Category: 50592-87-5

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50592-87-5 as follows. Computed Properties of C7H15BrO

(3) Production of 4′-methoxyhexyloxy-biphenyl-4-carboxylic acid. 8.4 Grams of 1-bromo-6-methoxyhexane and 4.5 g of 4′-hydroxybiphenyl-4-carboxylic acid were refluxed in 100 ml of water and 400 ml of ethanol for 4 hours. Concentrated hydrochloric acid was added to the reaction mixture so that the mixture showed pH 1, then 150 ml of water was added, and the resultant mixture was refluxed for 1 hour. The reaction mixture was cooled to precipitate a crystal, and the crystal was recovered by filtration. The so-obtained crystal was recrystallized from acetone. Yield 55%.

According to the analysis of related databases, 50592-87-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Gas Chemical Company, Inc.; US5340498; (1994); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50592-87-5 as follows. category: ethers-buliding-blocks

In an appropriate vessel for microwave was mixed 1-bromo-6-methoxyhexane (183 mg ; 0.94 mmol ; 1eq) and tributylphosphine (209 mg (95% pure : 220 mg) ; 1.03 mmol ; 1.1 eq) under inert atmosphere (glove box). Then the mixture was irradiated under microwave (200W) at 130C for 2 hours. The obtained viscous mixture was washed, triturated and centrifuged twice with Et2O, then the supernatant was removed and the obtained residue was taken up into DCM and dried over high vacuum. It led to a pale yellow oil (338 mg ; 0.85 mmol ; 90%). 1H-NMR (CDCl3, 400MHz): delta 3.36 (t, 2H, J 6.4 Hz), 3.31 (s, 3H), 2.41 (m, 8H), 1.47-1.61 (br, 18H), 1.41 (quint, 2H, J 7.2), 0.96 (t, 9H, J 6.6 Hz). 13C-NMR (101 MHz ; CDCl3): delta 72.5, 58.7, 30.7, 29.3, 25.7, 24.1, 22, 19.5, 19, 13.6 ; 9 signals obscured or overlapping. 31P-NMR (162 MHz ; CDCl3): delta 33.78. ESI MS : 317.3 m/z : M+ ; 713.5 m/z : [Br-M+]M+. Elemental analysis: calc % (C19H42BrOP 1/3 CH2Cl2): C, 53.24 ; H, 9.85. Found %: C, 52.94 ; H, 10.22.

According to the analysis of related databases, 50592-87-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Brunel, Frederic; Lautard, Christelle; Garzino, Frederic; Giorgio, Suzanne; Raimundo, Jean M.; Bolla, Jean M.; Camplo, Michel; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3770 – 3773;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem