Category: 50868-73-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50868-73-0, name is 2-Methoxy-6-methylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Methoxy-6-methylaniline

Examples 9 and 10 2 g of 1,2,3,4-Tetrafluoroanthraquinone and 25 g of 2-methoxy-6-methylaniline were charged in a 50 cc, four necked flask and then the reaction was carried out at 80C for about 4 hours.. After completion of reaction, 2-methoxy-6-methylaniline was distilled out from the reaction solution, and a column purification using a column with a silica gel was effected to give rise to 1.04 g of 2-(2-methoxy-6-methylanilino)-1,3,4-trifluoroanthraquinone (Reference Dye 7′) (yield 36.7 mol%) and 1.05 g of 2,3-bis(2-methoxy-6-methylanilino)-1,4-difluoroanthraquinone (Dye 8) (yield 28.6 mol%).. The physical properties of Reference Dye 7′ and analytical values defining the compound are tabulated in Table 2 and the physical properties of Dye 8 and analytical values defining the compound are tabulated in Table 3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NIPPON SHOKUBAI CO., LTD.; EP833203; (2004); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 50868-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50868-73-0 name is 2-Methoxy-6-methylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b) Preparation of intermediate 4; 3.3 g of intermediate 3 (24.1 mmoles) were dissolved in acetic acid (15 ml). Iodine monochloride (5.87g, 36 mmoles) was added. The mixture was stirred at room temperature for 30 minutes and was evaporated. The residue was suspended in an aqueous solution of Na2CC>3 and was extracted with dichloromethane. After drying the dichloromethane extract on MgSCU, it was evaporated and the residue was purified on a silica gel column using dichloromethane as eluent. Yield : 0.758g (13%) of intermediate 4 (CI-MS : 264 [M+H]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxy-6-methylaniline, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; ARTS, Frank, Xavier, Jozef, Herwig; WO2006/15985; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 50868-73-0,Some common heterocyclic compound, 50868-73-0, name is 2-Methoxy-6-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[1893] A solution of 2-methoxy-6-methylaniline (4 equivalents) in dichloromethane (0.2 M) was treated with pyridine (8 equivalents) followed by bromoacetyl chloride (1 equivalent). After 3 hours at room temperature, the mixture was treated with sodium carbonate (12 equivalents) and the product from Example 119A (3 equivalents) in dioxane:water (2:1). The heterogeneous mixture was heated to 40 C. overnight. The reaction mixture was cooled to room temperature, concentrated under reduced pressure and the residue triturated with 5% methanol:dichloromethane. The solid inorganic material was filtered and the filtrated concentrated and purified by HPLC. Isolated as an acetate salt. (45 mg, 44%). 1H NMR (300 MHz, DMSO-d6) delta1.71 (m, 2H), 1.99 (m, 4H), 2.15 (m, 3H), 2.30 (m, 2H), 3.10 (m, 1H), 3.15 (s, 2H), 3.75 (s, 3H), 6.86 (dd, J=9, 1.5 Hz, 2H), 7.16 (t, J=9 Hz, 1H), 7.30 (m, 2H), 7.45 (m, 1H), 8.26 (dd, J=4.5, 1.5 Hz, 1H), 8.95 (s, 1H); MS (DCI/NH3) m/e 340 (M+H-16)+; 356 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxy-6-methylaniline, its application will become more common.

Reference:
Patent; Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.; US2003/229094; (2003); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 50868-73-0,Some common heterocyclic compound, 50868-73-0, name is 2-Methoxy-6-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-methoxy-6-methylphenylaniline (137 mg) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to a solution of triphosgene (119 mg) in anhydrous dichloromethane (5 mL) at room temperature. After the dropwise addition was completed, a solution of 1-(2-methoxy-5-methyl-phenyl)-3-(4-piperazin-1-yl-phenyl)-urea (340 mg) obtained in Example (47a) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to the reaction mixture at room temperature. After 3 hours, the reaction mixture was concentrated and diluted with ethyl acetate and water. The deposited solid was collected by filtration, washed with hexane and ethyl acetate and dried under reduced pressure, and 361 mg (72%) of the title compound was obtained as a white powder. 1H-NMR spectrum (400MHz,DMSO-d6):delta(ppm)=9.10(1H, s), 8.07(1H, s), 7.99(1H, d, J=1.5Hz), 7.77(1H, s), 7.34(2H, d, J=8.6Hz), 7.10(1H, dd, J=7.9 and 7.9Hz), 6.96(2H, d, J=9.0Hz), 6.96(1H, d, J=9Hz), 6.88(1H, dd, J=7.4 and 7.4Hz), 6.82(1H, dd, J=8.4 and 8.4Hz), 6.72(1H, d, J=8.2Hz), 3.84(3H, s), 3.73(3H, s), 3.59(4H, t, J=4.1Hz), 3.07(4H, t, J=5.1Hz), 2.23(3H, s), 2.12(3H, s). MS(FAB) m/z:504 (M + H)+. Melting point: 200-203C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxy-6-methylaniline, its application will become more common.

Application of 50868-73-0,Some common heterocyclic compound, 50868-73-0, name is 2-Methoxy-6-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: 2-cyclopentyl-N-(2-methoxy-6-methylphenyl)acetamide 3-cyclopentylpropionyl chloride (2.24 g, 15.31 mmol) was added to a mixture of 2-methoxy-6-methylaniline (2.0 g, 14.58 mmol) and triethylamine (2.24 mL, 16.04 mmol) in DCM at 0 C. The reaction mixture was progressively warmed to room temperature and stirred overnight. Ethyl acetate (200 ml) was added to the reaction mixture which was washed twice with HCl aq., 1N (100 ml). The organic layer was dried over MgSO4 and concentrated. The oily crude product was subjected to crystallization form hexanes to yield to the title compound (3.55 g, 14.37 mmol, 99%) as white crystal.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxy-6-methylaniline, its application will become more common.

Reference:
Patent; Valeant Pharmaceuticals North America; US2008/45534; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem