Category: 53136-21-3

Clark, N. G.; Cranham, J. E.; Greenwood, D.; Marshall, J. R.; Stevenson, H. A. published an article in 1957, the title of the article was Toxicity of organic sulfides to the eggs and larvae of the glasshouse red spider mite. III. Benzyl phenyl sulfides substituted only by halogens.Synthetic Route of 53136-21-3 And the article contains the following content:

Nuclear halogenation had a strong effect on the biol. activity of benzyl Ph sulfide, which was virtually inactive. In monosubstituted compounds, substitution in the para position of the Ph moiety gave products much less active than the corresponding compounds substituted in the para position of the benzyl moiety. With substituted Ph compounds there was a general rise in activity from F through Cl and Br to I. With few exceptions, all compounds substituted by halogen in the para position of both nuclei or in the benzyl moiety only were of high activity. Position of substitution played a role in activity, ortho-substituted benzyl derivatives being relatively less active. Substitution by more than 1 halogen atom in either nucleus resulted in compounds of lower activity than the corresponding compounds substituted only in the para positions. The following newly synthesized compounds were among those evaluated: XC6H4CH2SC6H4Y (X, Y, and m.p. (or b.p.) given): H, p-F, 32.5-33°; H, I, 52-3°; H, 2,4,-5-Cl3, 118-19°; H, 2,5-Cl2, 65°; H, p-Br, 64-5°; H, p-I, 77°; p-F, H, 62-2.5°; p-F, p-F, 44.5-5.5°; p-F, I, 49-50°; p-F, p-Br, 56.5-7.5°; p-F, p-I, 75°; ο-Cl, p-F, b1.5, 141-3°; ο-Cl, I, b2.0 170°, m. 32°; m-Cl, p-F, b2.0 158-60°; m-Cl, I, b2.0 172-5°; I, H, 78°; I, p-F, 34.5-5.5°; I, I, 72°; I, 2,5-Cl2, 113-14°; I, 2,4,5-Cl3, 76-7°; I, p-Br, 87-8°; I, p-I, 102°; 2,4-Cl2, H, b1.5 163-5°; 2,4-Cl2, p-F, 167°; 2,4-Cl2, I, 58-9°; 2,6-Cl2, H, 39-40°; 2,6-Cl2, p-F, 51°; 2,6-Cl2, I, 69-70°; p-Br, H, 78°; p-Br, p-F, 44-5°; p-Br, I, 83-4°; p-Br, p-Br, 101°; p-Br, p-I, 116°; p-I, H, 88°; p-I, p-F, 56°; p-I, I, 101°; p-I, p-Br, 118°; and p-I, p-I, 131°. XC6H4CH2SOnC6H4Y (X, Y, n, and m.p. given): H, p-F, 1, 138-40°; H, p-F, 2, 153.5-4.5°; H, I, 1, 134°; H, I, 2, 144-5°; H, p-Br, 1, 141-2°; H, p-Br, 2, 158-9°; H. p-I, 1, 128°; H, p-I, 2, 182°; p-F, p-F, 1, 160-1°; p-F, p-F, 2, 186-7°; p-F, I, 2, 156-7°; p-F, p-Br, 2, 171.5-72°; p-F, p-I, 1, 171°; p-F, p-I, 2, 201°; o-Cl, p-F, 2, 107-8°; o-Cl, I, 1, 73-4°; o-Cl, I, 2, 120-1°; m-Cl, p-F, 1, 82.5-3.5°; m-Cl, p-F, 2, 135-6°; m-Cl, I, 1, 94-6°; m-Cl, p-Cl, 2, 125° and 130°; I, H, 1, 173°; I, H, 2, 190°; I, p-F, 1, 125-6°; I, p-F, 2, 144-5°; I, I, 1, 124°; I, I, 2, 150°; I, p-Br, 1, 132-3°; I, p-Br, 2, 169-70°; I, p-I, 1, 159°; I, p-I, 2, 194°; p-Br, H, 1, 179°; p-Br, H, 2, 192-3°; p-Br, p-F, 1, 141°; p-Br, p-F, 2, 160-1°; p-Br, I, 1, 135-6°; p-Br, I, 2, 158-9°; p-Br, p-Br, 1, 145-6°; p-Br, p-Br, 2, 179-80°; p-Br, p-I, 1, 180°; p-Br, p-I, 2, 213°; p-I, H, 1, 191°; p-I, H, 2, 209°; p-I, p-F, 1, 171°; p-I, p-F, 2, 196°; p-I, I, 1, 153°; p-I, I, 2, 187°; p-I, p-Br, 1, 171°; p-I, p-Br, 2, 202°; p-I, p-I, 1, 197°; and p-I, p-I, 2, 239°. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Synthetic Route of 53136-21-3

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Synthetic Route of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Holt, H. S.; Reid, E. E. published an article in 1924, the title of the article was Effect of sulfur on the color of triphenylmethane dyes.Name: Benzyl(4-bromophenyl)sulfane And the article contains the following content:

S in the p-position has a decided auxochrome effect on the color and the shift is towards the blue. S in the o-position has a similar effect but _to a less degree. Increasing the mol. weight of the alkyl groups results in a loss of some of the auxochrome effect. In general the auxochrome effect of the various groups is in the order SMe, OMe, Me. The following thioethers were made from the NH2 derivative through the Sandmeyer reaction (% yields in parentheses): o-bromophenyl isopropyl sulfide, b11 130-5°, d2525 1.2804 (35); Ph derivative, b12 175-7°, d2525 1.3733 (50); p-bromophenyl Me sulfide, m. 27° (55); iso-Pr derivative, b11 120°, d2525 1.2338 (60); iso-Bu derivative, b15, 140-3°, d2525 1.1467 (37); benzyl derivative, m. 48° (50); p-bromophenyl Me sulfone, m. 97.5° (50). These Br derivatives were then changed into the Grignard reagent and reacted with Michler’s ketone; dyes could not be prepared containing the Ph and benzyl sulfide or Me sulfone groups, because the Grignard reaction did not take place with these derivatives The following colors were produced on wool by the substituted malachite greens thus obtained (1st color, o-derivative; 2nd, p-): unsubstituted, yellowish green; Me, dull bluish green, bright yellowish green; OMe, dull yellowish green, same; SMe, bluish green (turquoise), dull reddish blue; SCHMe2,-, dull blue gray; SC5H11 (iso),-, dull yellowish green. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Name: Benzyl(4-bromophenyl)sulfane

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Degani, Jacopo; Tiecco, Marcello; Tundo, Antonio published an article in 1962, the title of the article was Homolytic reactions. VI. Reactions between diaryl disulfides and benzyl radicals.Electric Literature of 53136-21-3 And the article contains the following content:

cf. ibid. 1204; CA 56, 5870f. The reactions of diaryl disufides, XC6H4SSC6H4X (I), with PhCH2+ (II) are studied, II being prepared by the addition of 29 g. tert-butyl peroxide to a toluene (150 ml.) solution of I and refluxing 24 hrs. Thus, 14.3 g. I (X = Cl) and II yielded (by chromatography on Al2O3, eluting with petroleum ether) traces of p-ClC6H4SMe, identified as its sulfone, m. 96°, and of diphenylethane, m. 52°, 3.3 g. p-ClC6H4SCH2Ph, m. 52-3°, and 0.5 g. oil from which further chromatographic separation yielded α-(p-chlorophenylthio)diphenylethane, m. 46°, (p-ClC6H4S)2CH2, m. 43-4°, (p-ClC6H4S)2CHPh, m. 60-1°, and unreacted I. Elution with ligroine yielded 0.2 g. unknown compound, m. 77°, 0.3 g. (p-ClC6H4SCHPh)2 m. 210-11°. and 0.15 g. of another unknown compound, m. 120°. Elution with 1:1 ligroine-C6H6, followed by C6H6, yielded tars; elution with CHCl3 yielded 0.25 g. p-C6H4SOCH2Ph, m. 135°. The reaction of 10 g. I (X = H) and II yielded traces of Ph2CH2, thioanisole (sulfone m. 80-1°), 5.2 g. benzyl phenyl sulfide, m. 40-1°, little (PhS)2CH2, m. 40°, Ph2CHPh, m. 52° α-phenylthiodiphenylethane, and an unidentified S compound, m. 60-6° later, (PhCHSCPh)2, m. 194° and benzyl phenyl sulfoxide, m. 124°, and another unknown compound m. 101-3° were recovered. With 18.5 g. I (X = Br) and II, the products separated were (PhCH2)2, m. 52°, p-bromothioanisole, m. 37-8°, 4.6 g. p-BrC6H4SCH2Ph, m. 64°, a little α-(p-bromophenylthio)diphenylethane, m. 66° p-BrC6H4SCH2SC6H4Br, m. 77°, (p-BrC6H4S)2CHPh, m. 79-80% an unidentified S compound, m. 135-6°, and p-bromophenyl benzyl sulfoxide, m. 141-2°. Starting with 11.3 g. p-chlorobenzyl phenyl sulfide and II, the reaction products yielded 1.1 g. α-(p-chlorophenylthio)diphenylethane, m. 46°, 0.3 g. (p-ClC6H4SCHPh)2, m. 210-11°, and traces of an identified compound, m. 120% also obtained from I (X = Cl). Refluxing 12 g. p-ClC6H4SMe in 120 ml. ClPh with 21.2 g. tert-butyl peroxide 24 hrs. yielded (p-ClC6H4S)2CH2, m. 43-4°, (p-ClC6H4SCH2)2, m. 94°, an unknown compound, m. 77°, and tars. Also prepared were α-phenylthiodiphenylethane, m. 148° (by refluxing in alc. the Na derivative of PhSH and α-chlorodiphenylethane 1 hr.); α-(p-bromophenylthio)diphenylethane, prisms, m. 66° (ligroine); and α-(p-chlorophenylthio)diphenylethane, prisms, m. 46° (ligroine), by analogous methods. It is concluded that the diaryl disulfides react with the benzyl radicals forming first thioanisoles and benzyl aryl sulfides, which react in turn to form a variety of other sulfur derivatives The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Electric Literature of 53136-21-3

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Electric Literature of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Benati, L.; Tiecco, M.; Tundo, A. published an article in 1963, the title of the article was Homolytic reactions. VII. Benzyl aryl sulfides.Synthetic Route of 53136-21-3 And the article contains the following content:

cf. CA 58, 13830c; 59, 6293f. By heating benzyl aryl sulfides and tert-butyl peroxide, meso- and dl-1,2-bis(arylthio)-1,2-diphenylethanes were obtained: their configurations were established through trans elimination of thiophenol and synthesis from erythro and threo-1-chloro-2arylthio-1,2-diphenylethanes and thiophenates, p-XC6H4SCH2Ph (I) (X = Br) (II) (9 g.), and 50 ml. tert-butyl peroxide (III) refluxed 10 hrs. and cooled gave 1.8 g. meso-(p-XC6H4SCHPh)2 (meso-IV) (X = Br) (V), m. 223°; the mother liquor chromatographed on Al2O3 yielded 3.3 g. II, m. 64°, 0.6 g. V, and 1.5 g. dl-IV (X = Br) (VI), m. 125-6° (EtOH). V was also obtained from erythro-1-(p-bromophenylthio)-2-chloro-1,2-diphenylethane and p-BrC6H4SNa (VII), and V. was also obtained from threo-1-(p-bromophenylthio)-2-chloro-1,2-diphenylethane with VII. Similarly, 9 g. I (X = Cl) and 50 ml. III gave 2.4 g. meso-IV (X = Cl), m. 209-10°, and 1.6 g. dl-IV (X = Cl), m. 121-2°. I (X = H) (10 g.) furnished meso-IV (X = H), m. 193-4° (EtOH), and 1.8 g. dl-IV (X = H), m. 119-20°. V (1 g.) in 200 ml. tetrahydrofuran (THF) was treated 15 hrs. with NaNH2 prepared from 0.87 g. Na and 500 ml. NH3, evaporated, diluted with Et2O and H2O to give 0.6 g. V; the Et2O residue dissolved in AcOH, filtered, treated with H2O2 1 hr. on a water bath, cooled, and diluted with H2O gave some cis-1-(p-bromophenylsulfonyl)stilbene, m. 194-6°. VI (0.5 g.) in 100 ml. THF treated 15 hrs. with NaNH2 (prepared from 0.12 g. Na and 250 ml. NH3), evaporated, diluted with Et2O and H2O, Et2O evaporated, and the residue chromatographed on Al2O3 gave 0.2 g. trans-pbromophenylthiostilbene, m. 92-3°, and 0.2 g. VI. transStilbene (10 g.) in 250 ml. anhydrous CHCl3 treated with 10 g. pBrC6H4SCl in 50 ml. CHCl3 gave erythro-1-(p-bromophenylthio)-2-chloro-1,2-diphenylethane (VIII), m. 145-7° (C6H6-ligroine). VIII (8.1 g.) in 300 ml. Et2O treated 10 hrs. with NaNH2 (prepared from 1.4 g. Na and 500 ml. NH3) and worked up furnished 2.6 g. cis-1-(p-bromophenylthio)stilbene (IX), m. 104-5°. IX (1 g.) in Et2O treated with NaNH2 yielded, after treatment with H2O2, trans-1-(p-bromophenylsulfonyl)stilbene, m. 146-7°. Cis-stilbene and p-BrC6H4SCl furnished threo-1(p-bromophenylthio)-2-chloro-1,2-diphenylethane (X), m. 702° (ligroine). X and NaNH2 in NH3 yielded 95% trans-1-(pbromophenylthio)stilbene, m. 92-3°. VIII (1 g.) in 90 ml. 80% EtOH and 75 ml. dioxane treated 4 hrs. at 50° with pBrC6H4SNa (XI) (prepared from 0.5 g. p-BrC6H4SH and 0.06 g. Na in 10 ml. EtOH) gave V. X treated as above with XI furnished VI. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Synthetic Route of 53136-21-3

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Synthetic Route of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 5, 1958, Stevenson, Herbert A.; Clark, Nigel B.; Marshall, John R.; Greenwood, Douglas; Cranham, John E.; Higgons, Dennis J.; Brookes, Robert F. published a patent.Category: ethers-buliding-blocks The title of the patent was Benzyl phenyl sulfides and acaricidal compositions therefrom. And the patent contained the following:

Na (1.0 g.) is dissolved in 6.3 g. p-BrC6H4SH and 100 ml. anhydrous EtOH, 6.9 g. p-BrC6H4CH2Cl added, the mixture refluxed 1.5 hrs., cooled, poured into 150 ml. H2O, the precipitate filtered off, and recrystallized to give p-BrC6H4SCH2C6H4Br-p, m. 106-7°. Similarly are prepared the following p,p’-substituted analogs (benzyl substituents, phenyl substituents, and m.p. given): Br, H, 78-9°; Br, F, 48-9°; Br, Cl, 87-8°. NaOH is used instead of Na to prepare the following compounds: Cl, Br, 87-8°; F, F, 56.5-7.5°; Cl, I, 102°; I, Cl, 101°; I, I, 130-1°; H, I, 75-7°; I, F, 54.5-6.0°; I, H, 87-8.5°; F, I, 74-5°; I, Br, 117-18°; Br, I, 115-16°. Na and EtOH are used in preparing the following compounds: MeO, Cl, 80°; MeO, MeO, 89-90°; Cl, Me, 70°; Cl, CH2:CHCH2O, 38°; MeO, H, 86°; Me, Me, 67-8°; Me, H, 69-70°; F, Me, 61.5-2.5°; Me, Cl, 80-1°; Me, F, 44.5-5.5°; MeO, F, 71.5-2.5°; Br, Br, 101°; Cl, Br, 87-8°; Br H, 78°; Br, F, 44-5°; Br, Cl, 83-4°; F, Br, 56.5-7.5°; F, MeO, 57.5-8.5°; I, Cl, 101°; Cl, I, 102°. Other compounds prepared were: 4-Cl, 5,2-ClMe, 65-5.5°; H, 2,5-Cl2, 65° [cf. Brit. 713,-984, 745,360; Brit. 738,170 (C.A. 50, 10334b); Brit. 758,926 (C.A. 51, 11394h and C.A. 51, 1267g)]. The compounds are useful in the control of eggs and active stages of Acari, particularly Tetranychidae. The compounds are useful in aerosols, dusts, emulsion, and dispersions. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Category: ethers-buliding-blocks

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 27, 2011, Schwede, Wolfgang; Klar, Ulrich; Moeller, Carsten; Rotgeri, Andrea; Bone, Wilhelm published a patent.Category: ethers-buliding-blocks The title of the patent was 17-Hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives as progesterone receptor antagonists and their preparation and use in the treatment of diseases. And the patent contained the following:

The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives of formula I exhibiting progesterone-antagonistic effects and to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular uterine fibroids (myomas, uterine leiomyomas), endometriosis, menorrhagia, meningiomas, hormone-dependent mammary carcinomas and menopause-associated troubles, or for fertility control and emergency contraception. Compounds of formula I wherein R1 is SH and derivatives, S(O)H and derivatives, SO2H and derivatives, SONH2 and derivatives, (un)substituted aryl, etc.; X is O, NOH and derivatives and NNHSO2H and derivatives; and stereoisomers, salts, solvates, solvated salts, and all crystal modifications thereof, are claimed. Example compound II was prepared by addition of pentafluoroiodoethane to (5’R,8’S,10’R,13’S,14’S)-5,5,13′-trimethyl-1′,2′,6′,7′,8′,12′,13′,14′,15′,16′-decahydro-17’H-spiro[1,3-dioxan-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-one, followed by conjugate addition of 1-bromo-4-methylthiobenzene in the presence of magnesium and copper, and deacetalization. All the invention compounds were evaluated for their progesterone receptor antagonistic activity. From the assay, it was determined that compound II exhibited IC50 values of 0.011 nmol/L and 0.012 nmol/L towards progesterone receptor A and B, resp. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Category: ethers-buliding-blocks

The Article related to estradiene aryl preparation progesterone receptor antagonist, Steroids: Estranes and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 27, 2011, Schwede, Wolfgang; Klar, Ulrich; Moeller, Carsten; Rotgeri, Andrea; Bone, Wilhelm published a patent.HPLC of Formula: 53136-21-3 The title of the patent was 17-Hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives as progesterone receptor antagonists and their preparation and use in the treatment of diseases. And the patent contained the following:

The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives of formula I exhibiting progesterone-antagonistic effects and to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular uterine fibroids (myomas, uterine leiomyomas), endometriosis, menorrhagia, meningiomas, hormone-dependent mammary carcinomas and menopause-associated troubles, or for fertility control and emergency contraception. Compounds of formula I wherein R1 is SH and derivatives, SOH and derivatives, SO2H and derivatives, SONH2 and derivatives, (un)substituted aryl, etc.; X is O, NOH and derivatives and NNHSO2H and derivatives; and stereoisomers, salts, solvates, solvated salts, and all crystal modifications thereof, are claimed. Example compound II was prepared by addition of pentafluoroiodoethane to (5’R,8’S,10’R,14’S)-5,5,13′-trimethyl-1′,2′,6′,7′,12′,13′,14′,15′,16′-decahydro-17’H-spiro[1,3-dioxan-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-one, followed by conjugate addition of 1-bromo-4-methylthiobenzene in the presence of magnesium and copper, and deacetalization. All the invention compounds were evaluated for their progesterone receptor antagonistic activity. From the assay, it was determined that compound II exhibited IC50 values of 0.011 nmol/L and 0.012 nmol/L towards progesterone receptor A and B, resp. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).HPLC of Formula: 53136-21-3

The Article related to estradiene aryl derivative preparation progesterone receptor antagonist treatment disease, Steroids: Estranes and other aspects.HPLC of Formula: 53136-21-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 22, 2010, Hamada, Maiko; Nakamura, Mitsuharu; Kiuchi, Masatoshi; Marukawa, Kaoru; Tomatsu, Ayumi; Shimano, Kyoko; Sato, Noriko; Sugahara, Kunio; Asayama, Mahoko; Takagi, Kan; Adachi, Kunitomo published an article.Recommanded Product: Benzyl(4-bromophenyl)sulfane The title of the article was Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1 Agonists with Reduced Effect on Heart Rate. And the article contained the following:

A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate receptor-1 (S1P1) receptor agonists with potent immunomodulatory activity accompanied by little or no effect on heart rate. Many of the synthesized compounds sufficiently decreased the number of peripheral blood lymphocytes. Some of the phosphates had potent agonism at S1P1 but no agonism at S1P3, which had been reported to be a receptor responsible for heart rate reduction Although high S1P1/S1P3 selectivity was considered to be favorable to reduce the effect on heart rate, almost all the phosphates showed a remarkable heart rate lowering effect in vivo. The results suggest that other factors in addition to S1P3 agonism should be responsible for the heart rate reduction caused by S1P1 agonists. Only 2-amino-2-[2-[2′-fluoro-4′-(4-methylphenylthio)biphenyl-4-yl]ethyl]propane-1,3-diol (6d) was identified as a desired S1P1 receptor agonist having both the immunomodulatory activity and an attenuated effect on heart rate by a unique screening flow using in vivo evaluating systems primarily. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Recommanded Product: Benzyl(4-bromophenyl)sulfane

The Article related to multiple sclerosis immunomodulators agonists decrease heart rate, Pharmacology: Structure-Activity and other aspects.Recommanded Product: Benzyl(4-bromophenyl)sulfane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Semple, Graeme; Santora, Vincent J.; Smith, Jeffrey M.; Covel, Jonathan A.; Hayashi, Rena; Gallardo, Charlemagne; Ibarra, Jason B.; Schultz, Jeffrey A.; Park, Douglas M.; Estrada, Scott A.; Hofilena, Brian J.; Smith, Brian M.; Ren, Albert; Suarez, Marissa; Frazer, John; Edwards, Jeffrey E.; Hart, Ryan; Hauser, Erin K.; Lorea, Jodie; Grottick, Andrew J. published an article in 2012, the title of the article was Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).Application In Synthesis of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

The design of a new clin. candidate histamine-H3 receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described. Phenethyl-R-2-methylpyrrolidine containing biphenylsulfonamide compounds were modified by replacement of the sulfonamide linkage with a sulfone. One compound from this series, APD916 (I) increased wakefulness in rodents as measured by polysomnog. with a duration of effect consistent with its pharmacokinetic properties. The identification of a suitable salt form of I allowed it to be selected for further development. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application In Synthesis of Benzyl(4-bromophenyl)sulfane

The Article related to biaryl sulfone derivative preparation histamine h3 antagonist sar, apd916 h3 antagonist wakefulness, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of Benzyl(4-bromophenyl)sulfane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 7, 2012, Sakai, Norio; Miyazaki, Takahiro; Sakamoto, Tomohiro; Yatsuda, Takuma; Moriya, Toshimitsu; Ikeda, Reiko; Konakahara, Takeo published an article.SDS of cas: 53136-21-3 The title of the article was Single-step thioetherification by indium-catalyzed reductive coupling of carboxylic acids with thiols. And the article contained the following:

Direct thioetherification from a variety of aromatic carboxylic acids and thiols using a reducing system combined with InBr3 and 1,1,3,3-teramethyldisiloxane (TMDS) in a one-pot procedure is demonstrated. It was also found that a system combined with InI3 and TMDS underwent thioetherification of aliphatic carboxylic acids with thiols. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).SDS of cas: 53136-21-3

The Article related to carboxylic acid thioetherification reductive coupling thiol indium catalyst, Aliphatic Compounds: Alcohols and Thiols and other aspects.SDS of cas: 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem