Category: 51388-20-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51388-20-6, name is 4-(Benzyloxy)aniline hydrochloride, A new synthetic method of this compound is introduced below., HPLC of Formula: C13H14ClNO

Example 52-1 NL- (4-benzyloxyphenyl)-4-methoxybenzamidine To a solutionof 4-benzyloxyaniline hydrochloride (3g) in tetrahydrofuran (15ML), 1.OM sodium bis (trimethylsilyl) amide in tetrahydrofuran (26. 7ML) wasadded dropwise at room temperature. After the mixture was stirred for20min, anisonitrile (1.69g) was added.The reaction mixture was stirred for 4hrs, and then poured into 300ML OFice-water. The precipitates were collected by filtration, washed withdiisopropyl ether to give the target compound (3.3g).1H NMR (200MHZ, DMSO-D6, D) : 3.8 (3H, s), 5.05 (2H, s), 6.09 (2H, bs),6.74-6. 8 (2H, m), 6.96 (4H, d, J=8.5Hz), 7.29-7. 49 (5H, m), 7.92 (2H,d, J=8.9Hz).MS m/e: 333 (M+H) +.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; WO2004/99130; (2004); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51388-20-6, name is 4-(Benzyloxy)aniline hydrochloride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 51388-20-6

Preparation XXVIII Methyl 2-methyl-2-[[4-(phenylmethoxy)phenyl]amino]propionate 3 g (15 mmol) of 4-(phenylmethoxy)aniline and 5.5 g (30 mmol) of methyl 2-bromo-2-methylpropionate are mixed and 1.95 g of sodium bicarbonate are added. The reaction medium is stirred for 5 h at 140 C. and then cooled and taken up with 50 ml of water and 100 ml of ethyl ether. The aqueous phase is separated off and re-extracted with 50 ml of ethyl ether and the combined organic phases are washed with water and then dried over sodium sulfate and concentrated under reduced pressure. The residue is purified by chromatography on silica gel using a cyclohexane/ethyl acetate mixture (8/2; v/v) as the eluent to give the expected product in the form of a beige crystalline solid (yield=75%). M.p.<50 C. The synthetic route of 51388-20-6 has been constantly updated, and we look forward to future research findings. Reference:
Patent; Binet, Jean; Boubia, Benaissa; Chaput, Evelyne; Edgar, Alan; Ou, Khan; Ratel, Philippe; Samreth, Soth; Thomas, Didier; US2006/25589; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

51388-20-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51388-20-6, name is 4-(Benzyloxy)aniline hydrochloride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 29: 6-(at) f 2-((at)2- f (2-aminoethyl)oxyl ethyl(at) oxy)ethyll oxy)-1-ethyl-4-oxo-1,4-dihydro-3- quinolinecarboxylic acid formate a) Ethyl 4-oxo-6-[(phenylmethyl)oxy]-1,4-dihydro-3-quinolinecarboxylate p-Benzyloxy aniline hydrochloride (25 g) was shaken with 1M NaOH (120 mL) and diethyl ether (200 mL). The organic layer was washed with brine, dried (MgS04) and evaporated to a solid (21.3 g). This material was heated with ethoxymethylene malonate (27.9 g) at 130C for 1.5 h using a Dean and Stark condenser. Dowtherm (100 mL) was added and the mixture heated to 250C using a Dean and Stark condenser for 70 min. The mixture was cooled and treated with petroleum ether (bp 60-80C) to precipitate a brown solid. This was slurried in dichloromethane, the pale yellow solid was filtered and dried to give the title compound (11.06 g). (at)H-NMR(400 MHz, DMSO-d6) No.: 1.28 (3H, t, J = 7.2 Hz), 4.21 (2H, q, J = 7.2 Hz), 5.21 (2H, s), 7.3 (1H, m), 7.4 (3H, m), 7.4 (2H, m), 7.59 (1H, d, J=8.8 Hz), 7.66 (1H, d, J= 2.8 Hz) , 8.49 (1H, s) and 12.3 (lH, br).

The synthetic route of 4-(Benzyloxy)aniline hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PLIVA-ISTRAZIVACKI INSTITUT D.O.O.; WO2005/108413; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem