Category: 529-28-2

The author of 《Computationally Assisted Mechanistic Investigation into Hypervalent Iodine Catalysis: Cyclization of N-Allylbenzamide》 were Butt, Smaher E.; Das, Mirdyul; Sotiropoulos, Jean-Marc; Moran, Wesley J.. And the article was published in Journal of Organic Chemistry in 2019. Application of 529-28-2 The author mentioned the following in the article:

Previous exptl. work identified 2-iodoanisole as the best precatalyst for the oxidative cyclization of N-alkenylamides into 2-oxazolines. Herein, we describe our investigation into the effect on reaction rate based on the structure of the iodoarene precatalyst. We also reveal the mechanism of the cyclization based on DFT modeling and obtain a clear correlation between observed reaction rates and computationally derived activation energies for different iodoarenes. In addition, the rate-limiting step is shown to be the cyclization of the substrate which is zero order in the concentration of the iodoarene precatalyst. The rate of the cyclization is found to correlate with the ease of oxidation of the iodoarene, however the most easily oxidized iodoarenes generate iodine(III) species that decompose readily. Finally, loss of iodoarene from the cyclized intermediate can proceed by either ligand-coupling or SN2 displacement (reductive elimination), and this is shown to be substrate dependent. After reading the article, we found that the author used 1-Iodo-2-methoxybenzene(cas: 529-28-2Application of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Application of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Mechanochemical Pd(II)-Catalyzed Direct and C-2-Selective Arylation of Indoles》 were Das, Dharmendra; Bhutia, Zigmee T.; Chatterjee, Amrita; Banerjee, Mainak. And the article was published in Journal of Organic Chemistry in 2019. Safety of 1-Iodo-2-methoxybenzene The author mentioned the following in the article:

A mechanochem. method for the preparation of synthetically useful 2-arylindoles is developed using Pd(II) as the catalyst in the absence of phosphine ligands in a ball-mill. The developed protocol is highly C-2 selective and tolerant of structural variations with electron-rich and electron-deficient substituents both in indoles and iodoarenes. Arylation is possible in both unprotected indoles and N-protected indoles with the electron-donating group with the former substrate being relatively slower to react and little less yielding. Indoles with a deactivated five-membered ring could also take part in the reaction with ease. The scalability of the reaction was demonstrated by conducting the reaction in the gram scale. In general, the reactions were achieved in a shorter time than the conventional methods. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Safety of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Long-Distance Chirality Transfer from P-Ligand to Prochiral Dihydrosilanes via Pd(II) Aryl Iodide Complex in Pd-Catalyzed Silylation of Aryl Iodide: A DFT Study》 was published in Journal of Organic Chemistry in 2020. These research results belong to Yang, Jing-Jing; Xu, Zheng; Nie, Yi-Xue; Lu, Si-Qi; Zhang, Jin; Xu, Li-Wen. Recommanded Product: 1-Iodo-2-methoxybenzene The article mentions the following:

The mechanism of Pd-catalyzed desym. monoarylation of dihydrosilanes with aryl iodides in the presence of chiral TADDOL-derived phosphoramidite ligand toward deeper understanding of the stereoselectivity has been investigated using hybrid d. functional theory (DFT) methodol. The full catalytic cycle for the favorable reaction pathway, which is initiated by the oxidative addition of aryl iodide to monoligated Pd0 leading to the silylation product, was calculated The DFT calculation results indicate that the enantio-discriminating transmetalation between Pd-Ar bond of the Pd(II) aryl iodide complex and Si-H bond of the prochiral dihydrosilane was the enantioselectivity-determining step. On the basis of the structure of the transition state, the attractive aryl-aryl interactions between the aryl group of ligand, aryl iodide, and dihydrosilane were found to play an important role for the chiral transference from the chiral ligand to asym. cleavage of the Si-H bond of the prochiral dihydrosilane. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Recommanded Product: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Recommanded Product: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Native amine-directed site-selective C(sp3)-H arylation of primary aliphatic amines with aryl iodides》 was published in Chinese Chemical Letters in 2020. These research results belong to Pramanick, Pranab K.; Zhou, Zhibing; Hou, Zhenlin; Ao, Yufei; Yao, Bo. Product Details of 529-28-2 The article mentions the following:

A simple and efficient method for site-selective C(sp3)-H arylation of primary aliphatic amines by aryl iodides were established. In the presence of only 5 mol% Pd(OAc)2, a wide range of aliphatic amines including O-benzyl and O-silyl amino alcs. were arylated at γ- or δ-positions by aryl iodides containing a broad scope of functional groups. The synthetic application of this method had also been demonstrated by large-scale synthesis, the synthesis of a fingolimod analog and the conjugation with natural D-menthol and fluorescent 1,8-naphthalimide. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Product Details of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Product Details of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)-H functionalization》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Wan, Zi-juan; Yuan, Xiao-feng; Luo, Jun. COA of Formula: C7H7IO The article mentions the following:

An intriguing and mild method for visible light induced regioselective addition of arylpropiolic acids by attacking exclusively at the 3-position with cyclic/acyclic ethers was developed. A variety of 3,3-bis-substituted acrylic acids were successfully obtained in moderate to excellent yields. A plausible reaction mechanism involving an energy transfer induced radical addition in the presence of visible light and photocatalyst was proposed. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2COA of Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.COA of Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Chemistry – A European Journal included an article by Magne, Valentin; Ball, Liam T.. Electric Literature of C7H7IO. The article was titled 《Synthesis of Air-stable, Odorless Thiophenol Surrogates via Ni-Catalyzed C-S Cross-Coupling》. The information in the text is summarized as follows:

An efficient catalytic method for the preparation of S-(hetero)aryl isothiouronium salts ArSC(NH2)=NH2+ 3,5-(NO2)2C6H3C(O)O- (Ar = Ph, thiophen-2-yl, 1H-pyrazol-4-yl, etc.) and demonstrates that these air-stable, odorless solids serving as user-friendly sources of thiophenols have been synthesized. Diverse isothiouronium salts featuring synthetically useful functionality are readily accessible by nickel-catalyzed C-S cross-coupling of (hetero)aryl iodides ArI and thiourea. Convenient, chromatog.-free isolation of these salts is achieved by precipitation, allowing the methodol. to be applied directly to large scales. Thiophenols are liberated from the corresponding isothiouronium salts upon treatment with a weak base, enabling an in situ release/S-functionalization strategy that entirely negates the need to isolate, purify or manipulate these noxious reagents. In the experiment, the researchers used 1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Electric Literature of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of 3-alkylideneisoindolin-1-ones via Sonogashira cyclocarbonylative reactions of 2-ethynylbenzamides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Albano, Gianluigi; Giuntini, Stefano; Aronica, Laura Antonella. Quality Control of 1-Iodo-2-methoxybenzene The article mentions the following:

Cyclocarbonylative Sonogashira reactions of ortho-ethynylbenzamides were investigated. The process was carried out under CO pressure, in the presence of a very small amount of PdCl2(PPh3)2 (0.4 mol %) as a catalytic precursor, and without the need for a Cu salt as co-catalyst. 2-Ethynylbenzamide reacted successfully with iodoarenes bearing electron-withdrawing and electron-donating groups giving rise to different classes of compounds depending on the solvent used. On the contrary, N-(4-chlorophenyl)-2-ethynylbenzamide afforded exclusively polyfunctionalized isoindolinones I [R = H, 4-ClC6H4; Ar = Ph, 2-MeOC6H4, 4-MeOC6H4, 4-ClC6H4, 4-CNC6H4] with high stereoselectivity towards (E) isomers. In the experimental materials used by the author, we found 1-Iodo-2-methoxybenzene(cas: 529-28-2Quality Control of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Quality Control of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of 1-Iodo-2-methoxybenzeneIn 2019 ,《Metal-free synthesis of gem-silylboronate esters and their Pd(0)-catalyzed cross-coupling with aryliodides》 was published in Organic & Biomolecular Chemistry. The article was written by Wu, Chaoqiang; Bao, Zhicheng; Xu, Xing; Wang, Jianbo. The article contains the following contents:

A transition-metal-free method for the synthesis of gem-silylboronate esters with arylboronic acids and trimethylsilyldiazomethane (TMSCHN2) has been developed. This transformation is a straightforward homologation of arylboronic acids and features wide substrate scope and good functional-group tolerance. The gem-silylboronate esters undergo efficient Suzuki-Miyaura cross-coupling with aryliodides and the silyl group of the product can be further functionalized. Tertiary carbon centers with different substituents can be constructed successfully by selective and sequential functionalization. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Quality Control of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Quality Control of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C7H7IOIn 2020 ,《Chemoselective Rhodium-Catalyzed Borylation of Bromoiodoarenes Under Mild Conditions》 appeared in Journal of Organic Chemistry. The author of the article were Varni, Anthony J.; Bautista, Michael V.; Noonan, Kevin J. T.. The article conveys some information:

A chemoselective rhodium-catalyzed borylation has been developed for the preparation of aryl boronate esters. The reaction proceeds under mild conditions with excellent selectivity for C-I bonds in bromoiodoarenes and exhibits broad functional group tolerance. This procedure can act as a complementary approach toward bifunctional arenes along with other metal-catalyzed borylations. Addnl., the reaction’s utility in the preparation of monomers for metal-catalyzed cross-coupling polymerization is demonstrated. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-2-methoxybenzene(cas: 529-28-2Synthetic Route of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Synthetic Route of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper/Nickel-Catalyzed Selective C-S/S-S Bond Formation Starting from O-Alkyl Phenylcarbamothioates》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Peng, Kang; Gao, Ming-Yuan; Yi, Yu-Yan; Guo, Jia; Dong, Zhi-Bing. Electric Literature of C7H7IO The article mentions the following:

A convenient and effective method is described to construct C-S/S-S bond starting from O-alkyl phenylcarbamothioates, giving diverse O-alkyl S-Ph phenylcarbonimidothioates and isothiourea disulfides, resp. The C-S bond formation products (O-alkyl S-Ph phenylcarbonimidothioates) were synthesized by using Cu2O as catalyst in water (without phase-transfer catalyst), and the S-S bond formation product (isothiourea disulfides) could be furnished catalyzed by NiBr2 at room temperature These transformations feature easy control, environmental friendliness, and good to excellent yields, which could be attractive in the selective C-S/S-S bond formation.1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Electric Literature of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem