Category: 36865-41-5

Electric Literature of 36865-41-5,Some common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred mixture of 51d (1.00 g, 1 eq) in DMSO (8 mL), is added Cs2CO3 (3.51 g, 3 eq). After stirring for 5 min, 2-bromoethyl methylether (0.62 mL, 1.5 eq) is added and the solution is stirred at RT during 18 h. The reaction mixture is quenched with H2O, extracted with EtOAc (3×), the combined organic extracts are washed with H2O (3×), brine, dried over Na2SO4 and concentrated. The resulting residue is purified by flash chromatography Hex/EtOAc (1:1) to give 51e (1.20 g, 98%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3-methoxypropane, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/261714; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 36865-41-5

To a solution of 4-bromo-1H-pyrazole (1.5 g, 10 mmol) in DMF (15 mL) were added cesium carbonate (5.1 g, 16 mmol) and 1-bromo-3-methoxypropane (1.6 mL, 14 mmol) . The mixture was stirred at rt for 8 h and diluted with water (30 mL) . The resulting mixture was extracted with DCM (30 mL × 3) . The combinded orgainc layers were dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE/EtOAc (v/v) 2/1 to give a light yellow oil product (2.1 g, 94) .[1268]MS (ESI, pos. ion) m/z: 219.1, 221.1 [M+1]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36865-41-5, its application will become more common.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHANG, Yingjun; CHENG, Changchung; HUANG, Jiuzhong; BAI, Shun; REN, Xingye; LI, Zhi; ZHOU, Youbai; (368 pag.)WO2016/615; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 36865-41-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36865-41-5, name is 1-Bromo-3-methoxypropane, This compound has unique chemical properties. The synthetic route is as follows.

A stirred solution of intermediate 23 (0.21 g, 0.53 mmol) in DMF (4.0 ml) at ambienttemperature was treated with sodium hydride (60% in mineral oil, 0.023 g, 0.58 mmol). After 5 minutes, the mixture was treated with 1 -bromo-3-methoxypropane (0.09 g, 0.58 mmol) and the resulting mixture was stirred at 50 C for 2.0 hours. The mixture was cooled to ambient temperature and partitioned between EtOAc and brine. The organic phase was dried over Na2SO4 and concentrated in vacuo. Trituration of the residue withEt20 afforded the desired product as a yellow solid (0.21 g, 88%). LCMS (Method B): R= 4.43 mi mlz [M+Hjb = 466/468/470.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3-methoxypropane. I believe this compound will play a more active role in future production and life.

36865-41-5, name is 1-Bromo-3-methoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 36865-41-5

To a solution of the compound of Reference Example 50 (114.3 mg, 0.182 mmol) in DMF (2 mL), potassium carbonate (50.3 mg, 0.364 mmol) and 1-bromo-3-methoxypropane (41.8 mg, 0.273 mmol) were added, and the mixture was stirred at 50C for 1 hour. A saturated aqueous solution of ammonium chloride was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of ammonium chloride twice and with a saturated saline solution once, then dried over sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain the title compound (121.2 mg, 95%). MS (ESI+) 700 (M+1, 68%)

The synthetic route of 36865-41-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36865-41-5, name is 1-Bromo-3-methoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: ethers-buliding-blocks

[00449] To a 100 mL single-neck flask were added 4-bromo-1 H-pyrazole (3.0 g, 20 mmol), 1-bromo-3-methoxypropane (3.7 g, 24 mmol), cesium carbonate (13 g, 39.90 mmol) and DMF (30 mL). The mixture was heated to 50 C and stirred overnight. The mixture was cooled to rt and to the mixture was added water (50 mL). The mixture was extracted with DC M (50 mL B 4).The combined organic layers were concentrated in vacuo, and the residue was purified by silica gel column chromatography (PE/EA (VN) = 1/1) to give the title compound as colorless oil (4.3 g, 20 mmol, 96%).MS (ESI, pos.ion) m/z: 219.0 [M÷H].

The synthetic route of 36865-41-5 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-3-methoxypropane

(R)-tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (7B) (9.95 mmol, 3.0 g) was added to a 200 mL round-bottomed flask equipped for stirring under nitrogen. DMF (50 mL) was added and the resultant solution was cooled to 0 C. with an ice bath. NaH (60% in mineral oil, 11.95 mmol, 0.478 g) was then added and the subsequent solution was allowed to stir under nitrogen for 0.5 hr. At this time 1-bromo-3-methoxypropane (12.44 mmol, 1.90 g) was added, the ice bath was removed and the reaction solution was allowed to warm to room temperature and stir fort hr. The reaction solution was then poured into ice-water, extracted with ethyl acetate, and washed once with saturated aqueous sodium chloride. The organic layer was collected and subsequently dried with anhydrous Na2SO4 and filtered. This filtrate was collected, concentrated, and dried in-vacuo affording a brown oil. This material was then purified by chromatography on silica gel (3-10% CH3OH in CH2Cl2) to afford (R)-tert-butyl 3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (7C) as a brown oil (9.63 mmol, 3.6 g, 96% yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.55-1.71 (br.s., 1H) 1.79-1.88 (br.s., 1H) 2.04-2.13 (m, 4H) 2.74-2.88 (br.s., 1H) 2.98-3.38 (m, 7H) 4.21-4.39 (m, 3H) 7.22-7.28 (m, 2H) 7.34-7.40 (dd, 1H, 6.57 Hz, 2.02 Hz) 7.72-7.77 (dd, 1H, 6.57 Hz, 2.02 Hz). ESI-MS: m/z 374.4 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36865-41-5, its application will become more common.

Application of 36865-41-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36865-41-5 as follows.

A 250 mL round-bottomed flask was charged with 5-bromo-2-chloro-phenol (22 g, 106 mmol), 1-bromo-3-methoxy-propane (19.5 g, 127 mmol), K2CO3 (30 g, 212 mmol) and DMF (50 mL). The resultant mixture was stirred at 50 C. for 3 hours, then ethyl acetate and water were added. The organic phase was separated, and then dried over anhydrous Na2SO4 and then concentrated to give 4-bromo-1-chloro-2-(3-methoxypropoxy)benzene (30 g).

According to the analysis of related databases, 36865-41-5, the application of this compound in the production field has become more and more popular.

Related Products of 36865-41-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36865-41-5 name is 1-Bromo-3-methoxypropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 5-bromo-2-chloro-phenol (22.0 g, 106 mmol), l-bromo-3-methoxy-propane (19.5 g, 127 mmol) and K2C03 (30 g, 212 mmol) in DMF (50 mL) was heated at 50 C for 3 hrs. Then the mixture was partitioned between ethyl acetate and water. The organic layer was separated, dried over anhydrous Na2S04 and concentrated under reduced pressure to give crude 4-bromo-l-chloro-2-(3-methoxypropoxy)benzene (30.0 g), which was used directly in the next step without further purification

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-3-methoxypropane, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xingchun; JIANG, Min; YANG, Song; (109 pag.)WO2016/128335; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36865-41-5, name is 1-Bromo-3-methoxypropane, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H9BrO

A solution of compound of Formula-Ill (lOOg) in toluene (600 ml) and Dimethylsulfoxide (60 ml) was added to potassium carbonate (185g) and l-Bromo-3-methoxypropane (130g) at 25-30C. The resulting reaction mixture was stirred at 85- 90C for 16h. After cooling, the solid was filtered and washed with water. The toluene layer of compound of Formula-IV was cooled to 0-5C and sodium borohydride (9gm) was added. To this reaction mixture methanol (50 ml) was added drop wise at 0-5C over a period of lh and stirred the reaction mixture at the same temperature for 2h. The reaction was quenched with dilute hydrochloric acid and stirred for 30 minutes. pH of the reaction mixture was adjusted to 7.0-7.5 with aq. Sodium hydroxide solution. Organic layer was separated and aqueous layer was extracted with toluene. Combined organic layers were dried and evaporated under reduced pressure to give compound of Formula- IV as residue. The residue was dissolved in dichloromethane and added to a solution of thionyl chloride in dichloromethane at 0-5C over a period of lh and stirred the reaction mixture at the same temperature for 2h. Dichloromethane was distilled under reduced pressure at 30-35C till no more distillate was collect. The compound was re-crystallized in hexanes to give tile compound as white solid. Yield: 125g; GC purity: 99%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MYLAN LABORATORIES LIMITED; RAMA, Shankar; VADALI, Lakshmana Rao; MANUKONDA, Seshadri rao; POTLA, Venkata Srinivas Rao; VADLAMUDI, Mohana Vamsi Krishna; DASARI, Srinivasa Rao; WO2013/171767; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 36865-41-5, name is 1-Bromo-3-methoxypropane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36865-41-5, Formula: C4H9BrO

To a suspension of Mg (911 mg, 37.5 mmol) and of iodine (one crystal) in dry THF (30 mL) was added dropwise 5% of the total amount of 1-bromo-3-methoxypropane (4.59 g, 30.0 mmol). The mixture was heated to reflux with the help of a heat gun until the Grignard formation had started. The rest of the 1-bromo-3-methoxypropane was added slowly, while an exothermic reaction proceeded. After the end of the addition, the reaction mixture was stirred under reflux for 20 min, and was allowed to cool to rt. This Grignard sol. (1M in THF, 23.5 mL, 23.5 mmol) was added dropwise to a mixture of 2-bromo-5-chloro-4-dimethoxymethyl-pyridine (2.50 g, 9.38 mmol) and Ni(dppp)Cl2 (495 mg, 0.938 mmol) in THF (50 mL) at 0 C. The reaction mixture was stirred at rt for 30 min, and was then heated to reflux for 2 h. The mixture was allowed to cool to rt, and was dissolved with EtOAc. This mixture was washed with aq. sat. NaHCO3. The org. layer was dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane?EtOAc/heptane 1:1) yielded the title compound (1.51 g, 62%). LC-MS: tR=0.80 min; ES+: 260.15.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-3-methoxypropane, and friends who are interested can also refer to it.

Reference:
Patent; Actelion Pharmaceuticals Ltd.; US2009/62342; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem