Category: 43229-65-8

Synthetic Route of 43229-65-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 43229-65-8, name is N-Benzyl-1-(4-methoxyphenyl)propan-2-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[0140] General procedure for Enantiomeric Separation of 2- benzylaminopropanes [(R)-10-14, (S)-10-14]. The appropriate racemic 2- benzylaminopropane (1 eq) was combined with the appropriate optically active mandelic acid (1 eq) in methanol (c= 0.5 M) and refluxed until the solution homogenized, then cooled to RT. The crystals were filtered, collected, and recrystallized twice from methanol (c = 0.3 M) to afford the optically active 2- benzylaminopropane ? mandelic acid salt. The salts were converted to the free amine for the purpose of collecting NMR and rotation data by partitioning the mandelic acid salt between 10% K2CO3 and CHCl3, drying organic extracts (Na2SO4) and evaporating; [0143] (R)-(-)-l-(4′-Methoxyphenyl)-2-benzylaminopropane [(R)-Il]. A sample of 3.02 g (11.8 mmol) of l-(4′-methoxyphenyl)-2-benzylaminopropane (42) was reacted with 1.8 g (11.8 mmol) f5rJ-(+)-mandelic acid to give 530 mg (35% based on enantiomeric abundance) of the free amine after workup. 1H NMR (CDCl3) delta 1.10 (d, 3H, J = 6.3 Hz), 2.57-2.76 (m, 2H), 2.88-2.94 (m, IH), 3.79 (s, 3H), 3.72-3.88 (m, 2H), 6.82 (d, 2H, J = 8.7 Hz), 7.07 (d, 2H, J= 8.4 Hz), 7.15-7.31 (m, 5H); MS (APCI+) m/z (rel): 256 (100); [alpha]D = -30.4 (c = 1.25 MeOH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2008/22038; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 43229-65-8, The chemical industry reduces the impact on the environment during synthesis 43229-65-8, name is N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, I believe this compound will play a more active role in future production and life.

1) A compound of the formula II (178.1 g) and a compound of the formula III (161.7 g) are added to a reaction flask and stirred.Heat to internal temperature 90-100 C, reaction 2-3h, to internal temperature 120-130 C, reaction 2-3h to complete(HPLC detection, the peak area is calculated according to the normalization method, and the compound of the formula III is less than 10%, the reaction is considered complete), and the compound of formula IV is obtained, 320.5g,After cooling to 70 ± 5 C, it was dissolved in anhydrous ethanol (220 mL) to prepare for the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangzhou Health Yuan Breathe Pharmaceutical Engineering Co., Ltd.; Shanghai Fangyu Health Pharmaceutical Technology Co., Ltd.; Yu Xiong; Xiao Duzheng; Zheng Guangji; Chen Yuhua; Yuan Xilun; (28 pag.)CN109535027; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 43229-65-8, The chemical industry reduces the impact on the environment during synthesis 43229-65-8, name is N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, I believe this compound will play a more active role in future production and life.

1) A compound of the formula II (178.1 g) and a compound of the formula III (161.7 g) are added to a reaction flask and stirred.Heat to internal temperature 90-100 C, reaction 2-3h, to internal temperature 120-130 C, reaction 2-3h to complete(HPLC detection, the peak area is calculated according to the normalization method, and the compound of the formula III is less than 10%, the reaction is considered complete), and the compound of formula IV is obtained, 320.5g,After cooling to 70 ± 5 C, it was dissolved in anhydrous ethanol (220 mL) to prepare for the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangzhou Health Yuan Breathe Pharmaceutical Engineering Co., Ltd.; Shanghai Fangyu Health Pharmaceutical Technology Co., Ltd.; Yu Xiong; Xiao Duzheng; Zheng Guangji; Chen Yuhua; Yuan Xilun; (28 pag.)CN109535027; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 43229-65-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 43229-65-8, name is N-Benzyl-1-(4-methoxyphenyl)propan-2-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[0140] General procedure for Enantiomeric Separation of 2- benzylaminopropanes [(R)-10-14, (S)-10-14]. The appropriate racemic 2- benzylaminopropane (1 eq) was combined with the appropriate optically active mandelic acid (1 eq) in methanol (c= 0.5 M) and refluxed until the solution homogenized, then cooled to RT. The crystals were filtered, collected, and recrystallized twice from methanol (c = 0.3 M) to afford the optically active 2- benzylaminopropane ? mandelic acid salt. The salts were converted to the free amine for the purpose of collecting NMR and rotation data by partitioning the mandelic acid salt between 10% K2CO3 and CHCl3, drying organic extracts (Na2SO4) and evaporating; [0143] (R)-(-)-l-(4′-Methoxyphenyl)-2-benzylaminopropane [(R)-Il]. A sample of 3.02 g (11.8 mmol) of l-(4′-methoxyphenyl)-2-benzylaminopropane (42) was reacted with 1.8 g (11.8 mmol) f5rJ-(+)-mandelic acid to give 530 mg (35% based on enantiomeric abundance) of the free amine after workup. 1H NMR (CDCl3) delta 1.10 (d, 3H, J = 6.3 Hz), 2.57-2.76 (m, 2H), 2.88-2.94 (m, IH), 3.79 (s, 3H), 3.72-3.88 (m, 2H), 6.82 (d, 2H, J = 8.7 Hz), 7.07 (d, 2H, J= 8.4 Hz), 7.15-7.31 (m, 5H); MS (APCI+) m/z (rel): 256 (100); [alpha]D = -30.4 (c = 1.25 MeOH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2008/22038; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A common heterocyclic compound, 43229-65-8, name is N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, molecular formula is C17H21NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 43229-65-8.

Synthesis of 4-benzyloxy-3-methoxymethyl-alpha[N-benzyl-N(alpha-methyl-4-methoxyphenethyl)amino]acetophenone Amounts of 39.5 g of the compound obtained in the step C1 and 57.7 g of N-benzyl-N(alpha-methyl-4-methoxyphenethyl)amine are stirred for 6 hours in 200 ml of acetonitrile. The crystals precipitated are filtered off, and the filtrate is concentrated, to give the object compound. The compound is used for the following step without purification.

The synthetic route of N-Benzyl-1-(4-methoxyphenyl)propan-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; US4317930; (1982); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem