Category: 321-28-8

On February 1, 2015, Kurata, Haruto; Gentry, Patrick R.; Kokubo, Masaya; Cho, Hyekyung P.; Bridges, Thomas M.; Niswender, Colleen M.; Byers, Frank W.; Wood, Michael R.; Daniels, J. Scott; Conn, P. Jeffrey; Lindsley, Craig W. published an article.Quality Control of 1-Fluoro-2-methoxybenzene The title of the article was Further optimization of the M5 NAM MLPCN probe ML375: Tactics and challenges. And the article contained the following:

This Letter describes the continued optimization of the MLPCN probe ML375, a highly selective M5 neg. allosteric modulator (NAM), through a combination of matrix libraries and iterative parallel synthesis. True to certain allosteric ligands, SAR was shallow, and the matrix library approach highlighted the challenges with M5 NAM SAR within in this chemotype. Once again, enantiospecific activity was noted, and potency at rat and human M5 were improved over ML375, along with slight enhancement in physiochem. properties, certain in vitro DMPK parameters and CNS distribution. Attempts to further enhance pharmacokinetics with deuterium incorporation afforded mixed results, but pretreatment with a pan-P 450 inhibitor (1-aminobenzotriazole; ABT) provided increased plasma exposure. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Quality Control of 1-Fluoro-2-methoxybenzene

The Article related to enantiospecific activity, m(5), matrix library, muscarinic receptor, negative allosteric modulator, pharmacokinetics, Pharmacology: Structure-Activity and other aspects.Quality Control of 1-Fluoro-2-methoxybenzene

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On May 1, 2012, Liu, Chang; Jin, Jing; Chen, Liang; Zhou, Jie; Chen, Xiaoguang; Fu, Decai; Song, Hongrui; Xu, Bailing published an article.Reference of 1-Fluoro-2-methoxybenzene The title of the article was Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. And the article contained the following:

A series of novel benzophenone derivatives were prepared and their inhibitory activities were evaluated on hPin1. Of all the synthesized compounds, the most active compound displayed inhibitory activities with an IC50 value of 5.99 μmol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The results of this research will shed light on further design and optimization of novel small mol. Pin1 inhibitors. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene

The Article related to benzophenone derivative preparation structure pin1 inhibitor, Pharmacology: Structure-Activity and other aspects.Reference of 1-Fluoro-2-methoxybenzene

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On June 18, 2019, Wei, Kajia; Cao, Xiaoxin; Gu, Wancong; Liang, Peng; Huang, Xia; Zhang, Xiaoyuan published an article.HPLC of Formula: 321-28-8 The title of the article was Ni-Induced C-Al2O3-Framework (NiCAF) Supported Core-Multishell Catalysts for Efficient Catalytic Ozonation: A Structure-to-Performance Study. And the article contained the following:

During catalytic ozonation, Al2O3-supported catalysts usually have stable structures but relatively low surface activity, while carbon-supported catalysts are opposite. To encourage their synergisms, we designed a Ni-induced C-Al2O2-framework (NiCAF) and reinforced it with a Cu-Co bimetal to create an efficient catalyst (CuCo/NiCAF) with a core-multishell structure. The partial graphitization of carbon adjacent to Ni crystals formed a strong out-shell on the catalyst surface. The rate constant for total organic carbon removal of CuCo/NiCAF (0.172 ± 0.018 min-1) was 67% and 310% higher than that of Al2O3-supported catalysts and Al2O3 alone, resp. The metals on CuCo/NiCAF contributed to surface-mediated reactions during catalytic ozonation, while the embedded carbon enhanced reactions within the solid-liquid boundary layer and in the bulk solution Moreover, carbon embedment provided a 76% increase in ·OH-production efficiency and an 86% increase in organic-adsorption capacity compared to Al2O3-supported catalysts. During the long-term treatment of coal-gasification wastewater (∼5 m3 day-1), the pilot-scale demonstration of CuCo/NiCAF-catalyzed ozonation revealed a 120% increase in ozone-utilization efficiency (ΔCOD/ΔO3 = 2.12) compared to that of pure ozonation (0.96). These findings highlight catalysts supported on NiCAF as a facile and efficient approach to achieve both high catalytic activity and excellent structural stability, demonstrating that they are highly viable for practical applications. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).HPLC of Formula: 321-28-8

The Article related to nickel carbon aluminum framework catalytic ozonation wastewater treatment, Placeholder for records without volume info and other aspects.HPLC of Formula: 321-28-8

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Beni, Ryan; Boadi, William; Karim, Kaleh; Alnakhli, Jawzah; Alhamed, Samiyah published an article in 2019, the title of the article was Synthesis and antiproliferative activities of triphenylmethanol conjugates of leuprorelin.SDS of cas: 321-28-8 And the article contains the following content:

Leuprorelin (LEP) is an FDA drug for breast cancer and prostate cancer treatment. There are several reported adverse effects such as transient hypertension, excessive salivation, and increased dysuria during treatment with LEP. In this study, the efficacy and toxicity of LEP were modified by using a drug delivery system to adjust the physicochem. properties. In this regard, Leuprorelin conjugates of triphenylmethanol derivatives (TPMs) were synthesized as prodrugs. Comparative antiproliferative assays showed that LEP-TPMs conjugates had significantly higher antiproliferative activities than the corresponding non-covalent phys. mixtures of the TPMs and LEP against human invasive ductal carcinoma (BT549), human prostate carcinoma (PC3), human lung cancer (A549) and mouse pre-adipocytes (3T3-L1) cells. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to leuprorelin triphenylmethanol conjugate antiproliferative invasive ductal prostate carcinoma adipocyte, Placeholder for records without volume info and other aspects.SDS of cas: 321-28-8

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Pisanenko, Dmitrii A.; Klimko, Yurii E.; Voljanskii, Yurii L. published an article in 2017, the title of the article was Synthesis and antimicrobial activity of some halogenated isopentyl phenols.SDS of cas: 321-28-8 And the article contains the following content:

Some halogenated isopentyl phenols were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Streptococcus viridans, Escherichia coli, Shigella flexneri, Salmonella typhi, Salmonella typhimurium, B.proteus vulgaris, Pseudomonas aeruginosa, Bacterium anthracoides, Bacterium subtilis, Klebsiella rhinoscleromatis and Candida albicans using the microdilution method. Antimicrobial tests results indicated that all compounds have reasonable activity. They displayed the highest antimicrobial activity against Streptococcus aureus, Streptococcus viridans and Candida albicans. The isopentyl phenols containing chlorine atoms were the most active than the fluorine containing phenols in the series against majority tested bacteria and fungi strains. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to staphylococcus escherichia streptococcus halogenated isopentyl phenol antimicrobial, Placeholder for records without volume info and other aspects.SDS of cas: 321-28-8

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On July 31, 2014, Vaz, Raquel V.; Magalhaes, Ana L.; Silva, Carlos M. published an article.Product Details of 321-28-8 The title of the article was Prediction of binary diffusion coefficients in supercritical CO2 with improved behavior near the critical point. And the article contained the following:

In this work, a predictive model for binary diffusivities at infinite dilution (D12) in SC-CO2 is proposed. It combines two terms – background and singular – with the objective to represent D12 accurately not only far but also near the critical point, where critical enhancement is always observed The model provides an average error of 6.20% for a large database including 149 systems and 4469 data points over wide ranges of temperature and pressure. The models selected for comparison (Wilke-Chang, Scheibel, Lusis-Ratcliff, Lai-Tan, Tyn-Calus and Reddy-Doraiswamy) achieve scattered and biased results, with average errors from 11.62-75.17%. In the whole, the new model exhibits an excellent performance for any kind of mols. in terms of size, mol. weight, polarity and sphericity, in all critical region. In order to help interested readers, a spreadsheet for the calculation of D12 is given in supplementary data. The input data is: temperature, pressure, CO2 viscosity, and solute properties (acentric factor, critical constants, molar volume at normal b.p., and mol. weight – given in this paper for the systems studied). The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Product Details of 321-28-8

The Article related to binary diffusion supercritical carbon dioxide critical point prediction, Unit Operations and Processes: Mass Transfer and other aspects.Product Details of 321-28-8

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On January 19, 2018, Tang, Ren-Jin; Milcent, Thierry; Crousse, Benoit published an article.Quality Control of 1-Fluoro-2-methoxybenzene The title of the article was Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol. And the article contained the following:

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcs. is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Addnl., the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Quality Control of 1-Fluoro-2-methoxybenzene

The Article related to haloarene haloheterocycle regioselective preparation, arene heterocycle regioselective halogenation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 1-Fluoro-2-methoxybenzene

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On November 30, 2013, Magalhaes, Ana L.; Vaz, Raquel V.; Goncalves, Ricardo M. G.; Da Silva, Francisco A.; Silva, Carlos M. published an article.Application In Synthesis of 1-Fluoro-2-methoxybenzene The title of the article was Accurate hydrodynamic models for the prediction of tracer diffusivities in supercritical carbon dioxide. And the article contained the following:

The tracer diffusion coefficients, D12, are fundamental properties for the design and simulation of rate-controlled processes. Nowadays, under the scope of the biorefinery concept and strict environmental legislation, the D12 values are increasingly necessary for extractions, reactions, and chromatog. separations carried out at supercritical conditions, particularly using carbon dioxide. Hence, the main objective of this work is the development of accurate and simple models for the pure prediction of D12 values in supercritical CO2. Two modified Stokes-Einstein equations (mSE1 and mSE2) are proposed and validated using a large database comprehending extremely distinct mols. in terms of size, mol. weight, polarity and sphericity. The global deviations achieved by the mSE1 (Eqs. (2) and (13)) and mSE2 (Eqs. (5), (13), (3), (4)) models are only 6.38% and 6.75%, resp., in contrast to the significant errors provided by known predictive correlations available in the literature: Wilke-Chang, 12.17%; Tyn-Calus, 17.01%; Scheibel, 19.04%; Lusis-Ratcliff, 27.32%; Reddy-Doraiswamy, 79.34%; Lai-Tan, 25.82%. Also, the min. and maximum deviations achieved by the new models are much smaller than those of the reference equations adopted for comparison. In conclusion, the mSE1 and mSE2 models can be recommended for the prediction of tracer diffusivities in supercritical CO2. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application In Synthesis of 1-Fluoro-2-methoxybenzene

The Article related to accurate hydrodynamic model prediction tracer diffusivities supercritical carbon dioxide, Unit Operations and Processes: Mass Transfer and other aspects.Application In Synthesis of 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
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On February 29, 2020, Aukland, Miles H.; Siauciulis, Mindaugas; West, Adam; Perry, Gregory J. P.; Procter, David J. published an article.Recommanded Product: 321-28-8 The title of the article was Metal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation. And the article contained the following:

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to arene heteroarene dibenzothiophene oxide photocatalyst regioselective cross coupling reaction, heterobiaryl preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 321-28-8

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On September 27, 2019, Devleshova, Natalia A.; Lozovskiy, Stanislav V.; Vasilyev, Aleksander V. published an article.Recommanded Product: 1-Fluoro-2-methoxybenzene The title of the article was Reactions of alkyl 4-hydroxybut-2-ynoates with arenes under superelectrophilic activation with triflic acid or HUSY zeolite: Alternative propargylation or allenylation of arenes, and synthesis of furan-2-ones. And the article contained the following:

Reactions of alkyl 4-aryl(or 4,4-diaryl)-4-hydroxybut-2-ynoates [Ar(H or Ar’)(OH)C4-C3≡C2-CO2Alk], (Ar = Ar’ = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, etc.; Alk = Me, Et) with arenes under the action of triflic acid TfOH or HUSY zeolite result in the formation of two main compounds, aryl substituted furan-2-ones I (Ar1 = Ar2 = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, etc.; Ar3 = 2,5-di-MeC6H3, 3,4-di-MeC6H3, 3-F,4-MeC6H3, etc.) or products of propargylation II (Ar1 = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, etc.; Ar3 = 2,5-di-MeC6H3, 3,4-di-MeC6H3, 3-F,4-MeC6H3, etc.; Alk = Me, Et) of electron rich arenes. Key reactive intermediates in these transformations are the corresponding O,O-diprotonated forms of starting butynoates, Ar(H or Ar’)(+OH2)C4-C3≡C2-C(=O+H)(OAlk), dehydration of which gives rise to mesomeric propargyl-allenyl cations Ar(H or Ar’)(OH)4C+-C3≡C2-C(=O+H)(OAlk) ↔ Ar(H or Ar’)(OH)4C = C3 = 2C+-C(=O+H)(OAlk), having two electrophilic centers on the carbons C4 and C2 resp. Reactions of these species with arenes at C4 lead to products of arene propargylation, alternatively, reactions at C2 result in allenylation of arenes, followed by further transformation into furan-2-ones. Using quantum chem. calculations by the DFT method, it has been shown that the reactivity of such propargyl-allenyl cations is mainly explained by orbital factors. Plausible reaction mechanism is discussed. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 1-Fluoro-2-methoxybenzene

The Article related to furanone propargylated ester preparation, alkyl hydroxybutynoate arene propargylation allenylation triflic acid zeolite, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Recommanded Product: 1-Fluoro-2-methoxybenzene

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