Category: 5111-65-9

Electric Literature of 5111-65-9, These common heterocyclic compound, 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

6-Methoxy-2-bromonaphthalene (0.97 g, 4.1 mmol) was dissolved in 20 mL of dry THF, protected under nitrogen, (3.4 mL, 8.2 mmol) was added, stirred for 1 hour, and then anhydrous DMF (0.941 mL, 12.3 mmol) was added dropwise at -78 C,The reaction was continued at 78 C for 1 hour, rose to room temperature, acidified to pH = 5 with 2N hydrochloric acid, extracted with ethyl acetate, washed with water, saturated brine Washed with anhydrous sodium sulfate, filtered and concentrated, n-hexane / ethyl acetate (15: 1) column chromatography to isolate 6-methoxy-2-naphthyl Aldehyde, the yield of 88.6%.

Statistics shows that 2-Bromo-6-methoxynaphthalene is playing an increasingly important role. we look forward to future research findings about 5111-65-9.

Reference:
Patent; Liaocheng University; Liu Guoyun; Yang Jie; Li Xiaoteng; Guo Shangjing; (19 pag.)CN105111054; (2017); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 5111-65-9, These common heterocyclic compound, 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 22 Preparation of 2-formyl-6-methoxynaphthalene n-BuLi in hexane (1.59M, 125 ml) was added dropwise to a solution of 2-bromo-6-methoxynaphthalene (42.27 g) in THF (600 ml) at -78 C. and was stirred at -78+ C. for 30 minutes. To the mixture was added DMF (28 ml), and the whole was allowed to warm to room temperature. The reaction mixture was acidified with HCl and extracted with ethyl acetate. The extract was dried and concentrated to give the titled compound (32.31 g) as a colorless solid. 1H-NMR (CDCl3) delta: 3.96 (3H, s), 7.15-7.30 (2H,m), 7.75-7.97(3H,m), 8.26 (1H,s), 10.10 (1H,s). IR (KBr): 2841, 1688, 1624, 1480, 1269, 1028, 856 cm-1.

The synthetic route of 5111-65-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6420375; (2002); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 5111-65-9, The chemical industry reduces the impact on the environment during synthesis 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, I believe this compound will play a more active role in future production and life.

A solution of 6-methoxy-2-bromonaphthalene (25 g) in tetrahydrofuran (300 ml) was cooled at -78C under a nitrogen atmosphere. n-Butyllithium (2.66 M solution in hexane) (42 ml) was added dropwise thereto over 1.5 hours, and the solution was stirred for 30 minutes. Triisopropyl borate (26.5 ml) was added dropwise thereto for 30 minutes, then the solution was stirred for 40 minutes while warming from -78C to 0C. 1N hydrochloric acid (200 ml) and ethyl acetate (200 ml) were sequentially added thereto, the solution was stirred, extracted with ethyl acetate, then washed with brine, dried over anhydrous magnesium sulfate, then the solvent was evaporated in vacuo, the resulting solid was washed with a hexane-diethyl ether system to provide the title compound (18 g).1H-NMR (400MHz, DMSO-d6); delta (ppm): 3.86 (s, 3H), 7.12 (d, 1H), 7.26 (s, 1H), 7.72 (d, 1H), 7.76-7.84 (m, 2H), 8.07 (brs, 2H), 8.27 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-6-methoxynaphthalene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai Co., Ltd.; EP1577288; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 5111-65-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, This compound has unique chemical properties. The synthetic route is as follows.

SYNTHESIS EXAMPLE 1; According to a reaction path of Reaction Scheme 1, compound 19 represented by Formula 19 was synthesized: Synthesis of Compound 19; Synthesis of Intermediate A; 7.5 g (32 mmol) of 2-bromo-6-methoxynaphthalene, 4.6 g (25 mmol) of phenoxazine, 3.7 g (38 mmol) of sodium tert-butoxide ((t-BuO)Na), 0.3 g (0.33 mmol) of Pd2(dba)3 [(tris(dibenzylidine acetone) dipalladium (0))], and 0.11 g (0.55 mmol) of tri(tert-butyl)phosphine were dissolved in 125 mL of toluene and were reacted for 12 hours at 80 C.After the reaction was completed, the reaction mixture was cooled down to an ambient temperature and 200 ml of distilled water was added and quenched. Then, xylene and water were extracted in the volume ratio of 1:1.The collected organic layer was dried and concentrated using MgSO4 and a column chromatography was performed using an eluant formed of toluene and hexane in the volume ratio of 1:2. The obtained effluent was concentrated and dried to obtain 6.8 g (Yield: 80%) of intermediate A. The structure of intermediate A was identified through 1H NMR spectroscopy.

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-6-methoxynaphthalene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Son, Jhun-Mo; Yu, Eun-Sun; Kwon, O-Hyun; Son, Young-Mok; Kim, Yu-Jin; US2007/176541; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Bromo-6-methoxynaphthalene

Under argon atmosphere, 2.37 g (0.01 mol) of 2-bromo-6-methoxynaphthalene and 40.578 g of Pd (PPh3)(0.5 mmol) of CuI, 0.095 g (0.5 mmol) of CuI and 30.131 g (0.5 mmol) of PPh. After the addition was completed, the mixture was purged with argon three times,Air was removed from the reaction flask, and then 15 ml of triethylamine, 1.96 ml of trimethylethynylsilane and 30 ml of tetrahydrofuran were added.After the addition was completed, the system was allowed to rise to 78 C for 20 h.The reaction mixture was filtered to remove a large amount of insoluble salts and solids. To the filtrate was added 150 ml of methylene chloride and the mixture was washed three times with 150 ml of 5% diluted hydrochloric acid. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. Ether to do the agent.After the column liquid was swirled to a white solid precipitation stopped rotating when placed at room temperature precipitated a large number of white solid, filtered and dried to give a white solid6-Methoxy-2-naphthylethynyltrimethylsilyl2.50 g, yield 98.4%

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; East China University of Science and Technology; Shen Dong; Liu Haipeng; Zheng Zhigang; (18 pag.)CN106336350; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5111-65-9, Computed Properties of C11H9BrO

6-Methoxy-2-naphthaldehyde ((a) Harvey, R. G.; Cortez, C.; Sawyer, T. W.; DiGiovanni, J.; J. Med. Chem. 1988, 31, 1308-1312. (b) Harvey, R. G.; Cortez, C. Tetrahedron, 1997, 53, 7101-7118) was prepared by formylation (Beringer, F. M.; Nathan, R. A. J. Org. Chem. 1969, 34, 685-689) of 6-methoxy-2-bromonaphthalene in 53% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-6-methoxynaphthalene, and friends who are interested can also refer to it.

Reference:
Patent; University of Pittsburgh; US6706839; (2004); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5111-65-9 as follows. HPLC of Formula: C11H9BrO

The B22 – 1 (1 g, 4.22 mmol) is dissolved in dioxane (5 ml) in, adding three (dibenzylidene acetone) two palladium (97 mg, 0 . 17 mmol) and 2 tert-butyl phosphine 2 ‘, 4′, 6’ – three isopropyl biphenyl (72 mg, 0 . 17 mmol), then adding dissolved in 5 ml water with potassium hydroxide (709 mg, 12 . 66 mmol), heating to 100 C reaction 1.5 hours. After cooling to room temperature by adding 2 N HCl (20 ml), stirring 1 hour after concentrating under reduced pressure, methylene chloride (30 ml * 3) extraction, the combined organic phase, dried with anhydrous sodium sulfate, concentrated under reduced pressure to get the yellow solid (435 mg, 59%).

According to the analysis of related databases, 5111-65-9, the application of this compound in the production field has become more and more popular.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 5111-65-9, Name is 2-Bromo-6-methoxynaphthalene, molecular formula is C11H9BrO, belongs to ethers-buliding-blocks compound, is a common compound. In a patnet, author is Ren, Zihe, once mentioned the new application about 5111-65-9, SDS of cas: 5111-65-9.

Observable carbon isotope fractionation in the photodegradation of polybrominated diphenyl ethers by simulated sunlight

In the present study, carbon isotope effects were investigated during the photodegradation of polybrominated diphenyl ethers (PBDEs) by compound-specific stable isotope analysis (CSIA). Five PBDE congeners (BDE 85, 99, 100, 153 and 154) in n-hexane were individually exposed to simulated sunlight for as long as 15 h, except for BDE 100 (24 h). Consecutive debromination of PBDE by photolysis in n-hexane was confirmed by the clear C-13 enrichment of mother congeners and successive depletion of delta C-13 values for the photodegradation products with decreasing degree of bromination, which can be attributed to mass-dependent isotope fractionation. The observed variation in the isotope fractionation trends for the para-debrominated products might be linked to the different photocatalytic activities of the PBDE congeners. Higher fractionation was observed for penta-BDEs (epsilon(c=) -2.2 +/- 0.45% and -2.3 +/- 0.26% for BDE 85 and BDE 99, respectively) compared to that for hexa-BDEs (epsilon(c=) -1.7 +/- 0.41%, and -1.3 +/- 0.12% for BDE 153 and BDE 154, respectively). Normal isotope effects (AKIE > 1) observed in our study supports the utility of CSIA for the evaluation of the photodegradation of PBDEs. (C) 2020 Elsevier Ltd. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 5111-65-9. The above is the message from the blog manager. SDS of cas: 5111-65-9.

Related Products of 5111-65-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 5111-65-9, Name is 2-Bromo-6-methoxynaphthalene, SMILES is C1=C2C(=CC=C1OC)C=C(Br)C=C2, belongs to ethers-buliding-blocks compound. In a article, author is Nguma, Ephantus, introduce new discover of the category.

Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress

Ethanolamine plasmalogen (PlsEtn) is a subtype of ethanolamine glycerophospholipids (EtnGpl). Recently, PlsEtn has attracted increasing research interest due to its beneficial effects in health and disease; however, its functional role in colonic health has not been well established. This study was conducted to determine the mechanism underlying the antiapoptotic effect of PlsEtn in human intestinal tract cells under induced inflammatory stress. Lipopolysaccharide induced apoptosis of differentiated Caco-2 cells, which was suppressed by EtnGpl in a dose-dependent manner. Cells treated with ascidian muscle EtnGpl containing high levels of PlsEtn demonstrated a lower degree of apoptosis, and downregulated TNF-alpha and apoptosis-related proteins compared to those treated with porcine liver EtnGpl containing low PlsEtn. This indicates that PlsEtn exerted the observed effects, which provided protection against induced inflammatory stress. Overall, our results suggest that PlsEtn with abundant vinyl ether linkages is potentially beneficial in preventing the initiation of inflammatory bowel disease and colon cancer.

Related Products of 5111-65-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5111-65-9.

In an article, author is Guo, Zhenghua, once mentioned the application of 5111-65-9, Safety of 2-Bromo-6-methoxynaphthalene, Name is 2-Bromo-6-methoxynaphthalene, molecular formula is C11H9BrO, molecular weight is 237.09, MDL number is MFCD00004062, category is ethers-buliding-blocks. Now introduce a scientific discovery about this category.

Preparation of PVDF membrane based on In-situ Template-TIPS technology and the investigation on membrane formation mechanism, microstructure regulation and permeability

In this work, poly(vinylidene fluoride) (PVDF) flat membrane was prepared via In-situ template-TIPS technology using poly(vinylpyrrolidone) (PVP) as template. The membrane formation mechanism and microstructure evolution of this method were expounded for the first time. The effect of PVP content on the crystallization behavior of the dope, the microstructure, the crystallization behavior and the permeability of the membrane was investigated in detail. Interestingly, the solidification of PVP from the diluent via air-cooling at room temperature not only hindered the PVDF crystallization, but also the growth of PVP led to the formation of porous surface and eliminated the thick and dense skin layer, and thus formed the inter-connected structure and higher porosity (The maximum porosity is 88.9%). The maximum pure water flux reached as high as 3420 L m(-2) h(-1). The membrane also indicated an excellent performance in rejection of bacteria and separation of petroleum ether/ water emulsion (nearly 100%). The alpha crystal phase was formed for the membrane by air-cooling at room temperature. The non-isothermal crystallization kinetics revealed that PVP can act as a heterogeneous nucleating agent for PVDF crystallization and hindered the growth of PVDF crystal in three-dimension. The research presented a novel and simple idea for tailoring the microstructure of membrane via TIPS process.

Interested yet? Read on for other articles about 5111-65-9, you can contact me at any time and look forward to more communication. Safety of 2-Bromo-6-methoxynaphthalene.