Category: 52244-70-9

Duan, Jicheng; Du, Yun-Fei; Pang, Xiaobo; Shu, Xing-Zhong published the artcile< Ni-catalyzed cross-electrophile coupling between vinyl/aryl and alkyl sulfonates: synthesis of cycloalkenes and modification of peptides>, Synthetic Route of 52244-70-9, the main research area is vinyl triflate alkyl sulfonate Nickel catalyst reductive cross coupling; peptide alkyl tosylate Nickel catalyst cross coupling.

The coupling reactions between vinyl/aryl and alkyl C-O electrophiles that can be derived from chem. feedstocks and naturally occurring functional groups was reported. This method provided an efficient approach to the synthesis of a wide range of functionalized, and/or secondary alkyl substituted cycloalkenes that are difficult to synthesize by conventional methods. The reaction proceeded with broad substrate scope, and tolerated various functional groups such as alc., aldehyde, ketone, ester, amide, alkene, alkyne, heterocycles, organotin and organosilicon compounds The synthetic utility of this method was demonstrated by providing facile access to important building blocks. The possibility to apply this method for late-stage modification of peptides was also demonstrated. A broad range of functionalized alkyl groups was selectively introduced into tyrosine in peptides via C-C bond formation, which was a challenge to the existing procedures.

Chemical Science published new progress about Alkanesulfonates Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Synthetic Route of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Baricelli, Pablo J.; Rodriguez, Mariandry; Melean, Luis G.; Borusiak, Margarita; Crespo, Isis; Pereira, Juan C.; Rosales, Merlin published the artcile< Hydroformylation of natural olefins with the [Rh(COD)(μ-OMe)]2/TPPTS complex in BMI-BF4/toluene biphasic medium: observations on the interfacial role of CTAB in reactive systems>, HPLC of Formula: 52244-70-9, the main research area is aldehyde preparation hydroformylation natural olefin rhodium catalyst ionic liquid.

The complex [Rh(COD)(μ-OMe)]2 in presence of TPPTS (TPPTS = triphenylphosphinetrisulfonate) was evaluated as catalyst precursor for the in situ hydroformylation of natural olefins (eugenol, estragole and safrole) in biphasic media BMIm-BF4/toluene. Under moderate reaction conditions, the substrates showed the following reactivity order: eugenol > estragole > safrole. The rhodium system showed a high activity and selectivity towards the desired aldehydes. It was found that the use of cetyltrimethylammoniun bromide (CTAB) as phase transfer agent inhibits the hydroformylation reaction. The catalytic phase can be recycled up to four times without evident loss of activity or selectivity. In this work we report the use of an ionic liquid with hydrophilic character, without using water in the reaction medium.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, HPLC of Formula: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tidwell, Thomas T. published the artcile< Oxidation of alcohols to carbonyl compounds via alkoxysulfonium ylides: the Moffat, Swern, and related oxidations>, Electric Literature of 52244-70-9, the main research area is review Compound; review Related; review Moffatt; review Oxidation; review Ylides; review Alkoxysulfonium; review Carbonyl; review Alc; review Swern; review Oxidation.

A review of the article Oxidation of alcs. to carbonyl compounds via alkoxysulfonium ylides: the Moffat, Swern, and related oxidations

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Maillard, Ludovic T.; Benohoud, Meryem; Durand, Philippe; Badet, Bernard published the artcile< A New Supported Reagent for the Parallel Synthesis of Primary and Secondary O-Alkyl Hydroxylamines through a Base-Catalyzed Mitsunobu Reaction>, Formula: C11H16O2, the main research area is supported hydroxyphthalimide parallel synthesis hydroxylamine Mitsunobu reaction; alkylation Mitsunobu alc polymer supported hydroxyphthalimide.

The growing field of applications of O-alkyl hydroxylamines in medicinal chem. and chem. biol. has motivated the search for a parallel synthesis. A solid-phase approach based on the alkylation by alcs. of a new supported N(hydroxy)phthalimide reagent using a Mitsunobu reaction followed by methylaminolysis was optimized. This study points out the importance of the linker and a specific base effect for the Mitsunobu reaction. A large variety of alcs. can be used to give with moderate to high yields diverse O-alkyl hydroxylamines in high purity.

Journal of Organic Chemistry published new progress about Hydroxylamines Role: SPN (Synthetic Preparation), PREP (Preparation) (O-alkyl derivatives). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chang, Che-Chien; Cao, Song; Kang, Soosung; Kai, Li; Tian, Xinyong; Pandey, Prativa; Dunne, Sara Fernandez; Luan, Chi-Hao; Surmeier, D. James; Silverman, Richard B. published the artcile< Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels CaV1.3 and CaV1.2>, Category: ethers-buliding-blocks, the main research area is dihydropyridine dicarboxylate derivative structure calcium channel blocker neuroprotective.

L-type Ca2+ channels in mammalian brain neurons have either a CaV1.2 or CaV1.3 pore-forming subunit. Recently, it was shown that CaV1.3 Ca2+ channels underlie autonomous pacemaking in adult dopaminergic neurons in the substantia nigra pars compacta, and this reliance renders them sensitive to toxins used to create animal models of Parkinson’s disease. Antagonism of these channels with the dihydropyridine antihypertensive drug isradipine diminishes the reliance on Ca2+ and the sensitivity of these neurons to toxins, pointing to a potential neuroprotective strategy. However, for neuroprotection without an antihypertensive side effect, selective CaV1.3 channel antagonists are required. In an attempt to identify potent and selective antagonists of CaV1.3 channels, 124 dihydropyridines (4-substituted-1,4-dihydropyridine-3,5-dicarboxylic diesters) were synthesized. The antagonism of heterologously expressed CaV1.2 and CaV1.3 channels was then tested using electrophysiol. approaches and the FLIPR Calcium 4 assay. Despite the large diversity in substitution on the dihydropyridine scaffold, the most CaV1.3 selectivity was only about twofold. These results support a highly similar dihydropyridine binding site at both CaV1.2 and CaV1.3 channels and suggests that other classes of compounds need to be identified for CaV1.3 selectivity.

Bioorganic & Medicinal Chemistry published new progress about L-type calcium channel blockers. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tamiz, Amir P.; Whittemore, Edward R.; Woodward, Richard M.; Upasani, Ravindra B.; Keana, John F. W. published the artcile< Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-methyl-D-aspartate (NMDA) receptors>, Application In Synthesis of 52244-70-9, the main research area is neuroprotectant SAR tetrahydropyridoindole derivative NMDA receptor; structure tetrahydropyridoindole derivative NR1A2B NMDA receptor; neurodegenerative disorder tetrahydropyridoindole derivative neuroprotective SAR.

A series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles was synthesized as potential antagonists for the NR1A/2B subtype of N-methyl-D-aspartate (NMDA) receptors. Assayed by elec. recording under steady-state conditions, 7-hydroxy-2-(4-phenylbutyl)-1,2,3,4-tetrahydropyrido-[3,4-b]indole (30) was the most potent compound in the series having an IC50 value of 50 nM at the NR1A/2B receptors.

Bioorganic & Medicinal Chemistry Letters published new progress about Crystal structure. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Shuguang; Wang, Yunxiang; Zhang, Jing; Zhao, Xiansi; Xu, Shihong published the artcile< Chemical components of edible oil fume in kitchen and its genotoxicity on Drosophila>, SDS of cas: 52244-70-9, the main research area is edible oil fume genotoxicity Drosophila.

The chem. components of the condensate of edible oil fume in kitchen and its genotoxicity on Drosophila were studied. The chem. components were analyzed by gas chromatog. and mass spectra (GC/MS) and the genotoxicity was studied by sex linked recessive lethal (SLRL) test in Drosophila. A total of 74 organic compounds were found in samples of condensed oil from the fume in kitchen. It included hydroxy acids, hydrocarbons, alcs., esters, aldehydes, ketones, aromatic compounds, and steroids, etc. The total mutagenicity rates in SLRL test induced by the samples at concentrations of 110, 320 and 960 mg/L were 0.1732%, 0.4306% and 0.1707% resp. The sterility rates of the first broods were 2.564%, 2.056% and 2.845% at above 3 concentrations resp. (P <0.05, as compared with the control). The mutagenicity rate of the second brood at 320 mg/L was 0.530% and of condensate of the third brood at 110 mg/L was 0.540% (P <0.001). Some of the compounds in the condensate of edible oil fume had high recessive lethal effect and genotoxic effect on the reproductive system of Drosophila. Weisheng Yanjiu published new progress about Alcohols Role: ADV (Adverse Effect, Including Toxicity), BSU (Biological Study, Unclassified), BIOL (Biological Study). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ferry, Angelique; Guinchard, Xavier; Retailleau, Pascal; Crich, David published the artcile< Synthesis, Characterization, and Coupling Reactions of Six-Membered Cyclic P-Chiral Ammonium Phosphonite-Boranes; Reactive H-Phosphinate Equivalents for the Stereoselective Synthesis of Glycomimetics>, Reference of 52244-70-9, the main research area is protecting group phosphonite borane disaccharide glycoside synthesis phostone phosphonylation; alkaloid glycoside disaccharide glycomimetic coupling phosphonite borane stereoselective synthesis.

Stereoselective syntheses of P-chiral ammonium phosphonite-borane complexes in the gluco- and manno-like series have been developed from P(V) phostone derivatives The coupling reactions of these phostone donors with alcs. have been investigated with particular emphasis on the influence of protecting groups and conditions on stereoselectivity. The phosphonite-borane complexes may be applied directly in the coupling reactions and the products oxidized in situ to give phostone-mimetics of disaccharides. On the basis of these studies, successful protocols were established for the synthesis of β-gluco and α- and β-manno-configured phostones of primary alcs, e.g. I . Deprotection of the dimeric compounds leads to novel families of α- or β-(1→6)-linked glycomimetics.

Journal of the American Chemical Society published new progress about Alkaloids Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Reference of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhou, Yali; Xu, Xingjun; Sun, Hongwei; Tao, Guanyu; Chang, Xiao-Yong; Xing, Xiangyou; Chen, Bo; Xu, Chen published the artcile< Development of highly efficient platinum catalysts for hydroalkoxylation and hydroamination of unactivated alkenes>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is platinum catalyst preparation; alkenyl alc platinum catalyst intramol hydroalkoxylation; alkene alc platinum catalyst intermol hydroalkoxylation; aminoalkene platinum catalyst intramol hydroamination; amine alkene platinum catalyst intramol hydroamination.

The design and discovery of “”donor-acceptor””-type platinum catalysts that were highly effective in both hydroalkoxylation and hydroamination of unactivated alkenes over a broad range of substrates under mild conditions were described. A number of alkene substitution patterns were accommodated, including tri-substituted, 1,1-disubstituted, (E)-disubstituted, (Z)-disubstituted and even mono-substituted double bonds. Detailed mechanistic investigations suggested a plausible pathway that included an unexpected dissociation/re-association of the electron-deficient ligand to form an alkene-bound “”donor-acceptor””-type intermediate. These mechanistic studies helped to understand the origins of the high reactivity exhibited by the catalytic system and provided a foundation for the rational design of chiral catalysts towards asym. hydrofunctionalization reactions.

Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rodrigues, Fabio M. S.; Kucmierczyk, Peter K.; Pineiro, Marta; Jackstell, Ralf; Franke, Robert; Pereira, Mariette M.; Beller, Matthias published the artcile< Dual Rh-Ru Catalysts for Reductive Hydroformylation of Olefins to Alcohols>, SDS of cas: 52244-70-9, the main research area is alc preparation regioselective chemoselective; olefin reductive hydroformylation rhodium ruthenium catalyst; alcohols; homogeneous catalysis; rhodium; ruthenium; tandem reactions.

An active and selective dual catalytic system to promote domino hydroformylation-reduction reactions is described. Apart from terminal, di- and trisubstituted olefins, for the first time the less active internal C-C double bond of tetrasubstituted alkenes can also be utilized. As an example, 2,3-dimethylbut-2-ene is converted into the corresponding n-alc. with high yield (90 %) as well as regio- and chemoselectivity (>97 %). Key for this development is the use of a combination of Rh complexes with bulky monophosphite ligands and the Ru-based Shvo’s complex. A variety of aromatic and aliphatic alkenes can be directly used to obtain mainly linear alcs.

ChemSusChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem