Category: 4637-24-5

《Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays》 was written by Parodi, Alice; Righetti, Giada; Pesce, Emanuela; Salis, Annalisa; Tasso, Bruno; Urbinati, Chiara; Tomati, Valeria; Damonte, Gianluca; Rusnati, Marco; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico. Quality Control of N,N-Dimethylformamide Dimethyl AcetalThis research focused onVX809 hybrid derivative preparation cystic fibrosis CFTR F508del; Aminoarylthiazole; CFTR Corrector; Cystic fibrosis; Docking; F508del-CFTR; Surface plasmon resonance. The article conveys some information:

Cystic fibrosis (CF) is the autosomal recessive disorder most recurrent in Caucasian populations. It is caused by different mutations in the cystic fibrosis transmembrane regulator protein (CFTR) gene, with F508del being the most common. During the last years, small-mol. therapy chosen to contrast CF relied on compounds that correct CFTR misfolding and ER retention (correctors such as VX-809), or defective channel gating (potentiators such as VX-770). Combination therapy with the two series of drugs has been applied, leading to the approval of several multi-drugs such as Orkambi. Despite this, this treatment proved to be only partially effective making the search for novel modulators an urgent need to contrast CF. Recently, we reported compound 2a as reference compound of a series of aminoarylthiazole-VX-809 hybrid derivatives exhibiting promising F508del-CFTR corrector ability. Herein, we report exploring the docking mode of the prototype VX-809 and of 2a in order to derive useful guidelines for the rational design of novel optimized analogs. To demonstrate exptl. their effective F508del-CFTR-binding and rescuing potential, the most promising derivatives had been synthesized and evaluated in biol. assays including YFP functional assay on F508del-CFTR CFBE41o-cells, trans epithelial elec. resistance (TEER) and surface plasmon resonance (SPR). This multidisciplinary strategy led to the discovery of a second series of hybrids including 7j and 7m endowed with higher potency than the prototype. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of N,N-Dimethylformamide Dimethyl Acetal

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Quality Control of N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Jung, Juyoung; Kwon, Jinsun; Hong, Soojung; Moon, An-Na; Jeong, Jinah; Kwon, Sungwook; Kim, Jeong-ah; Lee, Myoungjae; Lee, Hongsub; Lee, Jin Hee; Lee, Jeewoo. The article conveys some information:

A series of isosteric surrogates of the 4-Ph group in luminespib were investigated as new scaffolds of the Hsp90 inhibitor for the discovery of novel antitumor agents. Among the synthesized surrogates of isoxazole and pyrazole, compounds 4a, 5e and 12b exhibited potent Hsp90 inhibition in ATPase activity and Her2 degradation assays and significant antitumor activity in A2780 and HCT116 cell lines. Animal studies indicated that compared to luminespib, their activities were superior in A2780 or NCI-H1975 tumor xenograft models. A mol. modeling study demonstrated that compound 4a could fit nicely into the N-terminal ATP binding pocket. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Quality Control of N,N-Dimethylformamide Dimethyl Acetal

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In 2022,Bhat, Mashooq A.; Al-Omar, Mohamed A.; Naglah, Ahmed M.; Al-Dhfyan, Abdullah published an article in Polish Journal of Chemical Technology. The title of the article was 《Facile synthesis and anticancer activity of novel dihydropyrimidinone derivatives》.Application of 4637-24-5 The author mentioned the following in the article:

The enaminone, (2E)-3-(dimethylamino)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one was prepared by refluxing 3,4,5-trimethoxy acetophenone with DMF dimethylacetal (DMF-DMA) without solvent for 12 h. The dihydropyrimidinone derivatives (1-9) were prepared by reacting enaminone, substituted benzaldehydes and urea in glacial acetic acid. The compounds (1-9) were synthesized in significant yield using one step multicomponent reaction. Structures of all the novel synthesized compounds were characterized and confirmed by various spectroscopic methods. The compounds were evaluated for their anti-cancer activity against HepG2 cancer cell line. Compound 9 displayed significant anti-cancer activity. During the apoptotic assay, it showed a significant increase in necrosis from 1.97% to 12.18% as compared to the control. Mechanism of anti-proliferation was performed by cell cycle distribution assay, which showed a decrease in G2+M from 12.90 to 8.13 as compared to control. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application of 4637-24-5

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The author of 《2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development》 were Zhuo, Lin-Sheng; Xu, Hong-Chuang; Wang, Ming-Shu; Zhao, Xing-E.; Ming, Zhi-Hui; Zhu, Xiao-Lei; Huang, Wei; Yang, Guang-Fu. And the article was published in European Journal of Medicinal Chemistry in 2019. Application of 4637-24-5 The author mentioned the following in the article:

As part of our effort to develop new mol. targeted antitumor drug, a novel 2,7-naphthyridone-based MET kinase inhibitor, I, was identified. Knowledge of the binding mode of BMS-777607 in MET led to the design of new inhibitors that utilize novel 2,7-naphthyridone scaffold to conformationally restrain the key pharmacophoric groups (block C). Detailed SAR studies resulted in the discovery of a new MET inhibitor I, displaying favorable in vitro potency and oral bioavailability. More importantly, I exhibited excellent in vivo efficacy (tumor growth inhibition/TGI of 114% and 95% in 50 mg/kg, resp.) both in the U-87 MG and HT-29 xenograft models. The favorable drug-likeness of I indicated that 2,7-naphthyridinone may be used a promising novel scaffold for antitumor drug development. The preclin. studies of I are under way. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 4637-24-5

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Recommanded Product: 4637-24-5In 2022 ,《Regio- and stereoselective synthesis of spiro-heterocycles bearing the pyrazole scaffold via [3+2] cycloaddition reaction》 was published in Journal of Molecular Structure. The article was written by Islam, Mohammad Shahidul; Haukka, Matti; Soliman, Saied M.; Al-Majid, Abdullah Mohammed; Rahman, A. F. M. Motiur; Bari, Ahmed; Barakat, Assem. The article contains the following contents:

The utility of one-pot multicomponent based [3+2] cycloaddition reaction transformation to prepare a new two hybrids of spirooxindoles engrafted with pyrazole skeleton I (R1 = H and Cl; R2 = F and Cl) was reported. Upon treatment of the electron-deficient olefins based pyrazole motif with in situ the generated azomethine ylides (AY) of sarcosine with the 6-chloro-isatin afforded spiroadducts. To enlighten the regio- and diastereo-selectivity of these spiroheterocycles, single crystal X-ray diffraction anal. was presented. Using Hirshfeld calculations, many short distance contacts such as O…H, Cl…H, N…H, H…C, C…C and Cl…S have a great impact on the mol. packing and the crystal stability of I (R1 = H; R2 = F) and I (R1 = Cl; R2 = Cl). The latter showed some Cl…Cl inter halogen interactions (Cl1…Cl3; 3.358 Å ). Both compounds are polar where I (R1 = Cl; R2 = Cl) (3.995 Debye) has higher dipole moment than I (R1 = H; R2 = F) (3.414 Debye). The NMR chem. shifts were calculated and found in excellent correlations between the calculated and exptl. data were obtained (R2 = 0.94-0.98). In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 4637-24-5

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《Structural investigation of perfluorocarboxylic acid derivatives formed in the reaction with N,N-dimethylformamide dialkylacetals》 was written by Strozynska, Monika; Gross, Juergen H.; Schuhen, Katrin. Safety of N,N-Dimethylformamide Dimethyl Acetal And the article was included in European Journal of Mass Spectrometry in 2020. The article conveys some information:

A structural investigation of perfluorocarboxylic acid derivatives formed in the reaction with N,N-dimethylformamide dialkylacetals employing several techniques of mass spectrometry (MS) is described. Two derivatizing reagents, DMF di-Me acetal (DMF-DMA) and DMF diethylacetal (DMF-DEA) were used. In contrast to carboxylic acids, perfluorocarboxylic acids are not able to form alkyl esters as the main product in this reaction. We found that perfluorooctanoic acid (PFOA) forms a salt with N,N-dimethylformamide dialkylacetals. This salt undergoes a further reaction inside the injection block of a gas chromatograph (GC) by loss of CO2 and then forms 1,1-perfluorooctane-(N,N,N,N-tetramethyl)-diamine. The GC-MS experiments using both electron ionization (EI) and pos.-ion chem. ionization (PCI) revealed that the same reaction products are formed with either derivatizing reagent. Subjecting the perfluorocarboxylic acid derivative to electrospray ionization (ESI) and direct anal. in real time (DART), both pos.- and neg.-ion modes indicated that cluster ions are formed. In the pos.-ion mode, this cluster ion consists of two iminium cations and one PFOA anion, while in the neg.-ion mode, it comprises two PFOA anions and one cation. The salt structure was further confirmed by liquid injection field desorption/ionization (LIFDI) as well as IR spectroscopy. We propose a simple mechanism of N,N,N’,N’-tetramethylformamidinium cation formation. The structure elucidation is supported by specific fragment ions as obtained by GC-EI-MS and GC-PCI-MS anal.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Safety of N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of N,N-Dimethylformamide Dimethyl Acetal

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In 2019,Journal of the American Chemical Society included an article by Laguerre, Aurelien; Hauke, Sebastian; Qiu, Jian; Kelly, Martin J.; Schultz, Carsten. COA of Formula: C5H13NO2. The article was titled 《Photorelease of 2-Arachidonoylglycerol in Live Cells》. The information in the text is summarized as follows:

2-Arachidonoylglycerol (2-AG) is acting as a full agonist of cannabinoid receptor 1 and 2. Direct manipulation of 2-AG levels is a challenging task. The amphiphilic properties and the instability of 2-AG in aqueous media complicate its use as a drug-like mol. Addnl., inhibition of the protein machinery that regulates 2-AG levels may also affect other monoacylglycerols. Therefore, we developed a novel method to elevate 2-AG levels with a flash of light. The resulting tool is a photoactivatable “”caged”” 2-arachidonoylglycerol (cg2-AG) allowing for the rapid photorelease of the signaling lipid in live cells. We characterized the mechanism of uncaging and the effect of 2-AG on the regulation of the β-cell signaling network. After uncaging of 2-AG, we monitored calcium levels, CB1-GIRK channel coupling, and CB1-mediated inhibition of adenylate cyclase and protein kinase A activity. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).COA of Formula: C5H13NO2

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Application of 4637-24-5In 2022 ,《Insights into the crystal structure of two newly synthesized quinoxalines derivatives as potent inhibitor for c-Jun N-terminal kinases》 appeared in Journal of Biomolecular Structure and Dynamics. The author of the article were Abad, Nadeem; El Bakri, Youness; Lai, Chin-Hung; Karthikeyan, Subramani; Ramli, Youssef; Ferfra, Souad; Mague, Joel T.; Essassi, El Mokhtar. The article conveys some information:

Two new compounds namely, Et (2E)-3-(dimethylamino)-2-(3-methoxyquinoxalin-2-yl)propen-2-enoate () and Et 2-(3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydroquinoxalin-2-yl)-3-phenylpropanoate () have been synthesized from Et 2-(oxo-3,4-dihydroquinoxalin-2-yl) acetate (). The compounds were characterized using NMR (1H and 13C), Fourier transform IR and confirmed by single crystal X-ray diffraction studies. The quinoxaline portion of is almost planar with the substituent containing the dimethylamino and carboxyethyl groups rotated well out of its mean plane. In the crystal, C-H···O and C-H···N hydrogen bonds as well as C-H···Π(ring) interactions form chains having a U-shaped cross-section and running along the c-axis direction. Two sets of pair-wise C-H···O hydrogen bonds connect the chains into corrugated sheets. In, the three substituents on the dihydroquinoxaline moiety are rotated well out of its mean plane. Three sets of C-H···O hydrogen bonds as well as C-H···π(ring) and π-π-stacking interactions form layers approx. parallel to [001]. These are associated along the c-axis direction by addnl. C-H···π(ring) interactions. Addnl., the Hirshfeld surface analyses showed that the H···H contact is the most important interaction for both and In addition to this, mol. docking and dynamics studies were carried for these two compounds with the c-Jun N-terminal kinases (JNK1) mol.Communicated by Ramaswamy H. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application of 4637-24-5

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Gorgieva, Selestina; Osmic, Azra; Hribernik, Silvo; Bozic, Mojca; Svete, Jurij; Hacker, Viktor; Wolf, Sigrid; Genorio, Bostjan published their research in International Journal of Molecular Sciences in 2021. The article was titled 《Efficient chitosan/nitrogen-doped reduced graphene oxide composite membranes for direct alkaline ethanol fuel cells》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:

Herein, we prepared a series of nanocomposite membranes based on chitosan (CS) and three compositionally and structurally different N-doped graphene derivatives Two-dimensional (2D) and quasi 1D N-doped reduced graphene oxides (N-rGO) and nanoribbons (N-rGONRs), as well as 3D porous N-doped graphitic polyenaminone particles (N-pEAO), were synthesized and characterized fully to confirm their graphitic structure, morphol., and nitrogen (pyridinic, pyrrolic, and quaternary or graphitic) group contents. The largest (0.07%) loading of N-doped graphene derivatives impacted the morphol. of the CS membrane significantly, reducing the crystallinity, tensile properties, and the KOH uptake, and increasing (by almost 10-fold) the ethanol permeability. Within direct alk. ethanol test cells, it was found that CS/N rGONRs (0.07%) membrane (Pmax. = 3.7 mWcm-2) outperformed the pristine CS membrane significantly (Pmax. = 2.2 mWcm-2), suggesting the potential of the newly proposed membranes for application in direct ethanol fuel cells. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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《Stereoselective synthesis of trifluoromethyl-substituted 2H-furan-amines from enaminones》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Liang, Xiaoyu; Guo, Pan; Yang, Wenjie; Li, Meng; Jiang, Chengzhou; Sun, Wangbin; Loh, Teck-Peng; Jiang, Yaojia. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article mentions the following:

A straightforward strategy for synthesis of highly functionalized trifluoromethyl 2H-furans was described. The copper catalyzed method relies on a cascade cyclic reaction between enaminones and N-tosylhydrazones. This method allowed the synthesis of 2-amino-3-trifluoromethyl-substituted 2H-furan derivatives carrying a quaternary stereogenic center as single diastereomers. The proposed reaction mechanism involved an amino-cyclopropane intermediate formed in the cyclopropanation of enaminones. The developed method tolerated a broad spectrum of functionalities and the obtained 2H-furan derivatives were useful synthetic intermediates for preparing other trifluoromethyl-substituted compounds The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem