Category: 4637-24-5

《Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors》 was written by Jia, Haiyong; Yu, Ji; Du, Xianhong; Cherukupalli, Srinivasulu; Zhan, Peng; Liu, Xinyong. SDS of cas: 4637-24-5 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

This study focous on scaffold hopping, bioisosterism, and pharmacophore hybrid-based strategies to design and synthesize six series of various heterocycle derivatives (pyrazole, thiazole, pyrazine, pyrimidine, and pyridine) and screened for in vitro anti-HBV non-nucleoside activity. Drug candidate NZ-4 and AT-130 were used as lead compounds Several compounds exhibited prominent anti-HBV activity compared to lead compound NZ-4 and pos. drug Lamivudine, especially compound II-8b, showed the most prominent anti-HBV DNA replication activity (IC50 = 2.2 ± 1.1μM). Also compounds IV-8e and VII-5b showed the best in vitro anti-HBsAg secretion (IC50 = 3.8 ± 0.7μM, CC50 > 100μM) and anti-HBeAg secretion (IC50 = 9.7 ± 2.8μM, CC50 > 100μM) resp. Besides, II-8b was interact HBV capsid protein with good affinity constants (KD = 60.0μM), which was equivalent to lead compound NZ-4 (KD = 50.6μM). The preliminary structure-activity relationships (SARs) of the newly synthesized compounds were summarized, which may help researchers to discover more potent anti-HBV agents. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5SDS of cas: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 4637-24-5

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HPLC of Formula: 4637-24-5In 2019 ,《Synthesis and Antibacterial Evaluation of Some New Thiazole-Based Polyheterocyclic Ring Systems》 was published in Journal of Heterocyclic Chemistry. The article was written by Abdel-Latif, Ehab; Almatari, Altaf S.; Abd-ElGhani, Ghada E.. The article contains the following contents:

2-Cyanoacetamido-thiazole (I) was employed as a key for the construction of 6-cyano-7-oxo-7H-thiazolo[3,2-a]pyrimidine which underwent reaction with hydrazine, malononitrile, Et cyanoacetate, and/or various 1,3-bi-nucleophilic reagents furnished the corresponding tri-heterocyclic and tetra-heterocyclic ring systems. In addition, the reactions of I with various types of arylidene-malononitriles and/or Et 3-aryl-2-cyanoacrylates yielded the corresponding 1-thiazolyl-pyridine derivatives Furthermore, treatment of the precursor I with carbon disulfide and Me iodide afforded the ketene dithioacetal derivative which cyclized upon heating with hydrazine and/or 2-aminobenzimidazole into the corresponding derivatives of N-(thiazol-2-yl)-1H-pyrazole-4-carboxamide and N-(thiazol-2-yl)benzimidazo[1,2-a]-pyrimidine-3-carboxamide. The antibacterial properties of these thiazole-based heterocycles were examined against panel of two bacterial strains. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5HPLC of Formula: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.HPLC of Formula: 4637-24-5

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Product Details of 4637-24-5In 2020 ,《Convenient synthesis of novel sulfonamide derivatives as promising anticancer agents》 was published in Journal of Heterocyclic Chemistry. The article was written by El-Mekabaty, Ahmed; Awad, Hanem M.. The article contains the following contents:

Novel sulfonamide derivatives I [R = acetyl, 2-aminothiazol-4-yl, 4-oxo-3,1-benzoxazin-2-yl, etc.] were synthesized from the readily accessible N-(4-acetylphenyl)benzenesulfonamide I [R = acetyl]. Condensation of N-(4-acetylphenyl)benzenesulfonamide I [R = acetyl] with phenylhydrazine in refluxing Et alc. gave the corresponding phenylhydrazone I [R = N-anilino-C-methyl-carbonimidoyl], which was then added to the Vilsmeier-Haack reagent (POCl3/DMF) to give the 4-formylpyrazole derivative I [R = 4-formyl-1-phenyl-pyrazol-3-yl]. Fusion of I [R = acetyl] with thiourea in the presence of iodine at 130°C afforded the 2-aminothiazole derivative I [R = 2-aminothiazol-4-yl]. Refluxing I [R = acetyl] with an excess of N, N-dimethylformamide di-Me acetal furnished the enaminone I [R = 3-(dimethylamino)prop-2-enoyl]. The chem. reactivity of enaminone I [R = 3-(dimethylamino)prop-2-enoyl] toward some nitrogen and carbon nucleophiles has been studied to obtain polyfunctionalized heteroaromatic systems bearing a sulfonamide moiety. Besides, the enaminone I [R = 3-(dimethylamino)prop-2-enoyl] undergoes the Gewald reaction and reacts with Et cyanoacetate and elemental sulfur in the presence of morpholine to yield the 2-aminothiophene derivative I [R = 5-amino-4-ethoxycarbonyl-thiophene-2-carbonyl]. Moreover, the utility of I [R = 3-(dimethylamino)prop-2-enoyl] for the synthesis of 4-(phenylsulfonamido)benzoic acid I [R = carboxy] was investigated. The synthesized sulfonamides I were evaluated for their in vitro cytotoxic activities against two human cell lines, MCF-7 (breast adenocarcinoma cells) and RPE-1 (normal retina pigmented epithelium cells). The results revealed that compounds I [R = acetyl, N-anilino-C-methyl-carbonimidoyl, 4-formyl-1-phenyl-pyrazol-3-yl, 3-pyrazolyl, 2-oxo-1H-pyrimidin-4-yl, 2-aminopyrimidin-4-yl, 4-oxo-1H-quinoline-3-carbonyl, 5-acetyl-6-methyl-2-pyridyl, 5-amino-4-ethoxycarbonyl-thiophene-2-carbonyl, carboxy, 4-oxo-3,1-benzoxazin-2-yl] were potent cytotoxic effect on MCF-7 and less on RPE-1 cells compared to the pos. control doxorubicin. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Product Details of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Product Details of 4637-24-5

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Safety of N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Synthesis, X-ray analysis and computational studies of two novel thiophene derivatives*》 was published in Journal of Sulfur Chemistry. The article was written by Muhsinah, Abdullatif Bin; Alsayari, Abdulrhman; Algarni, H.; Soliman, Saied M.; Kheder, Nabila A.; Ghabbour, Hazem A.; Asiri, Yahya I.; Venkatesan, Kumar; Mabkhot, Yahia N.. The article contains the following contents:

The reaction of Et 3-oxobutanoate with carbon disulfide and chloroacetone in the presence of K2CO3 affords the unexpected thiophene derivative . Furthermore, refluxing compound with dimethylformamide-dimethylacetal (DMF-DMA) in DMF affords the enaminone derivative . The structures of these newly synthesized compounds were confirmed by means of various spectroscopic techniques, such as IR, MS, and NMR, as well as by X-ray diffraction. In addition, B3LYP/6-311G(d, p) basis sets were employed to optimize the mol. geometry of the two thiophene derivatives Furthermore, natural at. charges and frontier MO analyses were performed. Hirshfeld anal. of the mol. packing showed that H-H, O-H, C-H, and S-H are the most common intermol. interactions in both compounds Further anal. suggests that the O-H interactions are the most significant of these in compounds and . In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Safety of N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Safety of N,N-Dimethylformamide Dimethyl Acetal

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In 2019,Russian Journal of General Chemistry included an article by Dyachenko, I. V.. Synthetic Route of C5H13NO2. The article was titled 《2-Cyano-3-(dimethylamino)prop-2-ene Thioamide: A New Reagent for Synthesis of Functionalized 4-Unsubstituted Ethyl Nicotinates and Nicotinonitriles》. The information in the text is summarized as follows:

Condensation of cyclopent(hex)ylidenecyanothioacetamide with N, N-dimethylformamide di-Me acetal led to the formation of a new reagent for organic synthesis: 2-cyano-3-(dimethylamino)prop-2-ene thioamide. On its basis a series of Et nicotinates and nicotinonitriles were synthesized by a vinyl substitution reaction. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C5H13NO2

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AlMarzouq, Douaa Salman published their research in European Journal of Chemistry in 2021. The article was titled 《Reactions under increased pressure: the reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube》.Electric Literature of C5H13NO2 The article contains the following contents:

A one-pot two-component reaction of 3-oxo-2-arylhydrazones 4-XC6H4C(O)C(C(O)R)=NNH(4-R1C6H4) (X = H, Cl; R = H, OEt; R1 = H, Me) with active methylene nitriles such as malononitrile and benzoylacetonitrile under high pressure in a Q-tube safe reactor was reported. Comparison between conventional and Q-tube safe reactor-assisted synthesis of organic compounds was done by comparing total reaction time and percentage yield. The results show that the compound 5-cyano-6-oxo-1,4-diphenyl-1,6-dihydro-pyridazine-3-carboxylic acid Et ester was synthesized within 2 h in a yield of 97%. In addition, the pyrazolo[3,4-c]pyridines I were obtained in yields of 93 and 95% within 1 h reaction time, resp. The obtained results suggest that Q-tube safe reactor-assisted syntheses were led to higher product yields within very short reaction times.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C5H13NO2

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Recommanded Product: 4637-24-5In 2019 ,《Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors》 appeared in Journal of Medicinal Chemistry. The author of the article were Himmelbauer, Martin K.; Xin, Zhili; Jones, J. Howard; Enyedy, Istvan; King, Kristopher; Marcotte, Douglas J.; Murugan, Paramasivam; Santoro, Joseph C.; Hesson, Thomas; Spilker, Kerri; Johnson, Joshua L.; Luzzio, Michael J.; Gilfillan, Rab; de Turiso, Felix Gonzalez-Lopez. The article conveys some information:

Structural anal. of a known ASK1 inhibitor bound to its kinase domain led to the design and synthesis of the novel macrocyclic inhibitor I (cell IC50 = 1.2μM). The profile of this compound was optimized for CNS penetration following two independent strategies: a rational design approach leading to II and a parallel synthesis approach leading to III. Both analogs are potent ASK1 inhibitors in biochem. and cellular assays (II, cell IC50 = 95 nM; III, cell IC50 = 123 nM) and have moderate to low efflux ratio (ER) in an MDR1-MDCK assay (II, ER = 5.2; III, ER = 1.5). In vivo PK studies revealed that inhibitor II had moderate CNS penetration (Kp,uu = 0.17) and analog III had high CNS penetration (Kp,uu = 1.0).N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Recommanded Product: 4637-24-5

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Category: ethers-buliding-blocksIn 2019 ,《Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhu, Wen-Jing; Cui, Ben-Wen; Wang, Hui Min; Nan, Ji-Xing; Piao, Hu-Ri; Lian, Li-Hua; Jin, Cheng Hua. The article conveys some information:

Six series of 4-(benzo[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,-c]- pyridin-2-yl)pyrazoles have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymic assays. Among these compounds, the most active compound, I, inhibited ALK5 phosphorylation with an IC50 value of 0.030 μM in the enzymic assay. Compound I showed four-fold more potent activity against ALK5 kinase than the clin. candidate, compound LY-2157299. The selectivity index of I against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (II) and equally selective to that of EW-7197 (III). Compound I effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound I has the ability to inhibit the activation of HSC. Compound I is expected to be a preclin. candidate for the treatment of hepatic fibrosis. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Category: ethers-buliding-blocks

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Computed Properties of C5H13NO2In 2020 ,《Controllable Soil Degradation Rate of 5-Substituted Sulfonylurea Herbicides as Novel AHAS Inhibitors》 was published in Journal of Agricultural and Food Chemistry. The article was written by Zhou, Shaa; Meng, Fan-Fei; Hua, Xue-Wen; Li, Yong-Hong; Liu, Bin; Wang, Bao-Lei; Chen, Jie; Chen, An-Liang; Li, Zheng-Ming. The article contains the following contents:

Chlorsulfuron has been applied in wheat fields as a recognized herbicide worldwide, yet it was officially banned in China since 2014 for its soil persistence problem. On the basis of our previous research that 5-dimethylamino distinctively accelerated degradation rate in soils, a modified amino moiety (Ia-c) and monosubstituted amino group (Id-e) were introduced onto the fifth position of the benzene ring in sulfonylurea structures, as well as heterocyclic amino substituents (If-g) to seek a suitable soil degradation rate during such an in situ crop rotation system. Referring to the biol. data and ScAHAS inhibition and ScAHAS docking results, they turned out to be AHAS inhibitors with high potent herbicidal activities. The various influence on soil degradation rate along with crop safety indicated that different substituents on the fifth position have exerted an apparent impact. Their united study of structure-activity-safety-degradation relationship has great potential to provide valuable information for further development of eco-friendly agrochems. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Computed Properties of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Computed Properties of C5H13NO2

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Name: N,N-Dimethylformamide Dimethyl AcetalIn 2022 ,《New Synthesis of Tetrahydroisoquinolines》 was published in Russian Journal of Organic Chemistry. The article was written by Dyachenko, I. V.; Dyachenko, V. D.; Dorovatovskii, P. V.; Khrustalev, V. N.; Nenajdenko, V. G.. The article contains the following contents:

The reaction of cyclohexylidenecyanothioacetamide with N,N-dimethylformamide di-Me acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is formed, and refluxing in benzene leads to 2-cyano-3-(dimethylamino)prop-2-enethioamide. The structure of these products was studied by XRD analysts. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Name: N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem