Category: 39538-68-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39538-68-6, name is 2-Methoxy-4-methylaniline, A new synthetic method of this compound is introduced below., Safety of 2-Methoxy-4-methylaniline

General procedure: In a threaded ACE glass pressure tube with a sealed Teflon screw cap equipped with a magnetic stirring bar, a mixture of 11a (0.200 g, 1.65 mmol), 12a (0.185 g, 1.65 mmol), p-TsOH (0.028 g, 0.16 mmol), and MS 4A (0.20 g) in toluene (10 mL) was stirred and heated at 130 C for 4.5 h under microwave irradiation (100 W). The solvent was removed under vacuum and the residue purified by column chromatography (silica gel, hexane-EtOAc, 98:2) to give 7a (0.32 g, 91%) as a brownishoil; Rf = 0.75 (hexane-EtOAc, 7:3).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Hernandez-Benitez, R. Israel; Zarate-Zarate, Daniel; Delgado, Francisco; Tamariz, Joaquin; Synthesis; vol. 49; 18; (2017); p. 4357 – 4371;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 39538-68-6, name is 2-Methoxy-4-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39538-68-6, Recommanded Product: 2-Methoxy-4-methylaniline

Intermediate 43Preparation of 1-bromo-2-methoxy-4-methylbenzeneTo a solution of copper(II)bromide (6.35 g; 28.4 mmol) in acetonitrile (25 mL) was added tert-butyl nitrite (2.85 ml; 24.06 mmol) and the mixture was heated at 65 C. under nitrogen atmosphere. A solution of 2-methoxy-4-methylaniline (3 g, 21.87 mmol) in 25 ml acetonitrile was added carefully and the mixture was stirred for 20 min at 65 C. The solvent was removed under reduced pressure, the residue was dissolved in ethyl acetate and washed with a 5% solution of ammonia, water, a solution of EDTA, water and brine. The organic layer was dried over sodium sulphate, filtered and concentrated under reduced pressure. Purification by flash chromatography on silica gel using a gradient of ethyl acetate (2-50%) in heptane furnished 2.32 g (53%) of the title compound. 1H-NMR (300 MHz, CDCl3) (ppm) delta: 6.63-6.60 (m, 3H, 3×Harom.); 3.82 (s, 3H, OCH3); 2.26 (s, 3H, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-4-methylaniline, other downstream synthetic routes, hurry up and to see.

Electric Literature of 39538-68-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39538-68-6 as follows.

5.2 g of 2-methoxy-4-methylaniline was dissolved in 32 ml of water and 11.4 ml of concentrated hydrochloricacid, cooled to 0-5 C in an ice bath, and 2.88 g of sodium nitrite dissolved in 9 ml of water was added dropwise to theabove cooled solution. The mixture was stirred for 10 minutes in an ice bath and then 5.6 g of sodium acetate was added.The above reaction liquid was added dropwise to a hot (about 75 C) solution wherein 11 g of potassium ethyl xanthatewas dissolved in 51 ml of water, stirred for another 1 hour, cooled to room temperature, and extracted with ethyl acetate.After liquid separation, the organic phase was washed with saturated aqueous solution of sodium chloride and thendried over anhydrous sodium sulfate, filtered, concentrated, and then dissolved in a solution of 1.3 N potassium hydroxidein ethanol, and then added with 3 g of glucose and refluxed for 3 hours. The reaction mixture was concentrated and thepH was adjusted to about 1 with 6 N sulfuric acid in ice bath, and then 5.7 g of zinc powder was added and heated andstirred at 50 C for 30 minutes. The insoluble was filtered off and the filtrate was extracted with ethyl acetate. After liquidseparation, the organic phase was washed with saturated aqueous solution of sodium chloride and dried over anhydroussodium sulfate, filtered and concentrated, and the residue was separated by column chromatography (100% petroleumether) to afford 4.15 g of oily matter, yield 71%.1H NMR (300 MHz, DMSO-d6) delta 7.17 (s, 1H), 6.81 (s, 1H), 6.66 (s, 1H), 4.63 (s, 1H), 3.80 (s, 3H), 2.26 (s, 3H).

According to the analysis of related databases, 39538-68-6, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 39538-68-6, name is 2-Methoxy-4-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Methoxy-4-methylaniline

General procedure: To a magnetically stirred ice-bath cooled solution of the selected succinic monoamide derivative (4 mmol) in anhydrous dioxane (20 ml) neat oxalyl chloride was added (8 mmol). After stirring over 30 min the reaction mixture was warmed to room temperature. Two hours later, the reaction mixture was re-cooled to 0 C in ice bath followed by drop wise addition of the particular aromatic amine (4 mmol) in pyridine (10 mL) to the reaction mixture. After stirring over 30 min the reaction mixture was warmed to room temperature and allowed to stir over 24 h. Subsequently, the reaction was carefully quenched with saturated sodium bicarbonate solution (200 mL). Finally, the mixture was filtered to offer the products as whitish to gray solids that were re-crystallized from acetone (see Scheme 2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 39538-68-6, its application will become more common.

Reference:
Article; Habash, Maha; Taha, Mutasem O.; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4746 – 4771;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 39538-68-6, name is 2-Methoxy-4-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Methoxy-4-methylaniline

General procedure: To a magnetically stirred ice-bath cooled solution of the selected succinic monoamide derivative (4 mmol) in anhydrous dioxane (20 ml) neat oxalyl chloride was added (8 mmol). After stirring over 30 min the reaction mixture was warmed to room temperature. Two hours later, the reaction mixture was re-cooled to 0 C in ice bath followed by drop wise addition of the particular aromatic amine (4 mmol) in pyridine (10 mL) to the reaction mixture. After stirring over 30 min the reaction mixture was warmed to room temperature and allowed to stir over 24 h. Subsequently, the reaction was carefully quenched with saturated sodium bicarbonate solution (200 mL). Finally, the mixture was filtered to offer the products as whitish to gray solids that were re-crystallized from acetone (see Scheme 2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 39538-68-6, its application will become more common.

Reference:
Article; Habash, Maha; Taha, Mutasem O.; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4746 – 4771;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 39538-68-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39538-68-6, name is 2-Methoxy-4-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a magnetically stirred ice-bath cooled solution of the selected succinic monoamide derivative (4 mmol) in anhydrous dioxane (20 ml) neat oxalyl chloride was added (8 mmol). After stirring over 30 min the reaction mixture was warmed to room temperature. Two hours later, the reaction mixture was re-cooled to 0 C in ice bath followed by drop wise addition of the particular aromatic amine (4 mmol) in pyridine (10 mL) to the reaction mixture. After stirring over 30 min the reaction mixture was warmed to room temperature and allowed to stir over 24 h. Subsequently, the reaction was carefully quenched with saturated sodium bicarbonate solution (200 mL). Finally, the mixture was filtered to offer the products as whitish to gray solids that were re-crystallized from acetone (see Scheme 2).

The synthetic route of 2-Methoxy-4-methylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Habash, Maha; Taha, Mutasem O.; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4746 – 4771;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 39538-68-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39538-68-6, name is 2-Methoxy-4-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Malonyl diamide derivatives were prepared as described earlier.49 Briefly: To a magnetically stirred ice bath-cooled solution of the selected amine (14 mmol), and triethylamine (14 mmol, 1.4 g) in dioxane (20 ml), malonyl dichloride (1.0 g, 7.0 mmol) solution in dioxane (20 ml) was added dropwise over 15 min. The reaction mixture was stirred at 0 C for one hour. Subsequently, HCl (2 N, 50 ml) was added to the reaction suspension and stirred for 30 minutes. Finally, the mixture was filtered to afford the products as whitish to gray solids that were further washed by stirring in water (50 mL) for 30 min (Scheme 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-4-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Habash, Maha; Taha, Mutasem O.; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4746 – 4771;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 39538-68-6, name is 2-Methoxy-4-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39538-68-6, Recommanded Product: 2-Methoxy-4-methylaniline

To a test tube with a magnet stirrer bar was added N-methyl-2-{[2-(1 /-/-1 , 2, 4-triazol-1 – yl)-5- (trifluoromethyl) pyrimidin-4-yl] amino} benzamide (Compound 6, 0.200 g, 0.550 mmol) and 2-methoxy-4-methyl aniline (0.083 g, 0.606 mmol, 1 .1 eq.). To the mixture, trimethylacetic acid (1 .0 g, 9.791 mmol, 17.8 eq.) was added and the resulting suspension was stirred and heated in an oil bath set at 130 C. The progress of the reaction was monitored by HPLC. After 29 h the reaction mixture was cooled to room temperature, quenched with 3 N NaOH (3.9 ml_, 1 1 .75 mmol, 21 eq.) and diluted with toluene. Insoluble solids were filtered off and the layers were separated. The organic phase was washed with water and brine and then concentrated under vacuum. The residue was stirred in a mixture of heptanes and dichloromethane at room temperature and the resultant solids were collected by filtration and rinsed with heptane. The damp solid was dried under high vacuum to give 1 18 mg of the desired product as a pale solid. 1 H NMR {CDCI3}: 5(ppm) 10.75 (br s, 1 H, NH), 8.46 (d, J = 8.0 Hz, 1 H, ArH ), 8.36 (s, 1 H, ArH), 8.14 (d, J = 8.0 Hz, 1 H, ArH), 7.64 (br s, 1 H, NH), 7.45 – 7.49 (m, 2 H, 2X ArH), 7.13 (t, J = 8.0 Hz, 1 H, ArH), 6.72 (s, 1 H, ArH), 6.68 (d, J = 8.0 Hz, 1 H, ArH), 6.18 (br s, 1 H, NH), 3.88 (s, 3 H, OCH3), 3.02 (d, J = 4.0 Hz, 3 H, NCH3), 2.34 (s, 3 H, CH3). 19F NMR {CDC }: 5(ppm) 61 .4. HPLC: 97.2% area, Rt = 7.34 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-4-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OSI PHARMACEUTICALS, LLC; CASTELHANO, Arlindo L.; RECHKA, Josef A.; SENANAYAKE, Chandrawansha; DEVANATHAN, Krishnaswamy; GNANAVELU, Karunanidhi; WO2014/126954; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 39538-68-6, The chemical industry reduces the impact on the environment during synthesis 39538-68-6, name is 2-Methoxy-4-methylaniline, I believe this compound will play a more active role in future production and life.

Iron (5.35 g, 95.7 mmol) was added to a solution of 2-nitro-5-methylanisole (10, 4.00 g, 23.9 mmol) in ethanol (60 ml) and 6 M aqueous hydrochloric acid (30 ml), and the mixture was heated at reflux for 2 h. The reaction mixture was diluted with ethyl acetate and filtrated through Celite. Evaporation of the filtrate afforded crude 11. NaNO2 (2.11 g, 30.6 mmol) was added to a solution of crude 11 (2.80 g, 20.4 mmol) in THF (80 ml) and 4 M aqueous hydrochloric acid (40 ml) at 0 C. After 30 min, potassium iodide (4.80 g, 30.6 mmol) was added, and the mixture was heated at reflux for 3 h. The reaction mixture was diluted with ethyl acetate and water. The organic layer was washed with saturated sodium thiosulfate and brine, dried with sodium sulfate, and evaporated. Purification by silica gel column chromatography (n-hexane/ether 100:1 to 98:2) gave 12 (pale yellow oil, 3.77 g, 15.2 mmol, 65% for two steps). 1H NMR (500 MHz, CDCl3) delta 7.60 (d, 1H, J=7.9 Hz), 6.63 (d, 1H, J=1.2 Hz), 6.53 (dd, 1H, J=7.9, 1.2 Hz), 3.84 (s, 3H), 2.31 (s, 3H); 13C NMR (125 MHz, CDCl3) delta 157.84, 139.86, 138.96, 123.36, 112.07, 81.78, 56.18, 21.42; HRMS (FAB+) m/z 248.9780 [(M+H)+: calcd for C8H10OI, 248.9776].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-4-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Iwashita, Masazumi; Fujii, Shinya; Ito, Shigeru; Hirano, Tomoya; Kagechika, Hiroyuki; Tetrahedron; vol. 67; 33; (2011); p. 6073 – 6082;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem