Category: 33170-72-8

Synthetic Route of 33170-72-8, The chemical industry reduces the impact on the environment during synthesis 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, I believe this compound will play a more active role in future production and life.

A mixture of compound 2-bromofuranylpropionaldehyde dimethyl acetal (1.0 g, 4.74 mmol) and hydrochloric acid (1 M, 3 mL) was heated to 90C and stirred for 1 hour. The reaction solution was cooled to room temperature and then neutralized to pH of 7 with a solid of sodium bicarbonate. Then 2-amino-5-bromopyridine (360 mg, 2.08 mmol) and methanol (5 mL) were added successively, and the reaction solution was heated to 90C and stirred overnight. The reaction solution was evaporated under reduced pressure to remove the organic solvent, diluted with water (10 mL) and dichloromethane. The organic layer was seperated, washed with water, saturated brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give a crude product, which was purified by silica gel column chromatography to give compound 31-a as a gray solid (250 mg, 57%). LC-MS (ESI): m/z = 210.9 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,1-dimethoxypropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Yingli Pharmaceutical Co. Ltd.; XU, Zusheng; LOU, Yangtong; CHEN, Li; (95 pag.)EP3492461; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, A new synthetic method of this compound is introduced below., Recommanded Product: 33170-72-8

[0157] To a stirred solution of 3,5-bis(methylthio)-l ,2,4-triazin-6-amine (10.0 g, 53.19 mmol) and 2-bromo- 1 , 1 -dimethoxypropane (19.6 g, 319.14 mmol, 2 times added), in CH3CN (120 mL) was added (+/-)-camphor-10-sulfonic acid (3.70 gm, 15.95 mmol) and MS-4A (2 g). and the mixture was heated at 85 C for 40 h. The mixture was cooled to RT and concentrated under reduced pressure to reduce the volume to 30 mL. The obtained solid was filtered and washed with CH3CN (10 mL). The solid was dissolved in 20% MeOH in CH2CI2 and filtered, and the filtrate was concentrated under reduced pressure to afford 7- methyl-2,4-bis(methylthio)imidazo[l ,2-f][1,2,4]triazine as a pale brown solid (7 g, 58%). 1H NMR (300MHz, DMSO-J6) delta 7.59 (br s, IH), 2.63 (s, 3H), 2.60 (s, 3H), 2.48 (s, 3H); MS (ESI) m/z 227.12 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KALYRA PHARMACEUTICALS, INC.; BUNKER, Kevin, Duane; ABRAHAM, Sunny; HOPKINS, Chad, Daniel; PINCHMAN, Joseph, Robert; HUANG, Peter, Qinhua; SLEE, Deborah, Helen; (122 pag.)WO2016/183094; (2016); A1;,
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Synthetic Route of 33170-72-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33170-72-8 name is 2-Bromo-1,1-dimethoxypropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of methyl 5-amino-6-bromopyrazine-2-carboxylate (500 mg, 2.15 mmol, 1.00 equiv), 2-bromo-1,1-dimethoxypropane (1.2 g, 6.56 mmol, 3.00 equiv), p-toluenesulfonic acid (76 mg, 0.44 mmol, 0.20 equiv) in acetonitrile (20 mL) was stirred for 12 h at 80 C. The mixture was concentrated under vacuum and the residue was purified by a silica gel column eluting with dichloromethane/methanol (10:1). This resulted in 400 mg (69%) of the title compound as a yellow solid. LC-MS (ES, m/z): 270 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1,1-dimethoxypropane, and friends who are interested can also refer to it.

Reference:
Patent; Genentech, Inc.; Blaquiere, Nicole; Castanedo, Georgette; Feng, Jianwen A.; Hu, Baihua; Staben, Steven; Yuen, Po-wai; Wu, Guosheng; Lin, Xingyu; Burch, Jason; US2015/57260; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 33170-72-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 2: 1-(4-Bromo-pyridin-2-yl)-4,4-dimethoxy-butan-1-one (2)To a solution of (1) (8.86 g, 36.2 mmole) in 250 mL of anhydrous THF in a 3-neck flamed dried round bottom flask at -70 C. (acetone-dry ice bath) is slowly added the Grignard reagent prepared from bromopropionaldehyde dimethyl acetal (16.5 g, 90.4 mmol) and Mg turnings (4.39 g, 181 mmol) in anhydrous THF (250 mL), maintaining internal temperature around -68 C. to -70 C. After stirring at -70 C. for 2 hours, the reaction mixture is diluted with 200 mL of water with the dry ice bath removed. The mixture is poured into a separatory funnel, and the mixture is extracted 3 times with ethyl acetate (150 mL). The organic layers are combined and dried over Na2SO4 and the solvent evaporated leaving a thick yellow oil (11 g, 100% crude yield, MS ES+258.02).

The synthetic route of 2-Bromo-1,1-dimethoxypropane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Norvartis AG; US2011/65726; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 33170-72-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33170-72-8 as follows.

2-Bromo-1,1-dimethoxypropane (2a) (18 g, 98.34 mmol) was dissolved in chloroform (100 mL), trifluoroacetic acid (67.28 g, 590.03 mmol) was added and reacted at room temperature for 4 hours. The reaction solution was added with dichloromethane (30 mL) and water (15 mL), and the layers were extracted.The organic phase was washed with saturated brine (100 mL x 4), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure at 30 C to give the title compound 2b as a yellow liquid (5 g, 37% yield).

According to the analysis of related databases, 33170-72-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Wei Yonggang; Qiu Guanpeng; Lei Bolin; Li Yao; Wang Song; Zhu Guozhi; (39 pag.)CN106279128; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 33170-72-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33170-72-8 as follows.

[0322] To a stirred solution of iV-hydroxy-6-methoxy-5-(4-methyl- 1H-imidazol- 1-yl) picolinimidamide (1 g, 4 mmol) in DMSO (5 mL) at 0 C under an argon atmosphere were added potassium hydroxide (272 mg, 5 mmol) and 2-bromo-1,1-dimethoxypropane (814 mg, 4 mmol). The reaction mixture was warmed to room temperature and stirred for 24 h. After consumption of the starting material (monitored by TLC), the reaction mixture was diluted with ice cold water (30 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain N-((1,1- dimethoxypropan-2-yl) oxy)-6-methoxy-5-(4-methyl- 1 H-imidazol- 1 -yl) picolinimidamide Example 3 (300 mg, crude) as an off-white solid used in the next step without further purification. LCMS: 46.2%; 349.9 (M+1); (column; Ascentis Express C-18 (50 x 3.0 mm, 2.7tim); RT 1.63 mm; mobile phase: 0.025% Aq TFA+5% ACN: ACN+5% 0.025% Aq TFA; T/B%: 0.01/5, 0.5/5, 3/100, 5/100; flow rate: 1.2 mL/min) (Gradient); TLC: 30% EtOAc/ hexane (Rj: 0.6)

According to the analysis of related databases, 33170-72-8, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 33170-72-8

Step 1: (1,1-Dimethoxypropan-2-yl)hydrazine 6.25 g (34.1 mmol) of 2-bromo-1,1-dimethoxypropane and 6.65 ml (137 mmol) of hydrazine hydrate were stirred under reflux in an oil bath at 140 C. for 6 h. After cooling, the two-phase reaction mixture was extracted with 50 ml of tert-butyl methyl ether. The organic phase was filtered, the filtrate was concentrated on a rotary evaporator and the residue was dried under high vacuum. This gave 1.89 g (21% of theory) of a pale yellow oil which was reacted directly, without further purification, in the subsequent reaction.

The synthetic route of 33170-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; SUessMEIER, Frank; LOBELL, Mario; GRUeNEWALD, Sylvia; HAeRTER, Michael; BUCHMANN, Bernd; TELSER, Joachim; JOeRIssEN, Hannah; HEROULT, Melanie; KAHNERT, Antje; LUSTIG, Klemens; LINDNER, Niels; US2013/190290; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 33170-72-8

A solution of methyl 5-amino-6-bromopyrazine-2-carboxylate (500 mg, 2.15 mmol, 1.00 equiv),2-bromo-i,i-dimethoxypropane (1.2 g, 6.56 mmol, 3.00 equiv), p-toluenesulfonic acid (76 mg,0.44 mmol, 0.20 equiv) in acetonitrile (20 mL) was stuffed for 12 h at 80 C. The mixture was concentrated under vacuum and the residue was purified by a silica gel column eluting with dichloromethane/methanol (10:1). This resulted in 400 mg (69%) of the title compound as a yellow solid. LC-MS (ES, mlz): 270 [M+H].

The synthetic route of 33170-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, A new synthetic method of this compound is introduced below., Computed Properties of C5H11BrO2

(Cis) -2- [4- [3- (2H-1,2,3-triazol-2-yl) phenylamino](Amino) -5- (carbamoyl) pyrimidin-2-ylamino] cyclohexylcarbamate (1.0 g, 2 mmol) was dissolved in 20 mL DMF,2-Bromo-1,1-dimethoxypropane (1.8 g, 10 mmol) was added and the reaction was carried out at 60 C for 48 h.After adding ice-water, the mixture was extracted with ethyl acetate,Dried, concentrated and separated by silica gel column (methanol: methylene chloride = 1: 10) to give 110 mg of the product in 10% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KBP Biosciences Co., Ltd.; Wang, Aichen; Qian, Linyi; (29 pag.)CN104640863; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem