Category: 38256-93-8

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Name: 2-Methoxy-N-methylethanamine.

Miwa, Kazuhiro;Hitaka, Takenori;Imada, Takashi;Sasaki, Satoshi;Yoshimatsu, Mie;Kusaka, Masami;Tanaka, Akira;Nakata, Daisuke;Furuya, Shuichi;Endo, Satoshi;Hamamura, Kazumasa;Kitazaki, Tomoyuki research published 《 Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor》, the research content is summarized as follows. An orally active human gonadotropin-releasing hormone (GnRH) receptor antagonist, thieno[2,3-d]pyrimidine-2,4-dione derivative I (sufugolix), was previously discovered. To reduce the cytochrome P 450 (CYP) inhibitory activity and improve in vivo GnRH antagonistic activity, further optimization of this scaffold was carried out. The synthetic efforts were focused on chem. modification at the 5 and 3 positions of the thieno[2,3-d]pyrimidine-2,4-dione ring based on computational modeling, which resulted in the discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (II) as a highly potent and orally active GnRH antagonist. Compound II showed potent in vitro GnRH antagonistic activity in the presence of fetal bovine serum (FBS) without CYP inhibition. Oral administration of II maintained the suppressive effect of the plasma LH levels in castrated cynomolgus monkeys at a 3 mg/kg dose for more than 24 h. Compound II is currently under clin. development with the code name of TAK-385.

Name: 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Safety of 2-Methoxy-N-methylethanamine.

Miyazaki, Masaki;Naito, Hiroyuki;Sugimoto, Yuuichi;Kawato, Haruko;Okayama, Tooru;Shimizu, Hironari;Miyazaki, Masaya;Kitagawa, Mayumi;Seki, Takahiko;Fukutake, Setsuko;Aonuma, Masashi;Soga, Tsunehiko research published 《 Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold》, the research content is summarized as follows. With the aim of discovering potent inhibitors of the p53-MDM2 interaction and thus obtaining a potent anticancer drug, we have pursued synthesis and optimization of dihydroimidazothiazole derivatives, which have been discovered via scaffold hopping by mimicking the mode of interaction between MDM2 and Nutlins. Upon the discovery we encountered a problem involving the chem. instability of the scaffold, i.e., susceptibility to oxidation which led to imidazothiazole. In order to solve this problem and to obtain further potent compounds, we executed medicinal research and thus furnished the optimal compounds by incorporating the Me group onto the C-6 position to avoid the oxidation, and by modifying the C-2 moiety of the addnl. proline motif, which furnished high potency. The incorporation of the pyrrolidine moiety at the C-2 position raised another hydrophobic interaction site with MDM2 protein, which was generated by the induced-fitting observed by co-crystal structure anal. These optimal mols. showed significant improvement in potency when compared with the early leads.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Safety of 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Name: 2-Methoxy-N-methylethanamine.

Mohamad, Rapidah;Awang, Normah;Jotani, Mukesh M.;Tiekink, Edward R. T. research published 《 Distinct coordination geometries in bis[N,N-bis(2-methoxyethyl)dithiocarbamato-κ²S,S′]diphenyltin(IV) and bis[N-(2-methoxyethyl)-N-methyldithiocarbamato-κ²S,S′]diphenyltin(IV): crystal structures and Hirshfeld surface analysis》, the research content is summarized as follows. The crystal and mol. structures of two diphenyltin bis(dithiocarbamate)s, [Sn(C₆H₅)₂(C₅H₁₀NOS₂)₂], (I), and [Sn(C₆H₅)₂(C₇H₁₄NO₂S₂)₂], (II), are described. In (I), in which the metal atom lies on a twofold rotation axis, the dithiocarbamate ligand coordinates with approx. equal Sn-S bond lengths and the ipso-C atoms of the Sn-bound Ph groups occupy cis-positions in the resulting octahedral C₂S₄ donor set. A quite distinct coordination geometry is noted in (II), arising as a result of quite disparate Sn-S bond lengths. Here, the four S-donors define a trapezoidal plane with the ipso-C atoms lying over the weaker of the Sn-S bonds so that the C₂S₄ donor set defines a skewed trapezoidal bipyramid. The packing of (I) features supramol. layers in the ab plane sustained by methylene-C-H···π(Sn-aryl) interactions. In (II), supramol. chains along the b-axis direction are formed by methylene-C-O(ether) interactions; these pack with no directional interactions between them. A Hirshfeld surface anal. was conducted on both (I) and (II) and revealed the dominance of H···H interactions contributing to the resp. surfaces, i.e. >60% in each case, and other features consistent with the description of the mol. packing above.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Name: 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Safety of 2-Methoxy-N-methylethanamine.

Mohamad, Rapidah;Awang, Normah;Kamaludin, Nurul F.;Jotani, Mukesh M.;Tiekink, Edward R. T. research published 《 Di-n-butylbis[N-(2-methoxyethyl)-N-methyldithiocarbamato-κ²S,S′]tin(IV): crystal structure and Hirshfeld surface analysis》, the research content is summarized as follows. The complete mol. of the title compound, [Sn(C₄H₉)₂(C₅H₁₀NOS₂)₂], is generated by a crystallog. mirror plane, with the Sn^IV atom and the two inner methylene C atoms of the Bu ligands lying on the mirror plane; statistical disorder is noted in the two terminal Et groups, which deviate from mirror symmetry. The dithiocarbamate ligand coordinates to the metal atom in an asym. mode with the resulting C₂S₄ donor set defining a skew trapezoidal bipyramidal geometry; the Bu groups are disposed to lie over the longer Sn-S bonds. Supramol. chains aligned along the a-axis direction and sustained by methylene-C-H···S(weakly coordinating) interactions feature in the mol. packing. A Hirshfeld surface anal. reveals the dominance of H···H contacts in the crystal.

Safety of 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Application In Synthesis of 38256-93-8.

Mohamad, Rapidah;Awang, Normah;Kamaludin, Nurul Farahana;Jotani, Mukesh M.;Tiekink, Edward R. T. research published 《 Crystal structures and Hirshfeld surface analyses of bis[N,N-bis(2-methoxyethyl)dithiocarbamato-κ²S,S’]di-n-butyltin(IV) and [N-(2-methoxyethyl)-N-methyldithiocarbamato-κ²S,S’]triphenyltin(IV)》, the research content is summarized as follows. The crystal and mol. structures of the two title organotin dithiocarbamate compounds, [Sn(C₄H₉)₂(C₇H₁₄NO₂S₂)₂], (I), and [Sn(C₆H₅)₃(C₅H₁₀NOS₂)], (II), are described. Both structures feature asym. bound dithiocarbamate ligands leading to a skew-trapezoidal bipyramidal geometry for the metal atom in (I) and a distorted tetrahedral geometry in (II). The complete mol. of (I) is generated by a crystallog. twofold axis (Sn site symmetry 2). In the crystal of (I), mols. self-assemble into a supramol. array parallel to (10-1) via methylene-C-H···O(methoxy) interactions. In the crystal of (II), supramol. dimers are formed via pairs of weak phenyl-C-H···π(phenyl) contacts. In each of (I) and (II), the specified assemblies connect into a three-dimensional architecture without directional interactions between them. Hirshfeld surface analyses confirm the importance of H···H contacts in the mol. packing of each of (I) and (II), and in the case of (I), highlight the importance of short methoxy-H···H(butyl) contacts between layers.

Application In Synthesis of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. COA of Formula: C4H11NO.

Mohamad, Rapidah;Awang, Normah;Kamaludin, Nurul Farahana;Pim, Norraphat Uttraphan research published 《 Spectral characterization and X-Ray crystallographic studies of some triphenyltin(IV) dithiocarbamates compounds》, the research content is summarized as follows. Three novel triphenyltin(IV) compounds with N-(2-methoxyethyl)-N-methyldithiocarbamate (1), N-benzyl-N-phenethyldithiocarbamate (2) and N-methyl-N-hexyldithiocarbamate (3) ligands have been successfully synthesized via in situ insertion method. The newly synthesized compounds gave fairly sharp m.ps. indicating their purity and were successfully isolated as crystalline solids. All the compounds have been characterized by CHNS elemental anal., FT-IR, ¹H, ¹³C and ¹¹⁹Sn NMR spectroscopies. A single C-S vibration band around 1000cm^-1 was observed in all compounds, suggesting bidentate bonding of dithiocarbamate ligand to tin metal through both sulfur donor atoms. The crystal structures of all the compounds were determined by x-ray crystallog. All the compounds were crystallized in triclinic system. The single crystal x-ray diffraction data illustrated all three dithiocarbamato ligands are bidentate but in asym. fashion due to D (Sn-S) bond length and the geometry at the tin center is described as distorted trigonal bipyramidal.

COA of Formula: C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Recommanded Product: 2-Methoxy-N-methylethanamine.

Mohamad, Rapidah;Awang, Normah;FarahanaKamaludin, Nurul research published 《 Synthesis and characterization of new organotin (IV)(2-Methoxyethyl)- methyldithiocarbamate complexes》, the research content is summarized as follows. Three new organotin(IV) dithiocarbamate complexes (complexes 1-3) employing (2-methoxyethyl)-methylamine as their secondary amine were successfully synthesized in situ. Elemental anal. of the complexes gave the general formula of RnSn[S2CN(C2H4OCH3)(CH3)]n-2 where R = C4H9(Bu) and C6H5Phfor n = 2; R = C6H11 (Cy) for n = 3. The complexes were analyzed using FTIR and 1H, 13C, and 119Sn NMR. The important absorption peaks and chem. shift of NCS2 carbon were found in all the three complexes. 119Sn NMR suggested that tin atom in the complexes are coordinated by five and six coordination numbers

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Recommanded Product: 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Electric Literature of 38256-93-8.

Makino, Takuya;Ishida, Junya;Yamanaka, Toshio;Ohki, Hidenori;Uchida, Masao;Sawada, Masae;Barrett, David research published 《 Discovery of a novel 9-position modified second-generation anti-HCV candidate via bioconversion and semi-synthesis of FR901459》, the research content is summarized as follows. Evidence that hepatitis C virus (HCV) utilizes cellular cyclophilin proteins in the virus replication cycle has increased attention on cyclophilin inhibitors as attractive therapeutic targets in the treatment of HCV. Previous reports have described a number of non-immunosuppressive cyclophilin inhibitors, most of which require many synthetic steps for their preparation Sasamura et al. have previously reported the isolation of bioconversion derivative 4. This analog is a convenient starting point for optimization due to the presence of the readily modifiable primary hydroxyl group and because it shows moderate anti-HCV activity and decreased immunosuppressive activity. We have also established an efficient C-alkylation reaction at the 3-position. Through a detailed structure-activity relationship study, we discovered a new type of clin. candidate 14(I) which requires a short synthetic process and has potent anti-HCV activity and reduced immunosuppressive activity, as well as improved aqueous solubility and pharmacokinetics.

Electric Literature of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Recommanded Product: 2-Methoxy-N-methylethanamine.

Mammoliti, Oscar;Palisse, Adeline;Joannesse, Caroline;El Bkassiny, Sandy;Allart, Brigitte;Jaunet, Alex;Menet, Christel;Coornaert, Beatrice;Sonck, Kathleen;Duys, Inge;Clement-Lacroix, Philippe;Oste, Line;Borgonovi, Monica;Wakselman, Emanuelle;Christophe, Thierry;Houvenaghel, Nicolas;Jans, Mia;Heckmann, Bertrand;Saniere, Laurent;Brys, Reginald research published 《 Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis》, the research content is summarized as follows. Mounting evidence from the literature suggests that blocking S1P2 receptor (S1PR2) signaling could be effective for the treatment of idiopathic pulmonary fibrosis (IPF). However, only a few antagonists have been so far disclosed. A chem. enablement strategy led to the discovery of a pyridine series with good antagonist activity. A pyridazine series with improved lipophilic efficiency and with no CYP inhibition liability was identified by scaffold hopping. Further optimization led to the discovery of 40 (GLPG2938)(I), a compound with exquisite potency on a phenotypic IL8 release assay, good pharmacokinetics, and good activity in a bleomycin-induced model of pulmonary fibrosis.

Recommanded Product: 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Related Products of 38256-93-8.

Londregan, Allyn T.;Piotrowski, David W.;Wei, Liuqing research published ã€?Synthesis of Pyridazine-Based α-Helix Mimeticsã€? the research content is summarized as follows. A versatile synthesis of pyridazine-based small mol. α-helix mimetics is presented. Modular C-C, C-N, and C-O bond-forming reactions allow for the inclusion of a variety of aliphatic, basic, aromatic, and heteroaromatic side chain moieties. This robust synthesis is suitable for the preparation of small pyridazine-based libraries.

Related Products of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem