Category: 494-99-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, A new synthetic method of this compound is introduced below., 494-99-5

Then, 0.6 mol of the thus-obtained compound (VI-2) was dissolved in a 3.5-fold amount by weight, based on (VI-2), of carbon tetrachloride, and 0.66 mol of bromine gas was blown thereinto under reflux condition while irradiating with a mercury vapor lamp. The blowing was completed in 16 hours. After completion of the reaction, the solvent was distilled off to obtain 3,4-dimethoxybenzyl bromide (VII-2) in 92% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sumitomo Chemical Company, Limited; US4335263; (1982); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 494-99-5,Some common heterocyclic compound, 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, molecular formula is C9H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1 ,2-Dimethoxy-5-methyl-3,4-dinitro-benzene was synthesized by adding 15.0 g of 3,4- dimethoxytoluene portionwise to a mixture of 60 mL fumic nitric acid and 300 mL water keeping the temperature < 200C with the aid of an ice bath. The reaction was stirred for 1 h at 00C, quenched by the addition of ice and stirred for another 1 h. The yellow solid was filtered off, washed with ice cold water and dried in vacuo to yield 9.2 g of 1 ,2-dimethoxy- 5-methyl-3,4-dinitro-benzene as yellow solid.1H-NMR (CDCI3): 6.88 (s, 1 H); 4.01 (s, 3H); 3.98 (s, 3H); 2.52 (s, 3H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dimethoxy-4-methylbenzene, its application will become more common. Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/132679; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 494-99-5

3,4-Dimethoxytoluene (7.6 g, 50 mmol),Sodium bromate (6.0g, 40mmol),Sodium Bromide (8.2g, 80mmol)And carbon tetrachloride (18mL),Add to stirReturn condenser,In the reaction flask of thermometer and tail gas absorption device,Heat to reflux,Slowly add 1/2 volume of sulfuric acid (60mmol of concentrated sulfuric acid is diluted with 2mL of water and added within about 1.5h).Followed by gas chromatography,After the substrate is fully involved in the reaction (about 1 h),Quickly add 1/3 volume of initiator solution (1.12g ABVN dissolved in 7mL carbon tetrachloride),After the emergence of a vigorous reflux system,Continue to slowly add the remaining sulfuric acid and initiator solution (approx. 4.5 hours later),Continue the reaction until the product is no longer formed or the byproduct is significantly increased (about 1.5 h),To room temperature,filter,The filtrate was washed with 10 ml of sodium bicarbonate solution (5%).Liquid separation,The organic phase is dried over anhydrous sodium sulfate.concentrate,The crude product was purified by recrystallization (ethyl acetate:petroleum ether=1:13, volume ratio) to give 2-bromo-4,5-dimethoxybenzyl bromide (13.08 g).Yield 85%.

The synthetic route of 494-99-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang Normal University; Xiao Xiaohui; Chen Yufeng; (9 pag.)CN107417501; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 494-99-5, Recommanded Product: 1,2-Dimethoxy-4-methylbenzene

General procedure: A mixture of 3,4-disubstituetedtoluene (1 mmol), NBS(213 mg, 1.2 mmol) and AIBN(16 mg, 0.1 mmol) in anhydrous CCl4 (15 mL) was refluxed and monitored by TLC. After refluxing for 4 h, the reaction mixturewas filtered. The filtrate was concentrated to crude product, which was used inthe subsequent reaction without further purification

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dimethoxy-4-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ge, Bing-Chen; Feng, Hong-Fang; Cheng, Yu-Fang; Wang, Hai-Tao; Xi, Bao-Ming; Yang, Xue-Mei; Xu, Jiang-Ping; Zhou, Zhong-Zhen; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 440 – 445;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 494-99-5,Some common heterocyclic compound, 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, molecular formula is C9H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1 ,2-Dimethoxy-5-methyl-3,4-dinitro-benzene was synthesized by adding 15.0 g of 3,4- dimethoxytoluene portionwise to a mixture of 60 mL fumic nitric acid and 300 mL water keeping the temperature < 200C with the aid of an ice bath. The reaction was stirred for 1 h at 00C, quenched by the addition of ice and stirred for another 1 h. The yellow solid was filtered off, washed with ice cold water and dried in vacuo to yield 9.2 g of 1 ,2-dimethoxy- 5-methyl-3,4-dinitro-benzene as yellow solid.1H-NMR (CDCI3): 6.88 (s, 1 H); 4.01 (s, 3H); 3.98 (s, 3H); 2.52 (s, 3H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dimethoxy-4-methylbenzene, its application will become more common. Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/132679; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 494-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(a) 80.0 g (0.6 mole) of aluminium chloride are introduced in portions, while stirring, into a solution of 84.1 g (0.5 mole) of 1,2-dimethoxy-4-methylbenzene (homopyrocatechol dimethyl ether or 4-methylveratrole) in 750 ml of 1,2-dichloroethane, during which the temperature is maintained at 20 maximum by cooling with an ice bath. Then, at 15-20, 85.0 g (approximately 73 ml, 0.55 mole) of phenyl acetyl chloride are added dropwise in the course of one hour, during which there is moderate evolution of hydrogen chloride and the aluminium chloride is dissolved. The reaction mixture is then stirred at room temperature for a further 6 hours and subsequently poured into 3000 ml of a mixture of ice and water. The resulting layers are separated and the organic phase is washed in succession with 2N hydrochloric acid, twice with water, then with 1N sodium bicarbonate solution and a further twice with water, dried, filtered and concentrated by evaporation. The partially crystallized residue is caused to crystallise completely from ether/petroleum ether (boiling range 40-65), 1-(4,5-dimethoxy-2-methylphenyl)-2-phenyl-1-ethanone having a melting point of 45-48 being obtained.

The synthetic route of 1,2-Dimethoxy-4-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ciba-Geigy Corporation; US4500542; (1985); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,2-Dimethoxy-4-methylbenzene

General procedure: To a solvent of (bisacetoxyliodo)benzene (DAIB) (4.75g, 14.75mmol) in dry THF (20-30mL) was added trifluoroacetic acid (1.12g, 9.83mmol) and acetic acid (0.29g, 4.92mmol). The mixture stirred for 30 min, after which the compound added for benzylic C-H oxidation (2.46mmol) and further reacted for 24h. The progress of the chemical reaction was monitored using thin-layer chromatography with precoated silica gel 60 (0.25mm thickness) plates. The reaction was quenched with 1mL of sat. NaHCO3 (aq), and the solvent removed in vacuo on a rotatory evaporator. The residue was extracted with ethyl acetate (30mL¡Á2) and water (20mL). The combined organic extracts were washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 494-99-5.

Reference:
Article; Lin, Chun-Yu; Yang, Ping-Shin; Chou, Pang-Yu; Ong, Chi Wi; Tetrahedron Letters; vol. 59; 4; (2018); p. 365 – 367;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, A new synthetic method of this compound is introduced below., 494-99-5

Then, 0.6 mol of the thus-obtained compound (VI-2) was dissolved in a 3.5-fold amount by weight, based on (VI-2), of carbon tetrachloride, and 0.66 mol of bromine gas was blown thereinto under reflux condition while irradiating with a mercury vapor lamp. The blowing was completed in 16 hours. After completion of the reaction, the solvent was distilled off to obtain 3,4-dimethoxybenzyl bromide (VII-2) in 92% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sumitomo Chemical Company, Limited; US4335263; (1982); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A common compound: 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, belongs to ethers-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 494-99-5

(EThe compound 1,2-dimethoxy-4-methyl-benzene [25 g (0.164 mol)] was added to a mixture of POCl3 [151 g (0.987 mol)] and DMF [73 g (1 mol)] with stirring at 0 C. The viscous mixture was then heated to 80 C. and stirred there for 4 h. The reaction mix was then poured onto ice and then extracted with Et2O. The extract was dried (MgSO4) and the solvent removed. Flash chrom. with 10% EtOAc/Hexane afforded the desired aldehyde [26 g (0.144 mol)] 88% yield. A mixture of the above aldehyde [5.4 g (0.03 mol)], malonic acid [6.24 g (0.06 mol)], pyridine (20 mL) and piperidine (0.5 mL) was stirred at 80 C. for 1 h followed by stirring for 3 h at 115 C. The reaction was then poured into water (200 mL) and acidified with conc. HCl. The resulting white ppt. was filtered and vacuum dried. Yield=4.8 g (63% overall) MS (m/z): 223 [M+H]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 494-99-5, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Prosetta Antiviral, Inc.; ATUEGBU, Andy; SOLAS, Dennis; HURT, Clarence R.; KITAYGORODSKYY, Anatoliy; (141 pag.)US2016/168100; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem