Category: 52244-70-9

Reddy, Reddy Rajasekhar; Gudup, Satish Sonbarao; Ghorai, Prasanta published the artcile< Organocatalytic, Enantioselective Synthesis of Cyclohexadienone Containing Hindered Spirocyclic Ethers through an Oxidative Dearomatization/Oxa-Michael Addition Sequence>, Electric Literature of 52244-70-9, the main research area is cyclohexadienone enantioselective preparation spirocyclic ether oxidative dearomatization oxa Michael; asymmetric synthesis; chromans; organocatalysis; oxa-Michael addition; tetrahydrofurans.

An unprecedented enantioselective oxa-Michael reaction of α-tertiary alcs. using cinchona-alkaloid-based chiral bifunctional squaramide catalysts is reported. An oxidative dearomatization of phenol followed by an enantioselective oxa-Michael addition sequence provided a broad array of chiral sterically hindered tetrahydrofurans and tetrahydropyrans attached to a cyclohexadienone moiety in spiro fashion. In general, good yields and excellent enantioselectivities (up to 99 %) were observed The chiral oxo-cycles obtained have easily been transformed into chromans without disturbing the enantioselectivity.

Angewandte Chemie, International Edition published new progress about Dearomatization (oxidative). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fujio, Mizue; Taguchi, Miyako; Wada, Yoshiko; Seki, Yoji; Mishima, Masaaki; Tsuno, Yuho published the artcile< Carbon-13 NMR studies on reaction mechanisms. IV. Solvolysis of 4-aryl-n-butyl brosylates>, Reference of 52244-70-9, the main research area is solvolysis phenylbutyl brosylate kinetics; carbon NMR solvolysis kinetics; anchimeric assistance solvolysis kinetics.

The solvolysis of methoxy-substituted 4-phenylbutyl-1-13C (90% enriched) brosylate gave both open-chain ester products and isomeric products (e.g., 6- or 7-methoxytetralin-1-13C) via anchimerically-assisted pathways. The 13C NMR tracer technique was applied to the solvolysis mechanism and kinetics. Suitably positioned MeO groups accelerated the anchimerically assisted route. Transition states for the assisted pathways were discussed.

Memoirs of the Faculty of Science, Kyushu University, Series C: Chemistry published new progress about Acetolysis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Reference of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wen, Xiaojin; Li, Xinyao; Luo, Xiao; Wang, Weijin; Song, Song; Jiao, Ning published the artcile< Intramolecular Csp3-H/C-C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is pyrrolidine preparation; alkyl azide cyclization amination.

The intramol. Csp3-H and/or C-C bond amination was very important in modern organic synthesis due to its efficiency in the construction of diversified N-heterocycles. A novel intramol. cyclization of alkyl azides for the synthesis of cyclic imines I [Ar = Ph, 4-MeC6H4, 4-OMeC6H4, etc.; R = H, 2-Me, 2-Et, etc.] and tertiary amines II [n = 1, 2] through selective Csp3-H and/or C-C bond cleavage was reported. Two C-N single bonds or a C=N double bond were efficiently constructed in these transformations. The carbocation mechanism differed from the reported metal nitrene intermediates and therefore enabled metal-free and new transformation.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Xiaohuan; Deng, Zhijie; Tang, Pingping published the artcile< Direct Dehydroxytrifluoromethoxylation of Alcohols>, Application In Synthesis of 52244-70-9, the main research area is trifluoromethyl alkyl ether chemoselective preparation; etherification alc trifluoromethyl toluenesulfonate mediated cesium fluoride; dehydroxytrifluoromethylation primary secondary alc trifluoromethyl toluenesulfonate; fluoroformate intermediate dehydroxytrifluoromethylation alc trifluoromethyl toluenesulfonate; alcohols; nucleophilic substitution; synthetic methods; trifluoromethoxylation; trifluoromethyl arylsulfonate.

Primary alcs. and selected secondary alcs. underwent chemoselective direct dehydroxytrifluoromethoxylation with trifluoromethyl p-toluenesulfonate mediated by CsF and tetramethylammonium bromide in HMPA/DMA at 30-100° to yield trifluoromethyl ethers. The trifluoromethylation reaction is operationally simple and scalable, and proceeds under mild reaction conditions to provide access to a wide range of trifluoromethyl ethers from alcs.; functionalized natural products such as a deoxycholic acid-derived triol and pleuromutilin were also used as substrates.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Simon, Marc-Olivier; Girard, Simon A.; Li, Chao-Jun published the artcile< Catalytic Aerobic Synthesis of Aromatic Ethers from Non-Aromatic Precursors>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is cyclohexenone alc copper catalyzed aerobic oxidative condensation; aryl ether preparation.

Aryl ether formation is accomplished by oxidative condensation of alcs. and 2-cyclohexenones. The reaction complements the existing methods used by synthetic chemists to obtain aryl ethers, and allows a straightforward access to a wide range of functionalized products. In addition, the catalytic reaction with O2 as the oxidant generates water as the only byproduct and provides a “”greener”” approach to aryl ethers.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Jun; Peng, Chao; Yao, Bolin; Xu, Hua-Jian; Xie, Qiang published the artcile< Direct Deoxyfluorination of Alcohols with KF as Fluorine Source>, Quality Control of 52244-70-9, the main research area is triflate preparation; alc direct deoxyfluorination potassium fluoride transition metal free.

This report described a method for the deoxyfluorination of alcs. with KF as fluorine source via in situ generation of highly active CF3SO2F. Diverse functionalities including halogen, nitro, ketone, ester, alkene and alkyne are well tolerated. Mild condition, short reaction time and wide substrate scope enable this method an excellent choice for the construction of C-F bonds.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bach, Anders; Pizzirani, Daniela; Realini, Natalia; Vozella, Valentina; Russo, Debora; Penna, Ilaria; Melzig, Laurin; Scarpelli, Rita; Piomelli, Daniele published the artcile< Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies>, SDS of cas: 52244-70-9, the main research area is benzoxazolone carboxamide preparation SAR acid ceramidase inhibitory anticancer.

Ceramides are lipid-derived intracellular messengers involved in the control of senescence, inflammation, and apoptosis. The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity. AC inhibitors may be useful in the treatment of pathol. conditions, such as cancer, in which ceramide levels are abnormally reduced. Here, we present a systematic SAR investigation of the benzoxazolone carboxamides, a recently described class of AC inhibitors that display high potency and systemic activity in mice. We examined a diverse series of substitutions on both benzoxazolone ring and carboxamide side chain. Several modifications enhanced potency and stability, and one key compound with a balanced activity-stability profile I was found to inhibit AC activity in mouse lungs and cerebral cortex after systemic administration. The results expand our arsenal of AC inhibitors, thereby facilitating the use of these compounds as pharmacol. tools and their potential development as drug leads.

Journal of Medicinal Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evindar, Ghotas; Satz, Alexander L.; Bernier, Sylvie G.; Kavarana, Malcolm J.; Doyle, Elisabeth; Lorusso, Jeanine; Taghizadeh, Nazbeh; Halley, Keith; Hutchings, Amy; Kelley, Michael S.; Wright, Albion D.; Saha, Ashis K.; Hannig, Gerhard; Morgan, Barry A.; Westlin, William F. published the artcile< Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists>, Related Products of 52244-70-9, the main research area is amide arylalkoxyphenyl biarylalkoxyphenyl aryloxyphenyl preparation sphingosine phosphate receptor agonist; imidazole arylalkoxyphenyl biarylalkoxyphenyl preparation sphingosine phosphate receptor agonist.

In a search for potent and selective sphingosine-1-phosphate receptor agonists, the previously reported phenylamide and phenylimidazole scaffolds were utilized to explore extensive side-chain modifications to generate new mol. entities. A number of designed mols. demonstrated good selectivity and excellent in vitro and in vivo potency in both mouse and rat models. Oral administration of the lead mol. I (PPI-4667) demonstrated potent and dose-responsive lymphopenia.

Bioorganic & Medicinal Chemistry Letters published new progress about Amides, alkoxylated Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Liqiang; Sun, Pengli; Yan, Fulin published the artcile< Melamine-trisulfonic acid-catalyzed trimethylsilylation of alcohols and phenols>, Application In Synthesis of 52244-70-9, the main research area is alc trimethylsilylation melamine sulfonic acid catalyst; phenol trimethylsilylation melamine sulfonic acid catalyst; silyl ether preparation environmentally benign chem.

A highly convenient method for the trimethylsilylation of alcs. and phenols via treatment by hexamethyldisilazane in the presence of melamine trisulfonic acid as a catalyst was developed. A wide variety of hydroxyl groups were selectively protected under solvent-free conditions.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chu, Guo-Hua; Milano, Shawn; Kluth, Lisa; Rhodes, Michael; Boni, Riccardo; Johnson, David A.; Li, Pui-Kai published the artcile< Structure-activity relationship studies of the amide functionality in (p-O-sulfamoyl)-N-alkanoyl tyramines as estrone sulfatase inhibitors>, SDS of cas: 52244-70-9, the main research area is sulfamoylalkanoyl tyramine preparation estrone sulfatase inhibition.

Recently, we reported the synthesis and biochem. studies of a series of (p-O-sulfamoyl)-N-alkanoyl tyramines as nonsteroidal estrone sulfatase inhibitors. One of the most potent inhibitors in this series is (p-O-sulfamoyl)-N-tridecanoyl tyramine (I) with an IC50 value of 61.3 nM. In this study, we synthesized four analogs of this compound to investigate the structure-activity relationships of the amide functionality in (p-O-sulfamoyl)-N-tridecanoyl tyramine. Replacement of the amide functionality with an ethylene moiety resulted in complete loss of sulfatase inhibitory activity (IC50 of 61.3 nM vs. >20 μM). The keto, hydroxy, and ester analogs were 8-15 times less in affinity to the sulfatase than inhibitor I. However, their inhibitory activities are significantly higher than the ethylene analog. The results suggest that the amide functionality is favorable for sulfatase inhibitory activity and that there may be a hydrogen bonding component to the enzyme interaction in this region.

Steroids published new progress about Structure-activity relationship, enzyme-inhibiting. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem