Category: 4316-51-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C19H17NO

POCl3 (6 mL, 64.17 mmol) was carefully added to a solution of 4-methoxy-N,N-diphenylaniline (10 g, 36.32 mmol), DMF (5 mL, 64.85 mmol) and 50 mL of 1,2-dichloroethane. The mixture was refluxed for 4 h, then cooled to room temperature (r.t.), and poured into a saturated aqueous sodium acetate solution (100 mL). The product was extracted with dichloromethane. The organic layer was dried over anhydrous MgSO4. The solvent was evaporated by a rotary evaporator. The residue was purified by silica gel column chromatography using ethyl acetate: n-hexane (2:3) to give (1) (7.6 g, Yield: 69%). TOF/MS (ESI): found 326.1 (M+Na+). 1H NMR (300 MHz, CDCl3, delta): 9.79 (s, 1H, ArCHO), 7.68-6.89 (m, 14H, ArH), 3.83 (s, 3H, ArOCH3).

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Giang, Ha Ngoc; Kinashi, Kenji; Sakai, Wataru; Tsutsumi, Naoto; Journal of Photochemistry and Photobiology A: Chemistry; vol. 291; (2014); p. 26 – 33;,
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Application of 4316-51-2, A common heterocyclic compound, 4316-51-2, name is 4-Methoxytriphenylamine, molecular formula is C19H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Boron tribromide was added to a dichloromethane solution of 4-methoxytriphenylamine (formula (6)) while cooling, and the mixture was stirred at room temperature for 3 hours to obtain diphenylaminophenol (formula (7) in a yield of 90% It was.

The synthetic route of 4316-51-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YOKOHAMA NATIONAL UNIVERSITY; NAKAGAWA, TETSUYA; YOKOYAMA, YASUSHI; MIYASAKA, YOSUKE; (14 pag.)JP2018/20988; (2018); A;,
Ether – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C19H17NO

To a 250 mL four-necked flask was added a solution of 4-methoxytriphenylamine in DMF (previously prepared from 5.5 g of 4-methoxytriphenylamine dissolved in 75 mL of DMF), protected by nitrogen and magnetically stirred and cooled to 0 C. ,Using a constant pressure dropping funnel, 12.24g of POCl3 was slowly added dropwise to the reaction solution. After the addition was completed, the reaction conditions were maintained for 1h. Heating to 80 reaction.After the reaction was completed, the reaction mixture was poured into ice water and quenched, extracted with methylene chloride, washed with deionized water five times and anhydrous sulfurThe mixture was dried over magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The crude product was separated by column chromatography (petroleum ether / ethyl acetate = 10/1, v / v)Pure, to obtain a green oily liquid, the yield was 94.8%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4316-51-2.

Reference:
Patent; Hebei University of Science and Technology; Lv Haijun; Zhou Haoran; Jin Gengen; Yu Yifeng; Ma Weiqing; Kang Caihong; Wang Lili; (37 pag.)CN107298689; (2017); A;,
Ether – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 4316-51-2

POCl3 (6 mL, 64.17 mmol) was carefully added to a solution of 4-methoxy-N,N-diphenylaniline (10 g, 36.32 mmol), DMF (5 mL, 64.85 mmol) and 50 mL of 1,2-dichloroethane. The mixture was refluxed for 4 h, then cooled to room temperature (r.t.), and poured into a saturated aqueous sodium acetate solution (100 mL). The product was extracted with dichloromethane. The organic layer was dried over anhydrous MgSO4. The solvent was evaporated by a rotary evaporator. The residue was purified by silica gel column chromatography using ethyl acetate: n-hexane (2:3) to give (1) (7.6 g, Yield: 69%). TOF/MS (ESI): found 326.1 (M+Na+). 1H NMR (300 MHz, CDCl3, delta): 9.79 (s, 1H, ArCHO), 7.68-6.89 (m, 14H, ArH), 3.83 (s, 3H, ArOCH3).

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Giang, Ha Ngoc; Kinashi, Kenji; Sakai, Wataru; Tsutsumi, Naoto; Journal of Photochemistry and Photobiology A: Chemistry; vol. 291; (2014); p. 26 – 33;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 4316-51-2, A common heterocyclic compound, 4316-51-2, name is 4-Methoxytriphenylamine, molecular formula is C19H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) Synthesis of 4,4′-Diformyl-4″-methoxytriphenylamine (8c) Reactions were conducted in the same manner as in (4) in Example 2 except that 20.0 g (0.075 mol) of 4-methoxytriphenylamine (7c) was used in place of triphenylamine (7a). Thus, 19.0 g of 4,4′-diformyl-4″-methoxytriphenylamine (8c) was obtained. Theoretical yield, 76.5%; m.p., 113-114 C. Spectral data for this compound are as follows. 1 H-NMR spectrum (400 MHz, CDCl3, deltappm): 3.85 (3H, s), 6.94 (2H, d, J=9.0 Hz), 7.12 (2H, d, J=9.0 Hz), 7.17 (4H, d, J=8.7 Hz), 7.56 (4H, d, J=8.7 Hz), 9.88 (2H, s)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Takasago International Corporation; US5573878; (1996); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 4316-51-2, A common heterocyclic compound, 4316-51-2, name is 4-Methoxytriphenylamine, molecular formula is C19H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Boron tribromide was added to a dichloromethane solution of 4-methoxytriphenylamine (formula (6)) while cooling, and the mixture was stirred at room temperature for 3 hours to obtain diphenylaminophenol (formula (7) in a yield of 90% It was.

The synthetic route of 4316-51-2 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4316-51-2, name is 4-Methoxytriphenylamine, A new synthetic method of this compound is introduced below., HPLC of Formula: C19H17NO

Example 14 Synthesis of 4-methoxy-4′,4″-diformyltriphenylamine: 5 g (18.16 mmol) of 4-methoxyltriphenylamine, 5.66 g (77.5 mmol) of N,N-dimethylformamide, 11.5 g (75.0 mmol) of phosphorus oxychloride, 2.5 g (18.3 nmmol) of zinc chloride, and 100 ml of toluene were subjected to reaction, post-treatment and isolation in the same manner as in Example 12. The results are set forth in Table 13. The reaction product exhibited the following physical properties:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C19H17NO

Take compound I-TPA (4.40 g, 12.04 mmol)And purified DMF (31 mL) was added to a 100 mL round bottom flask and stirred at room temperature for 30 min until the compound I-TPA was completely dissolved.N-bromosuccinimide (2.84 g, 16 mmol) in portionsJoin the system,Stir at room temperature for 5 h. After the reaction is terminated,Diluted with dichloromethane and extracted with saturated brine until the aqueous phase was clear.MergedMachine phase, concentrated to no droplets,Chloroform / petroleum ether = 1/4 (v / v) as a rinse agent,Purified by silica gel column chromatography,The product was dried to a white oil, which was Intermediate 2-3, the actual yield was 4.70 g, and the yield was 75%.

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C19H17NO

General procedure: Ni(cod)2 (3.4 mg, 0.025 mmol), ICy¡¤HBF4 (4.0 mg, 0.025 mmol), NaOtBu (48 mg, 0.50 mmol) and toluene (0.50 mL) were added to a 10 mL-sample vial with a Teflon-sealed screwcap in a glovebox filled with nitrogen. The resulting mixture was stirred at room temperature for 3 min. An aryl methyl ether (0.25 mmol) in toluene (0.50 mL) and AlMe3 (1.8 M in toluene solution, 0.14 mL, 0.25 mmol) were then added to the vial and the screw cap was closed. The contents of the vial were stirred at 80 C for 6 or 18 h. The reaction mixture was cooled to room temperature, and the crude mixture was then treated with EtOH. The resulting mixture was filtered through a pad of silica gel, and then analyzed by GC. The filtrate was concentrated in vacuo to give a residue, which was purified by flash column chromatography over silica gel.

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Morioka, Toshifumi; Nishizawa, Akihiro; Nakamura, Keisuke; Tobisu, Mamoru; Chatani, Naoto; Chemistry Letters; vol. 44; 12; (2015); p. 1729 – 1731;,
Ether – Wikipedia,
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