Synthetic Route of 459-60-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 459-60-9, name is 1-Fluoro-4-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-Bromo-5-methoxybenzo[b]thiophene-2-carboxamidine hydrochloride Bromine (3.2 g, 20 mmol) was added dropwise to a solution of 4-fluoroanisole (2.52 g, 20 mmol) in CH2 Cl2 (20 ml) stirred under N2 at 25 C. After 30 minutes solid NaHCO3 was added cautiously with vigorous stirring until gas evolution died down. The mixture was then diluted with CHCl3 (30 mL), washed with water (2*25 mL) and saturated brine (30 mL), and dried (Na2 SO4). The solvent was removed under reduced pressure to give a quantitative yield of 2-bromo-4-fluoroanisole.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-4-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Eisai Co., Ltd.; US5340833; (1994); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem