Category: 4342-46-5

Reference of 4342-46-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 0.25 g (0.793 mmol) of 2,6-Difluoro-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile in DMSO (5 mL) was added 0.225 g (1.7446 mmol) DIEA and 0.186 g (1.438 mmol) of crude 4-Methoxy-cyclohexylamine. This was stirred at 100 C. for 18 hours and then poured into 25 mL water and extracted 3 times with CH2Cl2. The organic layers were dried over Na2SO4, concentrated and purified via chromatography (50% EtOAc/Hex) to give 0.163 g of 2-Fluoro-6-(4-methoxy-cyclohexylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile (48.5% yield). LCMS (m/z): M+H=425.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methoxycyclohexanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Huang, Kenneth He; Ommen, Andy J.; Barta, Thomas E.; Hughes, Philip F.; Veal, James; Ma, Wei; Smith, Emilie D.; Woodward, Angela R.; McCall, W. Stephen; US2008/269193; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4342-46-5, name is 4-Methoxycyclohexanamine, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

1200 mL of water was added to the autoclave.Turn on stirring,Add 40% Formamide 220g (2mol), After stirring for 10 minutes,1-amino-4-methoxycyclohexane 130 g (1 mol) was added,Then add ruthenium carbon catalyst 7g,Pass CO into the reactor,The pressure in the kettle reaches 0.2MPa,Raise the temperature to 50CInsulation 20hControl raw materials < 2%,The reaction is over,Cool down to 2530C,Dilute hydrochloric acid was added dropwise to the reaction solution.Adjust the pH to 5-6.There is a solid precipitated,Filter out products,The cake is shuffled onceObtained 169 g of cis-8-methoxy-1,3-diazaspiro[4,5]-indol-2,4-dione as a dry product.Yield 84.5%; According to the analysis of related databases, 4342-46-5, the application of this compound in the production field has become more and more popular. Reference:
Patent; Henan Longhu Biological Co., Ltd.; Mu Kairui; Guo Shuai; Xu Caiyun; (11 pag.)CN107721996; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 4342-46-5, These common heterocyclic compound, 4342-46-5, name is 4-Methoxycyclohexanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 7a-d (1.0 equiv.) and amine (2.0 equiv.) in dioxane was added glacial acetic acid (0.2 equiv.), then the mixture was stirred and heated at 110 C in a sealed tube for 10-20 h. The mixture was concentrated under vacuum, and the residue was purified by column chromatography on silica gel, using petroleum ether/ethyl acetate to afford target products 8-25.

The synthetic route of 4342-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Dongfeng; Liu, Yang; Zhang, Chunlin; Zhang, Hao; Wang, Bin; Xu, Jian; Fu, Lei; Yin, Dali; Cooper, Christopher B.; Ma, Zhenkun; Lu, Yu; Huang, Haihong; Molecules; vol. 19; 4; (2014); p. 4380 – 4394;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 4342-46-5, The chemical industry reduces the impact on the environment during synthesis 4342-46-5, name is 4-Methoxycyclohexanamine, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of 7a-d (1.0 equiv.) and amine (2.0 equiv.) in dioxane was added glacial acetic acid (0.2 equiv.), then the mixture was stirred and heated at 110 C in a sealed tube for 10-20 h. The mixture was concentrated under vacuum, and the residue was purified by column chromatography on silica gel, using petroleum ether/ethyl acetate to afford target products 8-25.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methoxycyclohexanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Dongfeng; Liu, Yang; Zhang, Chunlin; Zhang, Hao; Wang, Bin; Xu, Jian; Fu, Lei; Yin, Dali; Cooper, Christopher B.; Ma, Zhenkun; Lu, Yu; Huang, Haihong; Molecules; vol. 19; 4; (2014); p. 4380 – 4394;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 4342-46-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethylcyclohexane (1200 mL) was added to the autoclave, stirring was started, and 220 g (2 mol) of formamide was added to the solution at a concentration of 40%. After stirring for 10 minutes, 1-amino-4-methoxycyclohexane (130 g, 1 mol) was added. ,Into the reaction kettle to pass CO, so that the pressure in the kettle reaches 0.2MPa, heated to 130 C, heat 20h, in the control of raw materials <2%, the reaction is over, cooled to 25 ~ 30 C, dilute hydrochloric acid was added dropwise to the reaction solution , Adjust the pH to 5-6, there is a solid precipitation, filter out the product, filter cake shampoo once,cis-8-Methoxy-1,3-diazaspiro[4,5]-nonane-2,4-dione, 184 g, yield 92%. The synthetic route of 4-Methoxycyclohexanamine has been constantly updated, and we look forward to future research findings. Reference:
Patent; Henan Zi Wei Xing Chemical Co., Ltd.; Wu Doucan; Mao Longfei; Li Wei; Lu Zhiguo; Wang Zhenggang; Lu Biao; Jia Shuhong; Yuan Zhiguo; (10 pag.)CN107827881; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 4342-46-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 0.25 g (0.793 mmol) of 2,6-Difluoro-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile in DMSO (5 mL) was added 0.225 g (1.7446 mmol) DIEA and 0.186 g (1.438 mmol) of crude 4-Methoxy-cyclohexylamine. This was stirred at 100 C. for 18 hours and then poured into 25 mL water and extracted 3 times with CH2Cl2. The organic layers were dried over Na2SO4, concentrated and purified via chromatography (50% EtOAc/Hex) to give 0.163 g of 2-Fluoro-6-(4-methoxy-cyclohexylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile (48.5% yield). LCMS (m/z): M+H=425.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methoxycyclohexanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Huang, Kenneth He; Ommen, Andy J.; Barta, Thomas E.; Hughes, Philip F.; Veal, James; Ma, Wei; Smith, Emilie D.; Woodward, Angela R.; McCall, W. Stephen; US2008/269193; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 4342-46-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4342-46-5 as follows.

To a mixture of compound G36 (200 mg, 349 umol) and compound G37 (90.19 mg, 698 umol) in toluene (5 mL) were added Pd2(dba)3 (31.9 mg, 34.9 umol), t-BuONa (50.3 mg, 523 umol, 1.5 eq) and BINAP (21.7 mg, 34.9 umol), and the mixture was stirred at 95C for 4 hours to give a yellow mixture. LCMS showed the reaction was not completed. The mixture was stirred at 95C for another 6 hours to give a red mixture. TLC showed the reaction was completed. The mixture was partitioned between EtOAc (15 ml) and water (10 mL). The aqueous phase was extracted with EtOAc (10 mL x 2). The combined organic extract was washed with brine (130 mL), dried over Na2S04, filtered, concentrated under reduced pressure to give crude product. The crude product was purified by combi flash to afford compound G38 (130 mg) as a yellow solid.

According to the analysis of related databases, 4342-46-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; QURIENT CO., LTD.; LEAD DISCOVERY CENTER GMBH; NAM, Kiyean; KIM, Jaeseung; JEON, Yeejin; YU, Donghoon; SEO, Mooyoung; PARK, Dongsik; EICKHOFF, Jan; ZISCHINSKY, Gunther; KOCH, Uwe; (138 pag.)WO2019/197546; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 4342-46-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4342-46-5, name is 4-Methoxycyclohexanamine, This compound has unique chemical properties. The synthetic route is as follows.

High pressure reactor1200 mL of water was added thereto, stirring was started, 220 g (2 mol) of formamide having a concentration of 40% was added, and after stirring for 10 minutes, 130 g (1 mol) of 1-amino-4-methoxycyclohexane was added, and 7 g of a ruthenium carbon catalyst was further added. Passing CO into the reactor,Pressure in the kettleThe force reaches 0.2MPa, the temperature is raised to 50 C, the temperature is kept for 20h, and the medium-controlled raw material is <2%.After the reaction is completed, the temperature is lowered to 25 to 30 C, dilute hydrochloric acid is added dropwise to the reaction solution, the pH is adjusted to 5 to 6, a solid is precipitated, the product is filtered off, and the filter cake is washed once to obtain cis-8-methoxy-1. 3-Diazaspiro [4,5]-indol-2,4-dione 169g, yield 84.5%; The chemical industry reduces the impact on the environment during synthesis 4-Methoxycyclohexanamine. I believe this compound will play a more active role in future production and life. Reference:
Patent; Henan Longhu Biological Co., Ltd.; Wang Huiqin; Li Shouhu; Guo Shuai; Mao Longfei; (14 pag.)CN107827883; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H15NO

DIPEA (3.24 mL, 18.58 mmol) was added to ethyl 2,4-dichloropyrimidine-5-carboxylate (3.42 g, 15.5 mmol) and 4-methoxycyclohexan-l -amine (2.0 g, 15.5 mmol) in acetonitrile (80 mL) at 0C. The reaction mixture was stirred at rt for 16 h. The solvent was removed under reduced pressure. The crude product was purified by fee, eluting with 0 – 5% EtOAc in petroleum ether, to afford the title compound (3.60 g, 74%) as a white solid; NMR(400 MHz, CDCls) 1.26 – 1.50 (4H, m), 1.38 (3H, t), 2.02 – 2.18 (4H, m), 3.15 – 3.27 (1H, m), 3.37 (3H, s), 4.04 – 4.18 (1H, m), 4.35 (2H, q), 8.34 (1H, d), 8.66 (1H, s); mJz MH+314.

The synthetic route of 4342-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; TING, Attilla, Kuan, Tsuei; (103 pag.)WO2018/114999; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 4-Methoxycyclohexanamine

Water is added to the high-pressure reaction kettle 1200 ml, opening stirring, add concentration is 40% formamide 220 g (2 muM), stirring 10 min after, adding 1 – amino -4 – methoxy cyclohexane 130 g (1 muM), then adding carbon catalyst 7 g, in the reaction kettle access CO, make the kettle pressure reaches 0.2 mpa, heating to 50 C, thermal insulation 20 h, when the reaction solution 1 – amino -4 – methoxy cyclohexane content of less than 2% when the end of the reaction, lowering the temperature to 25 – 30 C, adding diluted hydrochloric acid to the reaction in the fluid drops, adjust the pH to 5 – 6, solids are separated out, to filter out the product, the filter cake washed mixing, cis – 8 – be methoxy – 1, 3 – diaza spiro [4, 5] decan – 2, 4 – dione dry – 155 g, yield 78%

The synthetic route of 4342-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Henan Zi Wei Xing Chemical Co., Ltd.; Mao Longfei; Wu Doucan; Li Wei; Lu Zhiguo; Wang Zhenggang; Lu Biao; Jia Shuhong; Yuan Zhiguo; (10 pag.)CN107857722; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem