Category: 3929-47-3

Fluorinated benzamide neuroleptics – 2. Synthesis and radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-[¹⁸F]fluoropropyl)-3-substituted-2-methoxybenzamides was written by Mukherjee, Jogeshwar. And the article was included in Applied Radiation and Isotopes in 1991.Category: ethers-buliding-blocks This article mentions the following:

Synthesis of a fluorinated benzamide neuroleptic (I) starting from 3-(3,4-dimethoxyphenyl)-1-propanol in 20-25% overall yield is reported. Radiosynthesis of II and III was carried out by nucleophilic substitution reaction of (S)-N-[1-ethyl-2-pyrrolidinyl)methyl-5-(3-tosyloxypropyl)-2-methoxybenzamide and (S)-N-[(ethyl-2-pyrrolidinyl)methyl]-5-(3-tosyloxypropyl)-2,3-dimethoxybenzamide resp., with no carrier added [¹⁸F]fluoride. Both, II and III were obtained in approx. 20-30% yields (EOS/EOB, decay corrected). Specific activities of 900-1700 Ci/mmol. for II and 800-1400 Ci/mmol. for III were obtained by reverse phase HPLC purification Total synthesis and purification time required for either II or III was 120 min from EOB. Preferential uptake of III was observed in the striatum region was observed Thus, this compound is a potentially useful ¹⁸F-fluorinated benzamide neuroleptic for imaging dopamine D-2 receptors noninvasively by using PET. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Category: ethers-buliding-blocks).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Substrate specificity and properties of the aryl-alcohol oxidase from the ligninolytic fungus Pleurotus eryngii was written by Guillen, Francisco;Martinez, Angel T.;Martinez, Maria Jesus. And the article was included in European Journal of Biochemistry in 1992.Related Products of 3929-47-3 This article mentions the following:

The production in a 5-1 fermenter of the extracellular enzymes laccase and aryl-alc. oxidase by the fungus P. eryngii was studied. The enzyme has been purified 50-fold by Sephacryl S-200 and Mono Q chromatog. Purified aryl-alc. oxidase is a unique flavoprotein with 15% carbohydrate content, a mol. mass of 72.6 kDa (SDS-PAGE) and a pI of 3.9. The enzyme presents wide specificity, showing activity on benzyl, cinnamyl, naphthyl, and aliphatic unsaturated alcs. Neither activity nor inhibition of veratryl alc. oxidation was found with saturated alcs., but competitive inhibition was produced by aromatic compounds which were not aryl-alc. oxidase substrates, such as phenol or 3-phenyl-1-propanol. From these results, it was apparent that a double bond conjugated with a primary alc. is necessary for substrate recognition by aryl-alc. oxidase, and that activity is increased by the presence of addnl. conjugated double bonds and electron donor groups. Both affinity and maximal velocity during enzymic oxidation of methoxybenzyl alcs. were affected in a similar way by ring substituents, increasing from benzyl alc. (K_m = 0.84 mM, V_max = 52 U/mg) to 4-methoxybenzyl alc. (K_m = 0.04 mM, V_max = 208 U/mg). Aryl-alc. oxidase presents also a low oxidase activity with aromatic aldehydes, but the highest activity was found in the presence of electron-withdrawing groups. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 3929-47-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-Functional Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward the Discovery of Biased Dopamine D1 Receptor Agonists was written by Li, Haoxi;Mirabel, Rosa;Zimmerman, Joseph;Ghiviriga, Ion;Phidd, Darian K.;Horenstein, Nicole;Urs, Nikhil M.. And the article was included in ACS Chemical Neuroscience in 2022.Recommanded Product: 3929-47-3 This article mentions the following:

Dopamine regulates normal functions such as movement, reinforcement learning, and cognition, and its dysfunction has been implicated in multiple psychiatric and neurol. disorders. Dopamine acts through D1- (D1R and D5R) and D2-class (D2R, D3R, and D4R) receptors and activates both G protein- and β-arrestin-dependent signaling pathways. Current dopamine receptor-based therapies are used to ameliorate motor deficits in Parkinson’s disease or as antipsychotic medications for schizophrenia. These drugs show efficacy for ameliorating only some symptoms caused by dopamine dysfunction and are plagued by debilitating side effects. Studies in primates and rodents have shown that shifting the balance of dopamine receptor signaling toward the arrestin pathway can be beneficial for inducing normal movement, while reducing motor side effects such as dyskinesias, and can be efficacious at enhancing cognitive function compared to balanced agonists. Several structure-activity relationship (SAR) studies have embarked on discovering β-arrestin-biased dopamine agonists, focused on D2 partial agonists, noncatechol D1 agonists, and mixed D1/D2R dopamine receptor agonists. Here, we describe an SAR study to identify novel D1R β-arrestin-biased ligands using A-86929, a high-affinity D1R catechol agonist, as a core scaffold to identify chem. motifs responsible for β-arrestin-biased activity at both D1 and D2Rs. Most of the A-86929 analogs screened were G protein-biased, but none of them were exclusively arrestin-biased. Addnl., various small-fragment mol. probes displayed weak bias toward the β-arrestin pathway. Continued in-depth SFSR (structure-functional selectivity relationship) studies informed by structure determination, mol. modeling, and mutagenesis studies will facilitate the discovery of potent and efficacious arrestin-biased dopamine receptor ligands. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Recommanded Product: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 3929-47-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Lewis acid-promoted cyclization of ethenetricarboxylate derivative aromatic compounds. Novel syntheses of oxindoles and benzofuranones via Friedel-Crafts intramolecular Michael addition was written by Yamazaki, Shoko;Morikawa, Satoshi;Iwata, Yuko;Yamamoto, Machiko;Kuramoto, Kaori. And the article was included in Organic & Biomolecular Chemistry in 2004.Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

A cyclization reaction of ethenetricarboxylate derivative aromatic compounds, in the presence of various Lewis acids, gave benzo-annulated cyclic compounds such as oxindoles, e.g., I, and benzofuranones by Friedel-Crafts intramol. Michael addition in high yields. The reaction of di-Et 2-[(N-methyl-N-phenylcarbamoyl)methylene]malonate in the presence of ZnCl₂ gave I in excellent yield. The reactions also proceeded with a catalytic amount of a Lewis acid such as AlCl₃, ZnCl₂, ZnBr₂, Sc(OTf)₃, or InBr₃. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Phosphorylated cyclopropanes in the synthesis of α-alkylidene-γ-butyrolactones: total synthesis of (±)-savinin, (±)-gadain and (±)-peperomin E was written by Lloyd, Matthew G.;Taylor, Richard J. K.;Unsworth, William P.. And the article was included in Organic & Biomolecular Chemistry in 2016.Formula: C11H16O3 This article mentions the following:

Phosphorylated cyclopropanes, generated via the Rh(II)-catalyzed intramol. cyclopropanation of α-(diethoxyphosphoryl)acetates, have been found to be useful precursors in the synthesis of α-alkylidene-γ-butyrolactones. These cyclopropyl intermediates undergo regioselective reductive ring-opening and subsequent Horner-Wadsworth-Emmons olefination to complete the synthesis. Total syntheses of (±)-savinin (I) and (±)-gadain (II), as well as the first total synthesis of (±)-peperomin E (III), are all described using this method. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Formula: C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Formula: C11H16O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hypervalent Iodine(III)-Induced Intramolecular Cyclization of α-(Aryl)alkyl-β-dicarbonyl Compounds: A Convenient Synthesis of Benzannulated and Spirobenzannulated Compounds was written by Arisawa, Mitsuhiro;Ramesh, Namakkal G.;Nakajima, Makiko;Tohma, Hirofumi;Kita, Yasuyuki. And the article was included in Journal of Organic Chemistry in 2001.Application of 3929-47-3 This article mentions the following:

A novel hypervalent iodine(III)-induced direct intramol. cyclization of α-(aryl)alkyl-β-dicarbonyl compounds has been described. Both meta- and para-substituted phenol ether derivatives containing acyclic or cyclic 1,3-dicarbonyl moieties at the side chain undergo this reaction in a facile manner. The reactions afford benzannulated and spirobenzannulated compounds that are of biol. importance. The reaction is found to be general, mild, and high yielding. The mechanism of the reaction has been shown to involve a cation radical intermediate. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Improved synthesis of natural ester sintenin and its analogues via Wittig reaction was written by Sharma, Mukul;Rajesh, U. Chinna;Rawat, Diwan S.. And the article was included in Journal of the Indian Chemical Society in 2013.Formula: C11H16O3 This article mentions the following:

The synthesis of a cytotoxic natural ester sintenin and twenty eight analogs including nitrogen-containing heterocyclic indole groups, saturated amides and unsaturated amides was carried out by a convenient one-pot Wittig reaction in aqueous medium with improved yield. A systematic structure activity relationship of sintenin ester was designed by chem. modified derivatives in order to get better cytotoxicity. The title compounds thus formed included 3,4-Dimethoxybenzenepropanoic acid 3-(3,4-dimethoxyphenyl)propyl ester (sintenin carboxylic acid ester) (I) and related substances. The synthesis of the target compounds was achieved by a reaction of benzenepropanoic acid derivatives with benzenepropanol derivatives Wittig reaction products included (2E)-3-(phenyl)-2-propenoic acid derivatives and (2E)-3-(phenyl)-2-propen-1-ol derivatives Amide analogs were prepared from (2E)-3-phenyl-2-propen-1-amine. Amide analogs thus formed included (2E)-3-(4-methylphenyl)-N-(3-phenylpropyl)-2-propenamide, 4-methyl-N-(3-phenylpropyl)benzenepropanamide. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Formula: C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Formula: C11H16O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Microwave irradiation of lignocellulosic materials V. Effects of microwave irradiation on enzymic susceptibility of crystalline cellulose was written by Azuma, Junichi;Asai, Toshihiro;Isaka, Masao;Koshijima, Tetsuo. And the article was included in Journal of Fermentation Technology in 1985.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

The usefulness of various treatments was compared in the enzymic saccharification of microwave-irradiated crystalline cellulose (Whatman CF11). The variations include the extent of enzymic saccharification, the treatment temperature suitable for enzymic saccharification, and the effects of AcOH, lignin, and monomeric lignin model compounds on the extent of enzymic saccharification. The effects of microwave irradiation alone were evaluated. When cellulose suspended in water was heated above 180°, partial acid hydrolysis occurred. The extent of hydrolysis increased with an increase in temperature but did not exceed 3% even at 235°, where 0.03 mequiv of acid and cellooligosaccharides having a d.p. of 2-6 as well as glucose were produced. Although the presence of AcOH increased reducing sugar production by a factor of 2.2-3.8, lignin did not induce degradation of cellulose. The extent of enzymic saccharification of cellulose was greatly enhanced by microwave irradiation pretreatment in the presence of water above 220° and reached 43.2% at 240° at cellulose and enzyme concentrations of 2.0 and 0.2%, resp. The presence of AcOH facilitated the enzymic susceptibility and the extent of saccharification reached 69.2% at 240°. Lignin also facilitated the enzymic susceptibility but its action was limited to temperatures below 200°, above which lignin inhibited enzymic attack. The enhancement of the enzymic susceptibility by lignin was further promoted by the addition of AcOH. In this case, the maximal extent of saccharification was 41.5% at 200°, indicating that the temperature needed to reach 42-43% saccharification could be lowered for 40° by a synergistic effect between lignin and AcOH. Combinations of AcOH and monomeric lignin model compounds also show synergistic effects. However, lignin model compounds did not inhibit the enzyme reaction above 200° in contrast to the case of lignin. An unsaturated C-C double bond in the substituent of benzene ring seems to be important in the synergistic effect, whereas phenolic OH groups are of minor importance. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog was written by Kodan, Atsushi;Yamaguchi, Tomohiro;Nakatsu, Toru;Sakiyama, Keita;Hipolito, Christopher J.;Fujioka, Akane;Hirokane, Ryo;Ikeguchi, Keiji;Watanabe, Bunta;Hiratake, Jun;Kimura, Yasuhisa;Suga, Hiroaki;Ueda, Kazumitsu;Kato, Hiroaki. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2014.Related Products of 3929-47-3 This article mentions the following:

P-glycoprotein is an ATP-binding cassette multidrug transporter that actively transports chem. diverse substrates across the lipid bilayer. The precise mol. mechanism underlying transport is not fully understood. Here, the authors present crystal structures of a eukaryotic P-glycoprotein homolog, CmABCB1 with ATPase activity from Cyanidioschyzon merolae, in 2 forms: unbound at 2.6-Å resolution and bound to a unique allosteric peptide inhibitor at 2.4-Å resolution The inhibitor clamped the transmembrane helixes from the outside, fixing the CmABCB1 structure in an inward-open conformation similar to the unbound structure, confirming that an outward-opening motion is required for the ATP hydrolysis cycle. These structures, along with site-directed mutagenesis and transporter activity measurements, revealed the detailed architecture of the transporter, including a gate that opens to extracellular side and 2 gates that open to intramembranous region and the cytosolic side. The authors propose that the motion of the nucleotide-binding domain drives those gating apparatuses via 2 short intracellular helixes, IH1 and IH2, and 2 transmembrane helixes, TM2 and TM5. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog was written by Kodan, Atsushi;Yamaguchi, Tomohiro;Nakatsu, Toru;Sakiyama, Keita;Hipolito, Christopher J.;Fujioka, Akane;Hirokane, Ryo;Ikeguchi, Keiji;Watanabe, Bunta;Hiratake, Jun;Kimura, Yasuhisa;Suga, Hiroaki;Ueda, Kazumitsu;Kato, Hiroaki. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2014.Related Products of 3929-47-3 This article mentions the following:

P-glycoprotein is an ATP-binding cassette multidrug transporter that actively transports chem. diverse substrates across the lipid bilayer. The precise mol. mechanism underlying transport is not fully understood. Here, the authors present crystal structures of a eukaryotic P-glycoprotein homolog, CmABCB1 with ATPase activity from Cyanidioschyzon merolae, in 2 forms: unbound at 2.6-Å resolution and bound to a unique allosteric peptide inhibitor at 2.4-Å resolution The inhibitor clamped the transmembrane helixes from the outside, fixing the CmABCB1 structure in an inward-open conformation similar to the unbound structure, confirming that an outward-opening motion is required for the ATP hydrolysis cycle. These structures, along with site-directed mutagenesis and transporter activity measurements, revealed the detailed architecture of the transporter, including a gate that opens to extracellular side and 2 gates that open to intramembranous region and the cytosolic side. The authors propose that the motion of the nucleotide-binding domain drives those gating apparatuses via 2 short intracellular helixes, IH1 and IH2, and 2 transmembrane helixes, TM2 and TM5. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem