Category: 51344-14-0

Reference of 51344-14-0, A common heterocyclic compound, 51344-14-0, name is N,N-Dimethyl-2-(p-tolyloxy)ethanamine, molecular formula is C11H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a test tube containing a magnetic bar was added aryl halide (1.0 mmol), Cu2O (14.3 mg, 0.1 mmol), KOH (169 mg, 3.0 mmol), 2-dimethylaminoethanol (0.3 mL, 3.0 mmol), and DMSO/H2O (1.5 mL/0.5 mL). After flushing with argon, the mixture was stirred in a preheated oil bath at 100 C for 24 h. After cooled to ambient temperature, the reaction mixture was distributed in aqueous HCl (5 %) and ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous MgSO4, and concentrated under vacuum. The crude product was further purified by column chromatography (EtOAc/n-Hexane) to provide the phenols.

The synthetic route of 51344-14-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kim, Jihye; Battsengel, Oyunsaikhan; Liu, Yajun; Chae, Junghyun; Bulletin of the Korean Chemical Society; vol. 36; 12; (2015); p. 2833 – 2840;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 51344-14-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51344-14-0, name is N,N-Dimethyl-2-(p-tolyloxy)ethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

58.9 g (0.495 mol) of potassium bromide,Hydrogen peroxide 60 ml,Water 60 ml and 150 ml of chloroform were added to a liter of three bottles,Drop under ice bath32 ml concentrated sulfuric acid,Drop finished, remove the ice bath,Add 4- (2-dimethylaminoethoxy) toluene134 g (0.75 mol),The reaction solution was refluxed under light for 2 h,After completion of the reaction, the organic layer was separated, dried over anhydrous sodium sulfate, And the crude product was distilled under reduced pressure to give 185 g of a pale yellow liquid in a yield of 96%.

The synthetic route of N,N-Dimethyl-2-(p-tolyloxy)ethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Cheng Lian Pharmaceutical Technology Co., Ltd.; Liu Hui; (5 pag.)CN106748821; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem