhibitor antibacterial agent, streptococcus pneumoniae leucyl trna synthetase inhibitor antibacterial agent preparation, anti-pneumonia, benzhydrol-oxaborole, s. pneumonia leurs (spleurs), structure-activity relationship and other aspects.Computed Properties of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 24, 2021, Ftouh, Soumia; Bourgeade-Delmas, Sandra; Belkadi, Mohamed; Deraeve, Celine; Hemmert, Catherine; Valentin, Alexis; Gornitzka, Heinz published an article.COA of Formula: C13H11BrS The title of the article was Synthesis, Characterization, and Antileishmanial Activity of Neutral Gold(I) Complexes with N-heterocyclic Carbene Ligands Bearing Sulfur-Containing Side Arms. And the article contained the following:

With an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available medical treatments involve side effects, including toxicity, nonspecific targeting, and resistance development. Thus, new antileishmanial chem. entities are of the utmost importance to fight against this disease. The authors showed in previous studies that Au(I) complexes bearing N-heterocyclic carbene (NHC) ligands with N- or S-containing side arms have interesting biol. activities in the field of cancer, malaria and leishmaniasis. The present study evaluates the in vitro antileishmanial effects on L. infantum axenic amastigotes and their cytotoxicity for the human THP1 cell line of a new family of six new imidazolium salts and their corresponding neutral (NHC)AuICl complexes. All new compounds were characterized by classical anal. methods, and five Au complexes were analyzed by x-ray structure determinations One proligand has moderate activity (IC50 = 8.24μM) while four of the six Au complexes have IC50 values in the low or sub μM range (0.15-1.3μM), including three with selectivity index (SI) values between 46 and 108. These results suggest remarkable leishmanicidal activity in vitro for three new neutral (NHC)Au(I)Cl complexes, making them candidates for further in vivo studies, which are under study. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to gold arylimidazolylidene complex sulfur side arm preparation antileishmanial activity, crystal structure gold arylimidazolylidene complex sulfur containing side arm, mol structure gold arylimidazolylidene complex sulfur containing side arm, arylimidazolylidene ligand preparation reaction gold chloride and other aspects.COA of Formula: C13H11BrS

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem