Category: 529-28-2

《Palladium-catalyzed β-arylation of cyclic α,β,-unsaturated O-methyl oximes with aryl iodides》 was published in Chemical & Pharmaceutical Bulletin in 2020. These research results belong to Akagi, Yusuke; Fukuyama, Shiori; Komatsu, Toshiya. Electric Literature of C7H7IO The article mentions the following:

A Pd-catalyzed β-arylation of cyclic α,β-unsaturated O-Me oximes with substituted iodobenzenes was reported. This reaction showed complete regioselectivity and excellent functional group tolerance. The β-arylation of 2-cyclohexen-1-one O-Me oxime (existing as 2:1 E/Z mixture) with certain aryl iodides such as 4-iodoanisole afforded only β-arylated (E)-O-Me oximes. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Electric Literature of C7H7IO

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Ether – Wikipedia,
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Synthetic Route of C7H7IOIn 2019 ,《Synthetic utilization of tetrafluoroethylene-containing silyl reagent (CH2=CHCF2CF2SiEt3) in Cu(I)-mediated cross-coupling reaction with various iodoarenes》 was published in Journal of Fluorine Chemistry. The article was written by Yakushijin, Ryosuke; Yamada, Shigeyuki; Konno, Tsutomu. The article contains the following contents:

The synthetic utilization of thermally stable as well as easy-handling tri-Et (1,1,2,2-tetrafluorobut-3-en-1-yl)silane as the tetrafluoroethylenating agent through Cu(I)-mediated cross-coupling reaction with various iodoarenes, which offered a promising building block for versatile CF2CF2-containing organic mols. through easy carbon chain elongation at both ends were revealed. Specifically, the above tetrafluoroethylene-containing silyl reagent, readily prepared from com. available 4-bromo-3,3,4,4-tetrafluorobut-1-ene, smoothly reacted with various iodoarenes in the presence of Cu(I), Ag(I) and pyridine in DMF at 60° for 16 h, the corresponding CF2CF2-containing aromatic compounds being afforded in moderate to good yields. Addnl., it was revealed that the coupling reaction dramatically facilitated when iodoarenes with an ortho-directing group, e.g., COOMe, were used as an electrophile, in which the acceleration effect was theor. proved to stabilize the whole reaction system by coordination of the carbonyl oxygen to the copper atom. After reading the article, we found that the author used 1-Iodo-2-methoxybenzene(cas: 529-28-2Synthetic Route of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Synthetic Route of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2021 ,《Modular Entry to Functionalized Tetrahydrobenzo[b]azepines via the Palladium/Norbornene Cooperative Catalysis Enabled by a C7-Modified Norbornene》 was published in Journal of the American Chemical Society. The article was written by Liu, Xin; Wang, Jianchun; Dong, Guangbin. The article contains the following contents:

Here, the authors report a straightforward method to synthesize THBAs (tetrahydrobenzo[b]azepines), e.g., I, directly from simple aryl iodides RI (R = 3-chlorophenyl, quinolin-6-yl, 4-(morpholinyl)-2-methylphenyl, etc.) via palladium/norbornene (Pd/NBE) cooperative catalysis. Capitalizing on an olefin-tethered electrophilic amine reagent, an ortho amination followed by 7-exo-trig Heck cyclization furnishes the seven-membered heterocycle. To overcome the difficulty with ortho-unsubstituted aryl iodide substrates, a unique C7-bromo-substituted NBE, II, to offer the desired reactivity and selectivity was discovered. In addition to THBAs, synthesis of other benzo-seven-membered ring compounds e.g., III, can also be promoted by II. Combined exptl. and computational studies show that the C7-bromo group in II plays an important and versatile role in this catalysis, including promoting β-carbon elimination, suppressing benzocyclobutene formation, and stabilizing reaction intermediates. The mechanistic insights gained could guide future catalyst design. The synthetic utility has been demonstrated in a streamlined synthesis of tolvaptan (IV) and forming diverse pharmaceutically relevant THBA derivatives Finally, a complementary and general catalytic condition to access C6-substituted THBAs from ortho-substituted aryl iodides has also been developed.1-Iodo-2-methoxybenzene(cas: 529-28-2Category: ethers-buliding-blocks) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of Chiral-Substituted 2-Aryl-ferrocenes by the Catellani Reaction》 was written by Thorat, Raviraj Ananda; Jain, Saket; Sattar, Moh.; Yadav, Prateek; Mandhar, Yogesh; Kumar, Sangit. Formula: C7H7IO And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A Pd-catalyzed and norbornene-mediated methodol. was developed for the synthesis of chiral 2-aryl-ferroceneamides from chiral 2-iodo-N,N-diisopropylferrocencarboxamide, iodoarenes, and alkenes using a JohnPhos ligand and K carbonate as a base in DMF at 105°. The developed three-component coupling protocol allows the compatibility of electron-withdrawing fluoro, chloro, ester, and nitro and electron-donating Me, methoxy, dimethoxy, benzyl ether-substituted iodo-benzenes, other iodoarenes, such as iodo-naphthalene, heteroarenes, such as iodothiophene, and terminating substrates, such as Me, Et, tert-Bu acrylates, and substituted styrenes with 2-iodo-N,N-diisopropylferrocencarboxamide. Also, the developed three-component Catellani method proceeded with the retention of the configuration of the planar chiral ferrocene, which depends on the role of the participating C-I bond in ferrocene. Consequently, the developed protocol enabled the formation of densely substituted chiral 2-aryl ferroceneamides, exhibiting good to excellent enantioselectivity. The conversion of an ester of the synthesized chiral 2-aryl ferroceneamides also was carried out to further accommodate the easily expendable acid and alc. functionalities. In the experiment, the researchers used many compounds, for example, 1-Iodo-2-methoxybenzene(cas: 529-28-2Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: 1-Iodo-2-methoxybenzeneIn 2021 ,《Design and Applications of a SO2 Surrogate in Palladium-Catalyzed Direct Aminosulfonylation between Aryl Iodides and Amines》 was published in Angewandte Chemie, International Edition. The article was written by Jia, Xiuwen; Kramer, Soeren; Skrydstrup, Troels; Lian, Zhong. The article contains the following contents:

A new SO2 surrogate is reported that is cheap, bench-stable, and can be accessed in just two steps from bulk chems. Essentially complete SO2 release is achieved in 5 min. Eight established sulfonylation reactions proceeded smoothly by ex situ formation of SO2 by utilizing a two-chamber system in combination with the SO2 surrogate. Furthermore, we report the first direct aminosulfonylation between aryl iodides and amines. Broad functional group tolerance is demonstrated, and the method is applicable to pharmaceutically relevant substrates, including heterocyclic substrates. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Name: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Name: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Liu, Feipeng; Dong, Zhe; Wang, Jianchun; Dong, Guangbin. Related Products of 529-28-2. The article was titled 《Palladium/Norbornene-Catalyzed Indenone Synthesis from Simple Aryl Iodides: Concise Syntheses of Pauciflorol F and Acredinone A》. The information in the text is summarized as follows:

To show the synthetic utility of palladium/norbornene (Pd/NBE) cooperative catalysis, here we report concise syntheses of indenone-based natural products, pauciflorol F and acredinone A, which are enabled by direct annulation between aryl iodides and unsaturated carboxylic acid anhydrides. Compared to the previous indenone preparation approaches, this method allows simple aryl iodides to be used as substrates with complete control of the regioselectivity. The total synthesis of acredinone A features two different Pd/NBE-catalyzed ortho acylation reactions for constructing penta-substituted arene cores, including the development of a new ortho acylation/ipso borylation. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Related Products of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Related Products of 529-28-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Gold-Catalyzed Chemoselective Couplings of Polyfluoroarenes with Aryl Germanes and Downstream Diversification》 was published in Journal of the American Chemical Society in 2020. These research results belong to Dahiya, Amit; Fricke, Christoph; Schoenebeck, Franziska. Quality Control of 1-Iodo-2-methoxybenzene The article mentions the following:

This report describes the chemoselective coupling of polyfluoroarenes with aryl germanes in the presence of aromatic C-I, C-Br, C-Cl, C-OTf, and C-SiMe3 groups, as well as demonstrates the further downstream diversification to give richly functionalized and highly fluorinated polyarenes. The strategy relies on an in situ Umpolung of the FnArH, followed by selective Au(I)/Au(III)-catalyzed coupling with electron-poor or -rich aryl germanes, even in the presence of challenging ortho-substituents, and widens the currently available coupling space in oxidative gold catalysis to previously inaccessible electron-poor/electron-poor biaryls.1-Iodo-2-methoxybenzene(cas: 529-28-2Quality Control of 1-Iodo-2-methoxybenzene) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Quality Control of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Supported Palladium-Gold Catalyzed Carbonylative Methylthioesterification of Aryl Iodides using Oxalic acid and DMSO as CO and CH3SH Surrogates》 was written by Sharma, Ajay Kumar; Ram, Shankar; Sheetal; Mehara, Pushkar; Chauhan, Arvind Singh; Das, Pralay. Recommanded Product: 1-Iodo-2-methoxybenzene And the article was included in Asian Journal of Organic Chemistry in 2020. The article conveys some information:

The polystyrene supported palladium-gold (Pd-Au@PS) catalyst was prepared and well characterized by HR-TEM, EDX, Elemental Mapping, XPS and P-XRD anal. The Pd-Au@PS NPs displayed the superior catalytic activity than their monometallic forms. First time, the catalyst was applied for methylthioesterification reaction of aryl iodides RI (R = Ph, 4-methylphenyl, naphthalen-1-yl, thiophen-2-yl, etc.) with oxalic acid and DMSO as in situ carbon monoxide (CO) and Me mercaptan (CH3SH) precursor. Yet, there is no report available where DMSO has been applied as CH3SH source for methylthioester RC(O)SCH3 synthesis. The CH3SH and CO are likely to poison the metal catalyst, whereas in Pd-Au@PS catalyst, the beneficial inter-electronic interaction between Pd and Au metals makes the catalyst highly reactive, poisoning resistant and recyclable during the transformation. Moreover, the developed protocol exhibits excellent functional group tolerance for various aryl iodides to deliver the desired products in moderate to very good yields. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-2-methoxybenzene(cas: 529-28-2Recommanded Product: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Recommanded Product: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,European Journal of Organic Chemistry included an article by Casotti, Gianluca; Iuliano, Anna; Carpita, Adriano. COA of Formula: C7H7IO. The article was titled 《Arylzinc Halides by Silver Catalyzed Zinc Insertion into Aryl Iodides》. The information in the text is summarized as follows:

A catalytic amount of silver acetate efficiently promotes direct insertion of zinc metal into aryl iodides, having different structure, in ethereal solvent. Electron-rich substrates also rapidly undergo oxidative metalation. The arylzinc iodides formed give Negishi coupling products under mild reaction conditions to obtain biaryls in high yields. Sensitive functional groups like aldehydes and primary amides are well-tolerated. In the experimental materials used by the author, we found 1-Iodo-2-methoxybenzene(cas: 529-28-2COA of Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.COA of Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Journal of Organometallic Chemistry included an article by Gholivand, Khodayar; Kahnouji, Mohammad; Maghsoud, Yazdan; Hosseini, Mahdieh; Mark Roe, Stephen. Product Details of 529-28-2. The article was titled 《Synthesis, structure, computational and catalytic activities of palladium complexes containing hydrazide based amino-phosphine ligands》. The information in the text is summarized as follows:

Two new N,N-bis(diphenylphosphino)amine ligands [where amine = N-aminophthalimide (L1 = (C6H4C2NO2)N(PPh2)2) and hydrazine (L2 = (Ph2P)2NNH2)] and their Pd(II) complexes, [{(C6H4C2NO2)N(PPh2)2}PdCl2] (C1) and [PdCl2{(Ph2P)2NNH2}] (C2) were synthesized and characterized by IR and NMR spectroscopies. Single crystal x-ray diffraction techniques were used to determine the crystal structures of the complexes. The catalytic activities of mentioned complexes in Heck coupling reactions were assessed. The NBO anal. was used to study the nature of the metal-ligand interactions. In the case of L2, preparation route could produced two different products (Pro.1 and Pro.2), but only one product was prepared in high purity. To address the reason for this manner, kinetics and thermodn. of two different pathways that could led to possible products were studied theor.1-Iodo-2-methoxybenzene(cas: 529-28-2Product Details of 529-28-2) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Product Details of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem