Category: 321-28-8

On May 31, 2018, Ogruc Ildiz, G.; Konarska, J.; Fausto, R. published an article.SDS of cas: 321-28-8 The title of the article was Structural transformations of 3-fluoro and 3-fluoro-4-methoxy benzaldehydes under cryogenic conditions: A computational and low temperature infrared spectroscopy investigation. And the article contained the following:

Structural transformations of 3-fluorobenzaldehyde (C7H5FO; 3FBA) and 3-fluoro-4-methoxybenzaldehyde (C8H7FO2; 3F4MBA), taking place in different solid phase environments and at low temperature, were investigated by IR spectroscopy, complemented by quantum chem. calculations undertaken at the DFT(B3LYP)/6-311++G(d,p) level of approximation The studied compounds were isolated from gas phase into cryogenic inert matrixes (Ar, Xe), allowing to characterize their equilibrium conformational composition in gas-phase at room temperature In both cases, two conformers differing by the orientation of the aldehyde moiety (with the carbonyl aldehyde bond cis or trans in relation to the aromatic ring fluorine substituent) were found to coexist, with the cis conformer being slightly more populated than the trans form. In situ narrowband UV irradiation of the as-deposited matrixes led either to preferential isomerization of the cis conformer into the trans form or decarbonylation of both conformers, depending on the used excitation wavelength. Deposition of the vapors of 3F4MBA only, onto the cold (15 K) substrate, produced an amorphous solid containing also both the cis and trans conformers of the compound Subsequent heating of the amorphous phase up to 268 K led to crystallization of the compound, which is accompanied by conformational selection, the cis form being the single species present in the crystal. The exptl. observed transformations of the studied compounds, together with the structural and vibrational results obtained from the performed quantum chem. calculations, allowed a detailed structural and vibrational characterization of the individual conformers. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to fluorobenzaldehyde photodecarbonylation conformational isomerization ir spectra, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.SDS of cas: 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ding, Wei; Wang, Chen; Tan, Jie Ren; Ho, Chang Chin; Leon, Felix; Garcia, Felipe; Yoshikai, Naohiko published an article in 2020, the title of the article was Site-selective aromatic C-H λ3-iodanation with a cyclic iodine(III) electrophile in solution and solid phases.Recommanded Product: 321-28-8 And the article contains the following content:

An efficient and site-selective aromatic C-H λ3-iodanation reaction was achieved using benziodoxole triflate (BXT) as an electrophile under room temperature conditions. The reaction tolerated a variety of electron-rich arenes and heteroarenes to afford the corresponding arylbenziodoxoles I [R = 4-OMeC6H4, 2,4-di-MeC6H3, 2-thienyl, etc.] in moderate to good yields. The reaction could also be performed mechanochem. by grinding a mixture of solid arenes and BXT under solvent-free conditions. The arylbenziodoxoles could be used for various C-C and C-heteroatom bond formations and are also amenable to further modification by electrophilic halogenation. DFT calculations suggested that the present reaction proceeded via a concerted λ3-iodanation-deprotonation transition state, where the triflate anion acts as an internal base. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to arylbenziodoxole site selective preparation, arene benziodoxole triflate site selective aromatic iodanation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jovene, Cyril; Marrot, Jerome; Jasmin, Jean-Philippe; Chugunova, Elena; Goumont, Regis published an article in 2016, the title of the article was A Synthetic Pathway to Substituted Benzofuroxans through the Intermediacy of Sulfonates: The Case Example of Fluoro-Nitrobenzofuroxans.Name: 1-Fluoro-2-methoxybenzene And the article contains the following content:

Benzofuroxans are well known compounds that continue to attract particular attention since the discovery of 4,6-dinitrobenzofuroxan (DNBF) back in 1899. It has been shown that these compounds possess biol. activities that are related to their electronic behaviors and the positioning of substituents borne by the heterocycles. In this paper, we report the first synthesis of 4-fluoro-6-nitrobenzofuroxan and 6-fluoro-4-nitrobenzofuroxan; the altered positions of the substituents enabling us to carry out structural and reactivity comparisons, with DNBF and 4,6-difluorobenzofuroxan. These compounds have been unambiguously characterized through NMR and radiocrystallog. studies. Two main synthetic pathways involving fluoroanisoles and fluorophenols, cheap and easily available chems., have been successfully developed. Finally, benzofurazan analogs have been prepared via deoxygenation of corresponding benzofuroxans with tri-Et phosphite. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to benzofuroxan preparation sulfonate substitution heterocyclization, benzofurazan preparation deoxygenation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 31, 2016, Boursalian, Gregory B.; Ham, Won Seok; Mazzotti, Anthony R.; Ritter, Tobias published an article.COA of Formula: C7H7FO The title of the article was Charge-transfer-directed radical substitution enables para-selective C-H functionalization. And the article contained the following:

Efficient C-H functionalization requires selectivity for specific C-H bonds. Progress has been made for directed aromatic substitution reactions to achieve ortho and meta selectivity, but a general strategy for para-selective C-H functionalization has remained elusive. Herein we introduce a previously unappreciated concept that enables nearly complete para selectivity. We propose that radicals with high electron affinity elicit arene-to-radical charge transfer in the transition state of radical addition, which is the factor primarily responsible for high positional selectivity. We demonstrate with a simple theor. tool that the selectivity is predictable and show the utility of the concept through a direct synthesis of aryl piperazines. Our results contradict the notion, widely held by organic chemists, that radical aromatic substitution reactions are inherently unselective. The concept of radical substitution directed by charge transfer could serve as the basis for the development of new, highly selective C-H functionalization reactions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).COA of Formula: C7H7FO

The Article related to regioselective radical aromatic substitution arene selectfluor, piperazine aryl regioselective preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C7H7FO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 27, 2013, Ye, Yingda; Sanford, Melanie S. published an article.Application of 321-28-8 The title of the article was Mild Copper-Mediated Fluorination of Aryl Stannanes and Aryl Trifluoroborates. And the article contained the following:

This communication describes a mild copper-mediated fluorination of aryl stannanes and aryl trifluoroborates with N-fluoro-2,4,6-trimethylpyridinium triflate. This protocol demonstrates broad substrate scope and functional group tolerance, and does not require the use of any noble metal additives. The reaction is proposed to proceed via an arylcopper(III) fluoride intermediate. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application of 321-28-8

The Article related to copper catalyst fluorination aryl stannane trifluoroborate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 16, 2018, Tang, Ren-Jin; Milcent, Thierry; Crousse, Benoit published an article.Application of 321-28-8 The title of the article was Bisulfate Salt-Catalyzed Friedel-Crafts Benzylation of Arenes with Benzylic Alcohols. And the article contained the following:

A method of direct Friedel-Crafts benzylation of arenes with benzylic alcs. using cheap and readily available bisulfate salt as the catalyst in hexafluoroisopropanol, is reported. The catalytic system is powerful with a quite diverse group of functionalized arenes and benzylic alcs. These mild conditions provide a straightforward synthesis of a variety of unsym. diarylmethanes in high yield with good to high regioselectivity. An SN1 mechanism involving activation of the hydroxy group through a hydrogen bond is proposed. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application of 321-28-8

The Article related to arene benzylic alc friedel crafts benzylation bisulfate, diarylmethane preparation, bisulfate friedel crafts benzylation catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 7, 2020, Panigrahi, Adyasha; Whitaker, Daniel; Vitorica-Yrezabal, Inigo J.; Larrosa, Igor published an article.Electric Literature of 321-28-8 The title of the article was Ag/Pd Cocatalyzed Direct Arylation of Fluoroarene Derivatives with Aryl Bromides. And the article contained the following:

Diverse C-H functionalizations catalyzed by Pd employ Ag(I) salts added as halide abstractors or oxidants. Recent reports have shown that Ag can also perform the crucial C-H activation step in several of these functionalizations. However, all of these processes are limited by the wasteful requirement for (super)stoichiometric Ag(I) salts. Herein, we report the development of a Ag/Pd cocatalyzed direct arylation of (fluoroarene) chromium tricarbonyl complexes with bromoarenes. The small organic salt, NMe4OC(CF3)3, added as a halide abstractor, enables the use of a catalytic amount of Ag, reversing the rapid precipitation of AgBr. We have shown through H/D scrambling and kinetic studies that a (PR3)Ag-alkoxide is responsible for C-H activation, a departure from previous studies with Ag carboxylates. Furthermore, the construction of biaryls directly from the simple arene is achieved via a one-pot chromium tricarbonyl complexation/C-H arylation/decomplexation sequence using (pyrene)Cr(CO)3 as a Cr(CO)3 donor. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Electric Literature of 321-28-8

The Article related to biaryl preparation, fluoroarene chromium tricarbonyl complex bromoarene arylation silver palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Electric Literature of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 31, 2013, Liu, Zong-ying; Wang, Yue-ming; Han, Yan-xing; Liu, Ling; Jin, Jie; Yi, Hong; Li, Zhuo-rong; Jiang, Jian-dong; Boykin, David W. published an article.Recommanded Product: 1-Fluoro-2-methoxybenzene The title of the article was Synthesis and antitumor activity of novel 3,4-diaryl squaric acid analogs. And the article contained the following:

A series of novel 3,4-diaryl squaric acid analogs 4a-r related to combretastatin A-4 (CA4) using squaric acid as the cis-restricted linker were prepared and studied for their anticancer activity against selected human cancer cell lines. New compounds 4g, 4k, 4m, 4n, 4p, 4q and 4r exhibit strong activities against human leukemia cells with IC50 values of ≤20 nM and compounds 4k, 4n, 4p, 4q and 4r showed potent activities against a panel of human tumor cell lines. Compounds 4n and 4p arrest tumor cell cycle in G2-M phase. Computational modeling anal. suggests that the binding mechanism of compound 4n to the colchicine binding site on the microtubules is similar to that of CA4. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 1-Fluoro-2-methoxybenzene

The Article related to antitumor diaryl squaric acid analog, 3,4-diaryl squaric acid analogs, anticancer, cytotoxic agents, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Recommanded Product: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 21, 2018, Ho, Yee Ann; Leiendecker, Matthias; Liu, Xiangqian; Wang, Chengming; Alandini, Nurtalya; Rueping, Magnus published an article.Product Details of 321-28-8 The title of the article was Nickel-Catalyzed Csp2-Csp3 Bond Formation via C-F Bond Activation. And the article contained the following:

A nickel-catalyzed cross coupling of aryl fluorides via C-F bond activation has been developed. The alkylation method allows selective replacement of aryl fluorides by alkyl groups and enables the synthesis of diverse and otherwise difficult to access scaffolds in good yields. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Product Details of 321-28-8

The Article related to alkylarene preparation, aryl fluoride alkyl grignard reagent cross coupling nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Product Details of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 11, 2018, Su, Ji; Chen, Qian; Lu, Le; Ma, Yuan; Auyoung, George Hong Lok; Hua, Ruimao published an article.SDS of cas: 321-28-8 The title of the article was Base-promoted nucleophilic fluoroarenes substitution of C-F bonds. And the article contained the following:

With the use of KOH/DMSO as the superbase medium, the nucleophilic fluoroarene substitution for C-F bonds was presented. The transformation proceeds smoothly with the use of fluoroarenes such as 2-fluoro-benzamide, 3-fluorobenzaldehyde, 3,4-difluoronitrobenzene, etc. bearing not only electron-withdrawing group, but also electron-donating group and a variety of nucleophiles such as methanol, phenol, dimethylamine, 1H-pyrrole, benzamide, etc.. The double nucleophilic substitution using 3,4-difluoronitrobenzene and nucleophiles bearing ortho-dinucleophilic groups such as 1,2-ethanediol, 1,2-benzenediol, 2-amino-phenol results in the formation of 6-Nitro-2,3-dihydrobenzo[b][1,4]dioxine, 2-Nitrodibenzo[b,e][1,4]dioxine and 2-Nitro-10H-phenoxazine in moderate to good yields. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to ether preparation, fluoroarene alc nucleophilic substitution, arylamine preparation, amine fluoroarene nucleophilic substitution, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.SDS of cas: 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem