Category: 40925-69-7

Ochiai, Koji; Takita, Satoshi; Eiraku, Tomohiko; Kojima, Akihiko; Iwase, Kazuhiko; Kishi, Tetsuya; Fukuchi, Kazunori; Yasue, Tokutaro; Adams, David R.; Allcock, Robert W.; Jiang, Zhong; Kohno, Yasushi published the artcile< Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity>, Recommanded Product: 2-Amino-3-methoxyphenol, the main research area is pyridazinone dihydro heteroaromatic preparation antiinflammatory bronchodilatory activity.

(-)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits potent combined bronchodilatory and anti-inflammatory activity. A survey of potential bicyclic heteroaromatic replacement subunits for the pyrazolo[1,5-a]pyridine core of KCA-1490 has identified the 4-methoxy-2-(trifluoromethyl)benzo[d]thiazol-7-yl and 8-methoxy-2-(trifluoromethyl)quinolin-5-yl analogs as dual PDE3/4-inhibitory compounds that potently suppress histamine-induced bronchoconstriction and exhibit anti-inflammatory activity in vivo.

Bioorganic & Medicinal Chemistry published new progress about Anti-inflammatory agents. 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Recommanded Product: 2-Amino-3-methoxyphenol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kato, Eisuke; Oikawa, Kenichi; Takahashi, Keisuke; Kawabata, Jun published the artcile< Synthesis and the intestinal glucosidase inhibitory activity of 2-aminoresorcinol derivatives toward an investigation of its binding site>, Name: 2-Amino-3-methoxyphenol, the main research area is intestine glucosidase inhibitor aminoresorcinol derivative.

2-Aminoresorcinol is a potent and selective intestinal glucosidase inhibitor. Unlike the majority of glucosidase inhibitors, it shows an uncompetitive mode of inhibition. In this study, we tested the intestinal glucosidase inhibitory activity of various 2-aminoresorcinol derivatives We found that structural changes, in amino and two phenolic hydroxyl groups had a neg. impact on inhibitory activity, but methylation of the phenolic hydroxyl group was found to maintain its activity and replacement of the aromatic ring with an acyl or alkoxy carbonyl group at the 4th position also retained its activity. This enable us to design a mol. probe for further study of the inhibition mechanism of 2-aminoresorcinol.

Bioscience, Biotechnology, and Biochemistry published new progress about Carbonyl group. 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Name: 2-Amino-3-methoxyphenol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhou, Jianmin; Ma, Zhi-Yuan; Shonhe, Chantale; Ji, Su-Hui; Cai, Yun-Rui published the artcile< TEMPO-catalyzed electrochemical dehydrogenative cyclocondensation of o-aminophenols: synthesis of aminophenoxazinones as antiproliferative agents>, Synthetic Route of 40925-69-7, the main research area is aminophenol TEMPO catalyst electrochem dehydrogenative cyclocondensation green chem; aminophenoxazinone preparation antitumor SAR.

A TEMPO-catalyzed electrosynthetic method allowing the dehydrogenative cyclocondensation of o-aminophenols was reported. This mild and sustainable method proceeded in the absence of stoichiometric oxidants and used an easily available organo-electrocatalyst to access pharmaceutically valuable 2-aminophenoxazinones. Mechanistic studies indicated that the electrochem. generated TEMPO+ enables the oxidative radical homo-dimerization of o-aminophenols. The application of electrosynthesis provides an approach for the synthesis of pseudo-aminophenoxazinone alkaloids with improved structural diversification and bioactivities.

Green Chemistry published new progress about Amino phenols Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Synthetic Route of 40925-69-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gu, Lijun; Jin, Cheng; Guo, Junming; Zhang, Lizhu; Wang, Wei published the artcile< A novel strategy for the construction of substituted benzoxazoles via a tandem oxidative process>, Name: 2-Amino-3-methoxyphenol, the main research area is toluene aminophenol tandem oxidative cyclization iron bromide catalyst; benzoxazole preparation.

A practical and simple synthesis of benzoxazoles from easily available substrates was developed. The protocol is triggered by an iron-catalyzed tandem oxidative process from simple toluene derivatives and 2-aminophenols. This method represents a straightforward approach to access substituted benzoxazoles.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Name: 2-Amino-3-methoxyphenol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shenghur, Abraham; Weber, Kevin H.; Nguyen, Nhan D.; Sontising, Watit; Tao, Fu-Ming published the artcile< Theoretical Study of the Hydrogen Abstraction of Substituted Phenols by Nitrogen Dioxide as a Source of HONO>, Name: 2-Amino-3-methoxyphenol, the main research area is nitrogen dioxide hydrogen abstraction phenol nitrous acid formation.

The mild yet promiscuous reactions of nitrogen dioxide (NO2) and phenolic derivatives to produce nitrous acid (HONO) have been explored with d. functional theory calculations The reaction is found to occur via four distinct pathways with both proton coupled electron transfer (PCET) and hydrogen atom transfer (HAT) mechanisms available. While the parent reaction with phenol may not be significant in the gas phase, electron donating groups in the ortho and para positions facilitate the reduction of nitrogen dioxide by electronically stabilizing the product phenoxy radical. Hydrogen bonding groups in the ortho position may addnl. stabilize the nascent resonantly stabilized radical product, thus enhancing the reaction. Catechol (ortho-hydroxy phenol) has a predicted overall free energy change ΔG0 = -0.8 kcal mol-1 and electronic activation energy Ea = 7.0 kcal mol-1. Free amines at the ortho and para positions have ΔG0 = -3.8 and -1.5 kcal mol-1; Ea = 2.3 and 2.1 kcal mol-1, resp. The results indicate that the hydrogen abstraction reactions of these substituted phenols by NO2 are fast and spontaneous. Hammett constants produce a linear correlation with bond dissociation energy (BDE) demonstrating that the BDE is the main parameter controlling the dark abstraction reaction. The implications for atm. chem. and ground-level nitrous acid production are discussed.

Journal of Physical Chemistry A published new progress about Abstraction reaction enthalpy. 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Name: 2-Amino-3-methoxyphenol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem