Category: 38256-93-8

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Safety of 2-Methoxy-N-methylethanamine.

Zhang, Yu;Yang, Xinye;Yao, Qizheng;Ma, Dawei research published 《 CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary Amines》, the research content is summarized as follows. DMPAO (I) has been found to be a powerful ligand to enable copper-catalyzed coupling of aryl halides with aliphatic acyclic secondary amines take place under relatively mild conditions, and coupling of aryl halides with primary amines and cyclic secondary amines proceeds at low catalyst loading.

Safety of 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. COA of Formula: C4H11NO.

Zhao, Hua;Martin, Caden J.;Larm, Nathaniel E.;Baker, Gary A.;Trujillo, Tyler C. research published 《 Enzyme activation by water-mimicking dual-functionalized ionic liquids》, the research content is summarized as follows. Biocatalytic synthesis represents a green alternative to metal-catalyzed reactions. However, enzymes typically display much lower catalytic activities in nonaqueous solvents than in aqueous media. To mimic the aqueous environment for enzyme activation, this study designed a series of sixteen dual-functionalized ionic liquids (ILs) that contain both glycol ether (hydrogen-bond acceptor) and tert-alc. (hydrogen-bond donor) groups. These “water-like” ILs enabled high transesterification activities for immobilized Candida antarctica lipase B (CALB) known as Novozym 435 and immobilized Bacillus licheniformis protease (known as subtilisin A), resp. Several water-mimicking ILs containing 2-3 vol% water significantly increased the CALB activity by 1.8-fold of that in tert-butanol, and 1.6-fold of that in diisopropyl ether (both organic solvents are highly enzyme-compatible). To a smaller degree, subtilisin was activated by these ionic solvents up to 1.2-fold (with 100% selectivity at 2 vol% water) than by diisopropyl ether. Fluorescence emission spectra suggested that the characteristic emission maximum peaks were maintained in “water-like” ILs in most cases.

COA of Formula: C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Application of C4H11NO.

Zhao, Junjun;Gou, Shaohua;Zhang, Xiaobing;Liang, Yan;Fang, Lei research published 《 Novel [1,2,4] Triazol [4,3-a] Pyridine Derivatives as Potential Selective c-Met Inhibitors with Improved Pharmacokinetic Properties》, the research content is summarized as follows. Total twenty-nine [1,2,4]triazolo[4,3-a]pyrazine derivatives were designed and synthesized. The target compounds, especially 4aa, showed potent activity to inhibit c-Met both in an enzyme assay and a cellular assay. The comprehensive screening for the inhibition of 60 different kinases revealed that 4aa could selectively inhibit c-Met while had no effect on other kinases, indicating 4aa is an excellent c-Met selective inhibitor. The flow cytometry studies found that 4aa had a similar behavior to the pos. control SGX-523 in terms of causing the tumor cell apoptosis and blocking cell-cycle progression. More importantly, 4aa showed much better pharmacokinetic properties than SGX-523. Altogether, the findings suggested the target compounds may be potential anti-tumor drug candidates.

Application of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Quality Control of 38256-93-8.

Zhou, Jingwei;Li, Lamei;Wang, Songping;Yan, Ming;Wei, Wentao research published 《 Catalyst-free photodecarbonylation of ortho-amino benzaldehydes》, the research content is summarized as follows. A catalyst-free photodecarbonylation of the aldehydes I (R = H, 2-F, 4-Br, 3-CN, etc.; R¹ = Me, Et, n-Bu, Bn; R² = Me, prop-2-en-1-yl, Bn, etc.; R¹R² = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₆-, etc.) based on the conformational-selectivity design strategy has been discovered. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into the ortho-position of the aldehyde group. A diverse array of tertiary amines II is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Quality Control of 38256-93-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Related Products of 38256-93-8.

Zhou, Jingwei;Wang, Songping;Duan, Wentao;Lian, Qi;Wei, Wentao research published 《 Catalyst-free photoinduced selective oxidative C(sp³)-C(sp³) bond cleavage in arylamines》, the research content is summarized as follows. Due to the directional nature of sp³-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp³)-C(sp³) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on authors’ well-designed C-C single bond cleavage mechanism, authors discovered a means of photoinduced selective oxidative C(sp³)-C(sp³) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O₂ as a benign oxidant under very mild conditions. The utility of methodol. was demonstrated by the C(sp³)-C(sp³) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, this methodol. is noteworthy, not only it does not require any catalysts, but also it provides valuable possibilities for the scalable functionalization of clin. drugs and natural products.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Related Products of 38256-93-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Name: 2-Methoxy-N-methylethanamine.

Zhou, Yuntao;Ye, Hebo;You, Lei research published 《 Reactivity-Based Dynamic Covalent Chemistry: Reversible Binding and Chirality Discrimination of Monoalcohols》, the research content is summarized as follows. In an effort to develop reactivity-based dynamic covalent bonding and to expand the scope and application of the dynamic covalent chem., in situ-generated simple generic iminium ions were utilized for the dynamic covalent binding of monoalcs. with high affinity. Hammett anal. was conducted to manipulate the equilibrium and correlate with the reactivity of reactants. The structural features of aldehydes and secondary amines were identified, and both polar and steric effects have significant impact on the binding. In particular, the substrates which can participate in π-π and polar-π interactions are able to afford apparent equilibrium constants in the magnitude of 10⁴ M^-2, demonstrating the power of weak supramol. forces to stabilize the dynamic covalent assembly. The generality of the assembly was validated with a series of mono secondary alcs. To showcase the practicality of our system, chirality discrimination and ee measurement of chiral secondary alcs. were achieved.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Name: 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application In Synthesis of 38256-93-8.

Zhu, Yuqin;Ma, Yuxiang;Zu, Weidong;Song, Jianing;Wang, Hua;Zhong, You;Li, Hongmei;Zhang, Yanmin;Gao, Qianqian;Kong, Bo;Xu, Junyu;Jiang, Fei;Wang, Xinren;Li, Shuwen;Liu, Chenhe;Liu, Haichun;Lu, Tao;Chen, Yadong research published 《 Identification of N-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis》, the research content is summarized as follows. A series of N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives with NF-κB inducing kinase (NIK) inhibitory activity were obtained through structure-based drug design and synthetic chem. Among them, 4-(3-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-morpholinophenyl)-2-(thiazol-2-yl)but-3-yn-2-ol (12f)(I) was identified as a highly potent NIK inhibitor, along with satisfactory selectivity. The pharmacokinetics of 12f and its ability to inhibit interleukin 6 secretion in BEAS-2B cells were better than compound 1 developed by Amgen. Oral administration of different doses of 12f in an imiquimod-induced psoriasis mouse model showed effective alleviation of psoriasis, including invasive erythema, swelling, skin thickening, and scales. The underlying pathol. mechanism involved attenuation of proinflammatory cytokine and chemokine gene expression, and the infiltration of macrophages after the treatment of 12f. This work provides a foundation for the development of NIK inhibitors, highlighting the potential of developing NIK inhibitors as a new strategy for the treatment of psoriasis.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Application In Synthesis of 38256-93-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application of C4H11NO.

Xu, Xianjun;Feng, Huangdi;Van der Eycken, Erik V. research published 《 Microwave-Assisted Cu(I)-Catalyzed Synthesis of Unsymmetrical 1,4-Diamino-2-butynes via Cross-A³-Coupling/Decarboxylative A³-Coupling》, the research content is summarized as follows. 1,4-Diamino-2-butynes display both chem. and physiol. properties. Here a highly efficient synthesis avenue to generate unsym. 1,4-diamino-2-butynes has been developed by microwave-assisted Cu(I)-catalyzed cross-A3-coupling/decarboxylative coupling of two different amines, formaldehyde, and propiolic acid through a domino process. This multicomponent reaction provides a series of target products in moderate to good yields with high chemoselectivity.

Application of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Safety of 2-Methoxy-N-methylethanamine.

Yamazaki, Shoko;Naito, Taku;Tatsumi, Taiki;Kakiuchi, Kiyomi research published 《 Synthesis of Piperidines via Intramolecular Hydride Transfer from α-Amino sp³ Carbon Atoms to Ethenetricarboxylate-Derived Fragments and Further Cyclization》, the research content is summarized as follows. The cyclization of amides derived from ethenetricarboxylic acid bearing tert-amino groups wsa examined The amides were efficiently converted to piperidine derivatives (2-piperidones) upon heating in a polar solvent (e. g., DMSO or DMF) via intramol. hydride transfer and subsequent ring closure. The reaction was less efficient in the presence of a Lewis acid. The reactivity varies depending on the alkyl substituents of tert-amino groups, probably due to steric effects. The hydride transfer/cyclization mechanism was investigated by DFT calculations The reaction of the carboxylic acid and relatively bulky diamines such as diisopropyl-substituted diamine in the presence of amide condensation reagents at 60 ° gave the piperidine derivatives in a one-pot reaction. The reaction of the diisopropylamine substituted piperidine product with primary amines gave secondary amine-substituted piperidines.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Safety of 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Reference of 38256-93-8.

Yamazaki, Shoko;Naito, Taku;Niina, Mamiko;Kakiuchi, Kiyomi research published 《 Lewis Acid Catalyzed Cyclization Reactions of Ethenetricarboxylates via Intramolecular Hydride Transfer》, the research content is summarized as follows. Catalytic cyclization of amides of ethenetricarboxylate bearing ether and acetal groups has been examined The reaction of the amides bearing cyclic ether and acetal groups in the presence of Lewis acid such as Sc(OTf)₃ gave spirocyclic piperidine derivatives as major products. The cyclized products may be formed via intramol. hydride transfer. The reaction mechanism was examined by the DFT calculations The scope and limitations of the hydride transfer/cyclization reactions of amides of ethenetricarboxylates was investigated, and morpholine formation by intramol. oxy-Michael addition was also found.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Reference of 38256-93-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem