Category: 295376-21-5

Application of 295376-21-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 295376-21-5, name is 1-Bromo-2-fluoro-3-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

At room temperature, add 20 mL of toluene, compound 3-2 (4.8 g, 23.18 mmoL),Tris (dibenzylideneacetone) dipalladium (0.28g, 0.31mmoL),Tris (o-methylphenyl) phosphorus (0.19g, 0.62mmoL), replaced with nitrogen three times,The temperature was raised to 60 to 70 C. Add the toluene solution of compound 2 in the three-necked bottle R1 dropwise,After the dropwise addition, keep it at 60 70 for 1h;The reaction solution was filtered through celite, and the filtrates were combined and washed with 20 mL of water.It was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated in vacuo to about 20 mL at 50 C, and cooled to 20-30 C. 160 mL of n-heptane was added dropwise to precipitate a solid, which was filtered to obtain a off-white solid, without further drying One-step synthesis

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-fluoro-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lizhu Group Xin Beijiang River Pharmaceutical Co., Ltd.; Wang Biao; Peng Murong; Huang Lixia; Chen Guo; Li Chengbo; Feng Qiqing; (16 pag.)CN110372608; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

295376-21-5, name is 1-Bromo-2-fluoro-3-methoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1-Bromo-2-fluoro-3-methoxybenzene

A 250ml three-necked flask was charged with 5 g (24.4 mmol) of 2-fluoro-3-methoxy-bromobenzene,13.5 g (103.74 mmol) of ethyl acetoacetate,55ml of dimethyl sulfoxide,L-proline 1.12 g (9.76 mmol),930 mg (4.88 mmol) of cuprous iodide,Under the protection of nitrogen, 32 g (97.6 mmol) of cesium carbonate was added, and the reaction was kept at 60 to 70 C for 4 to 5 hours.Stop the reaction, add 40 ml of saturated ammonium chloride solution, stir to dissolve, add 40 ml * 2 ethyl acetate for extraction, combine the ethyl acetate layers, wash the layers with saturated brine, and perform column chromatography (mobile phase ethyl acetate: petroleum ether = 1:15)5.4 g (21.3 mmol) of compound I was obtained as a pale yellow oil with a yield of 87.2%.

The synthetic route of 295376-21-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 295376-21-5, name is 1-Bromo-2-fluoro-3-methoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 295376-21-5

A compound of formula 6a (20.50 g, 100 mmol), 7a (15.62 g, 120 mmol) and dimethyl sulfoxide (102 mL) were added to a three-neck flask.After stirring and stirring, cuprous iodide (1.90 g, 10 mmol), L-valine (1.15 g, 10 mmol), potassium carbonate (27.64 g, 200 mmol),Vacuum switching nitrogen 3 times,The temperature is raised to 45 to 50 C for 6 to 8 hours.After completion of the reaction, the reaction was quenched by the addition of ammonium chloride solution (204 mL), and extracted with ethyl acetate (102 mL), and the organic phase was combined and washed with saturated brine.Then, dry anhydrous sodium sulfate, concentrated to remove some solvent under reduced pressure, add petroleum ether to be beaten, filter, collect solids and dry to produce Product 8a (21.66 g, 74%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Zheng Xuchun; Zhang Yiping; Fu Chenchen; (12 pag.)CN108586359; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem