Category: 2982-54-9

Electric Literature of 2982-54-9,Some common heterocyclic compound, 2982-54-9, name is 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, molecular formula is C15H18ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The free base was made by partitioning the solid between Et2O and 2 M aq. NaOH solution. The organic layer was washed with sat. aq. NaCl solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-(4-benzyloxyphenyl)ethyl amine as a white solid, 8.92 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, its application will become more common.

Reference:
Patent; Rigel Pharmaceuticals, Inc.; Goff, Dane; Payan, Donald G.; Braselmann, Sylvia; US2013/237524; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2982-54-9,Some common heterocyclic compound, 2982-54-9, name is 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, molecular formula is C15H18ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 100 ml flask as added lH-pyrrolo[3,2-c]pyridine-2-carboxylic acid (100 mg and 0.617 mmol) 2-(4-(benzyloxy)phenyl)ethanamine HC1 (195 mg, 0.740 mmol) in DMF (10 ml) to give a light yellow suspension. HATU (352 mg, 0.925 mmol) and DIEA (319 mg, 2.467 mmol) were added. The mixture was stirred at RT for 16 hours. Added water and extracted with ethyl acetate (3 x 20 mL). The organic layers were combined and washed with water (3 x 20 mL). The organic was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure The Biotage purification affordedl40 mg of the product (61%). ¾ NMR (DMSO-d6). delta 13.00 (s, 1H), 9.30 (s, 1H), 9.00 (m, 1H), 8.37 (d, H), 7.78 (d, 1H), 7.52(s, 1H), 7.30-7.47 (m, 5H), 7.18(d, 2H), 6.90(d, 2H), 5.02(s, 2H), 3.37(m, 2H0, 2.80(m, 2H). LC-MS: 472.25 (M+l)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, its application will become more common.

Reference:
Patent; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; HAN, Bingsong; KUNTZ, Judith D.; LIN, Jian; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZHENG, Xiaozhang; WO2012/154194; (2012); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 2982-54-9, These common heterocyclic compound, 2982-54-9, name is 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4. Preparation of 3-((2-(4-benzyloxy-phenyl)-ethylamino)-methyl)-7-methyl-chromen-2-one: 7-Methyl-2-oxo-2H-chromen-3-carbaldehyde (380mg, 2.02mmol) (ScetharamaiyerPadmanabhan, Ravikumar Peri and David J. Triggle, Syn. Comm., 26(4), pp 827-831, 1996) and the compound (130mg, 0.40mmol) prepared in the step 3 were dissolved in dried THF (6ml) and methanol (12ml). thereto triethylamine (0.96ml, 6.87mmol) was added and the reaction mixture was stirred at room temperature for 3 hours. Thereafter, the temperature was lowered to O0C, and thereto acetic acid (0.41ml, 7.07mmol) and sodiumborohydride (0.178mg, 2.83mmol) were added, and the reaction mixture was stirred at O0C for 2 hours. Ice water (0.1ml) was added to quench the reaction, and aqueous layer was extracted with ethyl acetate. Combined organic layer was concentrated under reduced pressure. The residue was purified by column chromatography (n-hexane:ethyl acetate = 1:1) to give 240mg (yield: 29.1%, white solid) of the target compound. 1H-NMR (CDC13, 400MHz) delta 6.79-7.79(m, 13H), 5.05(s, 2H), 4.57(m, IH),2.78-3.54(m, 6H), 2.28(s, 3H)

Statistics shows that 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride is playing an increasingly important role. we look forward to future research findings about 2982-54-9.