Category: 456-49-5

Some common heterocyclic compound, 456-49-5, name is 1-Fluoro-3-methoxybenzene, molecular formula is C7H7FO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7FO

The 3-fluoro anisole (15 g, 119 mmol) was placed in THF (300 mL) and cooled to about -78 C., and then n-BuLi (89 mL 1.6 M in hexanes) was added while maintaining the temperature at around -70 C. The mixture was stirred for about 15 minutes, and bromine (18.9 g, 119 mmol) was added over 10 minutes. The mixture was warmed to r.t. and stirred overnight. The mixture was quenched with water, diluted with ether (500 mL) and partitioned between water/ether (1/1 300 mL). The water layer was back extracted with ether (250 mL), and the combined organic fractions were dried, filtered and concentrated. The dark residue was distilled under house vacuum (product 115-130 C.) to recover about 13.8 g of the product as a gray oil (57%/).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 456-49-5, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 456-49-5, name is 1-Fluoro-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Fluoro-3-methoxybenzene

The 3-fluoro anisole (15 g, 119 mmol) was placed in THF (300 mL) and cooled to about -78 C., and then n-BuLi (89 mL 1.6 M in hexanes) was added while maintaining the temperature at around -70 C. The mixture was stirred for about 15 minutes, and bromine (18.9 g, 119 mmol) was added over 10 minutes. The mixture was warmed to r.t. and stirred overnight. The mixture was quenched with water, diluted with ether (500 mL) and partitioned between water/ether (1/1 300 mL). The water layer was back extracted with ether (250 mL), and the combined organic fractions were dried, filtered and concentrated. The dark residue was distilled under house vacuum (product 115-130 C.) to recover about 13.8 g of the product as a gray oil (57%/).

According to the analysis of related databases, 456-49-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Briner, Karin; Doecke, Christopher William; Mancuso, Vincent; Martinelli, Michael John; Richardson, Timothy Ivo; Rothhaar, Roger Ryan; Shi, Qing; Xie, Chaoyu; US2004/82590; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 456-49-5 as follows. Recommanded Product: 1-Fluoro-3-methoxybenzene

To a solution of n-butyllithium (2.6 M, n-hexane solution, 12.7 mL, 33 mmol) dissolved in THF (100 mL) was addeddropwise a solution of 3-fluoroanisole (3.44 mL, 31.1 mmol) dissolved in THF (10 mL) at -78 C. After stirring for 10min at the same temperature, to the mixture was added dropwise a solution of iodine (9.14 g, 36.0 mmol) dissolved inTHF (60 mL) at -78 C. After stirring for 30 min at the same temperature, to the mixture were added aqueous saturatedammonium chloride (20 mL) and then aqueous saturated sodium thiosulfate (40 mL). The mixture was extracted withn-hexane (20 mL ¡Á 3), and the combined organic extract was washed with brine (20 mL), dried (Na2SO4), and afterfiltration, the filtrate was concentrated under reduced pressure. The residue was purified by flash columnchromatography (silica-gel 156 g, n-hexane/EtOAc = 5/1) to give 3-fluoro-2-iodoanisole (7.03 g, 27.9 mmol, 93.0%) asa colorless oil.

According to the analysis of related databases, 456-49-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yoshida, Suguru; Nagai, Akira; Uchida, Keisuke; Hosoya, Takamitsu; Chemistry Letters; vol. 46; 5; (2017); p. 733 – 736;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 456-49-5, name is 1-Fluoro-3-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 456-49-5, 456-49-5

EXAMPLE 3 A solution of butyllithium in hexanes (2.5 M; 15.9 ml) was added to a stirring solution of 3-fluoroanisole (5.0 g) in dry tetrahydrofuran (100 ml) at -78 C. and the mixture stirred at that temperature for 30 min. Dry dimethylformamide (3.1 ml) was added and the mixture stirred and allowed to warm to ambient temperature during one hour. Water (150 ml) was added and the mixture extracted with ethyl acetate (3*100 ml). The combined extracts were washed with brine (100 ml), dried over magnesium sulphate, and the solvent removed in vacuo. Distillation of the residue under reduced pressure gave 2-fluoro-6-methoxybenzaldehyde (4.6 g) as an oil b.p. 120 C. at 10.66 mbar.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Knoll Aktiengesellschaft; US5935973; (1999); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

456-49-5,Some common heterocyclic compound, 456-49-5, name is 1-Fluoro-3-methoxybenzene, molecular formula is C7H7FO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of -butyllithium (5.0 mL, 7.93 mmol, 1.6 M in -hexane) in freshly distilled THF (20 mL) at -70 C were added a solution of compound 1-1 (1.0 g, 7.93 mmol) in THF (10 mL) and a solution of I2 (2.32 g, 9.12 mmol) in THF (15 mL) dropwise respectively. At the end of the addition, the mixture was stirred for 20 mins and allowed to warm up to -60 C and then an aqueous solution of sodium thiosulfate (3.0 mL, 10%) was added to the mixture. After the reaction was completed, the mixture was quenched by adding an aqueous ammonium chloride solution (10 mL) slowly. The THF was removed in vacuo and the aqueous phase was extracted with -hexane (50 mL x 3). The combined organic layers were washed with an aqueous sodium thiosulfate solution (10%) and water, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as oil (1.6 g, 80%). The compound was characterized by the following spectroscopic data: lli NMR (400 MHz, CDCI3): delta 6.79, 6.77, 6.75 (d, dd, d, 1H), 6.63, 6.62, 6.60, 6.58 (s, d, d, s, 1H), 6.53-6.52, 6.51-6.50 (m, m, 1H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Fluoro-3-methoxybenzene, its application will become more common.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; HU, Bailin; LI, Shifeng; WU, Xiwei; TANG, Changhua; WANG, Chenglin; FANG, Qinghong; YU, Quanxing; ZHANG, Zhikeng; WO2014/131315; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem