Category: 3929-47-3

Structure-Functional Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward the Discovery of Biased Dopamine D1 Receptor Agonists was written by Li, Haoxi;Mirabel, Rosa;Zimmerman, Joseph;Ghiviriga, Ion;Phidd, Darian K.;Horenstein, Nicole;Urs, Nikhil M.. And the article was included in ACS Chemical Neuroscience in 2022.Recommanded Product: 3929-47-3 This article mentions the following:

Dopamine regulates normal functions such as movement, reinforcement learning, and cognition, and its dysfunction has been implicated in multiple psychiatric and neurol. disorders. Dopamine acts through D1- (D1R and D5R) and D2-class (D2R, D3R, and D4R) receptors and activates both G protein- and 閻?arrestin-dependent signaling pathways. Current dopamine receptor-based therapies are used to ameliorate motor deficits in Parkinson’s disease or as antipsychotic medications for schizophrenia. These drugs show efficacy for ameliorating only some symptoms caused by dopamine dysfunction and are plagued by debilitating side effects. Studies in primates and rodents have shown that shifting the balance of dopamine receptor signaling toward the arrestin pathway can be beneficial for inducing normal movement, while reducing motor side effects such as dyskinesias, and can be efficacious at enhancing cognitive function compared to balanced agonists. Several structure-activity relationship (SAR) studies have embarked on discovering 閻?arrestin-biased dopamine agonists, focused on D2 partial agonists, noncatechol D1 agonists, and mixed D1/D2R dopamine receptor agonists. Here, we describe an SAR study to identify novel D1R 閻?arrestin-biased ligands using A-86929, a high-affinity D1R catechol agonist, as a core scaffold to identify chem. motifs responsible for 閻?arrestin-biased activity at both D1 and D2Rs. Most of the A-86929 analogs screened were G protein-biased, but none of them were exclusively arrestin-biased. Addnl., various small-fragment mol. probes displayed weak bias toward the 閻?arrestin pathway. Continued in-depth SFSR (structure-functional selectivity relationship) studies informed by structure determination, mol. modeling, and mutagenesis studies will facilitate the discovery of potent and efficacious arrestin-biased dopamine receptor ligands. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Recommanded Product: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Lewis acid-promoted cyclization of ethenetricarboxylate derivative aromatic compounds. Novel syntheses of oxindoles and benzofuranones via Friedel-Crafts intramolecular Michael addition was written by Yamazaki, Shoko;Morikawa, Satoshi;Iwata, Yuko;Yamamoto, Machiko;Kuramoto, Kaori. And the article was included in Organic & Biomolecular Chemistry in 2004.Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

A cyclization reaction of ethenetricarboxylate derivative aromatic compounds, in the presence of various Lewis acids, gave benzo-annulated cyclic compounds such as oxindoles, e.g., I, and benzofuranones by Friedel-Crafts intramol. Michael addition in high yields. The reaction of di-Et 2-[(N-methyl-N-phenylcarbamoyl)methylene]malonate in the presence of ZnCl₂ gave I in excellent yield. The reactions also proceeded with a catalytic amount of a Lewis acid such as AlCl₃, ZnCl₂, ZnBr₂, Sc(OTf)₃, or InBr₃. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Combined lignin defunctionalisation and synthesis gas formation by acceptorless dehydrogenative decarbonylation was written by Zhang, Zhenlei;Zijlstra, Douwe S.;Lahive, Ciaran W.;Deuss, Peter. J.. And the article was included in Green Chemistry in 2020.SDS of cas: 3929-47-3 This article mentions the following:

The valorization of lignin, consisting of various phenylpropanoids building blocks, is hampered by its highly functionalized nature. The absence of the 绾?carbinol group in an unnatural C2 灏?O-4 motif compared to the native lignin C3 灏?O-4 motif provides great opportunities for developing new valorization routes. Thus efficient defunctionalisation approaches that transform the C3 灏?O-4 motif into a simplified C2 灏?O-4 motif are of interest. Based on a study with a series of model compounds, we established a feasible application of an iridium-catalyzed acceptorless dehydrogenative decarbonylation method to efficiently remove the 绾?carbinol group in a single step. This defunctionalisation generates valuable synthesis gas, which can be collected as a reaction product. By this direct catalytic transformation, a yield of ~70% could be achieved for a C3 灏?O-4 model compound that was protected from undergoing retro-aldol cleavage by alkoxylation of the benzylic secondary alc. in the 浼?position. A phenylcoumaran model compound containing a 绾?carbinol group as well as a benzylic primary alc. also proved to be reactive under dehydrogenative decarbonylation conditions, which can further contribute to the reduction of the structural complexity of lignin. Notably, the liberation of synthesis gas was confirmed and the signals for the defunctionalized C2 灏?O-4 motif were observed when this dehydrogenative decarbonylation approach was applied on organosolv lignins. This selective defunctionalized lignin in conjunction with the formation of synthesis gas has the potential to enhance the development of profitable and sustainable biorefineries. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3SDS of cas: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Metabolism of alkenebenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers was written by Solheim, Einar;Scheline, Ronald R.. And the article was included in Xenobiotica in 1976.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

In the rat eugenol Me ether (I) [93-15-2] underwent oxidation of the allylic side chain to form 3 metabolites, 2 of which were excreted as glycine conjugates. Other metabolic reactions were hydroxylation of the benzene ring, O-demethylation, and 2 oxidation reactions; 63-95% of the initial dose was accounted for. The major metabolic path of isoeugenol Me ether (II) [93-16-3] was via cinnamoyl derivatives, but O-demethylation, and oxidation also occurred. Most of the metabolites of I and II were also found in the bile. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of heavy metal residues in mechanical pulp on color reversion was written by Park, Je-Seung;Yoon, Byung-Ho. And the article was included in Palpu, Chongi Gisul in 1995.COA of Formula: C11H16O3 This article mentions the following:

The amount of heavy metal, i.e., Cu, Fe, or Mn, removed by the chelating agent used in the pretreatment for H₂O₂ bleaching was investigated, and the effect of heavy metal and lignin (I) model added to bleached thermomech. pulp (BTMP) and filter paper followed by photoirradiation on discoloration was examined Treatment with DTPA showed the most efficient chelating effect among 3 chelating agents, i.e., EDTA, DTPA, and STPP, which were added to unbleached TMP. Much of the Fe remained after chelation, but Mn was easily removed. The heavy metal added artificially to BTMP showed a decrease of brightness with increasing irradiation time. The formation of a complex between I and Fe conspicuously decreased brightness. The successive doping of Fe and 3,4-dihydroxy benzaldehyde among combinations of heavy metals and I models added artificially to BTMP showed a remarkable drop in brightness. This was caused by the easy formation of a complex between the heavy metal and I having neighboring OH groups. When the heavy metal and I model were artificially, resp. or together, added to filter paper, even filter paper treated with only Fe decreased in brightness. This was caused by the oxidation of cellulose itself and the formation of a little complex between the heavy metal and cellulose. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3COA of Formula: C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.COA of Formula: C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Analytical pyrolysis of lignin: products stemming from 灏?5 substructures was written by Kuroda, Ken-ichi;Nakagawa-Izumi, Akiko. And the article was included in Organic Geochemistry in 2006.Related Products of 3929-47-3 This article mentions the following:

Five phenolic 2-arylcoumarans containing a 灏?5 linkage: I (R = CH₂OH, R’ = CH:CHCH₂OH) (II), I (R = CH₂OH, R’ = CH:CHCHO) (III), I (R = Me, R’ = CH:CHCH₂OH) (IV), I (R = Me, R’ = CH:CHCHO) (V), I (R = Me, R’ = CH:CHMe) (VI), and diazomethane-methylated II (VII), were pyrolyzed at 500鎺?for 4 s. The products were analyzed by gas chromatog. and gas chromatog./mass spectrometry. The major products of II–V and VII were 4-methylguaiacol (VIII) and 1,2-dimethoxy-4-methylbenzene, resp., stemming from the A moiety of the 2-arylcoumarans. I–V having the ring B with a CH:CHCH₂OH or CH:CHCHO side chain provided VIII in a larger yield than dehydrodiisoeugenol VI having the ring B with a CH=CHCH₃ side chain; the yields of 4 were 閳?.6, 5.7-4.6, and 0.9 mol% from II, III–V and VI, resp. Characterization of the dimeric products of II showed the 浼?aryl ether opened-dimers with the hydrogenated C浼?C灏?bond being the precursors of VIII. Based on these results, guaiacyl and syringyl 灏?5 substructures were proposed as potential pyrolytic origins for VIII and 3,5-dimethoxy-4-methylphenol in anal. pyrolysis of soft- and hardwood lignins. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Production of secondary metabolites including a new metabolite p-methoxyphenylpropanol by the brown-rot fungus Lentinus lepideus was written by Ohta, Akira;Shimada, Mikio;Hattori, Takefumi;Higuchi, Takayoshi;Takahashi, Munezoh. And the article was included in Mokuzai Gakkaishi in 1990.Safety of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

The secondary metabolites which were biosynthesized from glucose by the brown-rot fungus L. lepideus grown in cultures with varying amounts of nitrogen nutrients were determined The low nitrogen concentration culture produced much greater amounts of the metabolites per nitrogen gram unit than did the high nitrogen concentration culture. A new secondary metabolite, p-methoxyphenylpropanol, was isolated from the cultures of this fungus. Incubation of the cultures with p-coumaric acid, p-methoxycinnamic acid, ferulic acid, isoferulic acid, and Me ferulate yielded a variety of phenylpropanol derivatives A possible biosynthetic route for p-methoxyphenylpropanol is discussed. Among 75 species of white-rot and brown-rot fungi examined, only the brown-rot fungus Daedalea鑱?em>dickinsii produced Me p-methoxycinnamate. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Safety of 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Safety of 3-(3,4-Dimethoxyphenyl)propan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo was written by Samara, Pinelopi;Christoforidou, Nikoleta;Lemus, Christelle;Argyropoulou, Aikaterini;Ioannou, Kyriaki;Vougogiannopoulou, Konstantina;Aligiannis, Nektarios;Paronis, Efthimios;Gaboriaud-Kolar, Nicolas;Tsitsilonis, Ourania;Skaltsounis, Alexios-Leandros. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 3929-47-3 This article mentions the following:

Oleuropein is a glucosylated seco-iridoid present in olive fruits and leaves. Due to its broad spectrum of biol. activities, including anticancer properties, oleuropein has attracted scientific attention for the past 20 years. The promising antiproliferative activity of an olive leaf extract enriched in oleuropein against a series of human cancer cell lines, prompted us to proceed with the semi-synthesis of 51 analogs of oleuropein. Following their initial screening against the estrogen receptor neg. breast cancer cell line SKBR3, 7 analogs were shown to display significant cytotoxicity and were further tested against 6 addnl. solid tumor-derived and leukemic cell lines. The analog with the most promising antitumor activity (24) was selected for more detailed studies. 24 was non-toxic to peripheral blood mononuclear cells derived from healthy blood donors when tested at concentrations close to its half maximal inhibitory concentration In vivo administration of 24 in melanoma-bearing mice resulted in reducing tumor size in a dose-dependent manner and in inducing anti-melanoma-reactive immune responses. Our results suggest that analog 24, emerging from the initial structure of oleuropein, represents a promising lead structure for further optimization. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Total Synthesis and Evaluation of B-Homo Palmatine and Berberine Derivatives as p300 Histone Acetyltransferase Inhibitors was written by Yang, Zhongzhen;Zhang, Yong;Chen, Xin;Li, Weijian;Li, Guo-Bo;Wu, Yong. And the article was included in European Journal of Organic Chemistry in 2018.Related Products of 3929-47-3 This article mentions the following:

Palmatine and berberine, structurally similar isoquinoline alkaloids exhibiting a broad range of biol. activities, were recently found to inhibit p300 histone acetyltransferase (HAT), a potential therapeutic target for treating transcriptional activator-driven malignancies and diseases. Here, we report the first total synthesis of B-homo palmatine and berberine derivatives, which were synthesized from 3,4-dimethoxybenzaldehyde and benzo[d][1,3]dioxole-5-carbaldehyde in nine steps in 13.8% and 16.9% overall yields, resp. A number of other new B-homo palmatine and berberine derivatives were also prepared These derivatives display good inhibitory activity against p300 HAT; compound I manifests the most potent inhibition with an IC₅₀ value of 0.42 娓璏. Cell-based assays revealed that I exhibits certain inhibitory activity against HCG27, HT1080, and Z-138 cell lines, and no visible activity towards other cancer cell lines tested, reflecting that I has low cytotoxicity and acts against some types of cancer cells. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cinnamic acid bridges between cell wall polymers in wheat and phalaris internodes was written by Thi Bach Tuyet Lam;Iiyama, Kenji;Stone, Bruce A.. And the article was included in Phytochemistry in 1992.Related Products of 3929-47-3 This article mentions the following:

A method has been devised for the quant. determination of cinnamic acids participating in ester-ether bridges between cell wall polymers based on the different reactivities of free carboxylic acids and their esters towards borohydride reductants and the different susceptibilities of cinnamic acid ester and benzyl ether linkages to alk. treatments. Lignin-polysaccharide containing fractions extracted with dioxane-H₂O from cell walls of wheat (Triticum鑱?em>aestivum) and phalaris (Phalaris鑱?em>aquatica) internodes are hydrogenated using a Pd/C catalyst at room temperature to convert cinnamic acids to their corresponding dihydrocinnamic acids. The sample is subsequently reduced with LiBH₄ in ether-toluene to convert ester-linked dihydrocinnamates to their corresponding alcs. and hydrolyzed with 4M NaOH at 170鎺? and the dihydrocinnamic acid derivatives released from their etherified forms were determined by GC. Using model compounds it was shown that these reactions proceeded quant. The results indicate that all of the etherified ferulic acid in the dioxane-H₂O-soluble fractions of walls of wheat and phalaris internodes is also ester-linked. It has been calculated that there are nine to 10 ferulic acid ester-ether bridges for every 100 C₆-C₃ lignin monomers. p-Coumaric acid is not involved in ester-ether bridges. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem