Category: 4637-24-5

COA of Formula: C5H13NO2In 2021 ,《Design, synthesis, X-ray analysis, and biological screening of new oxime and enaminone thiazoline-2-thione derivatives》 was published in Journal of Molecular Structure. The article was written by Asiri, Yahya I.; Muhsinah, Abdullatif Bin; Alsayari, Abdulrhman; Ghabbour, Hazem A.; Almarhoon, Zainab M.; Al-aizari, Faiz A.; Venkatesan, Kumar; Tasqeeruddin, Syed; Sulthana, Syeda Shaheen; Mabkhot, Yahia N.. The article contains the following contents:

A series of 12 new thiazoline-2-thione derivatives (oxime and enaminone) I (R = Me, hydroxy, 4-chlorophenyl, carbamoyl, etc.; R1 = H, Me), II (R2 = hydroxy, 2-phenylhydrazin-1-yl, hydrazinyl) and III. were synthesized using an appropriate synthetic route. The characterization of the newly synthesized compounds I, II and III was performed using X-ray single-crystal diffractometry, elemental anal., 1H NMR, 13C NMR, IR, and MS techniques. These compounds I, II and III were then evaluated for their biol. activities against a variety of microbes and human cancer cell lines. These results revealed that the prepared thiazoline derivatives I (R = hydroxy, 4-chlorophenyl; R1 = H), II (R2 = 2-phenylhydrazin-1-yl, hydrazinyl) and III showed potent antifungal activity against Aspergillus fumigatus, comparable to the standard drugs. Addnl., all the thiazoline derivatives, I, II and III except compound II (R2 = hydrazinyl), were effective against Candida albicans. The tested thiazolines also demonstrated potent antibacterial activity comparable to the standard drugs for all tested Gram-pos. and Gram-neg. bacterial species. The cytotoxicity evaluation of synthesized compounds II (R2 = hydroxy), I (R = azanyl; R1 = H) and III against two cancer cell lines (HCT-116 and HepG-2) revealed that they had moderate cytotoxic activities, with compound I (R = azanyl; R1 = H) showing the best cytotoxic activity against the HCT-116 (IC50 = 79μg/mL) and HepG-2 (IC50 = 49μg/mL) cell lines. These findings open the pathway for the development of new lead compounds with chemotherapeutic properties. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C5H13NO2

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Synthetic Route of C5H13NO2In 2019 ,《Synthesis and photochromism of some mono and bis (thienyl) substituted oxathiine 2,2-dioxides》 was published in Organic & Biomolecular Chemistry. The article was written by Aiken, Stuart; Gabbutt, Christopher D.; Heron, B. Mark; Rice, Craig R.; Zonidis, Dimitrios. The article contains the following contents:

1,2-Oxathiine 2,2-dioxides have been obtained from their resp. 3,4-dihydro-4-dimethylamino precursors, for the first time, by a mild Cope elimination of the 4-dimethylamino function. The application of the 1,2-oxathiine 2,2-dioxide scaffold in materials chem. is exemplified by the efficient P-type photochromism of the 5,6-bis(2,5-dimethyl-3-thienyl) substituted oxathiine 2,2-dioxides. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C5H13NO2

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The author of 《A Convenient Synthetic Route of Diethyl (4-Oxo-chromeno[2,3-d]pyrimidin-2(5)-yl)phosphonates》 were Ali, Tarik E.; Assiri, Mohammed A.; Hassanin, Noha M.; Yahia, I. S.; Hussien, Mai S. A.. And the article was published in Journal of Heterocyclic Chemistry in 2019. Quality Control of N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

Novel di-Et (4-oxo-3,4-dihydro-2H-chromeno[2,3-d]pyrimidin-2-yl)phosphonate as two enantiomers and di-Et (4-oxo-1,5-dihydro-4H-chromeno[2,3-d]pyrimidin-5-yl) phosphonate were obtained in easy procedure via reaction of 2-imino-2H-chromene-3-carboxamide, DMF dimethyl-acetal, and di-Et phosphite in a simple one pot. Possible reaction mechanisms are proposed. The structures of the obtained products were confirmed by elemental analyses and spectral tools. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Quality Control of N,N-Dimethylformamide Dimethyl Acetal

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The author of 《Crystal Structures of Spiro Derivatives Including 6,10-Dioxaspiro[4.5]decane-7,9-dione Group and Their Spectral Studies》 were Zeng, Wulan; Wang, Xia. And the article was published in Journal of Chemical Crystallography in 2019. Formula: C5H13NO2 The author mentioned the following in the article:

A new intermediate, I (C22H30N2O8) was attained by reaction of 6,10-dioxaspiro[4.5]decane-7,9-dione with 1,1-dimethoxy-n,n-dimethyl-methanamine in ethanol. The two oxaspirocyclic compounds, 8-[[(2-methylphenyl)amino]methylene]-6,10-dioxaspiro[4.5]decane-7,9-dione (2-C16H17NO4) and 8-[[(2-methylphenyl)amino]methylene]-6,10-dioxaspiro[4.5]decane-7,9-dione (3-C16H17NO4) were prepared by adding 2-methylbenzenamine and 3-methylbenzenamine into to the ethanol solution of I, resp. Two crystals (I and C16H17NO4 ) were determined by single-crystal X-ray diffraction. The compound of I includes one (C5H13N2)+ cation and one (C17H17O8)- anion, which indicates it is a salt. There is no classical hydrogen bonds in I. However, there is one kind of N-H···O intramol. interactions and one kind of C-H···O intermol. interactions in (2-C16H17NO4). In addition, the fluorescence spectra of 2-C16H17NO4 and 3-C16H17NO4 in dilute ethanol were studied, which they exhibit purplish red emission and reddish purple emission, resp. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H13NO2

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《Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors》 was written by Liu, Ju; Gong, Yilin; Shi, Jiantao; Hao, Xuechen; Wang, Yang; Zhou, Yunpeng; Hou, Yunlei; Liu, Yajing; Ding, Shi; Chen, Ye. Quality Control of N,N-Dimethylformamide Dimethyl Acetal And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

Three series of novel 4-phenoxypyridine derivatives containing 4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide, 5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxamide and 4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide moieties, I [R1 = H, 4-F, 4-Cl, 2-F, 2-Cl, 4-MeO], II [R2 = H, 4-CF3, 3,4-(MeO)2, etc.], and III [R3 = H, 2-F, 3-Cl-4-F, etc.], resp., were synthesized and evaluated for their in-vitro inhibitory activities against c-Met kinase and cytotoxic activities against A549, H460, and HT-29 cancer cell lines. The results indicated that most of the compounds showed moderate to good antitumor activities. The most promising compound, III [R3 = H] (IV) (with c-Met IC50value of 0.016μM) showed remarkable cytotoxicity against A549, H460 and HT-29 cell lines with IC50 values of 1.59μM, 0.72μM and 0.56μM, resp. Their preliminary structure-activity relationship (SARs) studies indicate that linker 4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide was preferred, and electron-withdrawing groups on the terminal Ph rings are beneficial for improving the antitumor activities. Furthermore, colony formation, acridine orange/ethidium bromide (AO/EB) staining, apoptosis, and wound-healing assay of compound IV were performed on HT-29 and/or A549 cell lines. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of N,N-Dimethylformamide Dimethyl Acetal

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In 2019,European Journal of Chemistry included an article by Nongrum, Stability; Das, Susma; Khanikar, Shikpika; Vishwakarma, Jai Narain. SDS of cas: 4637-24-5. The article was titled 《Synthesis, structural elucidation and X-ray crystallographic studies of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)prop-2-en-1-one》. The information in the text is summarized as follows:

A new enaminone was synthesized by reacting 3,5-bis-(trifluoromethyl)acetophenone and N,N-dimethylformamide di-Me acetal and its detailed structural and crystalline properties were studied. The crystal data were found to be as C13H11F6NO, monoclinic, space group P21/c (number 14), a = 8.1556(8) Å, b = 24.877(3) Å, c = 7.6067(7) Å, β = 116.745(6)°, V = 1378.2(3) Å3, Z = 4, T = 293(2) K, μ(MoKα) = 0.150 mm-1, Dcalc = 1.500 g/cm3, 40777 reflections measured (5.594° ≤ 2θ ≤ 56.786°), 3413 unique (Rint = 0.1040, Rsigma = 0.0584) which were used in all calculations The final R1 was 0.0771 (I > 2σ(I)) and wR2 was 0.2541 (all data). The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5SDS of cas: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.SDS of cas: 4637-24-5

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In 2019,Journal of Heterocyclic Chemistry included an article by Wang, Xianheng; Chen, Song; Zhao, Changkuo; Long, Liangye; Wang, Yuhe. COA of Formula: C5H13NO2. The article was titled 《Preparation of Dolutegravir Intermediate Diastereomer》. The information in the text is summarized as follows:

A convenient method was developed to prepare the diastereomer of dolutegravir tricyclic intermediate in the catalysis of EDCI/DMAP in up to 87% yield. Different solvents, temperature, and times were optimized. The synthesized diastereomer 6′ could be used as a standard for the industrial manufacture requirement of dolutegravir active pharmaceutical ingredient. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.COA of Formula: C5H13NO2

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Ether – Wikipedia,
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In 2019,Journal of Molecular Structure included an article by Sanad, Sherif M. H.; Hanna, Demiana H.; Mekky, Ahmed E. M.. Recommanded Product: 4637-24-5. The article was titled 《Regioselective synthesis of novel antibacterial pyrazole-benzofuran hybrids: 2D NMR spectroscopy studies and molecular docking》. The information in the text is summarized as follows:

The acetyl derivative bearing benzofuran moiety, its enaminone and different hydrazines are used as synthons for the regioselective synthesis of substituted pyrazoles. Their structures were elucidated by 2D 1H-1H COSY, 1H-1H NOESY and 1H-13C HMBC NMR, spectrometry. Also, a series of novel pyrazole-benzofuran hybrids have been synthesized by the regioselective cycloaddition of enaminone to hydrazonyl chlorides. The series was elucidated by IR, 1H-NMR, 13C-NMR, 2D1H-1H COSY, 1H-1H NOESY and 1H-13C HMBC NMR spectrometry as well as elemental analyses. The series was subjected for testing their antimicrobial activities. Pyrazole derivative I showed the highest inhibitory activity against all different bacterial strains with min. inhibitory concentration values of 7.81, 15.6, 15.6 and 3.91 μg/mL against Staphylococcus aureus, Streptococcus mutans, Escherichia coli and Klebsiella pneumonia, resp., as compared to standard drugs for gram-pos. and neg. bacterial strains. The structure-activity relationship studies and mol. docking were performed to explain the inhibitory activities. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Recommanded Product: 4637-24-5

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The author of 《Improved Synthetic Process of Dimethyl 4-Oxo-4H-pyran-3,5-dicarboxylate》 were Hu, Xinquan; Ding, An; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Jin, Liqun. And the article was published in Organic Process Research & Development in 2019. Product Details of 4637-24-5 The author mentioned the following in the article:

A reported two-step procedure for preparing di-Me 4-oxo-4H-pyran-3,5-dicarboxylate was extensively optimized. It was found that the reactions can be carried out in toluene as a single solvent and the product was directly obtained by a simple filtration. More importantly, considering potential solvent recovering and recycling, the effluent of the process can be remarkably reduced. This new process facilitated the potential scale-up with com. significance. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Product Details of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 4637-24-5

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In 2019,Angewandte Chemie, International Edition included an article by Chen, Jie; Guo, Pan; Zhang, Jianguo; Rong, Jiaxin; Sun, Wangbin; Jiang, Yaojia; Loh, Teck-Peng. Name: N,N-Dimethylformamide Dimethyl Acetal. The article was titled 《Synthesis of Functionalized α-Vinyl Aldehydes from Enaminones》. The information in the text is summarized as follows:

An efficient RhII-catalyzed synthesis of functionalized α-vinyl aldehydes with high E/Z stereoselectivity was developed. The reaction mediates the cyclopropanation of enaminones with vinyl carbenoids that are generated from cyclopropenes in situ to give the aminocyclopropane intermediates. Selective C-C bond cleavage of the cyclopropane intermediates leads to formation of α-vinyl aldehyde derivatives with high E/Z selectivity. This method proceeds at room temperature under very mild reaction conditions and works with a broad substrate scope.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: N,N-Dimethylformamide Dimethyl Acetal

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