Category: 31465-36-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31465-36-8, name is 4-(4-Methoxyphenoxy)aniline, A new synthetic method of this compound is introduced below., Recommanded Product: 31465-36-8

PREPARATION 11 2-Amino-6-(4-methoxyphenoxy)benzothiazole Following a procedure similar to that described in Preparation 1, 13.50 g of the title compound were obtained as light brown fine crystals, melting at 165-167 C., from 15.00 g of 4-(4-methoxyphenoxy)aniline.

The synthetic route of 31465-36-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sankyo Company, Limited; US5002942; (1991); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 31465-36-8, These common heterocyclic compound, 31465-36-8, name is 4-(4-Methoxyphenoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of a 3{1,1} (1.4 g, 5.53 mmol) and phenyl isothiocyanate (1.08 mL, 8.27 mmol) in anhyd DMF (8.0 mL) was stirred at room temperature for 6-7 h. Thereafter the reaction mixture was diluted with 50 mL H2O and extracted with EtOAc (4 x 20 mL). The combined organic layer was dried over anhyd Na2SO4, concentrated and the residue thus obtained was purified through silica-gel column chromatography using EtOAc-Hexanes (70-90:30-10, v/v) as eluent to yield 4{1,1,1} as a white solid (1.7 g, 80%).

The synthetic route of 31465-36-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mishra, Amita; Batchu, Harikrishna; Srivastava, Kumkum; Singh, Pratiksha; Shukla, Pravin K.; Batra, Sanjay; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1719 – 1723;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 31465-36-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31465-36-8 name is 4-(4-Methoxyphenoxy)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 3-aminobenzensulfoneamide (2.3g, 13.3 mmol) in DMF (12 ml), K2CO3 (3.8 g, 27.0 mmol)and ethylbromoacetate (2.67 g, 16.0 mmol) were added at ambient temperature. The reaction mixture was stirred for 15 hours atroom temperature. The reaction mixture was quenched with sat. NH4Cland extracted with EtOAc. The combined extracts were washed with brine, driedover MgSO4 and evaporated down. Theresidue was purified by silica gel column chromatography to give 2.44 g ofdesired 2h-1 in 71 % yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(4-Methoxyphenoxy)aniline, and friends who are interested can also refer to it.

Reference:
Article; Teno, Naoki; Gohda, Keigo; Wanaka, Keiko; Tsuda, Yuko; Sueda, Takuya; Yamashita, Yukiko; Otsubo, Tadamune; Bioorganic and Medicinal Chemistry; vol. 22; 7; (2014); p. 2339 – 2352;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31465-36-8, name is 4-(4-Methoxyphenoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 4-(4-Methoxyphenoxy)aniline

EXAMPLE 1 In this experiment, 1,3-bis(4-(4-hydroxyphenoxy)phenyl)urea was synthesized utilizing a three step procedure. In the first step of this procedure ethyl(4-(4-methoxyphenoxy)phenyl)carbamate was synthesized by reacting 4-(4-methoxyphenoxy)aniline in the presence of pyridine and ethyl chloroformate according to the following reaction: In the procedure used 23.7 mmol of starting material, 100 ml of DCM and 46.5 mmol of pyridine were combined in a round bottom flask and cooled to a temperature of 0 C. Then 34.8 mmol of ethyl chloroformate was added drop wise over time and maintained at a temperature of 0 C. Then the reaction product was quenched with hydrochloric acid (HCl), dried, concentrated, washed with hexanes solvent, and dried. In this step of the procedure a yield of about 94 percent was attained. In the second step of the procedure was then carried out according to the following reaction scheme where 1,3-bis(4-(4-Methoxyphenoxy)phenyl)urea was made from ethyl(4-(4-Methoxyphenoxy)phenyl)carbamate and 4-(4-Methoxyphenoxy)aniline in the presence of toluene and trimethyl aluminum: In this step of the procedure 4-(4-methoxyphenoxy)aniline was dissolved in toluene (1:25 in toluene) and cooled to a temperature -5 C. Trimethyl aluminum (AlCH3)3 was then added over time under positive nitrogen (N2) pressure with a significant exotherm being experienced). Ethyl(4-(4methoxyphenoxy)phenyl)carbamate was then added as a solid in small portions and heated to a temperature of 80 C. for 8 hours. It was then cooled and quenched with hydrochloric acid (HCl). This step was conducted using caution because the hydrochloric acid generates a significant exothermic reaction and gas formation. The resulting paste was filtered, rinsed with ether and water and was then dried under vacuum with a yield of 79% being attained. The following reaction was carried out as the third and final step of the synthesis procedure wherein the 1,3-bis(4-(4-hydroxyphenoxy)phenyl)urea (U-2EPO) was made from 1,3-bis(4-(4-methoxyphenoxy)phenyl)carbamate in dichloromethane and tetrabromoborane (BBr3):

The synthetic route of 31465-36-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ruffer, JR., Ronald Q.; (10 pag.)US2016/89919; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem