Electric Literature of 399-54-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 399-54-2 name is 4-Fluoro-1-methoxy-2-methylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 5 (not according to the invention) 56 g of 2-methyl-4-fluoro-methoxy-benzene were introduced into 150 ml of dichloromethane at 10 C. and 85 g of nitrating acid (HNO3 content 33%) were added dropwise in 30 minutes. The mixture was then stirred for 1 hour at 10 C. and 1 hour at 20 C. The reaction mixture was subsequently poured onto ice, extracted using dichloromethane, and the organic phase was separated off and distilled. The product passing over at 130 to 132 C. at 20 mbar was collected and filtered off with suction after stirring with 50 ml of n-hexane. 26 g of 2-methyl-3-nitro-4-fluoro-methoxy-benzene having a melting point of 38 to 40 C. were obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-1-methoxy-2-methylbenzene, and friends who are interested can also refer to it.