Category: 52244-70-9

Bam, Radha; Pollatos, Alexandros S.; Moser, Austin J.; West, Julian G. published the artcile< Mild olefin formation via bio-inspired vitamin B12 photocatalysis>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is haloalkane cobalamin catalyst regioselective photochem dehydrohalogenation; alkene preparation; alkyl sulfonate cobalamin catalyst regioselective photochem olefination; olefin preparation.

A light-driven B12-based catalytic system that leverages this reactivity to convert alkyl electrophiles to olefins under incredibly mild conditions using only earth abundant elements was reported. Further, this process exhibited a high level of regioselectivity, producing terminal olefins in moderate to excellent yield and exceptional selectivity. Finally, it was able to access a hitherto-unknown transformation, remote elimination, using two cobalt catalysts in tandem to produce subterminal olefins with excellent regioselectivity. Together, vitamin B12 to be a powerful platform for developing mild olefin-forming reactions was showed.

Chemical Science published new progress about Alkanesulfonates Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pingali, Harikishore; Jain, Mukul; Shah, Shailesh; Basu, Sujay; Makadia, Pankaj; Goswami, Amitgiri; Zaware, Pandurang; Patil, Pravin; Godha, Atul; Giri, Suresh; Goel, Ashish; Patel, Megha; Patel, Harilal; Patel, Pankaj published the artcile< Discovery of a highly orally bioavailable c-5-[6-(4-methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is methanesulfonylhexyldioxanecarboxylic acid preparation hypoglycemic hypolipidemic.

A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted Ph group as a lipophilic tail have been prepared as agonists of PPARα and γ. C-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhagwat, Shripad S.; Gude, Candido; Boswell, Clay; Contardo, Nicolina; Cohen, David S.; Dotson, Ronald; Mathis, Janice; Lee, Warren; Furness, Patricia; Zoganas, Harry published the artcile< Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-[3-(3-pyridinyl)propyl]octanoic acid and analogs>, Application of C11H16O2, the main research area is chlorophenylsulfonylaminopyridinylpropyloctanoic acid preparation thromboxane antagonist; arylsulfonylaminopyridinylpropyloctanoic acid analog preparation thromboxane antagonist; thromboxane receptor antagonist synthase inhibitor arylsulfonylaminopyridinylpropyloctanoic.

The title compound [I, A = (CH2)2CO2H, B = (CH2)3Py, X = Cl; Py = 3-pyridyl] (II) and its analogs were synthesized and found to possess two activities, the inhibition of the biosynthesis of thromboxane A2 and antagonism of its receptors. Thus, II was prepared via arylsulfonylation of Et 6-amino-2-[(3-pyridinyl)propyl)]hexanoate, reduction, Wittig reaction with Ph3P:CHCO2Me, and treatment with NaBH4/CoCl2/MeOH. The in vitro and in vivo profile of these compounds as thromboxane receptor antagonists (TxRAs) and thromboxane synthase inhibitors (TxSls) is described. II and its analogs I [A = CO2H, NHCOCO2H, (CH2)3OH, SCH2CO2H, etc., B = (CH2)2OPy, CH2CH:CHPy, (CH2)2Im, X = F, OMe, N3, CF3, SO2Me; Im = 1-imidazolyl] displayed very potent TxRA activity in human washed platelets (IC50 ≈ 10-7-10-9 M) and dog saphenous vein (pA2 ≈ 9) and also potent TxSl activity (IC50 ≈ 10-9 M). The good bioavailability and the long duration of action of some of these compounds was demonstrated using ex vivo measurement of the TxRA and TxSl activities upon oral administration to guinea pigs. I [A = (CH2)2CO2H, B = (CH2)2OPy, X = Cl; A = SCH2CO2H, B = (CH2)3Py, X = Cl] and II potently inhibited arachidonic acid induced bronchoconstriction in guinea pigs.

Journal of Medicinal Chemistry published new progress about Thromboxane receptor TBXA2R Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Denning, Derek M.; Pedowitz, Nichole J.; Thum, Matthew D.; Falvey, Daniel E. published the artcile< Uncaging alcohols using UV or visible light photoinduced electron transfer to 9-phenyl-9-tritylone ethers>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is uncaging alc UV visible light photoinduced electron transfer; phenyl tritylone ether.

The clean and efficient photorelease of primary and secondary alcs. is reported from the deprotection of a new photoremovable protecting group, the 9-phenyltritylone (PTO) group. Deprotection is initiated by 350 nm excitation of the PTO chromophore in the presence of triethylamine or using 447 nm light in the presence of a visible light absorbing photocatalyst and triethylamine. Laser flash photolysis results are reported in support of a proposed deprotection mechanism for the release of alcs. on a ca. 20 μs time scale.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Junjun; Hua, Kaimin; Liu, Xiaofang; Deng, Yuchao; Wei, Baiyin; Wang, Hui; Sun, Yuhan published the artcile< Selective Production of Linear Aldehydes and Alcohols from Alkenes using Formic Acid as Syngas Surrogate>, Quality Control of 52244-70-9, the main research area is alkene formic acid rhodium regioselective hydroformylation catalyst; aldehyde linear preparation; formic acid alkene rhodium Shvo regioselective hydroxymethylation catalyst; alc linear preparation; formic acid; hydroformylation; hydroxymethylation; linear alcohol; tandem reaction.

Performing carbonylation without the use of carbon monoxide for high-value-added products is an attractive yet challenging topic in sustainable chem. Herein, effective methods for producing linear aldehydes or alcs. selectively with formic acid as both carbon monoxide and hydrogen source have been described. Linear-selective hydroformylation of alkenes proceeds smoothly with up to 88% yield and >30 regioselectivity in the presence of single Rh catalyst. Strikingly, introducing Ru into the system, the dual Rh/Ru catalysts accomplish efficient and regioselective hydroxymethylation in one pot. The present processes utilizing formic acid as syngas surrogate operate simply under mild condition, which opens a sustainable way for production of linear aldehydes and alcs. without the need for gas cylinders and autoclaves. As formic acid can be readily produced via CO2 hydrogenation, the protocols represent indirect approaches for chem. valorization of CO2.

Chemistry – A European Journal published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sasaki, Shigeki; Kurosaki, Fumie; Haradahira, Terushi; Yamamoto, Fumihiko; Maeda, Jun; Okauchi, Takashi; Suzuki, Kazutoshi; Suhara, Tetsuya; Maeda, Minoru published the artcile< Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains>, Application In Synthesis of 52244-70-9, the main research area is carbon 11 phenylalkylamine brain NMDA receptor PET.

Two new 11C-labeled ligands, N-(3-(4-hydroxyphenyl)propyl)-3-(4-methoxyphenyl)propylamine ([11C]2) and N-(3-(4-hydroxyphenyl)butyl)-3-(4-methoxyphenyl)butylamine ([11C]3) were designed based on bis(phenylalkyl)-amines which have been reported as polyamine site antagonists with high-selectivity for NR1A/2B NMDA receptors, and radiolabelling of the corresponding phenol precursors with [11C]methyl iodide was readily accomplished. The in vitro inhibition experiments using rat brain slices showed that [11C]2 and [11C]3 share the binding sites with spermine and/or ifenprodil but not with CP-101,606, a highly potent NR2B-selective NMDA antagonist, and that divalent cations such as Zn2+ produced significant inhibition of both [11C]2 and [11C]3 bindings. I.v. injection of [11C]3 in mice showed almost homogenous distribution throughout the brain. Attempts to block the tracer uptake of [11C]3 by pre-injection with the unlabeled 3 or spermine in rats were unsuccessful, but a small decrease in the cerebral uptake of [11C]3 by co-treatment with the unlabeled 3 was observed in a monkey PET study. The present findings indicate that none of these 11C-labeled analogs have potential for PET study of binding sites on the N-methyl-D-aspartate (NMDA) receptors.

Biological & Pharmaceutical Bulletin published new progress about Brain. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hernan-Gomez, Alberto; Rodriguez, Monica; Parella, Teodor; Costas, Miquel published the artcile< Electrophilic Iron Catalyst Paired with a Lithium Cation Enables Selective Functionalization of Non-Activated Aliphatic C-H Bonds via Metallocarbene Intermediates>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is diazoester alkyl substituted iron lithium intramol alkylation catalyst; cyclopentane ester stereoselective preparation; C−H activation; carbenes; iron; lithium; reaction mechanisms.

Combining an electrophilic iron complex [Fe(Fpda)(THF)]2 [Fpda=N,N’-bis(pentafluorophenyl)-o-phenylenediamide] with the pre-activation of α-alkyl-substituted α-diazoesters reagents by LiAl(ORF)4 [ORF= OC(CF3)3] provides unprecedented access to selective iron-catalyzed intramol. functionalization of strong alkyl C(sp3)-H bonds. Reactions occur at 25 °C via α-alkyl-metallocarbene intermediates, and with activity/selectivity levels similar to those of rhodium carboxylate catalysts. Mechanistic investigations reveal a crucial role of the lithium cation in the rate-determining formation of the electrophilic iron-carbene intermediate, which then proceeds by concerted insertion into the C-H bond.

Angewandte Chemie, International Edition published new progress about Alkylation catalysts (intramol.). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fatori, D.; Hunter, W. M. published the artcile< Radioimmunoassay for serum paraquat>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is paraquat determination serum radioimmunoassay; radioimmunoassay paraquat tracer serum.

Two variants of a radioimmunoassay for the bipyridylium herbicide paraquat (I) [4685-14-7] are described. Both employ antiserum raised to I-BSA which was covalently linked to particulate solid-phase support media. The rapid assay for clin. use employed a 3H-labeled I tracer, required no agitation and yielded results in the range 10-2500 ng/mL serum in 20 min from receipt of sample. The more sensitive assay, designed for research purposes, employed a 125-iodinated tracer, required 2 h continuous agitation but can detect I at 091 ng/mL in simple aqueous solution or 0.25 ng/mL serum. Results from rapid clin. assay agree well with the existing colorimetric method.

Clinica Chimica Acta published new progress about Blood analysis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Atkinson, Robert S.; Green, Richard H. published the artcile< 1,5-Hydride shifts in acyclic systems containing α,β-unsaturated ketones and p-methoxyphenyl groups>, Reference of 52244-70-9, the main research area is ketone unsaturated rearrangement mechanism; hydride shift rearrangement ketone.

D-labeling showed that the acid-catalyzed rearrangement of p-HOC6H4(CH2)2CR2CH2CH:CHCOMe (I, R = H) to 2-(p-hydroxyphenyl)cyclohexyl Me ketone involved an intramol. H shift. A similar rearrangement was observed for I (R = Me) and its aromatic Me ether but not analogous products were obtained from p-MeOC6H4CHR(CH2)2CH:CHCOMe (R = H, p-MeOC6H4) under the same reaction conditions.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Hydride shift. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Reference of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nouaille, Augustin; Pannecoucke, Xavier; Poisson, Thomas; Couve-Bonnaire, Samuel published the artcile< Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis>, Name: 4-(4-Methoxyphenyl)-1-butanol, the main research area is trisubstituted fluoroalkene preparation stereoselective ruthenium catalyst; terminal alkene fluoroalkene cross metathesis.

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Author’s thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, found as the Me 2-fluoroacrylate. Authors reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with Me 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products.

Advanced Synthesis & Catalysis published new progress about Catalysis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Name: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem