Category: 33797-34-1

Quality Control of (3-Methoxy-2-methylphenyl)methanolOn May 4, 2018 ,《α-Ketocarbenium Ions Derived from Orthoquinone-Containing Polycyclic Aromatic Compounds》 appeared in Organic Letters. The author of the article were Urakawa, Kazuki; Kawabata, Yuta; Matsuda, Masaki; Sumimoto, Michinori; Ishikawa, Hayato. The article conveys some information:

α-Ketocarbenium ions derived from synthesized orthoquinone-containing polycyclic aromatic compounds were generated in the presence of Bronsted acids such as sulfuric acid, trifluoromethanesulfonic acid, and fluorosulfonic acid. The prepared α-ketocarbenium ions were stabilized by conjugation of the aromatic moiety. In addition, unique absorption properties of the α-ketocarbenium ions were observed and identified on the basis of the calculated absorption spectra. It was suggested that the zigzag-shaped architecture stabilizes the newly discovered α-ketocarbenium ions derived from orthoquinone-containing polycyclic aromatic compounds The experimental process involved the reaction of (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Quality Control of (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Quality Control of (3-Methoxy-2-methylphenyl)methanolAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Wan Shin; Shalit, Zachary A.; Nguyen, Sidney M.; Schoepke, Emmalie; Eastman, Alan; Burris, Thomas P.; Gaur, Arti B.; Micalizio, Glenn C. published their research in Nature Communications on December 31 ,2019. The article was titled 《A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ》.Name: (3-Methoxy-2-methylphenyl)methanol The article contains the following contents:

A concise asym. route to forging natural and unnatural (enantiomeric) C19 and C20 tetracyclic terpenoid skeletons (1S,13S,15R)/(1R,13R,15S)/(1S,13R,15S)/(1R,13S,15R)-I (R = H, Me) and (2S,13S,15R)/(2R,13R,15S)-II (R1 = H, Me) suitable to drive medicinal exploration was reported. While efforts have been focused on establishing the chem. science, early investigations reveal that the emerging chem. technol. can deliver compositions of matter that are potent and selective agonists of the estrogen receptor beta, and that are selectively cytotoxic in two different glioblastoma cell lines (U251 and U87). In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Name: (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: (3-Methoxy-2-methylphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products》 was written by Gilmartin, Philip H.; Kozlowski, Marisa C.. Computed Properties of C9H12O2 And the article was included in Organic Letters on April 17 ,2020. The article conveys some information:

A mild and efficient method for the vanadium-catalyzed intramol. coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor. The experimental part of the paper was very detailed, including the reaction process of (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Computed Properties of C9H12O2)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Computed Properties of C9H12O2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: (3-Methoxy-2-methylphenyl)methanolOn March 11, 2000, Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav published an article in Tetrahedron Letters. The article was 《Synthesis of isothiochroman 2,2-dioxide and 1,2-benzoxathiin 2,2-dioxide gyrase B inhibitors》. The article mentions the following:

The design, synthesis, and in-vitro biol. evaluation of isothiochroman 2,2-dioxide and 1,2-benzoxathiin 2,2-dioxide analogs of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzoxathiin 2,2-dioxide series display improved inhibitory potency in neg. supercoiling of relaxed DNA gyrase. In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Recommanded Product: (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Recommanded Product: (3-Methoxy-2-methylphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Steroid compounds. IX. Experiments on the synthesis of conessine. Synthesis of tetracyclic intermediates》 was published in Indian Journal of Chemistry in 1971. These research results belong to Mukharji, P. C.; Sircar, J. C.; Devasthale, V. V.. Application of 33797-34-1 The article mentions the following:

Condensation of 2-(2-methyl-3-methoxyphenyl)ethyl bromide with dimethyl cyclopentanone-2,3-dicarboxylate followed by cyclodehydration, catalytic hydrogenation and conversion of the secondary methoxycarbonyl group to a methyl ketone gave I. This, on Leuckart reaction with MeNHCHO gave stereospecifically II, which on reduction and demethylation gave the III, corresponding to the BCDE rings of conessine. Leuckart reaction of I and IV with HCONH2 gave a mixture of two epimeric lactams, in contrast to complete stereospecificity observed in the reaction with MeNHCHO. In addition to this study using (3-Methoxy-2-methylphenyl)methanol, there are many other studies that have used (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Application of 33797-34-1) was used in this study.

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application of 33797-34-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kurata, Haruto; Kusumi, Kensuke; Otsuki, Kazuhiro; Suzuki, Ryo; Kurono, Masakuni; Komiya, Takaki; Hagiya, Hiroshi; Mizuno, Hirotaka; Shioya, Hiroki; Ono, Takeji; Takada, Yuka; Maeda, Tatsuo; Matsunaga, Norikazu; Kondo, Tetsu; Tominaga, Sachiko; Nunoya, Ken-ici; Kiyoshi, Hidekazu; Komeno, Masaharu; Nakade, Shinji; Habashita, Hiromu published their research in Journal of Medicinal Chemistry on December 14 ,2017. The article was titled 《Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases》.Product Details of 33797-34-1 The article contains the following contents:

The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine3-carboxylic acid (I) (13n, ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5, is described. While it has been revealed that the modulation of the S1P1 receptor is an effective way to treat autoimmune diseases such as relapsing-remitting multiple sclerosis (RRMS), it was also reported that activation of the S1P3 receptor is implicated in some undesirable effects. The authors carried out a structure-activity relationship (SAR) study of hit compound 6 with an amino acid moiety in the hydrophilic head region. Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of I as a clin. candidate that exhibited >30 000-fold selectivity for S1P1 over S1P3 and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED50 = 0.029 mg/kg, 24 h after oral dosing). In the experimental materials used by the author, we found (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Product Details of 33797-34-1)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of 33797-34-1 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Brown, Charles; Sikkel, Bernardus J.; Carvalho, Christopher F.; Sargent, Melvyn V. published their research in Journal of the Chemical Society on December 31 ,1982. The article was titled 《A new phenanthrene synthesis》.Safety of (3-Methoxy-2-methylphenyl)methanol The article contains the following contents:

Treatment of substituted (Z)-2-chlorostilbenes with activated Mg, prepared by reduction of MgCl2 with K in THF containing KI, gave phenanthrenes. E.g., treatment 2-ClC6H4CH:CHC6H4R-2 (R = H, OMe) with activated Mg in refluxing THF for 12 h gave phenanthrenes I (R = H, OMe) in 83 and 76% yield, resp. The reaction mechanism involves homolytic substitution. The experimental process involved the reaction of (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Safety of (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Safety of (3-Methoxy-2-methylphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C9H12O2On October 22, 2015 ,《Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists》 was published in Journal of Medicinal Chemistry. The article was written by Taylor, Simon J.; Demont, Emmanuel H.; Gray, James; Deeks, Nigel; Patel, Aarti; Nguyen, Dung; Taylor, Maxine; Hood, Steve; Watson, Robert J.; Bit, Rino A.; McClure, Fiona; Ashall, Holly; Witherington, Jason. The article contains the following contents:

This article describes the finding of substantial upregulation of mRNA and enzymes of the cytochrome P 450 1A family during a lead optimization campaign for small mol. S1P1 agonists. Fold changes in mRNA up to 10 000-fold for CYP1A1 in vivo in rat and cynomolgus monkey and up to 45-fold for CYP1A1 and CYP1A2 in vitro in rat and human hepatocytes were observed Challenges observed with correlating induction in vitro and induction in vivo resulted in the implementation of a short, 4 day in vivo screening study in the rat which successfully identified noninducers. Subtle structure-activity relationships in this series of S1P1 agonists are described extending beyond planarity and lipophilicity, and the impact and considerations of AhR and CYP1A induction in the context of drug development are discussed. In addition to this study using (3-Methoxy-2-methylphenyl)methanol, there are many other studies that have used (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Electric Literature of C9H12O2) was used in this study.

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Electric Literature of C9H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Syntheses related to etiojervane. III. The synthesis of 1,8-dimethyl – 7 – methoxy – 1,2,3,4,4a,9a – hexahydrofluoren – 2-one》 was published in Journal of Organic Chemistry in 1962. These research results belong to Barnes, Roderick A.; Sedlak, Michael. Application of 33797-34-1 The article mentions the following:

cf. CA 57, 2156h. The cyclization of 1-(methoxybenzyl)cyclohexanol did not yield a hexahydrofluorene but rather a substance believed to be 2-methoxy-5,6,7,8,9,10-hexahydro-5,9-methano-benzocyclooctene (I). In an alternate approach the alkylation of Hagemann’s ester with benzyl chloride was found to take place at the 2-position. The alkylation products from benzyl chloride and substituted benzyl chlorides could be cyclized either before or after reduction of the double bond to fluorene derivatives The carboxyl group of 7-methoxy-1,8-dimethyl-1,2,3,4,4a,9a-hexahydrofluorene-2-carboxylic acid was degraded to yield II, which should be readily convertible to a degradation product of jervine. In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Application of 33797-34-1)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Application of 33797-34-1 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Herdman, Christine A.; Devkota, Laxman; Lin, Chen-Ming; Niu, Haichan; Strecker, Tracy E.; Lopez, Ramona; Liu, Li; George, Clinton S.; Tanpure, Rajendra P.; Hamel, Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G. published their research in Bioorganic & Medicinal Chemistry on December 15 ,2015. The article was titled 《Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization》.Related Products of 33797-34-1 The article contains the following contents:

The discovery of 3-methoxy-9-(3′,4′,5′-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol (a benzosuberene-based analog referred to as KGP18) was originally inspired by the natural products colchicine and combretastatin A-4 (CA4). The relative structural simplicity and ease of synthesis of KGP18, coupled with its potent biol. activity as an inhibitor of tubulin polymerization and its cytotoxicity (in vitro) against human cancer cell lines, has resulted in studies focused on new analog design and synthesis. The goal was to probe the relationship of structure to function in this class of anticancer agents. A series of twenty-two new benzosuberene-based analogs of KGP18 was designed and synthesized. These compounds vary in their methoxylation pattern and sep. incorporate trifluoromethyl groups around the pendant aryl ring for the evaluation of the effect of functional group modifications on the fused six-membered aromatic ring. In addition, the 8,9-saturated congener of KGP18 has been synthesized to assess the necessity of unsaturation at the carbon atom bearing the pendant aryl ring. Six of the mols. from this benzosuberene-series of compounds were active (IC50 < 5 μM) as inhibitors of tubulin polymerization while four analogs were comparable (IC50 approx. 1 μM) in their tubulin inhibitory activity to CA4 and KGP18. The potency of a bis-trifluoromethyl analog I and the unsaturated KGP18 derivative II as inhibitors of tubulin assembly along with their moderate cytotoxicity suggested the potential utility of these compounds as vascular disrupting agents (VDAs) to selectively target microvessels feeding tumors. Accordingly, water-soluble and DMSO-soluble phosphate prodrug salts of each were synthesized for preliminary in vivo studies to assess their potential efficacy as VDAs. In the part of experimental materials, we found many familiar compounds, such as (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Related Products of 33797-34-1)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Related Products of 33797-34-1 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem