Category: 38256-93-8

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Quality Control of 38256-93-8.

Gao, Meiping;Teng, Wei;Du, Zhenxia;Nie, Lei;An, Xiaoshuan;Liu, Wenwen;Sun, Xuechun;Shen, Zhengchao;Shi, Aijun research published 《 Source profiles and emission factors of VOCs from solvent-based architectural coatings and their contributions to ozone and secondary organic aerosol formation in China》, the research content is summarized as follows. Volatile organic compounds (VOCs) from solvent-based architectural coatings (SBACs) play an important role in photochem. air pollution with increasing consumption of architectural coatings in China. In this study, we collected 148 typical SBACs of 3 types in China. The TVOC emission factors and source profiles were established, the contributions of SBACs to ozone and secondary organic aerosol (SOA) formation were investigated. The VOC emissions and O₃ and SOA amounts formed in chem. reactions from SBACs in 2017 were estimated Key organic groups and VOC species with high reactivity were identified. According to the results, the TVOC emission factors were 507.17 g L^-1 for solvent-based anticorrosive coatings, 381.34 g L^-1 for solvent-based floor coatings and 459.68 g L^-1 for solvent-based fire-retardant coatings. The VOC emissions were 186,902.11 t, 88,225.41 t and 71,352.32 t; the O₃ amounts formed were 742,001.39 t, 397,896.60 t and 244,738.46 t; the SOA amounts formed were 3934.29 t, 2488.04 t and 1104.61 t, resp., from 3 types of SBACs in 2017. The O₃ production factors were 1781.82 g O₃ (kg paint)^-1, 1457.50 g O₃ (kg paint)^-1 and 1176.63 g O₃ (kg paint)^-1, the SOA production factors were 9.45 g SOA (kg paint)^-1, 9.11 g SOA (kg paint)^-1 and 5.31 g SOA (kg paint)^-1, for 3 types of SBACs. Priority should be given to organic group of aromatics and top 17 VOC species with high reactivity for O₃ and SOA eliminating strategies, especially three xylenes (o-xylene, m-xylene and p-xylene), ethylbenzene, tri-Me benzenes (1,3,5-tri-Me benzene, 1,2,3-Tri-Me benzene) and toluene.

Quality Control of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Quality Control of 38256-93-8.

George, Sheby Mary;Kim, Hyo-Suk;Oh, Hyun Ji;Lah, Myoung Soo;Jeon, Dong Ju;Park, Bo Keun;Han, Jeong Hwan;Kim, Chang Gyoun;Chung, Taek-Mo research published 《 Heteroleptic strontium complexes stabilized by donor-functionalized alkoxide and β-diketonate ligands》, the research content is summarized as follows. Heteroleptic complexes of strontium (1–7) were prepared by employing β-diketonates and donor-functionalized alkoxides as coordinating ligands. The results illustrate the effect of alkoxide substituent groups on the overall structures of the complexes. The presence of a terminal methoxy group in the alkoxide ligands gives trimeric complexes 1–4, whereas the substituents on the amine nitrogen prove to have less influence in determining the structure. The attempts to increase steric bulkiness of the aminoalkoxide ligands by introducing Et groups on the amine nitrogen and to the alkoxy carbon did not lead to a structural change from the dimeric form in 5–7 but resulted in structurally interesting strontium complexes. In trimeric complexes 2–4, the three strontium atoms were held together by two μ₃-O bonds using alkoxide oxygen atoms and two μ₂-O bonds using a combination of alkoxide and β-diketonate ligand oxygens. The strontium metal centers in these complexes exhibit seven-coordination states in 2 and 4, whereas 3 exhibits one six-coordinated and two seven-coordinated strontium metals in its structure. All of the complexes were characterized using FT-NMR, FTIR, elemental analyses, and thermogravimetric (TG) analyses.

Quality Control of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. COA of Formula: C4H11NO.

Ghoshal, Tanay;Nagar, Vishal;Vutla, Adilakshmi;Kotturi, Sharadsrikar;Kuttappan, Sasikumar research published 《 Synthesis of aminobenzoxazoles via simple, clean and efficient electrochemical redox reactions》, the research content is summarized as follows. An efficient single step process for the construction of pharmaceutically relevant substituted aminobenzoxazoles was described. Various electrodes and electrolytes combinations were carried out to harvest optimum coupling results. The presented C-N bond formation reaction methodol. was applied for the synthesis of biol. active compounds This methodol. saved reaction steps over traditional functionalization reactions.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., COA of Formula: C4H11NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Synthetic Route of 38256-93-8.

Davoren, Jennifer E.;Claffey, Michelle M.;Snow, Sheri L.;Reese, Matthew R.;Arora, Gaurav;Butler, Christopher R.;Boscoe, Brian P.;Chenard, Lois;DeNinno, Shari L.;Drozda, Susan E.;Duplantier, Allen J.;Moine, Ludivine;Rogers, Bruce N.;Rong, SuoBao;Schuyten, Katherine;Wright, Ann S.;Zhang, Lei;Serpa, Kevin A.;Weber, Mark L.;Stolyar, Polina;Whisman, Tammy L.;Baker, Karen;Tse, Karen;Clark, Alan J.;Rong, Haojing;Mather, Robert J.;Lowe, John A. III research published 《 Discovery of a novel Kv7 channel opener as a treatment for epilepsy》, the research content is summarized as follows. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous elec. activity during epileptic seizures. In an effort to identify a compound with such properties, the structure-activity relationship (SAR) and in vitro ADME for a series of heterocyclic Kv7.2-7.5 channel openers (I) was explored. PF-05020182 (II) demonstrated suitable properties for further testing in vivo where it dose-dependently decreased the number of animals exhibiting full tonic extension convulsions in response to corneal stimulation in the maximal electroshock (MES) assay. In addition, II significantly inhibited convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochem. properties, in vitro and in vivo activities of II support further development as an adjunctive treatment of refractory epilepsy.

Synthetic Route of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Synthetic Route of 38256-93-8.

Davoren, Jennifer E.;Claffey, Michelle M.;Snow, Sheri L.;Reese, Matthew R.;Arora, Gaurav;Butler, Christopher R.;Boscoe, Brian P.;Chenard, Lois;DeNinno, Shari L.;Drozda, Susan E.;Duplantier, Allen J.;Moine, Ludivine;Rogers, Bruce N.;Rong, SuoBao;Schuyten, Katherine;Wright, Ann S.;Zhang, Lei;Serpa, Kevin A.;Weber, Mark L.;Stolyar, Polina;Whisman, Tammy L.;Baker, Karen;Tse, Karen;Clark, Alan J.;Rong, Haojing;Mather, Robert J.;Lowe, John A. III research published 《 Discovery of a novel Kv7 channel opener as a treatment for epilepsy》, the research content is summarized as follows. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous elec. activity during epileptic seizures. In an effort to identify a compound with such properties, the structure-activity relationship (SAR) and in vitro ADME for a series of heterocyclic Kv7.2-7.5 channel openers (I) was explored. PF-05020182 (II) demonstrated suitable properties for further testing in vivo where it dose-dependently decreased the number of animals exhibiting full tonic extension convulsions in response to corneal stimulation in the maximal electroshock (MES) assay. In addition, II significantly inhibited convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochem. properties, in vitro and in vivo activities of II support further development as an adjunctive treatment of refractory epilepsy.

Synthetic Route of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Formula: C4H11NO.

Chen, Xinde;Wang, Kai;Xu, Wenwei;Ma, Quanxin;Chen, Minli;Du, Lili;Mo, Mingguang;Wang, Yiping;Shen, Jianhua research published 《 Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A₂ (Lp-PLA₂) Inhibitors as a Potential Therapy for Diabetic Macular Edema》, the research content is summarized as follows. Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is considered to be a promising therapeutic target for several inflammation-associated diseases. Herein, the authors describe the discovery of a series of pyrimidone derivatives as Lp-PLA₂ inhibitors. Systematic structural modifications led to the identification of several pyrimidone compounds with promising in vitro inhibitory potency and pharmacokinetic properties. Compound 2-(4-chloro-3-(trifluoromethyl)phenoxy)-5-(((1-methyl-6-morpholino-2-oxo-1,2-dihydropyrimidin-4-yl)oxy)methyl)benzonitrile (14c), selected for in vivo evaluation, demonstrated decent pharmacokinetic profiles and robust inhibitory potency against Lp-PLA₂ in Sprague-Dawley (SD) rats. Furthermore, (14c) significantly inhibited retinal thickening in STZ-induced diabetic SD rats as a model of diabetic macular edema (DME) after oral dosing for 4 wk. Taken together, these results suggested that (14c) can serve as a valuable lead in the search for new Lp-PLA₂ inhibitors for prevention and/or treatment of DME.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Formula: C4H11NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Name: 2-Methoxy-N-methylethanamine.

Cleghorn, Laura A. T.;Ray, Peter C.;Odingo, Joshua;Kumar, Anuradha;Wescott, Heather;Korkegian, Aaron;Masquelin, Thierry;Lopez Moure, Abraham;Wilson, Caroline;Davis, Susan;Huggett, Margaret;Turner, Penelope;Smith, Alasdair;Epemolu, Ola;Zuccotto, Fabio;Riley, Jennifer;Scullion, Paul;Shishikura, Yoko;Ferguson, Liam;Rullas, Joaquin;Guijarro, Laura;Read, Kevin D.;Green, Simon R.;Hipskind, Phil;Parish, Tanya;Wyatt, Paul G. research published 《 Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB》, the research content is summarized as follows. With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis there is a pressing need for new oral drugs with novel mechanisms of action. Herein, we describe the identification of a novel morpholino-thiophenes (MOT) series following phenotypic screening of the Eli Lilly corporate library against M. tuberculosis strain H37Rv. The design, synthesis, and structure-activity relationships of a range of analogs around the confirmed actives are described. Optimized leads with potent whole cell activity against H37Rv, no cytotoxicity flags, and in vivo efficacy in an acute murine model of infection are described. Mode-of-action studies suggest that the novel scaffold targets QcrB, a subunit of the menaquinol cytochrome c oxidoreductase, part of the bc1-aa3-type cytochrome c oxidase complex that is responsible for driving oxygen-dependent respiration.

Name: 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Application of C4H11NO.

Crosignani, Stefano;Pretre, Adeline;Jorand-Lebrun, Catherine;Fraboulet, Gaele;Seenisamy, Jeyaprakashnarayanan;Augustine, John Kallikat;Missotten, Marc;Humbert, Yves;Cleva, Christophe;Abla, Nada;Daff, Hamina;Schott, Olivier;Schneider, Manfred;Burgat-Charvillon, Fabienne;Rivron, Delphine;Hamernig, Ingrid;Arrighi, Jean-Francois;Gaudet, Marilene;Zimmerli, Simone C.;Juillard, Pierre;Johnson, Zoe research published 《 Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases》, the research content is summarized as follows. New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound, I, by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with K_i < 10 nM) but also excellent potencies in a human whole blood assay (IC₅₀ < 100 nM; PGD2-induced eosinophil shape change). Addnl. optimization of the pharmacokinetic characteristics led to the identification of several compounds suitable for in vivo testing. Of these, II (R¹ = n-Pr, R² = Me; R¹ = n-Pr, R² = F) were tested in two different pharmacol. models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg).

Application of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Recommanded Product: 2-Methoxy-N-methylethanamine.

Armani, Elisabetta;Capaldi, Carmelida;Bagnacani, Valentina;Saccani, Francesca;Aquino, Giancarlo;Puccini, Paola;Facchinetti, Fabrizio;Martucci, Cataldo;Moretto, Nadia;Villetti, Gino;Patacchini, Riccardo;Civelli, Maurizio;Hurley, Chris;Jennings, Andrew;Alcaraz, Lilian;Bloomfield, Dawn;Briggs, Michael;Daly, Stephen;Panchal, Terry;Russell, Vince;Wicks, Sharon;Finch, Harry;Fitzgerald, Mary;Fox, Craig;Delcanale, Maurizio research published 《 Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases》, the research content is summarized as follows. The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identification of a novel tetrahydronaphthalene series, characterized by nanomolar inhibition of p38α with selectivity over p38γ and p38δ isoforms. SAR optimization of 1c is outlined, where improvements in potency against p38α and ligand-enzyme dissociation kinetics led to several compounds showing pronounced anti-inflammatory effects in vitro (inhibition of TNFα release). Targeting of the defined physicochem. properties allowed the identification of compounds 3h, 4e, and 4f, which showed, upon intratracheal instillation, low plasma levels, prolonged lung retention, and anti-inflammatory effects in a rat acute model of a bacterial endotoxin-induced pulmonary inflammation. Compound 4e (I), in particular, displayed remarkable efficacy and duration of action and was selected for progression in disease models of asthma and chronic obstructive pulmonary disease (COPD).

Recommanded Product: 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Synthetic Route of 38256-93-8.

Azimioara, Mihai;Alper, Phil;Cow, Christopher;Mutnick, Daniel;Nikulin, Victor;Lelais, Gerald;Mecom, John;McNeill, Matthew;Michellys, Pierre-Yves;Wang, Zhiliang;Reding, Esther;Paliotti, Michael;Li, Jing;Bao, Dingjiu;Zoll, Jocelyn;Kim, Young;Zimmerman, Matthew;Groessl, Todd;Tuntland, Tove;Joseph, Sean B.;McNamara, Peter;Seidel, H. Martin;Epple, Robert research published 《 Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists》, the research content is summarized as follows. Systematic SAR optimization of the GPR119 agonist lead 1, derived from an internal HTS campaign, led to compound 29. Compound 29 displays significantly improved in vitro activity and oral exposure, leading to GLP1 elevation in acutely dosed mice and reduced glucose excursion in an OGTT study in rats at doses ≥10 mg/kg.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Synthetic Route of 38256-93-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem