Category: 39021-83-5

Adding a certain compound to certain chemical reactions, such as: 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39021-83-5, name: 1,4-Dimethoxy-2,3-dimethylbenzene

2.1.b 1-(chloromethyl)-2,5-dimethoxy-3,4-dimethylbenzene In a round bottom flask, methoxy- protected hydroquinone (1.10 g, 6.62 mmol) was dissolved in conc. HCl and stirred at rt. ZnCl2 (0.90 g, 6.62 mmol) and paraformaldehyde (0.27 g, 7.9 mmol) were then added and stirred at rt. After 2 h, water was added to the flask and the organics were extracted with ether (3*30 mL), dried over Na2SO4, and concentrated down to a green-brown solid. Flash column chromatography on silica gel in a solution of 2% ether:hexanes afforded an off-white solid that contained a 4:1 mixture of the inseparable mono- and dichloromethylquinone (1.12 g, 91%). This mixture was taken on to the next step without further purification.

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Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; US2007/203080; (2007); A1;,
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Application of 39021-83-5, These common heterocyclic compound, 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(bromomethyl)-1,4-dimethoxy-3-methylbenzeneInto a 50-mL round-bottom flask, was placed a mixture of 1,4-dimethoxy-2,3-dimethylbenzene (1.00 g, 6.02 mmol, 1.00 equiv)(Example 128), CCl4 (20 mL), NBS (1.20 g, 6.74 mmol, 1.10 equiv) and BPO (145 mg, 0.57 mmol, 0.10 equiv). The solution was stirred for 16 h at 80 C. After concentration, the residue was diluted with 50 mL of TBME and washed with 3×20 mL of brine. The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure. This resulted in 1.20 g (81%) of 2-(bromomethyl)-1,4-dimethoxy-3-methylbenzene as a brown crude solid.

Statistics shows that 1,4-Dimethoxy-2,3-dimethylbenzene is playing an increasingly important role. we look forward to future research findings about 39021-83-5.

Reference:
Patent; Global Blood Therapeutics, Inc.; Li, Zhe; Xu, Qing; Yu, Chul; Yee, Calvin; Gwaltney,, II, Stephen L.; Metcalf, Brian W.; Richards, Steven; Lardy, Matthew A.; Setti, Lina; Sham, Hing; US2015/315198; (2015); A1;,
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Electric Literature of 39021-83-5, The chemical industry reduces the impact on the environment during synthesis 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, I believe this compound will play a more active role in future production and life.

General procedure: A 100-mL round-bottomed flask was charged with 6 g of silica gel and set up tostir vigorously. Then, a solution of 2.75 g of cerium ammonium nitrate (CAN) (5.0mmol) in water (2.5 mL) was added dropwise. The stirring continued until a freeflowingyellow solid was obtained. DCM (25 mL) was then added to the flask. Thecorresponding substrates where dissolved in 2 mL of DCM and added to the stirredreaction mixture. The reaction was monitored by TLC and after complete consumptionof the starting materials the mixture was filtered through a sintered-glass funnel. Thesolid was washed with about 75 mL of DCM. After solvent removal the quinones wereobtained with high purity. 2,3-Dimethyl-1,4-benzoquinone (46): 1,4-dimethoxy-2,3-dimethylbenzene(43)6 (1 mmol, 166 mg) was used. 46 was obtained without the need of purification (85mg, 63% yield) as an orange powder; m.p. (C) = 54.9-56.4 (Petrol/CH2Cl2); HRMS(EI+): 136.0569 [M]+. Cald. for [C8H8O2]: 136.0524; 1H NMR (400 MHz, CDCl3) delta:6.70 (s, 2H), 2.01 (s, 6H); 13C NMR (100 MHz, CDCl3) delta: 187.4, 141.0, 136.2, 12.2.Data are consistent with those reported in the literature.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dimethoxy-2,3-dimethylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jardim, Guilherme A.M.; Silva, Thaissa L.; Goulart, Marilia O.F.; de Simone, Carlos A.; Barbosa, Juliana M.C.; Salomao, Kelly; de Castro, Solange L.; Bower, John F.; da Silva Junior, Eufranio N.; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 406 – 419;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C10H14O2

5.2. Formylation of Dimethoxybenzenes by Means of the Duff Reaction1 equivalent of dimethoxybenzene was dissolved in 20 ml of TFA and 1.05 equivalents or urotropin were added to the resulting solution. The reaction mixture was brought to reflux for 2 hours under anhydrous conditions. The TFA was evaporated off under reduced pressure, the residue was dissolved in 100 ml of ether and the organic solution was washed with water (3 times 50 ml) and then dried over MgSO4. The solvent was evaporated off and the residue was subjected to column chromatography, elution being carried out with an 80:20 mixture of light mineral spirit (60-80 C.):diethyl ether.5.2.1. 2,5-Dimethoxy-3,4-dimethylbenzaldehydeThe process was carried out as described in point 5.2 above, using 2.270 g (0.01366 mol) of 1,4-dimethoxy-2,3-dimethylbenzene. The title product was isolated in the form of a white solid (1.18 g, 44%).

The synthetic route of 39021-83-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; bioMerieux; US7626018; (2009); B2;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39021-83-5 as follows. Recommanded Product: 39021-83-5

A solution of 1,4-dimethoxy-2,3-dimethylbenzene 1 (1.00 g, 6.02 mmol) and N-bromosuccinimide (2.36 g, 13.2 mmol) in 1,1,1-trichloroethane (20 cm3) was heated under reflux for 1 h with visible irradiation. The mixture was filtered and the filtrate evaporated to leave the product 4 as a brown crystalline solid (0.55 g, 55%)

According to the analysis of related databases, 39021-83-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Aitken, R. Alan; Jethwa, Siddharth J.; Richardson, Neville V.; Slawin, Alexandra M.Z.; Tetrahedron Letters; vol. 57; 14; (2016); p. 1563 – 1566;,
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Electric Literature of 39021-83-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of 1,4-dimethoxy-2,3-dimethylbenzene 1 (1.50 g, 9.0 mmol), N-bromosuccinimide (6.43 g, 36.1 mmol) and benzoyl peroxide (0.22 g, 0.9 mmol) in benzotrifluoride (220 cm3) was heated under reflux for 2.5 h and then allowed to cool and filtered. The filtrate was evaporated to give an orange residue, shown by 1H NMR and TLC to contain a mixture of the desired product 2 and the ring brominated product 8. Recrystallisation (petroleum ether/ethyl acetate, 3:1) gave the desired product 2 (1.03 g, 35%) as a pale yellow solid, mp and 1H NMR data as above.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dimethoxy-2,3-dimethylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Aitken, R. Alan; Jethwa, Siddharth J.; Richardson, Neville V.; Slawin, Alexandra M.Z.; Tetrahedron Letters; vol. 57; 14; (2016); p. 1563 – 1566;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, molecular formula is C10H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1,4-Dimethoxy-2,3-dimethylbenzene

The compound 72 (5 g, 30.1 mmol) was dissolved in TFA (50 mL) and hexamine (4.7 g, 33.1 mmol) was added to the resulting solution. The reaction mixture was refluxed under dry conditions for 2 hours. The TFA was evaporated under reduced pressure and the residue was dissolved in EtOAc (100 mL) . and the The resulting organic solution was washed with water (3×50 mL) and then dried over Na2SO4. The solvent organic phase was evaporated concentrated in vacuum and the residue was subjected to silica gel column chromatography (petroleum ether/EtOAc 20: 1 to 10: 1) to giveproduct 73 (3.1 g, 53) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 39021-83-5, its application will become more common.

Reference:
Patent; XW LABORATORIES, INC.; XW LABORATORIES INC.; XIANG, Jia-Ning; QI, Zude; NING, Dezheng; LIU, Xianbo; (152 pag.)WO2019/33330; (2019); A1;,
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Related Products of 39021-83-5,Some common heterocyclic compound, 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, molecular formula is C10H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a magnetically stirred solution of 1 ,4-dimethoxy-2,3-dimethyl-benzene (13.90 g, 83.6 mmol) in carbon tetrachloride (300 mL) at room temperature was added N-bromo- succinimide (32.2 g, 176 mmol) in one portion, and the reaction mixture was heated up to 65C. Benzoyl peroxide (0.54 g, 2.23 mmol) was added at 65C, and the reaction mixture stirred for further 4 hours before cooling down to 55C. The reaction mixture was filtered, the solid washed with carbon tetrachloride, and the combined filtrates were concentrated in vacuo to yield 2,3-bis(bromomethyl)-1 ,4-dimethoxy-benzene (26.8 g, 82.7 mmol) in 99% yield.

The synthetic route of 39021-83-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOVERSYS AG; SCHNEIDER, Peter; RIEDL, Rainer; TIGGES, Marcel; GITZINGER, Marc; PIEREN, Michel; LEVI, Assaf; SEPHTON, Mark; SCHELLHORN, Birgit; ZUEGER, Patrik; BRAND, Michael; GYGAX, Daniel; SPIES, Peter; WO2014/118361; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 39021-83-5,Some common heterocyclic compound, 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, molecular formula is C10H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 2,3-Dimethyl-5,6-dinitro-1,4-dimethoxybenzene A solution of 2,3-dimethyl-1,4-dimethoxybenzene (16.6 g; o.1 mol) in acetic acid (100 mL) was cooled in an ice bath, then conc. HNO3 (40 mL) was added dropwise over 15 minutes. After the addition, the reaction mixture was stirred at ambient temperature for 3 hours, then heated at 50 C. for 20 minutes. Solution was concentrated to 75 mL under vacuum, then poured into ice-H2O (350 mL). The yellow precipitate (8.1 g) was collected. Recrystallization from EtOH gave 5.4 g (18.5% yield) of 2,3-dimethyl-5,6-dinitro-1,4-dimethoxybenzene as a yellow solid, m.p. 147-150 C.

The synthetic route of 39021-83-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wyeth; US6444694; (2002); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39021-83-5, Safety of 1,4-Dimethoxy-2,3-dimethylbenzene

Step 2 A solution of 1,4-dimethoxy-2,3-dimethyl-benzene (1 g) in dichloromethane was stirred and cooled in an ice-water bath, and TiCl4 (1.1 mL) was slowly added, followed by the addition of CHCl2OCH3 (0.58 g). The solution was stirred for another 15 min with ice-water bath, 30 min at RT, then 15 min at 35 C. Then the red solution was poured into ice and extract with dichloromethane. Workup and purification by chromatography (silicagel column, eluding with EtOAc/:hexane 1:4) gave 973 mg of 2,5-dimethoxy-3,4-dimethyl-benzaldehyde.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.