Category: 4637-24-5

《Simultaneous determination of nine perfluoroalkyl carboxylic acids by a series of amide acetals derivatization and gas chromatography tandem mass spectrometry》 was written by Ji, Yongyan; Cui, Zongyan; Li, Xuemin; Wang, Zhibin; Zhang, Jinjie; Li, Adan. Category: ethers-buliding-blocks And the article was included in Journal of Chromatography A in 2020. The article conveys some information:

A novel and simple derivatization method using a series of amide acetals as derivatization reagents, along with gas chromatog. tandem mass spectrometry (GC-MS/MS) anal., were developed and validated for simultaneous determination of 9 perfluoroalkyl carboxylic acids (PFCAs) in this study. The structures and fragmentation pathway of PFCAs derivatives were deduced and verified. The derivatization method developed in this study improved the sensitivity of the detection of PFCAs by GC. The applicability of 6 amide acetals for the derivatization of PFCAs was demonstrated. Derivatization conditions for 9 PFCAs were optimized with addition of 20μL of derivatization reagent and reaction at 35°C for 30 min. 9 PFCAs derivatives were confirmed to be stable over 15 days. The instrument detection limits (IDLs) were lower than 0.01 pg/μL. The intra and inter-day precisions were below 4.06% and 5.48%, resp. To demonstrate the utility of the derivatization method, the level of PFCAs in the marine products were detected. The alk. digestion followed by solid-phase extraction (SPE) cleanup method was used for pretreatment. The method detection limits (MDLs) ranged from 0.04 to 0.10 ng/g, and the spiked recoveries ranged between 54.72% and 107.29%, with relative standard deviation (RSD) of 1.53%-11.89%. Five PFCAs were detected in the range of 0.66 to 499.03 ng/g dry weight The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Komkov, A. V.; Baranin, S. V.; Dmitrenok, A. S.; Kolotyrkina, N. G.; Zavarzin, I. V. published their research in Russian Chemical Bulletin in 2021. The article was titled 《A new route to the synthesis of 4-amino-substituted pyrido[2,3-d]pyrimidin-5-one derivatives》.Category: ethers-buliding-blocks The article contains the following contents:

The reaction of 6-(R-amino)-5-acetyl-4-methylsulfonyl-2-phenylpyrimidines with amines was studied. 6-Arylamino derivatives reacted with alkylamines to form 6-alkylamino-4-arylamino-5-acetyl-2-phenylpyrimidines, which upon refluxing in benzene with DMF dimethylacetal are converted to 4-alkylamino-8-aryl-2-phenylpyrido[2,3-d]pyrimidin-5(8H)-ones, e.g. I. The cyclization proceeded selectively with participation of the arylamino group only, the alkylamino group being not involved. At the same time, refluxing of 5-acetyl-4,6-dibenzylamino-2-phenylpyrimidine with DMF dimethylacetal in toluene affords the product of condensation on the acetyl group, which upon refluxing in o-xylene transforms to 4-benzylamino-8-benzyl-2-phenylpyrido[2,3-d]pyrimidin-5(8H)-one. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Novel bis(pyrazole-benzofuran) hybrids possessing piperazine linker: Synthesis of potent bacterial biofilm and MurB inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Mekky, Ahmed E. M.; Sanad, Sherif M. H.. The article conveys some information:

Novel 1,4-bis[(2-(3-(dimethylamino)-1-oxoprop-2-en-1-yl)benzofuran-5-yl)methyl]piperazine I [X = Me2NCH:CHC(O)] was prepared and used as a key synthon for the this protocol. 1,3-Dipolar cycloaddition of this synthon with the appropriate hydrazonyl chlorides R1C(O)CCl:NNHR2 (R1 = Me, EtO; R2 = Ph, 4-ClC6H4, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4) afforded a new series of bis-pyrazoles I (X = 1-R2-3-(R1CO)-pyrazol-4-ylcarbonyl). Furthermore, the latter reacted with hydrazine hydrate to afford bis(pyrazolo[3,4-d]pyridazine)s I (X = 7-methyl-2-R2-2H-pyrazolo[3,4-d]pyridazin-4-yl, 7-oxo-2-R2-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-4-yl). Reaction of the synthon I [X = Me2NCH:CHC(O)] with hydrazine hydrate or phenylhydrazine afforded the corresponding bis(pyrazole)s I (X = 1H-pyrazol-3-yl, 1-phenyl-1H-pyrazol-5-yl), resp. The reaction of I (X = MeCO) with Ph hydrazine followed by treatment with DMF-DMA resulted in I (X = 1-phenyl-1H-pyrazol-4-yl). Various bacterial strains and cell lines were selected to study the in-vitro antibacterial and cytotoxic activities for the synthesized compounds The compound I [X = 1-(4-nitrophenyl)-3-acetyl-1H-pyrazol-4-ylcarbonyl; (II)] showed the best antibacterial efficacies with MIC/MBC values of 1.2/1.2, 1.2/2.4 and 1.2/2.4μM against each of E. coli, S. aureus and S. mutans strains, resp. In addition, the inhibitory activity of some compounds as MRSA and VRE inhibitors were studied. The compound II gave the best inhibitory activity with MIC/MBC values of 18.1/36.2, 9.0/18.1 and 18.1/18.1μM, resp., against MRSA (ATCC:33591 and ATCC:43300) and VRE (ATCC:51575) bacterial strains, resp. This compound also showed more effective biofilm inhibition activities than the reference Ciprofloxacin. The compound II showed IC50 values of 3.0 ±0.05, 3.2 ±0.08 and 3.3 ± 0.07μM against S. aureus, S. mutans and E. coli strains, resp. Furthermore, exptl. study showed excellent inhibitory activities of compounds I [X = 1-R2-3-(R1CO)-pyrazol-4-ylcarbonyl; R2 = 4-ClC6H4, 4-O2NC6H4] against MurB enzyme. The compound II gave the best MurB inhibitory activity with IC50 value of 3.1μM. The in-silico study was performed to predict the capability of compounds I [X = 1-R2-3-(R1CO)-pyrazol-4-ylcarbonyl; R2 = 4-ClC6H4, 4-O2NC6H4] as potential inhibitors of MurB enzyme. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Name: N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Substituent-Oriented Synthesis of Substituted Pyrazoles/Chromeno[3,2-c]pyrazoles via Sequential Reactions of Chromones/3-Chlorochromones and Tosylhydrazones》 were Dai, Tianzi; Li, Qunyi; Zhang, Xiaofei; Yang, Chunhao. And the article was published in Journal of Organic Chemistry in 2019. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

A facile and efficient synthetic strategy for the chemoselective synthesis of monocyclic/tricyclic-fused pyrazoles was developed, and it was oriented by different 3-position substituents (H or Cl) on the chromones. The reaction proceeded in a one-pot sequential way with a broad substrate scope and moderate to excellent yields. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,New Journal of Chemistry included an article by Balakrishna, C.; Gudipati, Ramakrishna; Kandula, Venu; Yennam, Satyanarayana; Uma Devi, P.; Behera, Manoranjan. Electric Literature of C5H13NO2. The article was titled 《T3P mediated domino C(sp2)-H sulfenylation/annulation of enaminones and methylsulfinyls for the synthesis of chromone thioether derivatives》. The information in the text is summarized as follows:

A new regioselective method for the synthesis of 3-(methylthio)-4H-chromen-4-one I (R = H, 6-Br, 6-F, etc.) and 3-(phenylthio)-4H-chromen-4-one derivatives II (R = H, 8-F, 6-Cl, etc.; R1 = H, 4-Me, 4-Cl) has been developed. The reaction between o-hydroxy-phenyl-functionalized enaminones and methylsulfinyl derivatives using T3P gave good yields of chromone thioether derivatives The reaction proceeds via domino chromone ring construction and C(sp2)-H bond sulfenylation under transition-metal-free conditions. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C5H13NO2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schlegel, Mark K.; Matsuda, Shigeo; Brown, Christopher R.; Harp, Joel M.; Barry, Joseph D.; Berman, Daniel; Castoreno, Adam; Schofield, Sally; Szeto, John; Manoharan, Muthiah; Charisse, Klaus; Egli, Martin; Maier, Martin A. published an article in 2021. The article was titled 《Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs》, and you may find the article in Nucleic Acids Research.Category: ethers-buliding-blocks The information in the text is summarized as follows:

We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc-siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a single GNA nucleotide placed within the seed region of the guide strand. Here, we report further investigation of the unique and poorly understood GNA/RNA cross-pairing behavior to better inform GNA-containing siRNA design. A reexamination of published GNA homoduplex crystal structures, along with a novel structure containing a single (S)-GNA-A residue in duplex RNA, indicated that GNA nucleotides universally adopt a rotated nucleobase orientation within all duplex contexts. Such an orientation strongly affects GNA-C and GNA-G but not GNA-A or GNA-T pairing in GNA/RNA heteroduplexes. Transposition of the hydrogen-bond donor/acceptor pairs using the novel (S)-GNA-isocytidine and -isoguanosine nucleotides could rescue productive base-pairing with the complementary G or C ribonucleotides, resp. GalNAc-siRNAs containing these GNA isonucleotides showed an improved in vitro activity, a similar improvement in off-target profile, and maintained in vivo activity and guide strand liver levels more consistent with the parent siRNAs than those modified with isomeric GNA-C or -G, thereby expanding our toolbox for the design of siRNAs with minimized off-target activity. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Russian Chemical Bulletin included an article by Vasil’ev, L. S.; Baranin, S. V.; Dmitrenok, A. S.; Zavarzin, I. V.. Related Products of 4637-24-5. The article was titled 《A new approach to CF3-containing 3,4-dihydroquinazolin-2(1H)-ones》. The information in the text is summarized as follows:

A new approach to CF3-containing 3,4-dihydroquinazolin-2(1H)-ones based on the condensation of 5-acetyl-6-methyl-1-phenyl-4-trifluoromethylpyrimidin-2(1H)-one with DMF di-Me acetal was suggested. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Related Products of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 4637-24-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Litvinova, Yulia M.; Gayfulin, Yakov M.; Samsonenko, Denis G.; Dorovatovskiy, Pavel V.; Lazarenko, Vladimir A.; Brylev, Konstantin A.; Mironov, Yuri V. published their research in Inorganica Chimica Acta in 2021. The article was titled 《Coordination polymers based on rhenium octahedral chalcocyanide cluster [Re6Se8(CN)6]4- and lanthanide ions solvated with dimethylformamide》.Category: ethers-buliding-blocks The article contains the following contents:

The authors demonstrate influence of the source of organic ligand on the formation of supramol. structures based on the octahedral metal clusters. Two series of coordination polymers based on the rhenium clusters [Re6Se8(CN)6]4- and Ln3+ complexes (Ln = Sm, Eu, Tb, Dy) with DMF were obtained. The first series was obtained by direct addition of DMF in the reaction mixture The series consist of the compounds crystallizing in trigonal crystal system, R3c space group, and possessing a framework porous structures composed of cluster anions and [Ln(DMF)3(H2O)2]3+ complexes. Compounds of the second series were obtained as a result of in situ generation of DMF by hydrolysis of N,N-dimethylformamide di-Me acetal (DMF DMA). These compounds were crystallized in orthorhombic crystal system, Pnma space group, and possessed a layered structure consisting of cluster anions and [Ln(DMF)2(H2O)2]3+ complexes. The difference in the structures formed depends on the source of DMF rather than other reaction conditions. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Faal, Masoud; Mahyari, Mojtaba; Hosseini, Seyed Ghorban; Tavangar, Saeed; Zarei, Mohammad Ali published an article in 2021. The article was titled 《Synthesis of poly(2,4,6-trinitrophenyl acetal acrylate) as a new energetic binder and calculation of its heat of formation: A theoretical and experimental study》, and you may find the article in Reactive & Functional Polymers.Recommanded Product: 4637-24-5 The information in the text is summarized as follows:

In recent years, acrylate binders were widely used in PBX production High loading of explosives and processability are the prominent features of these binders that researchers are trying to improve the energetic properties of these binders. In this research, a novel energetic binder of poly (2,4,6-trinitrophenylacetal acrylate) (PATNP) was synthesized through acetalization reaction Poly(glycerol monoacrylate) with 2,4,6-trinitrophenyl acetaldehyde in the presence of p-toluene sulfonic acid (PTSA) as the catalyst. The polymer structure was confirmed using 1H NMR and FT-IR. Thermal anal. obtained from the TGA curve of polymer shows that the addition of TNT derivatives significantly changes the thermal decomposition processes. In the TGA curve of PATNP, two main weight losses were observed with a decomposition percentage of 38 and 37%. The glass transition temperatures (Tg) of poly(glycerol monoacrylate) and PATNP were measured by DSC, and their Tg were obtained at -51° and -43°, resp. The heat of formation (HOF) and the HOMO-LUMO gap of PATNP was calculated using DFT computational method and compared with HTPB, AHTPB, and GAP binders. The HOF of PATNP for the monomer and dimer was obtained as 70.67 and 263.26 J/g, resp. The HOMO-LUMO gap for TNPA and PATNP was calculated at 3.7296 and 4.152 eV, resp. The obtained energetic polymer can have a potential application as the binder of PBXs. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mekky, Ahmed E. M.; Ahmed, Mohamed S. Mohamed; Sanad, Sherif M. H.; Abdallah, Zeinab A. published an article in 2021. The article was titled 《Bis(benzofuran-enaminone) hybrid possessing piperazine linker: Versatile precursor for microwave assisted synthesis of bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines)》, and you may find the article in Synthetic Communications.Recommanded Product: 4637-24-5 The information in the text is summarized as follows:

Herein efficient procedures for the synthesis of new piperazine-linked bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines) using bis(benzofuran-enaminone) hybrid as a key intermediate are reported. For this purpose, bis(enaminone) was reacted with a new series of 3-amino-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridines in pyridine under microwave irradiation at 120° for 90 min to afford the target bis(pyrimidines). In a two-steps synthetic route, bis(enaminone) was used to prepare a novel bis(3-amino-1H-pyrazolo[3,4-b]pyridine). Next, the former hybrid was reacted with two equivalent of the appropriate enaminones as well as arylidinemalononitriles in pyridine under microwave irradiation at 120° for 2 h to afford the target bis(pyrimidines). Furthermore, a mixture of bis(pyrazolopyridine) reacted with two equivalent of 1,3-diketones and β-ketoesters in glacial acetic acid was microwave irradiated at 130° for 90 min to give bis(2,4-disubstituted pyrimidines) and bis(2-substituted pyrimidin-4(1H)-ones), resp. The structures of the new hybrids were confirmed via considering their elemental analyses as well as their spectral data. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Recommanded Product: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem