Category: 4637-24-5

《Self-Waveguide Single-Benzene Organic Crystal with Ultralow-Temperature Elasticity as a Potential Flexible Material》 was written by Liu, Bin; Lu, Zhuoqun; Tang, Baolei; Liu, Hao; Liu, Huapeng; Zhang, Zuolun; Ye, Kaiqi; Zhang, Hongyu. Reference of N,N-Dimethylformamide Dimethyl AcetalThis research focused onwaveguide benzene crystal ultralow temperature elasticity potential flexible material; elasticity; flexible crystals; optical waveguides; organic crystals; ultralow temperature. The article conveys some information:

A highly emissive aromatic crystal combining ultralow-temperature elasticity and self-waveguide properties (when a crystal is excited, it emits light from itself, which travels through the crystal to the other end) based on a simple single-benzene emitter, is reported. This crystal displayed excellent elastic bending ability in liquid N (LN). Preliminary experiments on optical waveguiding in the bent crystal demonstrated that the light generated by the crystal itself could be confined and propagated within the crystal body between 170 and -196°. These results not only suggest a guideline for designing functional organic crystals with ultralow-temperature elasticity but also expand the application region of flexible materials to extreme environments, such as space technol. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Reference of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Reference of N,N-Dimethylformamide Dimethyl Acetal

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《Structure-based discovery of novel 4-(2-fluorophenoxy)quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Nan, Xiang; Li, Hui-Jing; Fang, Sen-Biao; Li, Qin-Ying; Wu, Yan-Chao. Formula: C5H13NO2 The article mentions the following:

In this study, two novel series of 6,7-dimethoxy-4-(2-fluorophenoxy)quinoline derivatives containing α-acyloxycarboxamide I [R1 = Me, n-Pr, t-Bu, cyclohexyl, phenyl; R2 = cyclopentyl, 2-thienyl, Ph, etc.] or α-acylaminoamide II [R3 = H, n-Bu, Ph, etc.] scaffolds were designed, synthesized and evaluated for their in-vitro biol. activities against c-Met kinase and four cancer cell lines (H460, HT-29, MKN-45 and MDA-MB-231). Most of the target compounds I and II exhibited moderate to significant potency and possessed selectivity for H460 and HT-29 cancer cell lines. The preliminary structure-activity relationships indicated that α-acyloxycarboxamide or α-acylaminoamide as 5-atom linker contributed to the antitumor potency. Among these compounds, compound I [R1 = t-Bu, R2 = 4-fluorophenyl] (c-Met IC50 = 2.43 nM, a multitarget tyrosine kinase inhibitor) exhibited the most potent inhibitory activities against H460, HT-29 and MDA-MB-231 cell lines with IC50 of 0.14 ± 0.03μM, 0.20 ± 0.02μM and 0.42 ± 0.03μM, which were 1.7-, 1.3- and 1.6-fold more active than foretinib, resp. In addition, concentration-dependent assay and time-dependent assay indicated compound I [R1 = t-Bu, R2 = 4-fluorophenyl] inhibited the proliferation of H460 cell in a time and concentration dependent manner. Moreover, docking studies revealed the common mode of interaction with the c-Met binding site, suggesting that compound I [R1 = t-Bu, R2 = 4-fluorophenyl] is a potential candidate for cancer therapy deserving further study. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C5H13NO2

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Sanad, Sherif M. H.; Ahmed, Mohamed S. Mohamed; Mekky, Ahmed E. M.; Abdallah, Zeinab A. published their research in Journal of Molecular Structure in 2021. The article was titled 《Regioselective synthesis and theoretical calculations of Bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines) linked to benzofuran units via piperazine spacer: A DFT, MM2, and MMFF94 study》.Related Products of 4637-24-5 The article contains the following contents:

Bis(enaminone), linked to benzofuran units via piperazine spacer, was prepared and used as a key intermediate in this study. It reacted for 8 h at reflux with two equivalent of 2-cyanothioacetamide in dioxane in the presence of TEA to give the corresponding bis(pyridine-2(1H)-thione) derivative The previous compound was reacted with two equivalent of iodomethane in methanolic sodium methoxide solution at reflux for 1 h to yield the corresponding bis(2-methylthiopyridine) derivative Boiling of the prior compound with hydrazine hydrate in pyridine at reflux for 12 h gave the precursor bis(3-amino-1H-pyrazolo[3,4-b]pyridine) derivative in a good yield. Next, a regioselective protocol was conducted for the synthesis of a diverse series of the target bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine) derivatives in good to excellent yields. The protocol involved the reaction of bis(3-amino-1H-pyrazolo[3,4-b]pyridine) with two equivalent of prop-2-en-1-ones in DMF in the presence of two equivalent of barium hydroxide at reflux for 5-7 h. To gain a better understanding of the regioselectivity observed in these reactions, DFT calculations were performed using B3LYP method and 6-31+G(d,p) basis set. The favored mechanism and the exptl. regioselectivity of this reaction were explained by calculations of activation energy, natural at. charge, Fukui indexes derived from d. functional theory, MM2, and MMFF94 calculations The current study demonstrated that using the previous computational tools, the regioselectivity of the applied reaction protocol could be correctly predicted. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Related Products of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 4637-24-5

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Jackson, Garrett D.; Tipping, Max B.; Taylor, Christopher G. P.; Piper, Jerico R.; Pritchard, Callum; Mozaceanu, Cristina; Ward, Michael D. published their research in Chemistry (Basel, Switzerland) in 2021. The article was titled 《A Family of Externally-Functionalised Coordination Cages》.Reference of N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:

New synthetic routes are presented to derivatives of a (known) M8L12 cubic coordination cage in which a range of different substituents are attached at the C4 position of the pyridyl rings at either end of the bis(pyrazolyl-pyridine) bridging ligands. The substituents are (i) -CN groups (new ligand LCN), (ii) -CH2OCH2-CCH (containing a terminal alkyne) groups (new ligand LCC); and (iii) -(CH2OCH2)3CH2OMe (tri-ethyleneglycol monomethyl ether) groups (new ligand LPEG). The resulting functionalised ligands combine with M2+ ions (particularly Co2+, Ni2+, Cd2+) to give isostructural [M8L12]16+ cage cores bearing 24 external functional groups; the cages based on LCN (with M2+ = Cd2+) and LCC (with M2+ = Ni2+) have been crystallog. characterised. The value of these is twofold: (i) exterior nitrile or alkene substituents can provide a basis for further synthetic opportunities via ′Click′ reactions allowing in principle a diverse range of functionalisation of the cage exterior surface. (ii) the exterior -(CH2OCH2)3CH2OMe groups substantially increase cage solubility in both water and in organic solvents, allowing binding constants of cavity-binding guests to be measured under an increased range of conditions. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Reference of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of N,N-Dimethylformamide Dimethyl Acetal

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Zheng, Bin; Wang, Shu-Qin; Zhang, Xiao-Ting; Huang, Wan-Yun published their research in Chinese Journal of Structural Chemistry in 2021. The article was titled 《Syntheses and crystal structures of a pair of Z-E enaminonitrile isomerisms》.Electric Literature of C5H13NO2 The article contains the following contents:

A pair of Z-E enaminonitrile isomerisms 2-(3,4-dimethoxyphenyl)-3-((3-methoxyphenyl)amino)acrylonitrile were synthesized and separated by flash column chromatog., and their structures were determined by IR, 1H NMR, 13C NMR, MS and single-crystal X-ray diffraction. The crystal of compound Z-isomer belongs to the monoclinic system, space group C2/c with a = 33.805(7), b = 5.4496(12), c = 18.401(4)Å, β = 112.45(2)°, V = 3133.1(12)Å3, Z = 8, μ = 0.091 mm-1, Dc = 1.143 g·cm-3, the final R = 0.0491 and wR = 0.1439 for 2764 observed reflections. The crystal of compound E-isomer belongs to the triclinic system, space group P1, with a = 8.8403(7), b = 9.0390(6), c = 12.0044(74)Å α = 72.075(5), β = 86.291(5), γ = 81.216(5)°, V = 901.82(10)Å3, Z = 2, T = 293(2) K, μ = 0.079 mm-1, Dc = 1.143 g·cm-3, the final R = 0.0474 and wR = 0.1377 for 3176 observed reflections. The crystal packing of Z and E isomers was governed by intermol. N(2)-H(2)···N(1) and N(2)-H(2)···O(2) interactions resp. to stabilize the structure. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C5H13NO2

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Ether – Wikipedia,
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In 2022,Hu, Tianwen; Xie, Yuanchao; Zhu, Fuqiang; Gong, Xudong; Liu, Yin; Xue, Haitao; Aisa, Haji A.; Shen, Jingshan published an article in Organic Process Research & Development. The title of the article was 《””One-Pot”” Synthesis of Molnupiravir from Cytidine》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

A one-pot process for preparing molnupiravir from cytidine was developed. The advantages of this synthesis were as follows: (1) The presence of N,N-dimethylformamide di-Me acetal (DMF-DMA) facilitated the selective protection of 2′,3′-dihydroxyls and amino of cytidine, which eliminated the neg. impact of these groups on the following isobutyrylation at 5′-hydroxyl. (2) Degradations of the product in the deprotection stage were avoided since a mild condition was used. (3) The achievement of deprotection and hydroxyamination in one single step improved the synthetic efficiency. (4) Molnupiravir with high purity (purity up to 99.7% analyzed by high-performance liquid chromatog. (HPLC)) was obtained in a yield of 63% through crystallizationN,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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《Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies》 was written by Othman, Ismail M. M.; Gad-Elkareem, Mohamed A. M.; Anouar, El Hassane; Snoussi, Mejdi; Aouadi, Kaiss; Kadri, Adel. Category: ethers-buliding-blocks And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

Thirteen fused pyridine derivatives have been designed, synthesized. Their in vitro antimicrobial activity was investigated against some pathogenic bacteria and fungi and the majority of them showed excellent to moderate activity, especially compounds I and II displaying the potent inhibitory effect against K. pneumoniae with MIC values of 2.44 mM and 8.10 mM, resp. Their pharmacokinetic assessment also revealed promising druglikeness characteristics and ADME properties. The binding interactions of the most active analogs were performed through mol. docking against Staphylococcus aureus tyrosyl-tRNA synthetase. Results revealed that the enhanced activity of compound I can be modulated by the establishment, in 10-tyrosyltRNA synthetase complex, of hydrogen bond interactions between the lone pair of sulfur atom of the thiophen-3-amine ring and the hydrogen atom of the hydroxyl group of TYR 170 of 3.80 Å . These findings suggest that analogs I and II can be served as best candidates for designing and discovering of novel antimicrobial agents. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: ethers-buliding-blocks

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Zhang, Changyuan; Qiu, Yun; Zhang, Jiantao; Chen, Lulu; Xu, Shuting; Guo, Huosheng; Luo, Jian; Tan, Yao published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《CAN-mediated Oxidative Coupling-Reaction of Xanthenes with Enaminones》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:

An efficient CAN-mediated C-C bond formation in the oxidative reactions of xanthenes with enaminones under mild reaction conditions was described. A variety of 9H-xanthene-9-ylidene aldehydes I [R = H, 2-Cl, 3-Ph, etc.; R1 = Ph, 2-thienyl, cyclohexyl, etc.; X = O, NMe, S] could be synthesized in up to 90% yield via one-pot manner with good functional group compatibility, which achieved the simultaneous construction of carbon-carbon double bond and carbon-oxygen double bond. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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Recommanded Product: N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Velaparthi, Upender; Darne, Chetan Padmakar; Warrier, Jayakumar; Liu, Peiying; Rahaman, Hasibur; Augustine-Rauch, Karen; Parrish, Karen; Yang, Zheng; Swanson, Jesse; Brown, Jennifer; Dhar, Gopal; Anandam, Aravind; Holenarsipur, Vinay K.; Palanisamy, Kamalavenkatesh; Wautlet, Barri S.; Fereshteh, Mark P.; Lippy, Jonathan; Tebben, Andrew J.; Sheriff, Steven; Ruzanov, Max; Yan, Chunhong; Gupta, Anuradha; Gupta, Arun Kumar; Vetrichelvan, Muthalagu; Mathur, Arvind; Gelman, Marina; Singh, Rajinder; Kinsella, Todd; Murtaza, Anwar; Fargnoli, Joseph; Vite, Gregory; Borzilleri, Robert M.. The article conveys some information:

Novel imidazole-based TGFβR1 inhibitors were identified and optimized for potency, selectivity, and pharmacokinetic and physicochem. characteristics. Herein, we report the discovery, optimization, and evaluation of a potent, selective, and orally bioavailable TGFβR1 inhibitor, 10 (BMS-986260). This compound demonstrated functional activity in multiple TGFβ-dependent cellular assays, excellent kinome selectivity, favorable pharmacokinetic properties, and curative in vivo efficacy in combination with anti-PD-1 antibody in murine colorectal cancer (CRC) models. Since daily dosing of TGFβR1 inhibitors is known to cause class-based cardiovascular (CV) toxicities in preclin. species, a dosing holiday schedule in the anti-PD-1 combination efficacy studies was explored. An intermittent dosing regimen of 3 days on and 4 days off allowed mitigation of CV toxicities in one month dog and rat toxicol. studies and also provided similar efficacy as once daily dosing. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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In 2019,Russian Journal of Organic Chemistry included an article by Hakobyan, R. M.. HPLC of Formula: 4637-24-5. The article was titled 《Synthesis of Symmetrical Bisisoquinolinediones》. The information in the text is summarized as follows:

A method of synthesis of 1,1′-(alkanediyl)bis{3-cyano-4-[4,5,5-trimethyl-2-oxo-5H-furan-3-yl]-pyridin-2(1H)-ones} from the corresponding lactones is developed. The synthesized compounds underwent intramol. cyclization to form sym. 7,7′-(alkanediyl)bis{5-amino-3,3-dimethylfuro[3,4-f]isoquinoline-1,6(3H,7H)-diones}. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5HPLC of Formula: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.HPLC of Formula: 4637-24-5

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Ether – Wikipedia,
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