Category: 52244-70-9

Xi, Xudong; Yin, Hongfang; Jin, Xiaojun; He, You published the artcile< Extraction of Notopterygium forbesii by supercritical CO2 extraction>, Quality Control of 52244-70-9, the main research area is Notopterygium supercritical carbon dioxide extraction.

The extracting process for Notopterygium forbesii by supercritical CO2 extraction was optimized. The best conditions of the extracting essential oil from root of Notopterygium forbesii by SFE-CO2 were studied and chem. composition was determined by using the GC-MS. The optimum process was as following: the temperature of extracting technique was 50°, pressure 25 MPa, extraction time 2 h and gas flow rate 65 kg/h-1. The extracting rate of essential oil was 8.8%, about 6 times to steam distillation And 159 kinds of compound was identified from extracting essential oil, furthermore compound containing Cl, S, B, F, the Si element had not been reported in the related literature. Temperature and pressure were the key factors which affected extracting efficiency and stability of Notopterygium forbesii by supercritical CO2 extraction

Yaowu Fenxi Zazhi published new progress about Essential oils Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dupuy, Stephanie; Zhang, Ke-Feng; Goutierre, Anne-Sophie; Baudoin, Olivier published the artcile< Terminal-Selective Functionalization of Alkyl Chains by Regioconvergent Cross-Coupling>, Formula: C11H16O2, the main research area is aryl triflate alkyl bromide palladium zinc Barbier Negishi coupling; alkyl linear arene preparation; C−C coupling; alkyl bromides; homogeneous catalysis; palladium; remote functionalization.

Hydrocarbons are still the most important precursors of functionalized organic mols., which has stirred interest in the discovery of new C-H bond functionalization methods. We describe herein a new step-economical approach that enables C-C bonds to be constructed at the terminal position of linear alkanes. First, we show that secondary alkyl bromides can undergo in situ conversion into alkyl zinc bromides and regioconvergent Negishi coupling with aryl or alkenyl triflates. The use of a suitable phosphine ligand favoring Pd migration enabled the selective formation of the linear cross-coupling product. Subsequently, mixtures of secondary alkyl bromides were prepared from linear alkanes by standard bromination, and regioconvergent cross-coupling then provided access to the corresponding linear arylation product in only two steps.

Angewandte Chemie, International Edition published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fanourakis, Alexander; Williams, Benjamin D.; Paterson, Kieran J.; Phipps, Robert J. published the artcile< Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation>, Product Details of C11H16O2, the main research area is heptafluorobutyl hydroxy butyl sulfamate preparation enantioselective; arylbutanol heptafluorobutyl sulfamate intermol amination rhodium catalyst.

A family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which the chiral cations are associated And derived from quaternized cinchona alkaloids, has been described. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates R(CH2)4OH (R = Ph, 1-naphthyl, 3-methylthiophen-2-yl, etc.) bearing pentyl hydroxyl groups. Addnl., the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of products RCH(NHS(O)2OCH2R1)(CH2)3OH (R1 = (CF2)2CF3) vs. Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.

Journal of the American Chemical Society published new progress about Amination catalysts (intermol., stereoselective). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Procopiou, Panayiotis A.; Browning, Christopher; Buckley, Jennifer M.; Clark, Kenneth L.; Fechner, Lise; Gore, Paul M.; Hancock, Ashley P.; Hodgson, Simon T.; Holmes, Duncan S.; Kranz, Michael; Looker, Brian E.; Morriss, Karen M. L.; Parton, Daniel L.; Russell, Linda J.; Slack, Robert J.; Sollis, Steven L.; Vile, Sadie; Watts, Clarissa J. published the artcile< The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis>, Related Products of 52244-70-9, the main research area is phthalazinone derivative preparation intranasal antihistamine H1 H3 allergic rhinitis.

A series of potent phthalazinone-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogs (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, resp., vs 9.7 for the clin. gold-standard azelastine), and H3 potency (pKi 9.6 and 9.5, resp., vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clin. dose, should limit the potential of engaging CNS-related side-effects associated with H1 or H3 antagonism.

Journal of Medicinal Chemistry published new progress about Alkylation. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xiong, Ni; Li, Yang; Zeng, Rong published the artcile< Iron-Catalyzed Photoinduced Remote C(sp3)-H Amination of Free Alcohols>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is alkanol diazene iron catalyst regioselective photoredox amination; aminoalkanol preparation.

A general photocatalytic protocol for the remote C(sp3)-H bond amination of free alkanols was reported. The electron transfer between the abundant and inexpensive catalyst FeCl3 and simple alkanols under blue LED irradiation enabled the alkoxy radical formation under mild redox-neutral conditions, without addnl. oxidant and prefunctionalization. The subsequent selective 1,5-hydrogen atom transfer (HAT) and amination provided a simple and efficient way to access mol. complexity from readily available and bulk alcs.

Organic Letters published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heck, Richard; Winstein, S. published the artcile< Neighboring carbon and hydrogen. XXVII. Ar1-5 aryl participation and tetralin formation in solvolysis>, Related Products of 52244-70-9, the main research area is .

p-MeOC6H4CH:CHCO2H added by means of a Soxhlet apparatus to 1.5 mole equivalents LiAlH4 yielded 44% p-MeOC6H4(CH2)3OH. 2,4-(MeO)2C6H3CH:CHCO2H (46 g.) reduced similarly with 12 g. LiAlH4 during 2 days gave 39% 2,4-(MeO)2C6H3(CH2)3OH, b3.5, 144-5°, nD25 1.5320, m. 36-8°. Ph(CH2)3CO2H reduced with LiAlH4 yielded Ph(CH2)4OH (I). I heated 1 hr. on the steam bath with Ac2O and a few drops pyridine gave the acetate (II), b8.5 120 °, nD25 1.4948. p-MeOC6H4(CH2)3CO2H reduced with LiAlH4 yielded 91.5% p-MeOC6H4(CH2)4OH (III), b1.5 125-30°, nD25 1.5200. 2,4-(MeO)2C6H3(CH2)3CO2H (IV) gave similarly 100% 2,4-(MeO)2C6H3(CH2)4OH (V), b2.5 157-61°, nD25 1.5296; p-nitrobenzoate (VI), m. 52-3° (from MeOH). Ph(CH2)3MgCl and ethylene oxide gave Ph(CH2)5OH, b3 110-13°, nD25 1.5149. The various primary alcs. were converted to the corresponding p-bromobenzenesulfonates (m.p. given) by the method described previously (Bs is used throughout this abstract to designate the group p-BrC6H4SO2): Ph(CH2)3OBs (VII), 35.5-7.5°; p-MeOC6H4(CH2)3OBs (VIII), 62-4°; 2,4-(MeO)2C6H3(CH2)3OBs (IX), 56-7°; Ph(CH2)4OBs (X), 21-3.5° (nD25 1.5694); p-MeOC6H4(CH2)4OBs (XI), 43-5°; 2,4-(MeO)2C6H3(CH2)4OBs (XII), 54.5-6.5°; Ph(CH2)5OBs (XIII), 34-5.5°. Glutaric anhydride (40 g.) and 50 g. m-C6H4(OMe)2 in 450 cc. purified tetrachloroethane treated at 0° with stirring with 100 g. anhydrous AlCl3 in small portions, the mixture kept about 0.5 hr. at 0°, treated with ice and dilute HCl, and worked up in the usual manner, and the product recrystallized from aqueous MeOH yielded 18 g. 2,4-(MeO)2C6H3CO(CH2)3CO2H (XIV), m. 106-7°. XIV (17 g.) refluxed 2 days with 50 g. Hg-Zn, 30 cc. PhMe, 30 cc. H2O, and 70 cc. concentrated HCl while 10 cc. concentrated HCl was added every 6 hrs., the PhMe phase extracted with aqueous NaHCO3, and the aqueous extract acidified gave 5.5 g. 2,4-(MeO)2C6H3(CH2)4CO2H (XV), m. 97-8.5° (from aqueous MeOH). XV reduced with LiAlH4 gave 96% 2,4-(MeO)2C6H3(CH2)5OH, b2 144-5°, nD25 1.5247; it gave with p-BrC6H4SO2Cl 90%-pure p-bromobenzenesulfonate (XVa). Ph(CH2)3CH(OH)Me (XVI) (15 g.), b1 80-4°, nD25 1.5108, in 75 cc. dry pyridine treated with 25 g. p-MeC6H4SO2Cl below room temperature, kept 2 hrs. at room temperature, and the product isolated with Et2O gave an oil which chromatographed on Al2O3 and eluted with C6H6-pentane yielded 9.5 g. p-toluenesulfonate (XVII) of XVI, nD25 1.5382. IV (16 g.) in 50 cc. Et2O added dropwise with stirring to MeLi from 25 g. MeI and 2.5 g. Li in 200 cc. Et2O, the mixture stirred 0.5 hr. and treated with cold dilute HCl, the Et2O layer worked up, and the product, b2 120-50°, reduced with LiAlH4 yielded 3.5 g. 2,4-(MeO)2C6H3(CH2)3CH(OH)Me b2 135-9°, nD25 1.5219, which gave a 70%-pure p-toluenesulfonate (XVIII), nD25 1.5250. The rates of the acetolysis in AcOH were determined by the method described previously (C.A. 51, 2830d) for the following compounds (temperature, M × 102 concentration of ester, and k in sec.-1 given): VII, 75.00°, 3.18, (1.07 ± 0.00)10-6; VII, 100.05°, 2.71, (1.17 ± 0.01)10-5; VIII, 75.00°, 3.04, (1.15 ± 0.03)10-6; IX, 75.00°, 2.57, 3.95 × 10-6; X, 75.00°, 3.09, (1.45 ± 0.03)10-6; X, 75.00°, 3.02, (1.49 ± 0.05)10-6; X, 100.05°, 3.68, (1.62 ± 0.01)10-5; XI, 75.00°, 2.66, (1.90 ± 0.01)10-6; XI, 100.05°, 2.16, (2.16 ± 0.01)10-5; XII, 75.00°, 2.66, (6.26 ± 0.06)10-6; XII, 100.00°, 1.94, (7.56 ± 0.05)10-5; XII (AcOH 0.0300M in LiClO4), 75.00°, 2.89, (7.2 ± 0.1)10-6; XIII, 75.00°, 2.77, (1.54 ± 0.03)10-6; XIII, 100.00°, 2.64, (1.65 ± 0.01)10-5; XVa, 75.00°, 2.40, (1.61 ± 0.03)10-6; XVa, 100.10°, 2.40, (1.76 ± 0.01)10-5. Similarly were determined the rates of the formolysis of the following compounds in 0.03151M HCO2Na in HCO2H (same data given): VII, 50.00°, 2.75, (1.54 ± 0.08)10-6; VII, 75.00°, 2.75, (1.99 ± 0.03)10-5; X (without added HCO2Na), 75.00°, 2.70, (3.35 ± 0.01)10-5; X, 75.00°, 2.68, (3.43 ± 0.03)10-5; X, 100.20°, 2.68, (3.13 ± 0.07)10-4; XI, 50.00°, 2.70, (5.03 ± 0.18)10-6; XI, 75.00°, 2.70, (6.08 ± 0.11)10-5; XII, 50.00°, 2.24, (2.58 ± 0.02)10-5; XII, 75.00°, 2.24, (3.40 ± 0.06)10-4; XVII, 25.00°, 3.13, (5.43 ± 0.10)10-5; XVIII, 25.00°, 3.63, (1.36 ± 0.13)10-4; XIII, 50.00°, 2.70, (2.90 ± 0.08)10-8; XIII, 75.00°, 2.70, (3.39 ± 0.02)10-5; XVa, 75.00, 2.69, (3.63 ± 0.11)10-5. The enthalpy (in kcal./mole) and the entropy (in e.u.) of the acetolysis were: VII, 24.0, -17.5; X, 23.9, -16.8; XI, 24.4, -15.0; XII, 25.0, -10.7; XIII, 23.8, -17.1; XVa, 23.9, -16.7; the same values for the formolysis were: VII, 22.2, -16.6; X, 22.0, -16.2; XI, 21.6, -16.1; XII, 22.4, -10.4; XIII, 21.3, -18.2. IX (18.4 g.) and 3.40 g. HCO2Na in 900 cc. dry HCO2H heated 6 hrs. at 75.0°, diluted with H2O, and extracted with Et2O, the extract washed, dried, and reduced with 2 g. LiAlH4, and the Et2O solution worked up gave a crude product which chromatographed on 500 g. Al2O3 and eluted with 5 l. pentane yielded 5.5 g. 2,3-dimethoxytetrahydronaphthalene (XIX), b2 102-5°, nD25 1.5454 (this material crystallized after several months, m. 36.5-38°; it gave with Br a monobromide, m. 78-80°). An addnl. 0.8 g. XIX, b3 110°, nD25 1.5401, was obtained by further elution with 4 l. Et2O; the column then eluted with 3 l. MeOH gave 0.7 g. V, b3 130°, which was converted to 0.8 g. VI, m. 49-51° (2nd crop, 0.1 g., m. 48-51°). XIX (2 g.) and 6 g. chloranil refluxed 15 hrs. in 20 cc. xylene yielded 1,3-C10H6(OMe)2 (XX), isolated as 0.8 g. picrate, m. 141-2°. V (2 g.) in 150 cc. 98-100% HCO2H heated 15 hrs. at 75° and the mixture worked up as described for the solvolysis run yielded 1.65 g. unchanged V, b2 150-2°, nD25 1.5296. V (0.5 g.) in 30 cc. 0.0315M HCO2Na in HCO2H heated 10 hrs. at 75° gave 0.35 g. unchanged V which yielded 0.40 g. VI, m. 50-3°. 1,3,2-(HO)2C10H5CO2Et (13 g.) treated with CH2N2 [from 15 g. H2NCON(NO)Me] in 200 cc. Et2O, the mixture allowed to stand overnight, the Et2O evaporated, the residual oil distilled, the distillate (11 g.), b2 155-75°, refluxed with 10 g. NaOH in 15 cc. H2O and 15 cc. EtOH overnight, the dark solution and solid treated with H2O and extracted with Et2O, and the residue from the extract distilled gave 2.8 g. dark oil, b3 145-50°, which chromatographed on Al2O3 readily lost its color but soon became colored again on standing; the purified XX had nD25 1.6140; picrate, long orange-red needles, m. 140-1° (from Et2O). XI (8 g.) in 700 cc. 0.03022M HCO2Na in dry HCO2H heated 42 hrs. at 75°, diluted with H2O, and extracted with pentane, the extract evaporated, the residue reduced with 1 g. LiAlH4, and the product chromatographed on 100 g. Al2O3 and eluted with 700 cc. pentane gave 1.65 g. 7-methoxytetrahydronaphthalene, b1.5 76°, nD25 1.5414; further elution with 600 cc. Et2O gave 1.55 g. III, b1.5 118-19°, nD25 1.5239. Dry HCO2Na (3.4 g.) in 1000 cc. dry HCO2H treated at 75.0° with 18.5 g. purified X, kept 66 hrs. at 76.0°, cooled, poured into 3 l. H2O, and extracted with pentane, the residue from the extract reduced with 2 g. LiAlH4, and the product chromatographed on 500 g. Al2O3 yielded 1.10 g. tetrahydronaphthalene (XXI), b22 101-3°, nD25 1.5388, which dehydrogenated with chloranil gave 80% C10H8, m. 75-7°; further elution of the column with MeOH yielded 5.4 g. I, b1.5 87-90°, nD25 1.5191. I (2.0 g.) and 0.6 g. p-MeC6H4SO3H in 100 cc. dry HCO2H heated 67 hrs. at 75.0°, cooled, poured into H2O, and extracted with pentane, and the residue from the extract reduced with LiAlH4 yielded 1.7 g. unchanged I, b10 124-7°, nD25 1.5189. Pure X (20.0 g.) added to 1200 cc. dry AcOH at 100.0°, the solution kept 101 hrs. at 100.0°, cooled, poured into 3 l. H2O, and extracted with pentane, the residue from the extract reduced with LiAlH4, and the product chromatographed on Al2O3 yielded 0.35 g. XXI, b10 75°, nD25 1.5370, and 6.85 g. I, b2 about 100°, nD25 1.5205. II (11.0 g.), 11.4 g. p-MeC6H4SO3H, and 1 cc. Ac2O in 1200 cc. dry AcOH kept 140 hrs. at 100.0° and the mixture processed in the usual manner with LiAlH4 reduction gave 8.2 g. I, b8.5 120-3°, nD25 1.5202. XVII (9.2 g.) (93% pure) and 2.45 g. dry HCO2Na in 600 cc. dry HCO2H kept 43.5 hrs. at 25.0° and worked up in the usual way yielded 2.05 g. hydrocarbon fraction, b25 112-15°, nD25 1.5229, and 2.20 g. XVI, b1.5 95-100°, nD25 1.5107. A 0.75-g. sample of the hydrocarbon fraction (containing 30% olefin) added to 1.0 g. OsO4 in 20 cc. Et2O containing 2 drops pyridine, kept 0.5 hr., treated with 150 cc. CH2Cl2, 2.5 g. KOH, and 2.5 g. mannitol in 50 cc. H2O, and shaken 2 hrs., the aqueous phase extracted with CH2Cl2, and the combined CH2Cl2 solutions worked up gave 0.4 g. 1-C10H7Me 55°, nD25 1.5323. XVI (5.0 g.) and 0.35 g. HCO2Na in 500 cc. HCO2H kept 41 hrs. at 25.0°, the mixture processed in the usual manner, and the product reduced with 1.5 g. LiAlH4 yielded 5.0 g. unchanged XVI, b8 117-20°, nD25 1.5108. XVI (4.4 g.) in 500 cc. HCO2H kept 27 days at 25° gave 0.06 g. hydrocarbon fraction and 4.0 g. XVI, b30 145-8°, nD25 1.5106. Olefin-hydrocarbon mixture (1.0 g.) from the solvolysis of XVII kept 42.5 hrs. at 25.0° with 0.050 g. pure HCO2Na in 150 cc. 98-100% HCO2H gave 0.95 g. product, nD25 1.5231, containing 26% olefin. Ph(CH2)3CH:CH2 (4.4 g.), b. 77-8°, nD25 1.5019, in 500 cc. 98-100% HCO2H kept 27 days at 25.0°, poured into H2O, and extracted with pentane, the residue from the extract reduced with LiAlH4, and the product chromatographed yielded 3.2 g. hydrocarbon, b30 106-8°, nD25 1.5054, and 1.0 g. alc., b2 95°, nD25 1.5099.

Journal of the American Chemical Society published new progress about Acetolysis. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Panda, Atulya Kumar published the artcile< A facile synthesis of di-O-methylcentrolobol>, Name: 4-(4-Methoxyphenyl)-1-butanol, the main research area is centrolobol methyl ether preparation; phenylbutyl bromide benzenepropanal Grignard.

A facile route to (±)-di-O-methylcentrolobol was explored starting from 4-oxo-4-(4-methoxyphenyl)butanoic acid and 4-methoxycinnamic acid.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 52244-70-9. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Name: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Taylor, Edward C.; Andrade, Juan G.; Rall, Gerhardus J. H.; Turchi, Ignatius J.; Steliou, Kosta; Jagdmann, G. Erik Jr.; McKillop, Alexander published the artcile< Thallium in organic synthesis. 61. Intramolecular capture of radical cations from thallium(III) trifluoroacetate oxidation of arylalkanoic acids and arylalkanols. New routes to oxygen heterocycles>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is thallium trifluoroacetate oxidation arylalkenoic acid; arylalkanol thallium trifluoroacetate oxidation; cyclization oxidative arylalkanoic acid arylalkanol; coumarin dihydro; spirocyclohexadienone lactone.

Treatment of electron-rich arylpropionic acids with (F3CCO2)3Tl (I) in F3CCO2H containing a small amount of BF3 etherate gave dihydrocoumarins and spirocyclohexadienone lactones by initial formation of aromatic radical cations followed by intramol. cyclization involving the side-chain carboxyl group. The scope and limitations of this reaction with respect to aromatic substitution and the length of the alkanoic acid side chain have been examined; the reaction has been extended with analogous results to 1-naphthalenylalkanoic acids. Oxidation of a series of homologous phenyl- and naphthalenyl-1-alkanols with I under similar conditions resulted in intramol. cyclization to give fused or pendant cyclic ethers. The observed propensity for intramol. cyclization may be due to complexation of both the aryl group and the side-chain basic substituent (-CO2H or -OH) with thallium(III).

Journal of the American Chemical Society published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Apelt, J.; Grassmann, S.; Ligneau, X.; Pertz, H. H.; Ganellin, C. R.; Arrang, J.-M.; Schwartz, J.-C.; Schunack, W.; Stark, H. published the artcile< Search for histamine H3 receptor antagonists with combined inhibitory potency at Nτ-methyltransferase: ether derivatives>, Product Details of C11H16O2, the main research area is histamine receptor antagonist methyltransferase inhibitor aryl piperidinopropyl ether preparation.

Several compounds containing an ether moiety derived from 4-(3-piperidinopropoxy)phenylaminoquinoline derivatives, such as FUB 836, were synthesized and tested for their affinity at cloned human histamine H3 (hH3) receptors and on the inhibition of rat histamine Nτ-methyltransferase (HMT). Besides different heterocycles, e.g. nitro- or amino-substituted pyridines, quinolines, benzothiazole or pyrroline, three classes of compounds were produced: heteroaromatic 3-piperidinopropyl ethers, keto- or imino-substituted 4-(3-piperidinopropyl)phenyl ethers and 4-(3-piperidinopropyl)phenyl ethers with substituted (alkyl)aminopyridines. Whereas the (3-piperidinopropoxy)heterocycles showed only moderate activities on both test models, the 4-(3-piperidinopropoxy)phenyl derivatives were identified as potent histamine H3 receptor ligands and/or HMT inhibitors. Ki values ≤ 0.42 nM were found for the affinity to the hH3 receptor. HMT inhibitory potency was identified with IC50 values about 0.3 μM for the most potent compounds in this series. Comparison of the pyridine-containing derivatives to recently published quinoline analogs showed a decrease in potencies for the pyridines. The dual activity, H3 receptor affinity and HMT inhibition, was moderate to good. For all compounds affinities at hH3 receptors were higher than their inhibitory HMT potencies.

Pharmazie published new progress about Histamine H3 receptor antagonists. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ihndris, Ray W.; Gouck, Harry K.; Bowen, C. V. published the artcile< Effect of promising insect repellents on plastics and paints>, Application In Synthesis of 52244-70-9, the main research area is .

Action of 380 repellents on Lucite, cellulose acetate, and Vinylite after 48 h. of contact are tabulated (studies in 1946). Sixty-eight of the compounds did not change any of the plastics. Lucite was attacked by 261, cellulose acetate by 126, and Vinylite by 251. Only 99 compounds attacked all 3. Results of studies in 1953 are shown in a tabulation of effects on paint, Plexiglas, Vinylite, rayon, and Plastocel of 136 repellents which had not proved unsatisfactory since 1946 for some other reason. All but 2 compounds affected paint; one of them, octyl crotonate, affected only varnish and vinylite, and the other, 3,6,8-trimethyl-4-nonyne-3-6-diol affected only varnish. Vinylite was damaged by 107, Plexiglas by 58, rayon by 55, and Plasticel by 46. In other tests only 2 chems., 2-benzyloxynaphthalene and 2-iso-pentyloxynaphthalene, affected polyethylene, and they only slightly. Fourteen materials slightly stained nylon. In still other tests, Lucite and Plexiglas were found to differ slightly in their resistance to various agents.

United States, Agricultural Research Service, [Report] ARS published new progress about Aromatic hydrocarbons Role: BIOL (Biological Study). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem